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Global trends in diabetic eye disease research from 2012 to 2021

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Neural Regeneration Research 2024年第10期19卷 2310-2320页

作者： Yuan Yuan Shangli Ji Yali song Zhaodi che Lu Xiao Shibo Tang Jia Xiao Aier School of Ophthalmology Central South UniversityChangshaHunan ProvinceChina Changsha Aier Eye Hospital ChangshaHunan ProvinceChina Aier Eye Institute ChangshaHunan ProvinceChina Department of Metabolic and Bariatric Surgery The First Affiliated Hospital of Jinan UniversityGuangzhouGuangdong ProvinceChina

Diabetic eye disease refers to a group of eye complications that occur in diabetic patients and include diabetic retinopathy, diabetic macular edema, diabetic cataracts, and diabetic glaucoma. However, the global epidemiology of these conditions has not been well characterized. In this study, we collected information on diabetic eye disease-related research grants from seven representative countries––the United States, China, Japan, the United Kingdom, Spain, Germany, and France––by searching for all global diabetic eye disease journal articles in the Web of Science and Pub Med databases, all global registered clinical trials in the Clinical Trials database, and new drugs approved by the United States, China, Japan, and EU agencies from 2012 to 2021. During this time period, diabetic retinopathy accounted for the vast majority(89.53%) of the 2288 government research grants that were funded to investigate diabetic eye disease, followed by diabetic macular edema(9.27%). The United States granted the most research funding for diabetic eye disease out of the seven countries assessed. The research objectives of grants focusing on diabetic retinopathy and diabetic macular edema differed by country. Additionally, the United States was dominant in terms of research output, publishing 17.53% of global papers about diabetic eye disease and receiving 22.58% of total citations. The United States and the United Kingdom led international collaborations in research into diabetic eye disease. Of the 415 clinical trials that we identified, diabetic macular edema was the major disease that was targeted for drug development(58.19%). Approximately half of the trials(49.13%) pertained to angiogenesis. However, few drugs were approved for ophthalmic(40 out of 1830;2.19%) and diabetic eye disease(3 out of 1830;0.02%) applications. Our findings show that basic and translational research related to diabetic eye disease in the past decade has not been highly active, and has yielded few new treatment methods and newly approved drugs.

关键词： clinical trials diabetic cataracts diabetic eye disease diabetic glaucoma diabetic macular edema diabetic retinopathy drug development global research publication research grant

Parthenolide inhibits the proliferation and induces the apoptosis of human uveal melanoma cells

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International Journal of Ophthalmology(English edition) 2019年第10期12卷 1531-1538页

作者： song-Tian che Li Bie Xu Li Hui Qi Peng Yu Ling Zuo Department of Ocular Fundus Disease the Second Hospital ofJilin UniversityChangchun130022Jilin ProvinceChina Department of Neurosurgery the First Hospital of JilinUniversityChangchun130022Jilin ProvinceChina

AIM: To explore the effect of parthenolide(PTL) on human uveal melanoma(UM) cells(C918 and SP6.5 cells) and its molecular mechanism. METHODS: Carboxyfluorescein succinimidyl amino ester(CFSE) assays and cell counting kit-8(CCK-8) were performed to detect the cell viability. Flow cytometry was used to analyze cell cycle and apoptosis. Quantitative realtime polymerase chain reaction(qRT-PCR) and Western blot assays were performed to measure proliferation-related and apoptosis-related factors.RESULTS: Firstly, PTL decreased the viability of C918 and SP6.5 cells in a dose-dependent manner, and the effect of PTL on C918 cells was stronger than on SP6.5;however, it did not affect normal cells. Secondly, PTL increased the proportion of cell number at cell cycle G1 phase in C918 cells, and decreased the proportion of cell number at S phase, but the proportion did not change at G2 phase. In addition, PTL induced the apoptosis of C918 cells, and decreased the expressions of Cyclin D1, B-cell lymphoma-2(Bcl-2) and B-cell lymphoma-extra large(Bcl-XL). Also, PTL increased Cyclin inhibition protein 1(P21), Bcl-2-associated X protein(Bax), Cysteinyl aspartate specific proteinas-3(Caspase-3) and Caspase-9 expression. However, the expression of Caspase-8 was not changed. CONCLUSION: PTL inhibites proliferation and induces apoptosis in UM cells by arresting G1 phase and regulating mitochondrial pathway, however, it does not affect normal cells.

