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Chinese Science Bulletin 1997年第19期42卷 1651-1655页

作者： Chen, YH song, jd Key Laboratory of Cell Biology Ministry of Public Health of China China Medical University Shenyang 110001 China

ENDOPLASMIC reticulum (ER) molecular chaperone glucose regulated protein (Grp94 ), a mem-ber of heat shock protein 90 family, is a relatively abundant luminal protein in the ER. Theexpression of the Grp94 gene is markedly increased under many stress conditions. Grp94 isprimarily involved in folding, assembly and translocation of proteins synthesized within

关键词： neoplasms endoplasmic reticulum molecular chaperone Crp94 differential expression.

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胰腺干细胞在糖尿病治疗中的应用

中国组织工程研究与临床康复 2007年第11期11卷 2160-2163页

作者：陈思娇李铁民宋今丹中国医科大学附属第一医院老年病教研室卫生部重点实验室中国医大细胞生物研究室辽宁省沈阳市110001

目的:本文就分离克隆胰腺干细胞,并将其定向诱导分化为功能性胰岛移植治疗糖尿病的研究作一综述。资料来源:应用计算机检索CBM和PubMed数据库1978-01/2006-12胰腺干细胞或胰岛干细胞移植治疗糖尿病的文章,检索词为"islet stem cell,panc... 详细信息

目的:本文就分离克隆胰腺干细胞,并将其定向诱导分化为功能性胰岛移植治疗糖尿病的研究作一综述。资料来源:应用计算机检索CBM和PubMed数据库1978-01/2006-12胰腺干细胞或胰岛干细胞移植治疗糖尿病的文章,检索词为"islet stem cell,pancreatic stem cell,diabetes mellitus,胰腺干细胞,胰岛干细胞,糖尿病"。资料选择:选择胰腺干细胞或胰岛干细胞移植治疗糖尿病的文章,排除重复研究。资料提炼:检索到CBM数据库中胰腺干细胞移植治疗糖尿病文章19篇,胰岛干细胞移植治疗糖尿病文章20篇;PubMed数据库中胰腺干细胞移植治疗糖尿病文章305篇。共纳入41篇。资料综合:糖尿病的治疗方法主要包括药物治疗、胰岛素注射、胰腺器官移植和胰岛细胞移植。胰腺器官移植和胰岛移植是治疗糖尿病的有效方法。由于缺乏完全合适的供体,胰腺器官移植的临床应用受到限制。与胰腺器官移植相比,胰岛细胞移植无需麻醉和剖腹,减小了对移植受体的损伤,降低了风险性。结论:体外分离、克隆人类胰腺干细胞,并定向诱导其分化为功能性胰岛移植治疗糖尿病,是解决胰岛供体短缺的有效途径,但是还没有人胰腺干细胞体外诱导胰岛移植治疗人类糖尿病的报道。

关键词：胰岛干细胞分离克隆糖尿病

Efficient measurement and optical proximity correction modeling to catch lithography pattern shift issues of arbitrarily distributed hole layer

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Frontiers of Mechanical Engineering 2024年第4期19卷 45-54页

作者： Yaobin FENG Jiamin LIU Zhiyang song Hao JIANG Shiyuan LIU State Key Laboratory of Inteligent Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhan 430074China Optics Valley Laboratory Wuhan 430074China

With the continued shrinking of the critical dimensions(CDs)of wafer patterning,the requirements for modeling precision in optical proximity correction(OPC)increase *** requirement extends beyond CD controlling accuracy to include pattern alignment accuracy because misalignment can lead to considerable overlay and metal-via coverage issues at advanced nodes,affecting process window and *** paper proposes an efficient OPC modeling approach that prioritizes pattern-shift-related elements to tackle the issue *** method integrates careful measurement selection,the implementation of pattern-shift-aware structures in design,and the manipulation of the cost function during model tuning to establish a robust *** experiments are performed on a via layer fabricated using a negative tone *** demonstrate that pattern shifts can be constrained within a range of+1 nm,remarkably better than the original range of±3 ***,simulations reveal notable differences between post OPC and original masks when considering pattern shifts at locations sensitive to this *** validation confirms the accuracy of the proposed modeling approach,and a firm consistency is observed between the simulation results and experimental data obtained from actual design structures.

