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A Prospective, Multicentric, Post Marketing Surveillance to Evaluate Efficacy & Safety of Ranitidine HCl (150 & 300 mg IR/CR) in Indian Patients with Gastroesophageal Reflux Disease (PROGRADE)

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Open Journal of Gastroenterology 2023年第7期13卷 237-249页

作者： Akash Shukla Anil Kumar Awasthi Ramesh Rao Dawesh Prakash Yadav Nilesh Nolkha Rajesh Pendlimari Sanjiv Dua Shrish bhatnagar Ravindra Mote Ashish Birla Jay Savai Kapil Mehta Shashank Salunke Department of Gastroenterology Gastro Universe Mumbai India Department of Medicine Ajanta Research Centre Ajanta Hospital & IVF Centre Lucknow India Departmentof Nephrology Sanjeevani Kidney Care Mumbai India Department of Gastroenterology Institute of Medical Sciences Banaras Hindu University Varanasi India Department of Rheumatology Wockhardt Hospitals Mumbai India Department of Gastroenterology Rajalakshmi Hospital and Research Center Bangalore India Department of General Surgery SaiKripa Hospital Mumbai India Department of Gastroenterology Sparsh Child Care and Gastro Centre Lucknow India Department of Clinical Research Mediclin Clinical Research Mumbai India Department of Medical Affairs JB Chemicals & Pharmaceuticals Ltd. Mumbai India

Purpose: Ranitidine hydrochloride (HCl) remains an important medication for treating acid-peptic ailments such as Gastroesophageal reflux disease (GERD). The main objective of this Post Marketing Surveillance (PMS) clinical study was to test the efficacy and safety of Ranitidine HCl in Indian patients suffering from GERD. Patients and Methods: Data of 2446 patients (1307 males;1121 females) from 21 centers across India were analyzed. Patients received either of the three treatments: Ranitidine HCl 150 mg twice a day (BID) (ARM-A), Ranitidine HCl 300 mg once daily (OD) or BID (ARM-B), and Ranitidine HCl 300 mg OD (ARM-C). Gastroesophageal Reflux Disease Symptom Assessment Scale (GSAS) score and Heartburn Severity score were used to assess the drug’s efficacy. The adverse events reported by patients or investigators were analyzed to assess the safety profile of Ranitidine. Results: Of the 2446 subjects screened, 2428 were enrolled. There was a significant reduction in GSAS scores from baseline to the end of the study visit in all three ARMs. The GSAS scores reduced from 2.02 to 0.23 in ARM-A, 2.01 to 0.24 in ARM-B, and 2.07 to 0.26 in ARM-C patients. In ARM A, 72.82% had 24 hours heartburn-free days, and 66.89% had 7 consecutive heartburn-free days, which was more significant than the other two ARMs. 128 (5.27%) patients reported ADRs due to Ranitidine HCl at different doses. The most frequently reported ADR was constipation (17.18%), followed by oliguria (14.06%), cold (13.28%), and dysuria (12.5%). Of 128 ADRs, 113 (88.28%) were mild, and only 11 (8.59%) ADRs were related to the study drug. No severe ADRs were reported during the study. Conclusion: Ranitidine HCl 150/300 mg tablet was found to be an effective and safe H2-receptor antagonist for treating GERD in Indian Patients.

关键词： Ranitidine Hydrochloride GERD Heartburn H2-Receptor Antagonists

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经胸腔置管给予滑石粉门诊治疗恶性胸腔积液

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中华结核和呼吸杂志 2018年第9期41卷 674-674页

作者： bhatnagar R Keenan EK Morley AJ 孙字新黄慧不详中国医学科学院北京协和医院呼吸内科 100730

背景欧美每年有超过750000例患者饱受恶性胸腔积液的折磨，对于住院患者来说，滑石粉胸膜固定术是最常用的治疗方法，门诊患者则经常采用胸腔置管引流胸腔积液的方法。本研究拟比较经胸腔置管给予滑石粉、单纯胸腔置管引流门诊治疗恶性... 详细信息

