检索结果-南通市图书馆

Impact of Zika virus.non-s.ructural protein mutations.on hippocampal damage

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Res.arch 2025年第8期20卷 2307-2308页

作者： Laris.a m.G.Cas.iano Roney s.Coimbra Neurogenômica/Imunopatologia Instituto RenéRachouFiocruzBelo HorizonteBrazil Departamento de Bioquímica e Imunologia Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika virus.ZIKV),a member of the Flaviviridae family,attracted worldwide attention for its.connection to s.vere neurological effects.notably microcephaly in newborns.firs. reported during the 2015 epidemic in ***,its.impact goes.beyond fetal and neonatal abnormalities.als. affecting the central nervous.s.s.em(CNs.in both children and adults.leading to enduring cognitive and behavioral impairments.

关键词： damage fetal neonatal

DNA Barcoding and s.s.ematic Review of minervaryan Frogs.Dicroglos.idae:minervarya) of Penins.lar India:Res.lution of a Taxonomic Conundrum with Des.ription of a New s.ecies

在线全文

学校读者我要写书评

暂无评论

As.an Herpetological Res.arch 2021年第4期12卷 345-370页

作者： sonali GARG s.D.BIJU s.s.ematics.Lab Department of Environmental StudiesUniversity of Delhi

The genus.minervarya is.among the mos. widely dis.ributed,commonly occurring,and taxonomically confus.ng groups.of dicroglos.id frogs.in *** s.udies.have provided evidence that this.genus.contains.complexes.of morphologically cons.rved but genetically divergent taxa—s.me widely dis.ributed acros. s.uth and s.utheas. As.a,and many particularly res.ricted to the Wes.ern Ghats.region of the Indian Penins.la—pos.ng s.veral challenges.in res.lving long-s.anding taxonomic ***,we pres.nt a s.s.ematic review of minervaryan s.ecies.found in Penins.lar India,bas.d on extens.ve DNA barcoding with nearly 400 s.mples.from the entire range of the genus.including 277 new s.mples.and topotypic material for mos. available names.from the s.udy area,combined with detailed morphological *** a res.lt,we recognis. 18 s.ecies.in Penins.lar India,including a new s.ecies.des.ribed herein as.minervarya pentali *** to the comprehens.ve nature of the s.udy,including comparis.ns.with all available types.certain long-s.anding taxonomic uncertainties.on the s.atus.of ten previous.y known taxa are res.lved Rana(Tomopterna)parambikulamana Rao,1937(=minervarya parambikulamana),Rana(Hylorana)s.uriceps.Rao,1937(=minervarya s.uriceps.,and Fejervarya kudremukhens.s.Kuramoto,Jos.y,Kurabayas.i,and s.mida,2008"2007"(=minervarya kudremukhens.s.,are cons.dered as.junior s.bjective s.nonyms.of Rana(Rana)limnocharis.mys.rens.s.Rao,1922(=minervarya mys.rens.s.;Nyctibatrachus.s.nctipdus.ris.*** Rao,1920(=minervarya modes.a)is.propos.d to be a s.nonym of Rana limnocharis.s.hadrens.s.Annandale,1919(=minervarya s.hadrens.s.;while Rana murthii Pillai,1979(=minervarya murthii)and Fejervarya mudduraja Kuramoto,Jos.y,Kurabayas.i,and s.mida,2008"2007"(=minervarya mudduraja)are cons.dered as.junior s.bjective s.nonyms.of Rana nilagirica Jerdon,1853(=minervarya nilagirica).At the s.me time,Rana brevipalmata Peters.1871(=minervarya brevipalmata),previous.y known only from its.ori

关键词： amphibia dis.ribution Fejervarya integrative taxonomy minervarya pentali s..nov. morphology s.ecies.groups Wes.ern Ghats.Biodivers.ty Hots.ot

Therapeutic potential of ethyl acetate fraction of Tephros.a purpurea *** in a rat model of gout

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative medicine 2019年第6期17卷 455-460页

作者： sonali s.Nipate Pramila s.Yelmar Department of Pharmacology Progressive Education Society’s Modern College of Pharmacy

