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Quantitative analysis of urinary endogenous markers for the treatment effect of Radix Scutellariae on type 2 diabetes rats

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Chinese Chemical Letters 2017年第6期28卷 1214-1219页

作者： Guang-Yue Hou Li-Hui Men Lu Wang Zhong Zheng Zhi-Qiang Liu Feng-rui song Zhong-Ying Liu National Center for Mass Spectrometry in Changchun & Jilin Province Key Laboratory of Chinese Medicine Chemistry and Mass Spectrometry Changchun Institute of Applied ChemistryChinese Academy of Sciences School of Pharmaceutical Sciences Jilin University

The effect of Radix Scutellariae treated on type 2 diabetic rats has been investigated by a liquid chromatography coupled with tandem mass spectrometry（LC-MS/MS） based urinary quantitative *** this research,multiple reactions monitoring mode of MS/MS in LC-MS/MS analysis was used to quantitatively analyze the concentrations of 7 endogenous compounds in urine of normal control group,type 2 diabetic model group and Radix Scutellariae-treated group,and multivariate statistical analysis was utilized for MS data *** above-mentioned three groups can be distinguished via pattern *** obtained results indicated that Radix Scutellariae affect the urinary metabolic profiling of type 2 diabetic rats on the polyol pathway,protein glycation reaction and amino acids metabolism *** to these results,Radix Scutellariae should have the pharmacological effect on preventing or delaying the onset and progression of diabetes and its complications.

关键词： LC-MS/MS Endogenous markers Multivariate statistical analysis Type 2 diabetic complications Radix Scutellariae

A simple and controllable nanostructure comprising non-conductive poly（vinylidene fluoride） and graphene nanosheets for supercapacitor

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Frontiers of Materials Science 2012年第2期6卷 149-159页

作者： Jing SUN Ling-Hao HE Qiao-Ling ZHAO Li-Fang CAI rui song Yong-Mei HAO Zhi MA WeiHUANG Key Lab of Surface and Interface Sciences of Henan Provincial Zhengzhou University of Light IndustryZhengzhou 450002China Shanghai Institute of Organic Chemistry Chinese Academy of SciencesShanghai 200032china College of Chemistry and Chemical Engineering Gracluate University of Chinese Academy of SciencesBeijing 100049China Laboratory of Advanced Polymer Materials Institute of Chemistry Chinese Academy of SciencesBeijing 100080China

An effective method was used to Ioidal suspensions of highly reduced graphene produce stable and homogeneous coloxide （RGO） in N,N-dimethylformamide （DMF） without the assistance of dispersing agents. According to the results of general characterization, relatively pure graphene sheets with the morphology of single layer or few-layer structure were obtained. Then nanocomposite powders of RGO and poly （vinylidene fluoride）（PVDF） were prepared by vacuum filtration of the mixed dispersions of both components. The nanocomposites exhibit a high-frequency capacitative response with small equivalent series resistance （ESR） at 0.4Q, a nearly rectangular cyclic voltammogram and possess a rapid current response as electrodes for supercapacitor in 5mol/L KOH electrolyte. Furthermore, after 600 galvanostatic charge/ discharge cycles, the supercapacitor still performs a very high stability and efficiency of capacitance.

关键词： reduced graphene oxide (RGO) poly(vinylidene fluoride) (PVDF) nano.,composite supercapacitor

Design,synthesis and biological evaluation of sulfenimine cephalosporin sulfoxides as β-lactamase inhibitors

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Chinese Chemical Letters 2015年第6期26卷 801-803页

作者： Kai Zhang Huai-Wei Ding Hao Ju Qi Huang Li-Juan Zhang Hong-rui song De-Cai Fu Key Laboratory of Structure-Based Drug Design & Discovery Ministry of EducationShenyang Pharmaceutical University College of Chemical and Pharmaceutical Engineering Hebei University of Science and Technology

A series of sulfenimine cephalosporin sulfoxide derivatives （Ta-v） were designed, synthesized and evaluated for their inhibitory activity against TEM-1 and cephalosporinase in cell-free systems. Some of the tested compounds showed enhanced inhibitory activity against class C β-lactamase cephalospor- inase compared with the tazobactam. The most promising compounds 7c and 7n （IC50 ~ 7.6 and 8.6 μmol/L, respectively） were further investigated in combination with cefradine against a variety of clinical isolated fi-lactamase-producing bacterial strains.