背景欧美每年有超过750000例患者饱受恶性胸腔积液的折磨，对于住院患者来说，滑石粉胸膜固定术是最常用的治疗方法，门诊患者则经常采用胸腔置管引流胸腔积液的方法。本研究拟比较经胸腔置管给予滑石粉、单纯胸腔置管引流门诊治疗恶性胸腔积液的疗效。方法本研究是由英国18个医疗中心参与、为期4年（2012年6月至2016年12月）、随机、单盲、安慰剂平行对照临床试验。

关键词：滑石粉胸膜固定术恶性胸腔积液胸腔置管引流门诊治疗对照临床试验住院患者治疗方法门诊患者

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临时内撑开在严重脊柱侧凸矫形中的辅助应用

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骨科动态 2007年第1期3卷 22-27页

作者： JACOB M. BUCHOWSKI RISHI bhatnagar DAVID L. SKAGGS PAUL D. SPONSELLER 仉建国（译） Investigation performed at the Department of Orthopaedic Surgery Johns Hopkins University School of Medicine Baltimore Maryland and the Division of Orthopaedic Surgery Childrens Hospital Los Angeles Los Angeles California 中国医学科学院北京协和医院骨科 100730

背景：Halo头颅环牵引作为严重、复杂、僵硬的脊柱侧凸矫形的辅助治疗方法已获得普遍认可。但它需要较长的住院时间，还存在相关并发症及一些禁忌证，如固定的颈椎不稳、脊柱后凸或椎管狭窄等。本文研究临时脊柱内撑开在严重脊柱侧凸矫... 详细信息

背景：Halo头颅环牵引作为严重、复杂、僵硬的脊柱侧凸矫形的辅助治疗方法已获得普遍认可。但它需要较长的住院时间，还存在相关并发症及一些禁忌证，如固定的颈椎不稳、脊柱后凸或椎管狭窄等。本文研究临时脊柱内撑开在严重脊柱侧凸矫形中的应用及其效果。方法：回顾性分析儿童严重脊柱侧凸行临时脊柱内撑开治疗的病例10例。我们的目的是：（1）评价临时内撑开对严重脊柱侧凸的矫形是否有帮助，（2）比较该方法与头颅环牵引的并发症。术前平均侧凸104°，所有病例均先行侧凸僵硬部分的后路松解（其中6例同时行前路松解），并在脊髓监护下植入脊柱撑开内置物。10例患者中4例行一次撑开操作（即初次手术或第一次撑开手术）后做融合术，6例行两次撑开操作（即初次手术或第一次撑开手术完成后再行第二次撑开手术）后做融合术。所有病例完成撑开操作后均行后路双棒内固定植骨融合术。在术前、每次脊柱内撑开操作后、固定融合手术后及末次随访时均摄X线片，测量侧凸的角度以明确矫形效果。结果：术前侧凸Cobb角平均104°。应用脊柱初次内撑开至最终融合前，侧凸平均矫形率为53％（104°-49°）[范围，39％（70°-43°）-79％（70°-15°）]。这一方法使患者获得了安全、逐步的侧凸矫形。初次手术至最终固定融合手术的时间间隔平均为2．4周。最终侧凸平均矫形率为80％（104°-20°）[范围，73％（131°-35°）-91％（110°10°）]，无神经并发症或感染发生。结论：临时脊柱内撑开可使严重脊柱侧凸经过脊柱融合获得最大的侧凸矫正，是治疗严重脊柱侧凸可供选择和有效的方法。可信水平：治疗性研究，Ⅳ级。进一步可信度参见作者介绍。

关键词：脊柱侧凸矫形脊柱撑开辅助应用严重脊柱侧凸辅助治疗方法植骨融合术相关并发症颅环牵引

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Persistent Zika Virus Infection Associated with Early Fetal Demise: A Case Report

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Open Journal of Obstetrics and Gynecology 2019年第5期9卷 698-706页

作者： Janice Pérez-Padilla Gabriela Paz-Bailey Dana Meaney-Delman Kate Doyle Joy Gary Dania M. Rodriguez Julu bhatnagar Nicole M. Pérez-Rodriguez Sara Montalvo Luisa Alvarado Tyler M. Sharp Centers for Disease Control and Prevention (CDC) Dengue Branch San Juan Puerto Rico CDC National Center for Emerging and Zoonotic Infectious Diseases Atlanta GA USA CDC Division of HIV/AIDS Prevention Atlanta GA USA CDC Division of HIV/AIDS Prevention Atlanta GA USA Ponce Health Sciences University/Saint Luke’s Episcopal Hospital Ponce Puerto Rico