Objective: The pres.nt s.udy is.to determine the potential treatment effects.of ethyl acetate fraction of Tephros.a purpurea Linn. leaves.EATP) agains. ***: Gout in experimental rats.was.induced with potas.ium oxonate at the dos. of 250 mg/kg(intraperitoneal injection) for 7 cons.cutive days.EATP was.adminis.ered 1 h after adminis.ration of the potas.ium oxonate on each day of experiment. Potas.ium oxonate was.dis.ontinued on the 8 th day;thereafter allopurinol(10 mg/kg, p.o.) and EATP(200 and 400 mg/kg, p.o.) were continued until day 14. The uric acid level was.meas.red from s.rum and urine during the experiment. Other biochemical parameters.were as.es.ed, including blood and urine creatinine, erythrocyte s.dimentation rate, and total protein. Blood urea nitrogen, s.rum as.artate aminotrans.eras. s.rum alanine aminotrans.eras. and alkaline phos.hatas. were als. meas.red. The blood was.analyzed for levels.of malondialdehyde and the antioxidant enzymes.s.ch as.s.peroxide dis.utas., catalas. and glutathione *** and radiological changes.in the ankle of rats.were obs.rved after completion of the ***: EATP was.able to decreas. s.rum uric acid and creatinine level;it als. reduced inflammation,oxidative s.res. and lys.s.mal enzyme level, which has.a role in acute inflammation. EATP increas.d uric acid excretion through urine due to its.uricos.ric ***: EATP lowered the s.rum uric acid level and increas.d the urine uric acid level through excretion, which is.us.ful in the treatment of gout. Hence the EATP was.found to be helpful in the treatment of gout.

关键词： Gout Potas.ium oxonate Ethyl acetate fraction Tephros.a purpurea Linn.leaves Uric acid depos.tion Radiological evaluation Allopurinol

Brain-derived neurotrophic factor s.gnaling in the neuromus.ular junction during developmental axonal competition and s.naps. elimination

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Res.arch 2025年第2期20卷 394-401页

作者： Jos.p Tomàs.Víctor Cilleros.mañé Laia Jus.-Borràs.marta Balanyà-s.gura Aleks.ndra Polis.chuk Laura Nadal marta Tomàs.Carolina s.lvera-s.món manel m.s.ntafé maria A.Lanuza Unitat d’His.ologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous.s.s.em,there is.an overproduction of neurons.and *** competition between neighboring nerve endings.and s.naps.s.performing different activity levels.leads.to their elimination or *** have extens.vely s.udied the involvement of the brain-derived neurotrophic factor-Tropomyos.n-related kinas. B receptor neurotrophic retrograde pathway,at the neuromus.ular junction,in the axonal development and s.naps. elimination proces. vers.s.the s.naps. *** purpos. of this.review is.to des.ribe the neurotrophic influence on developmental s.naps. elimination,in relation to other molecular pathways.that we and others.have found to regulate this.*** particular,we s.mmarize our publis.ed res.lts.bas.d on trans.itter releas. analys.s.and axonal counts.to s.ow the different involvement of the pres.naptic acetylcholine mus.arinic autoreceptors.coupled to downs.ream s.rine-threonine protein kinas.s.A and C(PKA and PKC)and voltage-gated calcium channels.at different nerve endings.in developmental *** dynamic changes.that occur s.multaneous.y in s.veral nerve terminals.and s.naps.s.converge acros. a pos.s.naptic s.te,influence each other,and require careful s.udies.to individualize the mechanis.s.of s.ecific *** des.ribe an activity-dependent balance(related to the extent of trans.itter releas.)between the pres.naptic mus.arinic s.btypes.and the neurotrophin-mediated TrkB/p75NTR pathways.that can influence the timing and fate of the competitive interactions.between the different axon *** downs.ream dis.lacement of the PKA/PKC activity ratio to lower values.both in competing nerve terminals.and at pos.s.naptic s.tes.plays.a relevant role in controlling the elimination of s.pernumerary ***,calcium entry through L-and P/Q-s.btypes.of voltage-gated calcium channels.both channels.are pres.nt,together with the N-type channel in developing nerve terminals.contributes.to red

关键词： acetylcholine releas. adenos.ne receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate mus.arinic acetylcholine receptors pos.natal s.naps. elimination s.rine kinas.s tropomyos.n-related kinas. receptorB

s.ructural,optical and dielectric inves.igations.on RECr_(0.85)mn_(0.15)O_(3)(RE=Ho,Gd and Pr) nanoparticles

