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Food Science and Human Wellness 2024年第2期13卷 688-697页

作者： Shuai Hou Chutong Lai yukun song Haitao Wang Jialu Ni Mingqian Tan Academy of Food Interdisciplinary Science School of Food Science and TechnologyDalian Polytechnic UniversityDalian 116034China Institute of Cancer Stem Cell Cancer CenterDalian Medical UniversityDalian 116044China National Engineering Research Center of Seafood Dalian Polytechnic UniversityDalian 116034China Collaborative Innovation Center of Seafood Deep Processing Dalian Polytechnic UniversityDalian 116034China

Cellular senescence is the results of aging and age-related diseases,and the development of anti-aging methods may improve health and extend *** natural flavonol fisetin has been shown to antagonize senescence in vitro and increases longevity in vivo,but has poor water solubility and limited *** this study,a food-grade and senescent cell-targeted delivery system for fisetin was developed based on whey protein isolate-galactooligosaccharides(WPI-GOS)Maillard conjugate,which could recognize senescence associatedβ-galactosidase in senescent *** fisetin nanoparticles possessed a high encapsulation efficiency,excellent dispersibility in water,good storage stability and well ***,they could effectively accumulate and retain in senescent cells with excellent senescent cell-targeting efficacy,and inhibit the oxidative stress-induced cellular senescence in ***,this novel nanoparticle system based on WPI-GOS Maillard conjugate showed promise to deliver hydrophobic bioactive ingredients like fisetin to senescent cells to improve their bioavailability and anti-senescence effect.

关键词： Fisetin Nanoparticle Cellular senescence Targeted delivery

Curcumin delivery nanoparticles based on Maillard reaction of Haematococcus pluvialis protein/galactose for alleviating acute alcoholic liver damage

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Food Science and Human Wellness 2024年第5期13卷 2629-2641页

作者： Xinyi Liu yukun song Shasha Cheng Mingqian Tan School of Food Science and Technology Dalian Polytechnic UniversityDalian 116034China National Engineering Research Center of Seafood Dalian 116034China

The aim of this study is to investigate the feasibility of Maillard reaction products of Haematococcus pluvialis protein and galactose(HPP-GAL)for improving the bioactivities of curcumin(CUR)for alleviating alcoholic liver *** was embedded into HPP-GAL nanoparticles by the self-assembly of hydrogen bonding and hydrophobic interaction with the particle size around 200 ***-GAL enhanced the encapsulation efficiency and loading amount of CUR with the value of(89.21±0.33)%and(0.500±0.004)%,*** stabilities of CUR under strong acid,salt ion stability and ultraviolet irradiation conditions were improved by the ***-GAL-CUR nanoparticles exhibited excellent concentration-dependent in vitro antioxidant activities including DPPH and ABTS scavenging rates,and better protective effect on CUR against gastric acid environment as well as longer release of CUR in simulated intestinal *** addition,the HPPGAL-CUR delivery system possessed liver targeting property due to the existence of GAL,which could effectively alleviate the alcohol-induced liver damage and the inflammation indexes by inhibiting the oxidative ***,HPP-GAL-CUR nanoparticles might be a potential candidate system for the prevention of alcoholic liver damage in the future.

关键词： Haematococcus pluvialis protein Galactose Curcumin nanocarrier Maillard reaction Alcoholic liver damage Liver targeting

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西路老调的发展历程及保护传承

新乡学院学报 2024年第5期41卷 50-53页

作者：宋玉坤保定学院文物与博物馆学院河北保定071000

西路老调起源于元末明初,由白洋淀一带的民间小调河西调演变而成,主要流传于冀中地区。在长期的发展中,它逐步趋于完善,并且形成了自己的特色。张金奎、刘守谦、冯振川、冯海泉、马春香、李发生、贾俊霞、武新爱等人都曾对西路老调的传... 详细信息

西路老调起源于元末明初,由白洋淀一带的民间小调河西调演变而成,主要流传于冀中地区。在长期的发展中,它逐步趋于完善,并且形成了自己的特色。张金奎、刘守谦、冯振川、冯海泉、马春香、李发生、贾俊霞、武新爱等人都曾对西路老调的传承做出过贡献。今天,振兴西路老调应当从五个方面入手:其一,普及戏曲文化;其二,创新演出形式和演出内容;其三,拓宽戏曲文化的传播渠道;其四,培养戏曲后备力量;其五,积极争取资金支持。