关键词： computational lithography optical proximity correction modeling pattern shift metrology

Computed tomography-based radiomics diagnostic approach for differential diagnosis between early-and late-stage pancreatic ductal adenocarcinoma

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1256-1267页

作者： Shuai Ren Li-Chao Qian Ying-Ying Cao Marcus J Daniels Li-Na song Ying Tian Zhong-Qiu Wang Department of Radiology Jiangsu Province Hospital of Chinese MedicineAffiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Department of Geratology Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese MedicineNanjing 210022Jiangsu ProvinceChina Department of Radiology NYU Langone HealthNew YorkNY 10016United States

BACKGROUND One of the primary reasons for the dismal survival rates in pancreatic ductal adenocarcinoma(PDAC)is that most patients are usually diagnosed at late *** is an urgent unmet clinical need to identify and develop diagnostic methods that could precisely detect PDAC at its earliest *** A total of 71 patients with pathologically proved PDAC based on surgical resection who underwent contrast-enhanced computed tomography(CT)within 30 d prior to surgery were included in the *** staging was performed in accordance with the 8th edition of the American Joint Committee on Cancer staging *** features were extracted from the region of interest(ROI)for each patient using Analysis Kit *** most important and predictive radiomics features were selected using Mann-Whitney U test,univar-iate logistic regression analysis,and minimum redundancy maximum relevance(MRMR)*** forest(RF)method was used to construct the radiomics model,and 10-times leave group out cross-validation(LGOCV)method was used to validate the robustness and reproducibility of the *** A total of 792 radiomics features(396 from late arterial phase and 396 from portal venous phase)were extracted from the ROI for each patient using Analysis Kit *** most important and predictive features were selected using Mann-Whitney U test,univariate logistic regression analysis,and MRMR *** method was used to construct the radiomics model with the nine most predictive radiomics features,which showed a high discriminative ability with 97.7%accuracy,97.6%sensitivity,97.8%specificity,98.4%positive predictive value,and 96.8%negative predictive *** radiomics model was proved to be robust and reproducible using 10-times LGOCV method with an average area under the curve of 0.75 by the average performance of the 10 newly built *** The radiomics model based on CT could serve as a promising non-invasive method in differential diag

关键词： Pancreatic ductal adenocarcinoma Radiomics Computed tomography American Joint Committee on Cancer staging

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DIY掌上计算机

无线电 2024年第1期 59-63页

作者： jd3096 不详

大家好,我是30岁开始学编程的大叔,因为之前并没有编程基础,所以开始学习的时候就选择了比较容易上手的MicroPython,然后便不断尝试实现自己的想法,今天给大家带来我DIY的掌上计算机。

关键词：掌上计算机 DIY 编程基础

Electrocatalytic Reduction of CO_(2)to CO with Almost 100%Faradaic Efficiency Using Oxygen-Vacancy Enriched Two-Dimensional MgO

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CCS Chemistry 2024年第6期6卷 1477-1486页

作者： Yu Han Sunggi An Xinyu Zhan Leiduan Hao Liang Xu song Hong Dongmin Park Yuxin Chen Yiwen Xu Jiwen Zhao Xinyi Tan Alex W.Robertson Yousung Jung Zhenyu Sun State Key Laboratory of Organic-Inorganic Composites College of Chemical EngineeringBeijing University of Chemical TechnologyBeijing 100029 Department of Chemical and Biomolecular Engineering(BK21four) Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141 Beijing Key Laboratory of Environmental Science and Engineering School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081 Department of Physics University of WarwickCoventry

The design and development of cheap,abundant,and efficient electrocatalysts for selective CO_(2)electroreduction is highly desirable yet remains an ongoing ***,we report on our discovery of the use of two-dimensional MgO rich in oxygen vacancies(VO)as an electrocatalyst for the efficient reduction of CO_(2)to yield CO in 1-butyl-3-methylimidazolium hexafluorophosphate dissolved in *** faradaic efficiency toward CO reaches as high as 99.6±0.24%with a current density of up to 40.8 mA cm−*** functional theory calculations illustrate that the introduction of VO in MgO substantially lowers the reaction-free energy for the transformation of ^(*)COO^(−) to ^(*)COOH,the potential determining step,which greatly boosts CO_(2)conversion *** work opens the way to realizing economic and efficient CO_(2)electrolysis of group II metals.

关键词： CO_(2)reduction electrocatalysis CO MgO ionic liquid oxygen-vacancy

Studies on an Immune Active Dodecapeptide Isolated from the Buckwheat Pollen

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Chinese Chemical Letters 1997年第7期8卷 607-610页

作者： song, YL Wang, XA He, SW Jin, S Liu, jd Wang, S BEIJING UNIV DEPT CHEMBEIJING 100871PEOPLES R CHINA BEIJING UNION MED COLL HOSP DEPT BIOMESSAGE & MODULATINST GERIATRBEIJING 100730PEOPLES R CHINA

A new basic dodecapeptide BPP was isolated from the water-extract of the buckwheat pollen (BP). The sequence of BPP, which was first reported, was determined by DABITC/PITC double coupling method, and confirmed by chemical synthesis. Some analogues of BPP were also synthesized by SPPS Method. The effect of these peptides on spleen lymphocytes from mice of Kunming inbred line and on release of SIL-2R from human lymphocytes were studied. The results showed that these peptides exhibit certain immune activity.

