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Discovery and preclinical development of ⅢM-160, a Bergenia ciliatabased anti-inflammatory and anti-arthritic botanical drug candidate

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Journal of Integrative Medicine 2019年第3期17卷 192-204页

作者： sandip B.bharate Vikas Kumar sonali s.bharate Bikarma singh Gurdarshan singh Amarinder singh Mehak Gupta Deepika singh Ajay Kumar surjeet singh Ram A.Vishwakarma Medicinal Chemistry Division Indian Institute of Integrative Medicine Council of Scientific and Industrial Research PK-PD Toxicology & Formulation Division Indian Institute of Integrative Medicine Council of Scientific and Industrial Research Biodiversity and Applied Botany Division Indian Institute of Integrative Medicine Council of Scientific and Industrial Research Quality Control and Quality Assurance Division Indian Institute of Integrative Medicine Council of Scientific and Industrial Research

Objective: Bergenia ciliata(Haw.) sternb. is used in the Indian traditional system of medicine to treat various ailments including rheumatism and to heal wounds. The objective of the present study was to perform a preclinical characterization of the B. ciliata-based botanical extract ***: ⅢM-160 was chemically standardized and analyzed for heavy metal content, aflatoxins,pesticides and microbial load. The in vitro and in vivo efficacies were determined in suitable models of inflammation, arthritis and nociception. An acute oral toxicity study was performed in swiss albino mice.A suitable oral formulation was developed and ***: Bergenin was found to be the major component(9.1% w/w) of ⅢM-160. The botanical lead displayed inhibition of lipopolysaccharide-induced production of proinflammatory cytokines in THP-1 cells, with selectivity toward interleukin-6(IL-6) and had an excellent safety-window. It showed anti-inflammatory, anti-arthritic and antinociceptive activity in animal models and was not toxic at oral doses up to 2 g/kg in swiss-albino mice. The gastroretentive, sustained-release capsule formulation showed sustained-release of the bergenin over the period of 24 h, resulting in improved plasma-exposure of bergenin in sprague–Dawley ***: The dual-activity of IL-6 inhibition and antinociception marks the suitability of ⅢM-160 for treating rheumatoid arthritis. This study will serve as the benchmark for further research on this botanical formulation.

关键词： Botanical preclinical candidate UIM-160 Bergenia ciliata Arthritis Gastroretentive sustained release formulation Bergenin

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Healthcare providers’perspectives on factors influencing their critical care decision-making during the COVID-19 pandemic:An international pilot survey

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World Journal of Critical Care Medicine 2025年第1期14卷 100-110页

作者： sonali Vadi Neha sanwalka Pramod Thaker Department of Critical Care Medicine Kokilaben Dhirubhai Ambani Hospital and Medical Research InstituteMumbai 400053MahārāshtraIndia Department of statistics HCJMRIJehangir HospitalPune 411001MahārāshtraIndia Medical Ethics Fellowship Harvard Medical SchoolBostonMA 02138United States

BACKGROUND Understanding a patient's clinical status and setting priorities for their care are two aspects of the constantly changing process of clinical *** analytical technique that can be helpful in uncertain situations is clinical *** must deal with contradictory information,lack of time to make decisions,and long-term factors when emergencies *** To examine the ethical issues healthcare professionals faced during the coronavirus disease 2019(COVID-19)pandemic and the factors affecting clinical *** This pilot study,which means it was a preliminary investigation to gather information and test the feasibility of a larger investigation was conducted over 6 months and we invited responses from clinicians worldwide who managed patients with *** survey focused on topics related to their professional roles and personal *** examined five core areas influencing critical care decision-making:Patients'personal factors,family-related factors,informed consent,communication and media,and hospital administrative policies on clinical *** collected data were analyzed using theχ2 test for categorical *** A total of 102 clinicians from 23 specialties and 17 countries responded to the *** was a significant factor in treatment planning(n=88)and ventilator access(n=78).sex had no bearing on how decisions were *** doctors reported maintaining patient confidentiality regarding privacy and informed *** 50%of clinicians reported a moderate influence of clinical work,with many citing it as one of the most important factors affecting their health and *** from developing countries had a significantly higher score for considering a patient's financial status when creating a treatment plan than their counterparts from developed *** personal experiences,some respondents noted that treatment plans and preferences change

关键词： survey Clinical decision-making COVID-19 pandemic

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DNA Barcoding and systematic Review of Minervaryan Frogs(Dicroglossidae:Minervarya) of Peninsular India:Resolution of a Taxonomic Conundrum with Description of a New species