Background: Infection with Zika virus (ZIKV) during pregnancy is known to cause birth defects and could also be linked to pregnancy loss. Case: A pregnant woman in Puerto Rico contracted ZIKV at 16 weeks gestation. ZIKV RNA persisted in serum from her initial test at 16 weeks through 24 weeks gestation, when fetal demise occurred, and was detected in placental tissue. Conclusion: Prolonged detection of ZIKV RNA in maternal serum was associated with ZIKV RNA detection in the placenta of a patient who experienced fetal demise. While detection of placenta ZIKV RNA does not establish that ZIKV conclusively caused the demise, these findings support emerging evidence that the placenta may serve as a reservoir for ZIKV, which may be associated with prolonged detection of ZIKV RNA in serum.

关键词： Zika Pregnancy Outcomes ZIKV Persistence

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克罗恩病T2加权成像的MRI纹理分析（MRTA）可为回肠切除的病人提供组织学和疾病活动性的信息

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国际医学放射学杂志 2017年第2期 238-239页

作者： J.Makanyanga B.Ganeshan M.Rodriguez-Justo G.bhatnagar A.Groves S.Halligan 陈皓 Center for Medical Imaging University College London and University College London Hospitals NIHR Biomedical Research Centre

摘要目的研究MRI纹理分析(MRTA)与MRI、组织学评估克罗恩病(CD)活动性的相关性。方法回顾性分析16例CD病人(平均年龄39.5岁,男9例)回肠切除术前的MR

关键词：克罗恩病局限性回肠炎肠炎活动性 MRTA T2 MRI 纹理分析

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应用肿瘤坏死因子抗体-α治疗克罗恩病的疗效监测:MR小肠成像整体积分(MEGS)与联合临床标准的比较

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国际医学放射学杂志 2016年第5期 582-583页

作者： D.Prezzi G.bhatnagar R.Vega J.Makanyanga S.Halligan S.A.Taylor 王宇航 Centre for Medical Imaging University College London

摘要目的应用MR小肠成像整体积分(MEGS)评价肿瘤坏死因子抗体-α(Anti-TNF-α)治疗克罗恩病(CD)的疗效。方法回顾性选择36例CD病人(平均年龄26岁,男20例,女16例),均拟行肿瘤坏死因子抗体-α治疗并已行基线MR小肠成像(MRE)检查。治疗过程... 详细信息

摘要目的应用MR小肠成像整体积分(MEGS)评价肿瘤坏死因子抗体-α(Anti-TNF-α)治疗克罗恩病(CD)的疗效。方法回顾性选择36例CD病人(平均年龄26岁,男20例,女16例),均拟行肿瘤坏死因子抗体-α治疗并已行基线MR小肠成像(MRE)检查。治疗过程中,对病人进行临床评估

关键词：克罗恩病局限性回肠炎肠炎坏死因子 MEGS 抗体积分积分学 MR 小肠

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测量眼压的一次性装置:评估其准确性的临床研究

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世界核心医学期刊文摘（眼科学分册） 2005年第12期1卷 44-44页

作者： bhatnagar A Gupta A.K 张鹏 Wolverhampton Eye Infirmary Compton Road Wolverhampton United Kingdom

Aims: We conducted a study to compare the accuracy of two commercially available disposable tonometry devices (the acrylic biprism, TonosafeTM and the silicone shield, TonoshieldTM)with the standard Goldmann ap planation ton-ometer (GAT). Methods: A total of 80 eyes of 40 patients were randomly assigned to two groups. Group A (40 eyes) had the intraocular pressure IOP measured using GAT and the acrylic biprism.(TonosafeTM), while Group B(40 eyes) had IOP measured using GAT and the disposable silicone shield (TonoshieldTM). IOP was measured using the GAT both before and after the disposable device and average of the two standard Goldmann readings was comparedwith the IOPmeasured using the disposable devices. Results: The mean difference in IOP in Group A was 0.29 mmHg (SD 0.54) (P=0.0018) while in Group B the mean difference in IOP was 2.09 mmHg (SD 1.23) (P < 0.0001). The Altman-Bland method was used to assess the agreement between two methods of clinical measurement. This shows a positive bias of 0.29 (95% confidence interval (CI) 0.11- 0.46) when using the disposable acrylic biprism and a positive bias of 2.09 (95% CI 1.69- 2.48) with the silicone shield. Conclusion: The IOP recorded using the disposable acrylic biprism (TonosafeTM) was in close agreement with the standard GAT. However, IOP readings obtained with the silicone shield (TonoshieldTM) tend to be higher than with the standard GAT. These facts should be kept in mind when recording IOP in clinical situations.