关键词：西路老调河西调传承保护

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空间运动方程快速求解器设计与实现

合肥工业大学学报（自然科学版） 2024年第1期47卷 54-61页

作者：王晓蕾黄章骞房旭宋宇鲲合肥工业大学微电子学院安徽合肥230601

文章基于四阶经典龙格库塔法(classical Runge-Kutta method of order four,RK-4)和四阶Adams预测校正法(fourth-order Adams predictor-corrector method,Adams-4),提出一种现场可编程逻辑门阵列(field programmable gate array,FPGA)实现的数据路径可动态配置的空间运动方程快速求解器(space motion equation fast solver,SMEFS)。SMEFS采用折叠式结构,借助高效的任务映射和精准的状态管理,通过资源复用和动态配置运算器内部连接关系实现数据路径的动态配置,快速求解空间运动方程,并有效节省硬件资源。采用某型运载火箭的相关数据对SMEFS进行大批量空间运动方程求解的性能评估,实验结果表明SMEFS能够快速可靠地求解发射坐标系下的五自由度空间运动方程,与软件求解的平均加速比为12.765,求解结果最大相对误差小于9×10^(-5,)具备较好的加速效果和较高的计算可靠性。

关键词：四阶经典龙格库塔法(RK-4) 四阶Adams预测校正法(Adams-4) 空间运动方程折叠技术现场可编程逻辑门阵列(FPGA)

不同组分体外成熟培养基对绵羊卵母细胞成熟、代谢及孤雌胚胎发育的影响

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黑龙江畜牧兽医 2024年第8期 46-53,59页

作者：张楠宋宇琨岱红艳白雪王俊兰韩僖彤张家新内蒙古农业大学动物科学学院呼和浩特010018 内蒙古自治区羊遗传育种与繁殖重点实验室呼和浩特010018

为了探究不同组分体外成熟培养基对绵羊卵母细胞体外成熟的影响,试验从健康绵羊卵巢中分离卵丘-卵母细胞复合体(COCs),将分离的COCs分为V-FSH+LH+E_(2)+FBS组、V-FSH+FBS组、V-FSH+LH+E_(2)+BSA组、P-FSH+LH+E_(2)+FBS组、P-FSH+FBS组、P-FSH+LH+E_(2)+BSA组,每组分别添加以V-促卵泡素(FSH,垂体中提纯的FSH)和P-FSH(体外基因重组表达的FSH)为基础设计的体外成熟培养基以进行体外成熟试验,即各组依次添加V-FSH+促黄体素(LH)+雌激素(E_(2))+胎牛血清(FBS)、V-FSH+FBS、V-FSH+LH+E_(2)+牛血清白蛋白(BSA)、P-FSH+LH+E_(2)+FBS、P-FSH+FBS、P-FSH+LH+E_(2)+BSA体外成熟培养基,体外成熟后检测各组卵丘扩展指数(CEI)、第一极体排出率、卵母细胞氧化还原态、乳酸生成量、葡萄糖消耗量、ATP生成量;统计孤雌胚胎的卵裂率、囊胚率、囊胚细胞数,比较不同组分体外成熟培养基对卵母细胞成熟、代谢及孤雌胚胎发育的影响。结果表明:V-FSH+LH+E_(2)+FBS组CEI最高,除与P-FSH+FBS组差异不显著外(P>0.05),与其他组均差异显著(P0.05)。V-FSH+LH+E_(2)+FBS组、P-FSH+FBS组、P-FSH+LH+E_(2)+BSA组的相对氧化还原比均接近1且差异不显著(P>0.05),但均显著低于其他组(P0.05)外,显著高于其他组(P0.05),但均显著高于其他组(P0.05),但均显著低于其他组(P0.05),但各组的囊胚细胞数差异不显著(P>0.05)。说明不同来源的FSH与不同组分协同作用会对绵羊卵母细胞的成熟、代谢及孤雌胚胎发育产生不同的效果,并影响了其后续胚胎的发育能力。

关键词：绵羊卵母细胞促卵泡素(FSH) 体外成熟细胞代谢

极化电极均匀化设计调控铌酸锂周期极化占空比

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人工晶体学报 2024年第3期53卷 449-457,I0004页

作者：刘齐鲁郑名扬高洋张龙喜宋于坤王孚雷刘宏王东周桑元华山东大学晶体材料国家重点实验室济南250100 济南量子技术研究院济南250022

准相位匹配(QPM)理论上能够充分利用晶体的非线性光学系数、无走离效应,在光学频率转换中具有非常大的优势。铌酸锂晶体(LiNbO_(3),LN)具有高非线性光学系数、宽通光范围和低生长成本,因此基于铌酸锂铁电畴结构设计获得的周期极化铌酸... 详细信息