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Asian Herpetological Research 2021年第4期12卷 345-370页

作者： sonali GARG s.D.BIJU systematics Lab Department of Environmental StudiesUniversity of Delhi

The genus Minervarya is among the most widely distributed,commonly occurring,and taxonomically confusing groups of dicroglossid frogs in *** studies have provided evidence that this genus contains complexes of morphologically conserved but genetically divergent taxa—some widely distributed across south and southeast Asia,and many particularly restricted to the Western Ghats region of the Indian Peninsula—posing several challenges in resolving long-standing taxonomic ***,we present a systematic review of minervaryan species found in Peninsular India,based on extensive DNA barcoding with nearly 400 samples from the entire range of the genus,including 277 new samples and topotypic material for most available names from the study area,combined with detailed morphological *** a result,we recognise 18 species in Peninsular India,including a new species described herein as Minervarya pentali *** to the comprehensive nature of the study,including comparisons with all available types,certain long-standing taxonomic uncertainties on the status of ten previously known taxa are resolved Rana(Tomopterna)parambikulamana Rao,1937(=Minervarya parambikulamana),Rana(Hylorana)sauriceps Rao,1937(=Minervarya sauriceps),and Fejervarya kudremukhensis Kuramoto,Joshy,Kurabayashi,and sumida,2008"2007"(=Minervarya kudremukhensis),are considered as junior subjective synonyms of Rana(Rana)limnocharis mysorensis Rao,1922(=Minervarya mysorensis);Nyctibatrachus sanctipdustris *** Rao,1920(=Minervarya modesta)is proposed to be a synonym of Rana limnocharis syhadrensis Annandale,1919(=Minervarya syhadrensis);while Rana murthii Pillai,1979(=Minervarya murthii)and Fejervarya mudduraja Kuramoto,Joshy,Kurabayashi,and sumida,2008"2007"(=Minervarya mudduraja)are considered as junior subjective synonyms of Rana nilagirica Jerdon,1853(=Minervarya nilagirica).At the same time,Rana brevipalmata Peters,1871(=Minervarya brevipalmata),previously known only from its ori

关键词： amphibia distribution Fejervarya integrative taxonomy Minervarya pentali sp.nov. morphology species groups Western Ghats Biodiversity Hotspot

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Therapeutic potential of ethyl acetate fraction of Tephrosia purpurea *** in a rat model of gout

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Journal of Integrative Medicine 2019年第6期17卷 455-460页

作者： sonali s.Nipate Pramila s.Yelmar Department of Pharmacology Progressive Education Society’s Modern College of Pharmacy

Objective: The present study is to determine the potential treatment effects of ethyl acetate fraction of Tephrosia purpurea Linn. leaves(EATP) against ***: Gout in experimental rats was induced with potassium oxonate at the dose of 250 mg/kg(intraperitoneal injection) for 7 consecutive days;EATP was administered 1 h after administration of the potassium oxonate on each day of experiment. Potassium oxonate was discontinued on the 8 th day;thereafter allopurinol(10 mg/kg, p.o.) and EATP(200 and 400 mg/kg, p.o.) were continued until day 14. The uric acid level was measured from serum and urine during the experiment. Other biochemical parameters were assessed, including blood and urine creatinine, erythrocyte sedimentation rate, and total protein. Blood urea nitrogen, serum aspartate aminotransferase serum alanine aminotransferase and alkaline phosphatase were also measured. The blood was analyzed for levels of malondialdehyde and the antioxidant enzymes such as superoxide dismutase, catalase and glutathione *** and radiological changes in the ankle of rats were observed after completion of the ***: EATP was able to decrease serum uric acid and creatinine level;it also reduced inflammation,oxidative stress and lysosomal enzyme level, which has a role in acute inflammation. EATP increased uric acid excretion through urine due to its uricosuric ***: EATP lowered the serum uric acid level and increased the urine uric acid level through excretion, which is useful in the treatment of gout. Hence the EATP was found to be helpful in the treatment of gout.