关键词：双棱镜压平测量方法临床应用

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基于增强CT机器学习模型和临床决策算法的肾囊性病变恶性风险分层

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国际医学放射学杂志 2022年第4期 495-495页

作者： J.Dana T.L.Lefebvre P.Savadjiev S.Bodard S.Gauvin S.R.bhatnagar 张雅欣

摘要目的使用基于增强CT的影像组学模型和临床决策算法鉴别肾囊性病变（CRL）良恶性。方法回顾性纳入2个医疗中心的2005—2018年18岁以上的CRL病人。参考

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支气管肺前肠畸形伴膈膨出

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世界核心医学期刊文摘（儿科学分册） 2006年第12期2卷 60-60页

作者： Singal A.K. Srinivas M. bhatnagar V. 刘凯 Department of Paediatric Surgery All India Institute of Medical SciencesNew DelhiIndia

Bronchopulmonary foregut malformations are uncommon anomalies,and their association with diaphragmatic eventration is rare. This report presents 2 cases with this ***,a simultaneous disturbance in the development of pulmonary vessels and developing esophagotracheal septum may explain the etiopathogenesis of this *** budding along the developing foregut tube may lead to foregut cysts. In both cases,the bronchopulmonary foregut malformations were excised,and the diaphragm was *** results of surgery were gratifying in both cases.

关键词：前肠气管食管隔肠囊肿肺芽发病机制

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Research and development of the back-end electronics for the two-dimensional improved resistive plate chambers in CMS upgrade

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Radiation Detection Technology and Methods 2021年第2期5卷 181-191页