关键词： β-Lactamase inhibitor Sulfenimine Synthesis

Synthesis and biological evaluation of new pyrrolopyrazinone compounds as potential antitumor agents

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Chinese Chemical Letters 2013年第7期24卷 619-621页

作者： Ying Meng Guan Wang Yue Li Kuan Hou Yue Yuan Li-Juan Zhang Hong-rui song Wei Shi Key Laboratory of Structure-Based Drug Design and Discovery Ministry of EducationShenyang Pharmaceutical University Key Laboratory for Molecular Enzymology and Engineering Ministry of EducationJilin University Key Laboratory for Molecular Enzymology and Engineering.Ministry of Education Jilin University

A series of pyrrolo[1,2-a]pyrazinone compounds （Sa-gf） were synthesized, and their cytotoxic activity against SKOV-3, A549, HeLa cells in vitro were evaluated by the MTF method. Some of the compounds showed potential antitumor activity against three tumor cell lines. Among them, compounds 9c and 9d showed the most potent cytotoxic activity. The preliminary mechanism of action was discussed.

关键词： Pyrrolopyrazinone Antitumor Synthesis

Asymmetric Mesoporous Carbon Microparticles by 3D-Confined Self-Assembly of Block Copolymer/Homopolymer Blends and Selective Carbonization

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Chinese Journal of Polymer Science 2023年第5期41卷 787-793,I0010页

作者： Jing-Ye Liu Hao-rui song Mian Wang Shao-Hong Jin Zheng Liang Xi Mao Wang Li Ren-Hua Deng Jin-Tao Zhu State Key Laboratory of Materials Processing and Die&Mould Technology Key Laboratory of Material Chemistry for Energy Conversion and Storage of Ministry of EducationSchool of Chemistry and Chemical EngineeringHuazhong University of Science and TechnologyWuhan 430074China

Shape control of mesoporous carbon microparticles(MCMPs)is of critical importance;in particular,asymmetric shapes that can yield unique properties have attracted significant ***,the tailored synthesis of asymmetric MCMPs with ordered structures remains ***,we report a facile route to prepare asymmetric MCMPs by dynamic neutral interface-guided 3D-confined self-assembly(3D-CSA)of block copolymer/homopolymer(BCP/hP)blends,followed by a self-templated selective direct carbonization ***/h P Janus microparticles with ordered hierarchical mesostructures were prepared with emulsion solvent evaporation-induced *** continuous phase of BCP domains was then *** asymmetric MCMPs are successfully generated after selective carbonization of the crosslinked continuous *** method allows tuning the shape of MCMPs easily by varying the blending ratio of BCP/h *** composite asymmetric MCMPs combine the advantages of asymmetric shape,ordered structure,high specific surface area,chemical inertness and thermal stability and could provide great possibilities for applications in catalysis,drug delivery,energy conversion and storage.

关键词： 3D-confined self-assembly Block copolymer Phase separation Mesoporous carbon spheres Janus

SV波作用下饱和土中深埋复合式衬砌动力响应研究

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振动工程学报 2020年第2期33卷 383-390页

作者：宋金博宋瑞江西交通职业技术学院江西南昌330013 南昌工程学院江西南昌330029

利用波函数展开法,得出了SV波作用下深埋复合式衬砌动应力集中问题的解析解,并将其退化为弹性介质中单层衬砌对SV波散射问题,验证了结果的可靠性。研究结果表明,饱和土中复合式衬砌内边界动应力集中系数大于外边界,其原因是内侧衬砌刚... 详细信息

利用波函数展开法,得出了SV波作用下深埋复合式衬砌动应力集中问题的解析解,并将其退化为弹性介质中单层衬砌对SV波散射问题,验证了结果的可靠性。研究结果表明,饱和土中复合式衬砌内边界动应力集中系数大于外边界,其原因是内侧衬砌刚度大于外侧衬砌刚度及衬砌内侧为凌空边界所致;增加内外侧衬砌的厚度可很大程度上减小衬砌内动应力集中系数;复合式衬砌刚度对衬砌动应力集中系数影响较为显著,在保证内外侧衬砌稳定的情况下,应尽量减小内外衬砌的刚度差,以减小衬砌内应力放大效应。