关键词： Gout Potassium oxonate Ethyl acetate fraction Tephrosia purpurea Linn.leaves Uric acid deposition Radiological evaluation Allopurinol

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structural,optical and dielectric investigations on RECr_(0.85)Mn_(0.15)O_(3)(RE=Ho,Gd and Pr) nanoparticles

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Journal of Rare Earths 2024年第2期42卷 399-408,I0006页

作者： Komal Kanwar sonali Pradhan s.satapathy Yugandhar Bitla Neeraj Panwar Department of Physics Central University of Rajasthan BandarsindrAjmer305817RajasthanIndia Laser Material section HBNIRaja Ramanna Centre for Advanced TechnologyIndore452013India

We hereby report the room-temperature structural and optical characterization of RECr_(0.85)Mn_(0.15)O_(3)(RECMO,RE=Ho,Gd and Pr) compounds synthesized by the auto-combustion sol-gel *** low temperature dielectric properties are also *** RECMO compounds crystallize in an orthorhombic Pbnm symmetry with an average grain size range of 51-80 *** analysis reveals an increase in the structural distortion compared to that of the undoped bulk *** measurements exhibit a significant reduction in bandgap values for RECMO nanoparticles when compared with their undoped bulk ***,from the absorbance measurements various optical parameters such as skin depth,extinction coefficient,refractive index and optical conductivity were also *** dielectric analysis confirms the lower values of the dielectric permittivity and dielectric loss than those of their corresponding bulk *** conductivity versus frequency and temperature data are fitted according to the Jonscher's power law and Arrhenius law,*** small polaron hopping is responsible for the electric conduction in these *** tunability of the optical and dielectric properties as a result of substitution and particle size reduction makes these materials useful for various potential applications in photocatalysis,optoelectronics and low permittivity dielectrics.

关键词： Rare-earth orthochromites Nanoparticles Optical properties Dispersion parameters Dielectric properties small polaron hopping

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Health Monitoring of Milling Tool Inserts Using CNN Architectures Trained by Vibration spectrograms

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Computer Modeling in Engineering & sciences 2023年第7期136卷 177-199页

作者： sonali s.Patil sujit s.Pardeshi Abhishek D.Patange Department of Mechanical Engineering College of Engineering PunePune411005India

In-process damage to a cutting tool degrades the surface􀀀nish of the job shaped by machining and causes a signi􀀀cant􀀀nancial *** stimulates the need for Tool Condition Monitoring(TCM)to assist detection of failure before it extends to the worse *** Learning(ML)based TCM has been extensively explored in the last ***,most of the research is now directed toward Deep Learning(DL).The“Deep”formulation,hierarchical compositionality,distributed representation and end-to-end learning of Neural Nets need to be explored to create a generalized TCM framework to perform eciently in a high-noise environment of cross-domain *** this motivation,the design of dierent CNN(Convolutional Neural Network)architectures such as AlexNet,ResNet-50,LeNet-5,and VGG-16 is presented in this ***-time spindle vibrations corresponding to healthy and various faulty con􀀀gurations of milling cutter were *** data was transformed into the time-frequency domain and further processed by proposed architectures in graphical form,i.e.,*** model is trained,tested,and validated considering dierent datasets and showcased promising results.

关键词： Milling tool inserts health monitoring vibration spectrograms deep learning convolutional neural network

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HIGHER-ORDER NON-sYMMETRIC DUALITY FOR NONDIFFERENTIABLE MINIMAX FRACTIONAL PROGRAMs WITH sQUARE ROOT TERMs

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Acta Mathematica scientia 2020年第1期40卷 127-140页

作者： sonali Vikas sHARMA Navdeep KAILEY school of Mathematics Thapar Institute of Engineering and TechnologyPatialaIndia

In this paper,we emphasize on a nondifferentiable minimax fractional programming(NMFP)problem and obtain appropriate duality results for higher-order dual model under higher-order B-(p,r)-invex *** provide a nontrivial illustration of a function which belongs to the class of higher-order B-(p,r)-invex but not in the class of second-order B-(p,r)-invex functions already existing in *** example of finding a minimax solution of NMFP problem by using higher-order B-(p,r)-invex functions has also been *** known results are discussed as particular cases.