作者： P.Cao Z-A.Liu J.Zhao H.Kou J.Tao J.Song W.Gong N.Wang A.Samalan M.Tytgat N.Zaganidis G.A.Alves F.Marujo F.Torres.Da.S.ilva.De.Araujo E.M.Da Costa D.De Jesus Damiao H.Nogima A.Santoro S.Fonseca De Souza A.Aleksandrov R.Hadjiiska P.Iaydjiev M.Rodozov M.Shopova G.Sultanov M.Bonchev A.Dimitrov L.Litov B.Pavlov P.Petkov A.Petrov S.J.Qian C.Bernal A.Cabrera J.Fraga A.Sarkar S.Elsayed Y.Assran M.El Sawy M.A.Mahmoud Y.Mohammed X.Chen C.Combaret M.Gouzevitch G.Grenier I.Laktineh L.Mirabito K.Shchablo I.Bagaturia D.Lomidze I.Lomidze V.bhatnagar R.Gupta P.Kumari J.Singh V.Amoozegar B.Boghrati M.Ebraimi R.Ghasemi M.Mohammadi Najafabadi E.Zareian M.Abbrescia R.Aly W.Elmetenawee N.De Filippis A.Gelmi G.Iaselli S.Leszki F.Loddo I.Margjeka G.Pugliese D.Ramos L.Benussi S.Bianco D.Piccolo S.Buontempo A.Di Crescenzo F.Fienga G.De Lellis L.Lista S.Meola P.Paolucci A.Braghieri P.Salvini P.Montagna C.Riccardi P.Vitulo B.Francois T.J.Kim J.Park S.Y.Choi B.Hong K.S.Lee J.Goh H.Lee J.Eysermans C.Uribe Estrada I.Pedraza H.Castilla-Valdez A.Sanchez-Hernandez C.A.Mondragon Herrera D.A.Perez Navarro G.A.Ayala Sanchez S.Carrillo E.Vazquez A.Radi A.Ahmad I.Asghar H.Hoorani S.Muhammad M.A.Shah I.Crotty Department of Physics and Astronomy Ghent UniversityProeftuinstraat 869000 GhentBelgium Centro Brasileiro Pesquisas Fisicas R.Dr.Xavier Sigaud150-UrcaRio de JaneiroRJ 22290-180Brazil Dep.de Fisica Nuclear e Altas Energias Instituto de FisicaUniversidade do Estado do Rio de JaneiroRua Sao Francisco Xavier524BR-Rio de Janeiro 20559-900RJBrazil Bulgarian Academy of Sciences Inst.for Nucl.Res.and Nucl.EnergyTzarigradsko shaussee Boulevard 721784 SofiaBulgaria Faculty of Physics University of Sofia5 James Bourchier Boulevard1164 SofiaBulgaria School of Physics Peking UniversityBeijing 100871China Institute of High Energy Physics UCAS/CAS19(B)Yuquan RoadShijingshan DistrictBeijing 100049China Universidad de Los Andes Apartado Aereo 4976Carrera 1Eno.18A 10BogotaCOColombia Egyptian Network for High Energy Physics Academy of Scientific Research and Technology101 Kasr El-Einy St.CairoEgypt The British University in Egypt(BUE) P.O.Box 43Elsherouk CitySuez Desert RoadCairo 11837Egypt Suez University Elsalam CitySuez-Cairo RoadSuez 43522Egypt Department of Physics Faculty of ScienceBeni-Suef UniversityBeni-SuefEgypt Center for High Energy Physics Faculty of ScienceFayoum UniversityEl-Fayoum 63514Egypt Univ Lyon Univ Claude Bernard Lyon 1CNRS/IN2P3IP2I LyonUMR 582269622 VilleurbanneFrance Georgian Technical University 77 Kostava Str.Tbilisi 0175Georgia Department of Physics Panjab UniversityChandigarh 160014India School of Particles and Accelerators Institute for Research in Fundamental Sciences(IPM)P.O.Box 19395-5531TehranIran School of Engineering Damghan UniversityDamghan ***Iran INFN Sezione di BariVia Orabona 470126 BariItaly INFN Laboratori Nazionali di Frascati(LNF)Via Enrico Fermi 4000044 FrascatiItaly INFN Sezione di NapoliComplesso Univ.Monte S.AngeloVia Cintia80126 NaplesItaly INFN Sezione di PaviaVia Bassi 6PaviaItaly INFN Sezione di Pavia and University of PaviaVia Bassi 6PaviaItaly Hanyang University 222 Wangsimni-roSageun-dongSeongdong

Purpose To complement and ensure redundancy in the endcap muon system of the Compact Muon Solenoid(CMS)detector and to extend the Resistive Plate Chamber(RPC)system coverage,improved RPCs(iRPCs)with either orthogonal layer strips with one-end electronics or single layer strips with two-end electronics providing more precise time measurement will be installed in the very forward pseudorapidity region of|η|<*** iRPC readout system needs to support twodimensional(2D)or two-end *** addition,it must combine detector data with Timing,Trigger and fast Control(TTC)and Slow Control(SC)into one data stream over a bi-directional optical link with a line rate of 4.8 Gb/s between the Front-End Electronics(FEE)and the Back-End Electronics(BEE).To fulfill these requirements,a prototype BEE for the iRPC 2D chamber has been researched and *** A Micro-Telecommunication and Computing Architecture(μTCA)-based processing card was designed in this study to establish a prototype system together with aμTCA *** Giga-Bit Transceiver(GBT)protocol is integrated to provide bi-directional communication between the FEE and BEE.A server is connected with the BEE by a Gigabit Ethernet(GbE)link for SC and a 10-GbE link for Data AcQuisition(DAQ).Results The Bit Error Rate(BER)test of the back-end board and a joint test with the iRPC 2D prototype chamber were *** less than 1.331×10−16 was *** timemeasurement with a resolution of 3.05 nswas successfully realized,and detector efficiencies of 97.7%for longitudinal strips and 96.0%for orthogonal strips were *** results demonstrate the correctness and reliability of the prototype *** The BEE prototype satisfies the requirements for the iRPC 2D chamber,and it worked stably and reliably during a long-term joint test run.

关键词： CMS iRPC TTC SC BEE μTCA GBT DAQ

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