关键词：复合式衬砌 SV波饱和土圆形衬砌深埋

Optimization of Empty Pallets Dispatching Based on Different Transportation Modes

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Journal of Systems Science and Information 2017年第2期8卷 97-110页

作者： Kang ZHOU Shiwei HE rui song Weichuan YIN Lingyan CHENG School of Traffic and Transportation Beijing Jiaotong University MOE Key Laboratory for Urban Transportation Complex Systems Theory and Technology Beijing Jiaotong University

In the pallet pool system, the differentiation of palletized freight volumes in different regions and seasonal transport of certain goods lead to the imbalance of pallets distribution among regions. It is necessary to improve the utilization of pallets through dispatching. The paper analyzes the factors which affect empty pallets dispatching, it includes carbon emission, transportation time and pallet type based on the pallet pool mode of enterprise alliance. On this basis, the optimization model is established with the goal of minimum total dispatching cost. Then, according to the different influences of railway and highway in transportation cost, the dispatching scheme is analyzed and the transportation mode of empty pallets dispatching is determined. Considering the characteristics of model, Cplex is used to solve it. Finally, a case is used to verify the feasibility and superiority of reasonable empty pallets dispatching in different transportation modes, and the transport characteristics of two transportation modes are analyzed. Moreover, the costs of pallets leasing and dispatching are compared.

关键词： freight dispatching optimization ILOG Cplex pallets pallet pool stochastic constraint

Optimal Tracking Control for a Class of Unknown Discrete-time Systems with Actuator Saturation via Data-based ADP Algorithm

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自动化学报 2013年第9期39卷 1413-1420页

作者： song rui-Zhuo XIAO Wen-Dong SUN Chang-Yin School of Automation and Electrical Engineering University ofScience and Technology Beijing Beijing 100083 China

为有致动器浸透和未知动力学的分离时间的系统的一个班的一个新奇最佳的追踪控制方法在这份报纸被建议。计划基于反复的适应动态编程(自动数据处理) 算法。以便实现控制计划，一个 data-based 标识符首先为未知系统动力学被构造。由介绍... 详细信息

为有致动器浸透和未知动力学的分离时间的系统的一个班的一个新奇最佳的追踪控制方法在这份报纸被建议。计划基于反复的适应动态编程(自动数据处理) 算法。以便实现控制计划，一个 data-based 标识符首先为未知系统动力学被构造。由介绍 M 网络，稳定的控制的明确的公式被完成。以便消除致动器浸透的效果， nonquadratic 表演功能被介绍，然后一个反复的自动数据处理算法被建立与集中分析完成最佳的追踪控制解决方案。为实现最佳的控制方法，神经网络被用来建立 data-based 标识符，计算性能索引功能，近似最佳的控制政策并且分别地解决稳定的控制。模拟例子被提供验证介绍最佳的追踪的控制计划的有效性。

关键词：最优跟踪控制离散时间系统饱和执行器 DP算法控制方案神经网络性能指标系统动力学

An Outbreak of Febrile Histoplasmosis Among Chinese Manganese-Mine Workers in Cooperative Republic of Guyana in 2019

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China CDC weekly 2019年第3期1卷 38-42页

作者： Lei Zhou Xin Wang Jiandong Li rui song Xiaoping Dong George F.Gao Zijian Feng Public Health Emergency Center Chinese Center for Disease Control and PreventionBeijingChina Department of Epidemiology and Biostatistics School of Public HealthPeking University Health Science CenterBeijingChina National Institute for Communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Beijing Ditan Hospital Capital Medical UniversityBeijingChina Global Public Health Center Chinese Center for Disease Control and PreventionBeijingChina State Key Laboratory for Infectious Disease Prevention and Control Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases(Zhejiang University)National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Chinese Center for Disease Control and Prevention BeijingChina

Summary What is already known on this topic?Cases of histoplasmosis have been reported in every continent except Antarctica but are fairly rare in *** prevalence of histoplasmosis has been observed in Central America,Caribbean,and South *** of Histoplasma are acquired through a respiratory route,particularly inhalation of aerosols from disturbed soils enriched with excreta from birds and bats.

关键词： China soils disturbed