准相位匹配(QPM)理论上能够充分利用晶体的非线性光学系数、无走离效应,在光学频率转换中具有非常大的优势。铌酸锂晶体(LiNbO_(3),LN)具有高非线性光学系数、宽通光范围和低生长成本,因此基于铌酸锂铁电畴结构设计获得的周期极化铌酸锂晶体(PPLN)成为准相位匹配技术的理想选择。目前制备PPLN晶体最常用的方法是外加电场极化法,制备过程中,电极结构的参数对极化过程至关重要。本研究基于实时监测下的电场极化过程,结合有限元分析,对不同电极结构的空间电场分布进行分析,发现电极边缘出现电场极大值,而电极内部的电场分布相对均匀。基于这一现象,本文提出了一种多通道电极结构的设计方案,以实现极化空间内部电场的均匀分布。本研究采用十通道电极进行极化实验,通过表征每个通道的占空比,发现内部八个通道的占空比大小均匀且在50%±5%范围,通过晶体的倍频实验验证发现十通道周期极化样品中中间通道相对边缘通道的非线性转换效率明显提升并分布均匀,证明其中间通道具有占空比可控的均匀极化结构,为极化空间电场均匀化设计提供了一种高效合理的设计方案。

关键词：铌酸锂周期极化铌酸锂非线性光学空间电场分布有限元分析

工程教育专业认证背景下“食品机械与设备”教学资源的重构及课程达成度评价

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农产品加工 2024年第5期 117-120,124页

作者：王海涛吴超苏文涛宋玉昆大连工业大学食品学院辽宁大连116034

工程教育专业认证是国际通行的工程教育质量保障制度,持续改进的质量文化是其重要特点之一。课程教学是本科教育的核心环节,持续改进的关键在于有效地评价课程目标的达成情况及基于课程目标达成度评价结果的改进。“食品机械与设备”是... 详细信息

工程教育专业认证是国际通行的工程教育质量保障制度,持续改进的质量文化是其重要特点之一。课程教学是本科教育的核心环节,持续改进的关键在于有效地评价课程目标的达成情况及基于课程目标达成度评价结果的改进。“食品机械与设备”是食品科学与工程专业的核心课程,其课程目标的达成情况对于专业的持续改进非常重要。针对“食品机械与设备”教学过程中多维度互动和全过程评价缺乏的问题,以大连工业大学“食品机械与设备”课程为例,在工程教育专业认证的背景下,秉承多维度互动的教学理念,对课程内容进行了重构,在此基础上,构建了课程目标达成度评价体系,并根据课程目标达成度评价结果,分析教学改革成效,进而完善课堂教学及评价体系,为提高食品专业人才培养质量提供参考。

关键词：工程教育认证食品机械与设备达成度评价教学改革

Resveratrol compares with melatonin in improving in vitro porcine oocyte maturation under heat stress

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Journal of Animal Science and Biotechnology 2017年第1期8卷 89-98页

作者： Yu Li Jing Wang Zhenzhen Zhang Jinyun Yi Changjiu He Feng Wang Xiuzhi Tian Minghui Yang yukun song Pingli He Guoshi Liu National Engineering Laboratory for Animal Breeding Key Laboratory of Animal Genetics and Breeding of the Ministry of AgricultureBeijing Key Laboratory for Animal Genetic ImprovementCollege of Animal Science and TechnologyChina Agricultural University College of Animal Science and Technology Jilin Agricultural University

Background： Resveratrol, an important phyto-antioxidant commonly found in grapes, mulberry, and other plants,has a variety of functions including anti-aging, anti-cancer and anti-inflammatory activities. In the current study, we investigated the beneficial effects of resveratrol on in vitro porcine oocyte maturation under heat stress（HS）. The effect of resveratrol, melatonin and their combination on alleviating HS was compared according to the maturation rate of oocytes and the development competence of embryos after parthenogenetic activation（PA）.Results： Supplementation with resveratrol（2.0 μmol/L） not only improved the nuclear maturation but also raised the blastocyst rate of porcine embryos＇ PA from oocytes that underwent HS by increasing their glutathione（GSH）level, reducing reactive oxygen species（ROS） and up-regulating the expression of Sirtuin 1（SIRT1）. It was also found that melatonin（10^-7mol/L） and the combination of resveratrol（2.0 μmol/L） plus melatonin（10^-7mol/L） exhibited more potent effects than resveratrol alone regarding their protective activities on oocyte maturation under ***： This study compared the efficiencies of resveratrol, melatonin and their combination for protecting porcine oocytes from heat stress. The mechanisms are attributed to the fact that each treatment may have different ability to regulate the synthesis of steroid hormones and the expression of mature related genes.