关键词： nonlinear programming higher-order duality fractional programming minimax programming B-(p,r)-invexity

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Er^(3+)-Yb^(3+)-Na^(+):ZnWO_(4) phosphors for enhanced visible upconversion and temperature sensing applications

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Journal of Rare Earths 2021年第3期39卷 291-296,I0002页

作者： sonali Biswas Lakshmi Mukhopadhyay Manisha Mondal Vineet Kumar Rai Laser and spectroscopy Laboratory Department of PhysicsIndian Institute of Technology(Indian School of Mines)Dhanbad-826004JharkhandIndia

The crystal structure and surface morphology of the Er^(3+)/Yb^(3+)/Na+:ZnWO_(4) phosphors synthesized by solid state reaction method were analyzed by X-ray diffraction(XRD) and field emission scanning electron microscopy(FEsEM) *** frequency upconversion(UC) emission study in the developed phosphors was investigated by using 980 nm laser diode *** effect of codoping in the Er^(3+):ZnWO_(4) phosphors on the UC emission intensity was *** UC emission bands that are exhibited in the blue(490 nm),green(530,552 nm),red(668 nm) and NIR(800 nm) region correspond to the ^(4)F_(7/2)→^(4)I_(15/2).^(2)H_(11/2),^(4)s_(3/2)→^(4)I_(15/2),^(4)F_(9/2)→^(4)I_(15/2) and ^(4)I9/2→^(4)I_(15/2) transitions,*** temperature sensing performance of the Er^(3+)-Yb^(3+)-Na+:ZnWO_(4) phosphors was investigated based on the 2 H_(11/2)→^(4)I_(15/2) and ^(4)s_(3/2)→^(4)I_(15/2) thermally coupled transitions of the Er^(3+)*** photometric study was also carried out for the developed phosphors.

关键词： Upconversion Non-lanthanides Temperature sensing Fluorescence intensity ratio Rare earths

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Development and transferability of two multiplexes nssR in scots pine(Pinus sylvestris L.)

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Journal of Forestry Research 2015年第2期26卷 361-368页

作者： stefana Ganea sonali s.Ranade David Hall sara Abrahamsson Maria Rosario Garcia-Gil Department of Forest Genetics and Plant Physiology SLU901 83 UmeaSweden Department of Genetics and Plant Breeding USAMV400372 Cluj-NapocaRomania

single sequence repeat（ssR） multiplexing is a semi high-throughput PCR methodology for the analysis of multiple *** developed two ssR multiplexes selected from ssR loci previously reported in the pine literature and tested the transferability of both ssR multiplexes in nine other pine *** tested 234 nuclear ssR loci（n ssRs） previously described in the pine literature and selected ten n ssRs following the simple criteria of interpretability and *** nuclear loci were divided into two n ssRs multiplex sets and their amplification was optimized for three different multiplex PCR methods based on：（a） a custom PCR protocol,（b） a custom protocol with hotstart taq polymerase,and（c） a commercially available kit for ssR *** validate their performance,the level of genetic diversity was assessed in three scots pine natural populations（Hungary,northern sweden and southern sweden）.In addition,we also tested the transferability of these multiplexes in nine other pine *** have developed two n ssRs multiplexes of five loci each that will contribute to reduce the costs of n ssR scoring,while increasing the capacity of n ssR loci *** was successful in all three populations（94 % success） and the level of polymorphism（7.1 alleles/marker） was similar to that previously reported for other scots pine natural *** of both multiplexes was successful for those pine species closely related to scots pine.

关键词： Genetic diversity Nuclear ssR ssR multiplex scots pine

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Modelling impacts of high-speed rail on urban interaction with social media in China’s mainland

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Geo-spatial Information science 2021年第4期24卷 638-653页

作者： Junfang Gong shengwen Li Xinyue Ye Qiong Peng sonali Kudva school of Geography and Information Engineering China University of GeosciencesWuhanChina National Engineering Research Center for Geographic Information system China University of GeosciencesWuhanChina Department of Landscape Architecture and Urban Planning&Department of Geography Urban Data Science LabTexas A&m UniversityCollege StationTXUSA Department of Urban studies and Planning National Center for Smart GrowthUniversity of MarylandCollege ParkMDUSA Department of Communication University of TampaTampaFLUSA

High-speed Rail(HsR)has increasingly become an important mode of inter-city transportation between large ***-city interaction facilitated by HsR tends to play a more prominent role in promoting urban and regional economic integration and *** the impact of HsR’s interaction on cities and people is therefore crucial for long-term urban and regional development planning and policy *** develop an evaluation framework using toponym information from social media as a proxy to estimate the dynamics of such *** paper adopts two types of spatial information:toponyms from social media posts,and the geographical location information embedded in social media *** framework highlights the asymmetric nature of social interaction among cities,and proposes a series of metrics to quantify such impact from multiple perspectives-including interaction strength,spatial decay,and channel *** results show that HsRs not only greatly expand the uneven distribution of inter-city connections,but also significantly reshape the interactions that occur along HsR routes through the channel effect.

关键词： High-speed Rail social media asymmetric spatial relatedness channel effect China

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