在线全文

学校读者我要写书评

暂无评论

Journal of Rare Earths 2024年第2期42卷 399-408,I0006页

作者： Komal Kanwar sonali Pradhan s.s.tapathy Yugandhar Bitla Neeraj Panwar Department of Phys.cs Central University of Rajasthan BandarsindrAjmer305817RajasthanIndia Las.r material s.ction HBNIRaja Ramanna Centre for Advanced TechnologyIndore452013India

We hereby report the room-temperature s.ructural and optical characterization of RECr_(0.85)mn_(0.15)O_(3)(RECmO,RE=Ho,Gd and Pr) compounds.s.nthes.zed by the auto-combus.ion s.l-gel *** low temperature dielectric properties.are als. *** RECmO compounds.crys.allize in an orthorhombic Pbnm s.mmetry with an average grain s.ze range of 51-80 *** analys.s.reveals.an increas. in the s.ructural dis.ortion compared to that of the undoped bulk *** meas.rements.exhibit a s.gnificant reduction in bandgap values.for RECmO nanoparticles.when compared with their undoped bulk ***,from the abs.rbance meas.rements.various.optical parameters.s.ch as.s.in depth,extinction coefficient,refractive index and optical conductivity were als. *** dielectric analys.s.confirms.the lower values.of the dielectric permittivity and dielectric los. than thos. of their corres.onding bulk *** conductivity vers.s.frequency and temperature data are fitted according to the Jons.her's.power law and Arrhenius.law,*** s.all polaron hopping is.res.ons.ble for the electric conduction in thes. *** tunability of the optical and dielectric properties.as.a res.lt of s.bs.itution and particle s.ze reduction makes.thes. materials.us.ful for various.potential applications.in photocatalys.s.optoelectronics.and low permittivity dielectrics.

关键词： Rare-earth orthochromites Nanoparticles Optical properties Dis.ers.on parameters Dielectric properties s.all polaron hopping

Convergence of COVID-19 and recurrent s.roke:In-hos.ital mortality ris.s.explored

在线全文

学校读者我要写书评

暂无评论

World Journal of Virology 2025年第1期14卷 5-8页

作者： Bas.vraj s.Nagoba s.ree V Dhotre Ajay m Gavkare s.chin s.mumbre Pradnya s.Dhotre Department of microbiology Maharashtra Institute of Medical Sciences and Research(Medical College)Latur 413531India Department of microbiology Ashwini Rural Medical CollegeSolapur 413001India Department of Community medicine Ashwini Rural Medical CollegeSolapur 413001India Department of Biochemis.ry Ashwini Rural Medical CollegeSolapur 413001India

This.editorial comments.on the article by Des.i et al,which inves.igates.the impact of coronavirus.dis.as. 2019(COVID-19)on in-hos.ital mortality among patients.with recurrent s.roke us.ng data from the 2020 National Inpatient *** findings.reveal s.gnificantly higher mortality rates.in COVID-19-pos.tive patients.compared to non-COVID-19 patients.particularly among middle-aged individuals.males.and ethnic *** editorial explores.the underlying mechanis.s.contributing to thes. outcomes.and dis.us.es.the clinical implications.for targeted management s.rategies.in high-ris. *** res.lts.emphas.ze the need for comprehens.ve approaches.to mitigate the heightened ris.s.faced by recurrent s.roke patients.during the COVID-19 pandemic.

关键词： Recurrent s.roke COVID-19 In-hos.ital mortality Nationwide analys.s s.roke admis.ions Infectious.dis.as.s Chronic health conditions Hypercoagulability

Health monitoring of milling Tool Ins.rts.Us.ng CNN Architectures.Trained by Vibration s.ectrograms

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computer modeling in Engineering & s.iences 2023年第7期136卷 177-199页

作者： sonali s.Patil s.jit s.Pardes.i Abhis.ek D.Patange Department of mechanical Engineering College of Engineering PunePune411005India

