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Long-term open circuit microbial electrosynthesis system promotes methanogenesis

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Journal of Energy Chemistry 2020年第2期29卷 3-6页

作者： Raúl Mateos Adrián Escapa María Isabel san-martín Heleen De Wever Ana Sotres Deepak Pant Chemical and Environmental Bioprocess Engineering Group Natural Resources Institute(IRENA)University of LeonLeon 24071Spain Department of Electrical Engineering and Automatic Systems Universidad de LeonLeon 24071Spain Reparation and Conversion Technology Flemish Institute for Technological Research(VITO)Mol 2400Belgium

Microbial electrosynthesis(MES) can potentially provide a mean for storing renewable energy surpluses as chemical energy. However, the fluctuating nature of these energy sources may represent a threat to MES, as the microbial communities that develop on the biocathode rely on the continuous existence of a polarized electrode. This work assesses how MES performance, product generation and microbial community evolution are affected by a long-period(6 weeks) power off(open circuit). Acetogenic and H2-producing bacteria activity recovered after reconnection. However, few days later syntrophic acetate oxidation bacteria and H2-consuming methanogens became dominant, producing CH4 as the main product, via electromethanogenesis and the syntrophic interaction between eubacterial and archaeal communities which consume both the acetic acid and the hydrogen present in the cathode environment. Thus,the system proved to be resilient to a long-term power interruption in terms of electroactivity. At the same time, these results demonstrated that the system could be extensively affected in both end product generation and microbial communities.

关键词： Biocathode Electromethanogenesis Microbial electrosynthesis Microbial community dynamics Methanogens Acetogens

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Metformin and colorectal cancer

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BIOCELL 2022年第1期46卷 51-59页

作者： GASTÓn AMABLE EDUARDO martÍnEZ-LEÓn MARÍA E.PICCO OSVALDO REY Consejo nacionalde Investigaciones Científicas y Técnicas Universidad de Buenos AiresInstituto de InmunologíaGenética y MetabolismoFacultadde Farmacia y BioquímicaHospital de Clínicas“Joséde San Martín”Ciudad Autónoma de Buenos AiresCP1120Argentina

Colorecal cancer(CRC)is one of the main causes of cancer-related mortality in the deweloped world despite recent developments in detection and treatment Several epidemiologial studis indicate that metformin,a widdy prescribed antidiabetic drug,exerts a protective effect on different cancers incuding ***,a recent double blind placebo controlled,randomized trial showed that metformin significantly decreased colorectal adenoma *** exploring the medhanism of action of metformin in cells derived from different types of ancers reported many efects including rapiratory chain complex 1 inhibition,Akt phosphorylation inhibition,ATP depltion,PKA activation and Wnt signaling ***,many of these results were obtained employing metformin at concentrations several fold higher than those achieved in target tissuas in diabetic patients receiving therapeutic recommended doses of *** contrast,recent studies obtained with metformin at concentrations compatible with those detected in human intestins revealed that metformin dicit responses that targetβ-catenin,PI3KAkt,E-adherin,pl20-catenin and focal adhesion kinase which are key molecules and signaling pathways associated to colorectal cancar *** brief review revisit several know aspects as well as nowd ones on the effects of metformin on cancer cells.

关键词： Metformin β-Catenin E-Cadherin Colorectal cancer AMPK PI3K/AKT FAK

Post-transplant biliary complications using liver grafts from deceased donors older than 70 years:Retrospective case-control study

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世界胃肠外科杂志:英文版(电子版) 2023年第8期15卷 1615-1628页

作者： Carlos Jimenez-Romero Iago Justo-Alonso Pilar del Pozo-Elso Alberto Marcacuzco-Quinto Cristina martín-Arriscado-Arroba Alejandro Manrique-Municio Jorge Calvo-Pulido Alvaro García-Sesma Ricardo san Román Oscar Caso-Maestro Unit of HPB Surgery and Abdominal Organs Transplantation `12 de Octubre´University HospitalMadrid 28041Spain Clinical Research Unit(I+12) `12 de Octubre´University HospitalMadrid 28041Spain Department of Radiology `12 de Octubre´University HospitalMadrid 28041Spain