关键词： BPP Studies on an Immune Active Dodecapeptide Isolated from the Buckwheat Pollen

基于空间自相关的常规城市公交车辆危险驾驶热点路段识别

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华南理工大学学报（自然科学版） 2024年第4期52卷 138-150页

作者：张文会刘拓宋雅靖苏嘉祺东北林业大学土木与交通学院黑龙江哈尔滨150040 比亚迪汽车工业有限公司商用车研究院广东深圳518118

为了获得公交危险驾驶状态的空间分布特征,采用空间自相关性分析方法,识别危险驾驶状态的空间集聚性,确定危险驾驶状态热点路段,并对显著性影响因素进行分析。首先,采集4个季度各1周公交车辆卫星定位数据样本,修复重复数据、异常数据和... 详细信息

为了获得公交危险驾驶状态的空间分布特征,采用空间自相关性分析方法,识别危险驾驶状态的空间集聚性,确定危险驾驶状态热点路段,并对显著性影响因素进行分析。首先,采集4个季度各1周公交车辆卫星定位数据样本,修复重复数据、异常数据和缺失数据,并以公交站点为节点划分空间区段,对每个区段进行编号;接着,将速度过快、急加速、急减速和急转弯确定为危险驾驶状态,参照车辆运动学特性获得4种危险驾驶状态阈值,并计算4种危险驾驶状态的统计学指标和全局莫兰指数,结果表明,公交车辆危险驾驶状态具有空间集聚性(空间随机分布概率p2.58),速度过快状态(全局莫兰指数为0.731)的空间集聚性最为显著;然后,分别对4种危险驾驶状态进行局部空间自相关性分析,绘制了90%、95%和99%置信度下的莫兰散点图和Lisa集聚图,结合城市地图,获得危险驾驶状态的热点路段;最后,选取路段长度、车道数、平直度等9个指标,对比分析了OLS模型、SLE模型、SEM模型和SDM模型的拟合优度,采用SDM模型获得4种危险驾驶状态的显著性影响因素。文中研究结果可为公交车辆危险驾驶状态空间识别、精细化安全运行管理提供理论依据。

关键词：交通运输工程公交车辆运行安全热点路段空间自相关

Analysis of Outage Capacity of NOMA： SIC vs. jd

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Tsinghua Science and Technology 2016年第5期21卷 538-543页

作者： Shuang Chen Kewu Peng Huangpin Jin Jian song Research Institute of Information Technology and Electronic Engineering Department Tsinghua National Laboratory for Information Science and Technology (TNList) Tsinghua University Beijing 100084 China

In fifth-generation wireless communication networks, Non-Orthogonal Multiple Access（NOMA） has attracted much attention in both academic and industrial fields because of its higher spectral efficiency in comparison with orthogonal multiple access. Recently, numerous uplink NOMA techniques have been proposed,some of which are based on Successive Interference Cancellation（SIC） and others on Joint Decoding（jd, or simultaneous decoding）. In this study, we analyze the outage capacities of SIC and jd in the case of single-block transmission over a two-user Gaussian multiple-access channel with partial channel state information at transmitter from the perspective of information theory. Results of the analysis and numerals show that compared to SIC, jd can achieve a sum-rate gain of up to 10% or sum-power gain of 0.8 dB.

关键词： multiple access channel successive interference cancellation joint decoding outage capacity

大数据发展和企业劳动收入份额——来自“国家级大数据综合试验区”的证据

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经济学动态 2024年第1期 111-128页

作者：宋华盛卢历祺浙江大学民营经济研究中心浙江大学经济学院 310058

本文通过构建理论模型刻画了大数据影响劳动收入份额的经济逻辑,并利用“国家级大数据综合试验区”作为准自然实验,使用双重差分法来检验大数据发展对中国上市公司劳动收入份额的影响。研究发现,大数据发展显著降低了企业的劳动收入份... 详细信息

本文通过构建理论模型刻画了大数据影响劳动收入份额的经济逻辑,并利用“国家级大数据综合试验区”作为准自然实验,使用双重差分法来检验大数据发展对中国上市公司劳动收入份额的影响。研究发现,大数据发展显著降低了企业的劳动收入份额。异质性结果表明,“国家级大数据综合试验区”显著降低了劳动密集型企业、融资约束更高的企业以及高新技术行业的劳动收入份额。进一步的影响机制分析发现,大数据发展通过促进企业技术进步对劳动收入份额产生影响;大数据发展促进了企业数字化转型,企业增加数字化资产投入,挤出了劳动投入,进而导致劳动收入份额下降。

关键词：大数据数字化转型劳动收入份额技术进步