关键词： parthenolide uveal melanoma proliferation apoptosis mitochondrial pathway

Carrimycin inhibits coronavirus replication by decreasing the efficiency of programmed–1 ribosomal frameshifting through directly binding to the RNA pseudoknot of viral frameshift-stimulatory element

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2567-2580页

作者： Hongying Li Jianrui Li Jiayu Li Hu Li Xuekai Wang Jing Jiang Lei Lei Han Sun Mei Tang Biao Dong Weiqing He Shuyi Si Bin Hong Yinghong Li Danqing song Zonggen Peng Yongsheng che Jian-Dong Jiang CAMS Key Laboratory of Antiviral Drug Research Institute of Medicinal BiotechnologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China Beijing Key Laboratory of Antimicrobial Agents Institute of Medicinal BiotechnologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China Key Laboratory of Biotechnology of Antibiotics the National Health and Family Planning Commission(NHFPC)Institute of Medicinal BiotechnologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China

The pandemic of SARS-CoV-2 worldwide with successive emerging variants urgently calls for small-molecule oral drugs with broad-spectrum antiviral activity.Here,we show that carrimycin,a new macrolide antibiotic in the clinic and an antiviral candidate for SARS-CoV-2 in phase III trials,decreases the efficiency of programmed–1 ribosomal frameshifting of coronaviruses and thus impedes viral replication in a broad-spectrum fashion.Carrimycin binds directly to the coronaviral frameshift-stimulatory element(FSE)RNA pseudoknot,interrupting the viral protein translation switch from ORF1a to ORF1b and thereby reducing the level of the core components of the viral replication and transcription complexes.Combined carrimycin with known viral replicase inhibitors yielded a synergistic inhibitory effect on coronaviruses.Because the FSE mechanism is essential in all coronaviruses,carrimycin could be a new broad-spectrum antiviral drug for human coronaviruses by directly targeting the conserved coronaviral FSE RNA.This finding may open a new direction in antiviral drug discovery for coronavirus variants.

关键词： Carrimycin Coronavirus Broad-spectrum antiviral activity Programmed-1 ribosomal frameshifting RNA pseudoknot Antiviral agent RNA target Synergistic inhibitory effect

THE EXIT PROBABILITIES OF BROWNIAN MOTION WITH VARIABLE DIMENSION APPLYING TO THE CONTROL OF POPULATION GROWTH

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International Journal of Biomathematics 2013年第5期6卷 1-12页

作者： LIXIN song WENBIN che DAWEI LU School of Mathematical Sciences Dalian University of Technology Dalian 116012 Liaoning P. R. China

热解温度对酸沉淀工业木质素快速热解液体产物的影响

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燃料化学学报 2008年第2期36卷 144-148页

作者：左宋林于佳车颂伟南京林业大学化学工程学院江苏南京210037

利用快速热解和气质联用技术，研究了酸沉淀工业木质素在400℃～700℃下快速热解液体产物的主要组分及其含量的变化。酸沉淀工业木质素快速热解液体产物中主要包括，与木质素的三种苯丙烷结构单元结构相似的苯酚、愈疮木酚和2，6-二甲... 详细信息

利用快速热解和气质联用技术，研究了酸沉淀工业木质素在400℃～700℃下快速热解液体产物的主要组分及其含量的变化。酸沉淀工业木质素快速热解液体产物中主要包括，与木质素的三种苯丙烷结构单元结构相似的苯酚、愈疮木酚和2，6-二甲氧基苯酚等酚类化合物，以及它们的甲基、乙基或丙基的单取代或多取代衍生物。在400℃-600℃，热解液体产物的组分及其相对含量的变化不显著；而在600℃-700℃，芳环上含甲氧基的酚类物质的相对含量急剧减少甚至消失，而苯酚的相对含量却急剧增加，达到27．81％，比400℃的增加了近2．5倍，同时芳烃化合物的相对含量增加，并出现苯丙呋喃、茚和萘等芳环化合物。

关键词：木质素热解温度快速热解液体产物气质联用

琥珀酸甲泼尼龙兔眼球周注射的药代动力学研究

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国际眼科杂志 2018年第2期18卷 235-238页

作者：车松天李旭吉林大学第二医院眼底病科中国吉林省长春市130041

目的:检测琥珀酸甲泼尼龙(methylprednisolone sodium succinate,MPS)兔眼球周注射后,MPS和其在眼内的代谢产物甲泼尼龙(methylprednisolone,MP)的分布及药代动力学情况。方法:兔眼球周注射琥珀酸甲泼尼龙钠10mg,采用质谱-液相色谱方法... 详细信息