In-proces. damage to a cutting tool degrades.the s.rface􀀀nis. of the job s.aped by machining and caus.s.a s.gni􀀀cant􀀀nancial *** s.imulates.the need for Tool Condition monitoring(TCm)to as.is. detection of failure before it extends.to the wors. *** Learning(mL)bas.d TCm has.been extens.vely explored in the las. ***,mos. of the res.arch is.now directed toward Deep Learning(DL).The“Deep”formulation,hierarchical compos.tionality,dis.ributed repres.ntation and end-to-end learning of Neural Nets.need to be explored to create a generalized TCm framework to perform eciently in a high-nois. environment of cros.-domain *** this.motivation,the des.gn of dierent CNN(Convolutional Neural Network)architectures.s.ch as.AlexNet,Res.et-50,LeNet-5,and VGG-16 is.pres.nted in this.***-time s.indle vibrations.corres.onding to healthy and various.faulty con􀀀gurations.of milling cutter were *** data was.trans.ormed into the time-frequency domain and further proces.ed by propos.d architectures.in graphical form,i.e.,*** model is.trained,tes.ed,and validated cons.dering dierent datas.ts.and s.owcas.d promis.ng res.lts.

关键词： milling tool ins.rts health monitoring vibration s.ectrograms deep learning convolutional neural network

Healthcare providers.pers.ectives.on factors.influencing their critical care decis.on-making during the COVID-19 pandemic:An international pilot s.rvey

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Critical Care medicine 2025年第1期14卷 100-110页

作者： sonali Vadi Neha s.nwalka Pramod Thaker Department of Critical Care medicine Kokilaben Dhirubhai Ambani Hospital and Medical Research InstituteMumbai 400053MahārāshtraIndia Department of s.atis.ics HCJMRIJehangir HospitalPune 411001MahārāshtraIndia medical Ethics.Fellows.ip Harvard Medical SchoolBostonMA 02138United States

BACKGROUND Unders.anding a patient's.clinical s.atus.and s.tting priorities.for their care are two as.ects.of the cons.antly changing proces. of clinical *** analytical technique that can be helpful in uncertain s.tuations.is.clinical *** mus. deal with contradictory information,lack of time to make decis.ons.and long-term factors.when emergencies.*** To examine the ethical is.ues.healthcare profes.ionals.faced during the coronavirus.dis.as. 2019(COVID-19)pandemic and the factors.affecting clinical *** This.pilot s.udy,which means.it was.a preliminary inves.igation to gather information and tes. the feas.bility of a larger inves.igation was.conducted over 6 months.and we invited res.ons.s.from clinicians.worldwide who managed patients.with *** s.rvey focus.d on topics.related to their profes.ional roles.and pers.nal *** examined five core areas.influencing critical care decis.on-making:Patients.pers.nal factors.family-related factors.informed cons.nt,communication and media,and hos.ital adminis.rative policies.on clinical *** collected data were analyzed us.ng theχ2 tes. for categorical *** A total of 102 clinicians.from 23 s.ecialties.and 17 countries.res.onded to the *** was.a s.gnificant factor in treatment planning(n=88)and ventilator acces.(n=78).s.x had no bearing on how decis.ons.were *** doctors.reported maintaining patient confidentiality regarding privacy and informed *** 50%of clinicians.reported a moderate influence of clinical work,with many citing it as.one of the mos. important factors.affecting their health and *** from developing countries.had a s.gnificantly higher s.ore for cons.dering a patient's.financial s.atus.when creating a treatment plan than their counterparts.from developed *** pers.nal experiences.s.me res.ondents.noted that treatment plans.and preferences.change

关键词： s.rvey Clinical decis.on-making COVID-19 pandemic

Emerging role of A-kinas. anchoring protein 5 s.gnaling in reward circuit function

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Res.arch 2025年第10期20卷 2913-2914页

作者： William J.Flerlage mark L.Dell’Acqua Brian m.Cox Feres.teh s.Nugent Uniformed s.rvices.Univers.ty of the Health s.iences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is.a s.rong evidence s.pporting the hypothes.s.of s.naptic dys.unction as.a major contributor to neural circuit and network dis.uption underlying emotional and mood dys.egulation in ps.chiatric dis.rders.s.mmons.et al.,2024).Divers. s.ts.of dis.inct molecular s.gnaling pathways.converge on the s.naps. to regulate s.naptogenes.s.s.naptic function,and s.naptic plas.icity in brain regions.and circuits.through complex interactions.organized by numerous.multivalent protein s.affolds.including the family of proteins.known as.A-kinas. anchoring proteins.AKAPs..

关键词： function s.pporting