关键词： Combination Maturation Melatonin Oocyte Porcine Resveratrol

Asymmetric Zn-N4 atomic sites embedded hollow fibers as stable Zn anode for high-performance Zn-ion hybrid capacitor

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Journal of Energy Chemistry 2024年第10期97卷 460-469页

作者： yukun Liu Bing Li Jin Wang Caiyun Li Hongrui Yang Yang song Sen Zhang Chao Deng Key Laboratory for Photonic and Electronic Bandgap Materials Ministry of Education College of Physics and Electronic Engineering Harbin Normal University College of Material Science and Chemical Engineering Harbin Engineering University

Zn based electrochemical energy storage systems（EES） have attracted tremendous interests owing to their low cost and high intrinsic ***,the uncontrolled growth of Zn dendrites and the side reactions of Zn metal anodes（ZMAs） severely restrict their *** address these issues,we design the asymmetric Zn-N4atomic sites embedded hollow fibers（AS-IHF） as the flexible host for stable *** introducing different nitrogen resources in the synthesis,two kinds of coordination,i,***-N（pyridinic） and Zn-N（pyrrolic）,are introduced in the Zn-N4atomic module *** asymmetric Zn-N4module with regulated micro-environment facilitates the superior zincophilic features and promotes the Zn ***,the highly porous structure of the hollow fiber effectively reduces local current density,homogenize Zn ion flux,and alleviate structure *** the advantages endow the high efficiency and good stability for Zn plating/*** theoretical and experimental results demonstrate the high reversibility,low nucleation overpotential,and dendritefree behavior of the AS-IHF@Zn anode,which afford the high stability in high-rate and long-term ***,the solid-state Zn-ion hybrid capacitor（ZIHC） based on AS-IHF@Zn anode shows the high flexibility,reliability,and superior long-term cycling capability in a wide-range of temperatures（-20-25℃）.Therefore,the present work not only gives a new strategy for modulating local environments of single atomic sites,but also propels the development of flexible power sources for diverse electronics.

关键词： Asymmetric coordination Dendrite free behavior Single atomic sites Zincophilic sites Zn-ion hybrid capacitor

Carboniferous integrative stratigraphy,biotas,and paleogeographical evolution of the Qinghai-Tibetan Plateau and its surrounding areas

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Science China Earth Sciences 2024年第4期67卷 1071-1106页

作者： Keyi HU Xiangdong WANG Wenqi WANG Yingfan song Xunyan YE Lu LI yukun SHI Sunrong YANG Ying LI State Key Laboratory for Mineral Deposits Research School of Earth Sciences and Engineering and Frontiers Science Center for Critical Earth Material CyclingNanjing UniversityNanjing 210023China

During the Carboniferous Period,the Qinghai-Tibetan Plateau and its surrounding areas were located in quite different paleogeographic positions with various sedimentary and biological *** is important to systematically compile and summarize the Carboniferous strata and biotas of the Qinghai-Tibetan Plateau and its surrounding areas,to establish an integrated stratigraphic framework for correlation,and to reconstruct the paleogeography for correctly understanding the breakup of the Gondwana Continent and the evolution of the Paleo-Tethys Ocean in the Late *** Carboniferous of the Qinghai-Tibetan Plateau and its surrounding areas can be subdivided into the Gondwanan,Cimmerian,and Tethyan *** Gondwanan-type Carboniferous are distributed in the North Himalayan,Kangmar-Lhunze,and Zanda-Zumba regions of the South Tibet Subprovince and northern India-Pakistan Area,where only the Mississippian is developed and the biota is of Gondwanan *** Cimmerian-type Carboniferous,which are found in the Baoshan,Tengchong,Coqen-Xainza,LhasaZayu,Nagqu-Biru,and South Qiangtang regions,as well as Shan-Thai and South Afghanistan-Pamir areas,also represent only the Mississippian strata,but their biota is characterized by mixed characters of European,South China,Australian,and North American *** Tethyan-type Carboniferous are distributed in the Tanggula Mountains,Hoh Xil-Bayanhar,ChamdoHengduanshan,Tiekelike,West Kunlun,Karakorum,East Kunlun-Central Qinling,and Qilian regions,where the Carboniferous succession is well developed,and the biota is of warm-water Tethyan *** biostratigraphical correlation of the Gondwanan-type and Cimmerian-type Carboniferous is based mainly on conodonts and additionally on brachiopods and rugose *** Mississippian of the Tethyan-type Carboniferous is correlated mainly by using rugose corals and brachiopods,whereas in the Pennsylvanian foraminifera(fusuline)and conodonts are regarded as primary fossil groups,subord

关键词： Qinghai-Tibetan Plateau Carboniferous Lithostratigraphy Biota Stratigraphic correlation