目的:检测琥珀酸甲泼尼龙(methylprednisolone sodium succinate,MPS)兔眼球周注射后,MPS和其在眼内的代谢产物甲泼尼龙(methylprednisolone,MP)的分布及药代动力学情况。方法:兔眼球周注射琥珀酸甲泼尼龙钠10mg,采用质谱-液相色谱方法检测MPS和MP在巩膜、脉络膜和视网膜、玻璃体、虹膜、房水、晶状体、视神经和血浆中的浓度。结果:球周注射琥珀酸甲泼尼龙钠后,MPS浓度在眼内组织中的达峰时间为注药后0.25~1h,在血浆中的达峰时间为注药后0.25h;MP浓度在眼内组织中的达峰时间为0.5~6h,在血浆中的达峰时间为注药后0.5h。MPS和MP在眼内各组织的达峰浓度由高到低依次为巩膜、视神经、脉络膜和视网膜、虹膜、晶状体,二者在晶状体内的浓度均为所有眼部组织中最低,且远远低于眼内其它组织的含量,但平均驻留时间最长。结论:球周注射MPS是一种有效的向眼组织传递药物的方式,且该药在眼内的分布有利于向巩膜、视神经和脉络膜视网膜给药,而不易被晶状体吸收。

关键词：球周注射琥珀酸甲泼尼龙药代动力学

锌诱导对力竭运动大鼠金属硫蛋白的影响及其对心肌的保护作用

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北京体育大学学报 2008年第2期31卷 196-198页

作者：宋晨张钧合肥工业大学体育部安徽合肥230009 扬州大学体育学院江苏扬州225002

通过预先用锌诱导后大鼠做力竭性运动，来观察锌诱导金属硫蛋白（MT）合成对心肌的保护作用及其可能机制。方法：选用健康雄性SD大鼠30只，体重220～250g，随机A、B、C分为3组，即：A组为对照组；B组为一次性力竭运动组；C组为锌＋一次... 详细信息

通过预先用锌诱导后大鼠做力竭性运动，来观察锌诱导金属硫蛋白（MT）合成对心肌的保护作用及其可能机制。方法：选用健康雄性SD大鼠30只，体重220～250g，随机A、B、C分为3组，即：A组为对照组；B组为一次性力竭运动组；C组为锌＋一次性力竭运动组，每组10只。满8周后，测定其心肌组织中的MT含量、组织中钙的含量、巯基（-SH）和丙二醛（MDA）含量、以及心肌中的谷胱甘肽过氧化物酶（GSH-px）和Na^＋-K^＋-ATP酶的活性。结果：1）与对照组相比，力竭运动组大鼠心肌组织中MT的含量较对照组显著降低（P〈0．05）；心肌组织中MDA含量和总钙量显著增高（P〈0．05）；-SH含量以及GSH-px活性和Na^＋-K^＋-ATP酶的活性显著降低（P〈0．05）。2）与力竭运动组相比；锌＋力竭运动组大鼠心肌组织中MT含量较力竭运动组显著增高（P〈0．05）；心肌组织中MDA含量和总Ca^2＋量显著降低（P〈0．05）；-SH含量及GSH-px活性和Na^＋-K^＋-ATP酶的活性显著增高（P〈0．05）。结论：预先用锌诱导可减少力竭运动后心肌组织中MT含量的显著下降，降低心肌组织脂质过氧化水平，提高抗氧化酶的活性，防止钙超载，对力竭运动后心肌细胞的损伤具有保护作用。MT和金属锌密切相关，二者的相互作用可能共同参与保护力竭运动后机体组织的损伤，并促进损伤组织的快速修复。

关键词：金属硫蛋白运动锌心肌细胞

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基于驾驶人有限理性的交织区换道行为决策

公路交通科技 2023年第9期40卷 166-174页

作者：车松珊钱勇生曾俊伟魏谞婷兰州交通大学交通运输学院甘肃兰州730070

为研究交织区域异质交通流的演变规律,采用对称指数移动平均滤波算法对车辆自然行驶轨迹数据进行了降噪处理,提取了车辆换道间距的分布情况,分析不同换道环境中驾驶人换道行为特征的差异性。通过综合考虑驾驶人决策行为的不确定性和主... 详细信息

为研究交织区域异质交通流的演变规律,采用对称指数移动平均滤波算法对车辆自然行驶轨迹数据进行了降噪处理,提取了车辆换道间距的分布情况,分析不同换道环境中驾驶人换道行为特征的差异性。通过综合考虑驾驶人决策行为的不确定性和主观偏好,建立了一种用于模拟有限理性决策心理的交织区元胞自动机动力学模型。首先,基于改进的前景理论引入驾驶人的换道偏好用以描述动态换道间距的感知程度。其次,针对交织区域的几何结构定义了交织车辆递增的换道心理,并构建了跟驰行为对前车的预估车速。最后,采用流量、密度、空间位置、换道分布等参数对模型进行综合评估。结果表明:在空间占有率相同的条件下,驾驶人有限理性动力学模型与传统模型相比,交织区域局部堵塞现象明显减少,局部小范围拥堵流能够快速产生相变;车辆的换道行为在交织区路段呈现正态分布特征,存在集群换道现象,当考虑驾驶人有限理性的决策心理,各车道的换道集中区域均不同程度地向上游移动;在空间占有率变化的情况下,路段通行能力和车辆行驶速度随着驾驶人冒险程度的增大而明显提升。驾驶人有限理性动力学模型能有效刻画驾驶人复杂的决策心理,重现更多的道路交通状态,进而为智能网联人车协同等相关研究提供参考。

关键词：交通工程换道决策动力学模型交织区域元胞自动机

右美托咪定对脊柱手术患者术中血流动力学和失血量的影响:系统回顾和荟萃分析

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Chinese Medical Sciences Journal 2024年第1期39卷 54-68,I0006页

作者：汪玫车建翔陈磊宋婷婷瞿金涛中国人民解放军联勤保障部队第925医院麻醉科贵阳550000 中国人民解放军联勤保障部队第925医院骨科贵阳550000

目的右美托咪定是一种高选择性的α2肾上腺素能受体激动剂,具有降低血压和心率的作用。本研究旨在探讨右美托咪定对脊柱手术患者术中血流动力学和失血量的影响。方法检索Web of Science、MEDLINE、EMBASE和Cochrane图书馆截至2023年2... 详细信息

目的右美托咪定是一种高选择性的α2肾上腺素能受体激动剂,具有降低血压和心率的作用。本研究旨在探讨右美托咪定对脊柱手术患者术中血流动力学和失血量的影响。方法检索Web of Science、MEDLINE、EMBASE和Cochrane图书馆截至2023年2月发表的随机对照研究,比较右美托咪定和生理盐水对脊柱手术术中血流动力学和失血量的影响。根据研究间的异质性采用固定或随机效应模型。结果纳入21项随机对照研究,共1388例患者。右美托咪定的使用增加了术中低血压(OR:2.11;95%CI:1.24-3.58;P=0.006)和心动过缓(OR:2.48;95%CI:1.57-3.93;P=0.0001)的总体风险。特别是在给予负荷剂量时,低血压(OR:2.00;95%CI:1.06-3.79;P=0.03)和心动过缓(OR:2.28;95%CI:1.42-3.66;P=0.0007)的风险更为显著。当右美托咪定与静脉麻醉联合使用时,患者更容易出现血流动力学不稳定的情况,包括低血压(OR:2.90;95%CI:1.24-6.82;P=0.01)和心动过缓(OR:2.66;95%CI:1.53-4.61;P=0.0005)。与吸入麻醉联合时,仅增加了心动过缓的风险(OR:4.95;95%CI:1.41-17.37;P=0.01)。然而,当与静吸复合麻醉联合使用时,并未增加低血压和心动过缓的风险。此外,右美托咪定还增加了重度低血压的风险(OR:2.57;95%CI:1.05-6.32;P=0.04),但对轻度低血压的影响并不显著。对于心动过缓而言,无论是轻度(OR:2.55;95%CJ:1.06-6.15;P=0.04)还是重度(OR:2.45;95%CI:1.43-4.20;P=0.001)的风险都有所增加。总体而言,右美托咪定对术中失血量的影响并不显著,但在与吸入麻醉联合时,失血量显著减少(MD:-82.97;95%CI:-109.04--56.90;P<0.001)。结论右美托咪定在脊柱手术过程中增加了低血压和心动过缓的风险。给予负荷剂量或与不同麻醉维持方式联合使用可能会对术中血流动力学和失血量产生不同的影响。然而,目前的研究结果仍需进一步证实和探讨。

关键词：右美托咪定术中血流动力学失血量脊柱手术