BACKGROUnD The shortage of liver grafts and subsequent waitlist mortality led us to expand the donor pool using liver grafts from older *** To determine the incidence,outcomes,and risk factors for biliary complications(BC)in liver transplantation(LT)using liver grafts from donors aged>70 *** Between January 1994 and December 31,2019,297 LTs were performed using donors older than 70 *** excluding 47 LT for several reasons,we divided 250 LTs into two groups,namely post-LT BC(n=21)and without BC(n=229).This retrospective case-control study compared both *** Choledocho-choledochostomy without T-tube was the most frequent technique(76.2%in the BC group vs 92.6%in the non-BC group).Twenty-one patients(8.4%)developed BC(13 anastomotic strictures,7 biliary leakages,and 1 nonanastomotic biliary stricture).nine patients underwent percutaneous balloon dilation and nine required a Rouxen-Y hepaticojejunostomy because of dilation *** incidence of post-LT complications(graft dysfunction,rejection,renal failure,and non-BC reoperations)was similar in both *** were no significant differences in the patient and graft survival between the ***,only three deaths were attributed to *** female donors were protective factors for BC,donor cardiac arrest was a risk *** The incidence of BC was relatively low on using liver grafts>70 *** could be managed in most cases by percutaneous dilation or Roux-en-Y hepaticojejunostomy,without significant differences in the patient or graft survival between the groups.

关键词： Older liver Liver transplant Biliary complications Biliary strictures Septuagenarian donors Octogenarian donors

Serum biomarkers for the differentiation of autoimmune pancreatitis from pancreatic ductal adenocarcinoma

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World Journal of Gastrointestinal Oncology 2023年第2期15卷 268-275页

作者： Octavio Caba Carmelo Diéguez-Castillo Joaquina martínez-Galán Irene González-Cebrián Cristina Jiménez-Luna Institute of Biopathology and Regenerative Medicine(IBIMER) University of GranadaGranada 18016Spain Biosanitary Institute of Granada(ibs.GRAnADA) 18014 GranadaSpain Department of Gastroenterology San Cecilio University HospitalGranada 18016Spain Department of Medical Oncology Virgen de las Nieves University HospitalGranada 18014Spain.Biosanitary Institute of Granada(ibs.GRANADA)18014 GranadaSpain Department of Digestive Cancer San Cecilio University HospitalGranada 18016Spain

Autoimmune pancreatitis(AIP),a chronic inflammation caused by the immune system attacking the pancreas,usually presents imaging and clinical features that overlap with those of pancreatic ductal adenocarcinoma(PDAC).Serum biomarkers,substances that quantitatively change in sera during disease development,are a promising non-invasive tool with high utility for differentiating between these *** this way,the presence of AIP is currently suspected when serum concentrations of immunoglobulin G4(IgG4)antibody are ***,this approach has some ***,IgG4 antibody concentrations are also elevated in sera from some patients with *** review focuses on the most recent and relevant serum biomarkers proposed to differentiate between AIP and PDAC,evaluating the usefulness of immunoglobulins,autoantibodies,chemokines,and *** proposed serum biomarkers have proven useful,although most studies had a small sample size,did not examine their presence in patients with PDAC,or did not test them in *** addition,current evidence suggests that a single serum biomarker is unlikely to accurately differentiate these diseases and that a set of biomarkers will be needed to achieve adequate specificity and sensitivity,either alone or in combination with clinical data and/or radiological images.

关键词： Autoimmune pancreatitis Pancreatic ductal adenocarcinoma Serum Biomarkers Differentiation

A Protocol for Fractal Studies on Porosity of Porous Media: High Quality Soil Porosity Images

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Journal of Earth Science 2017年第5期28卷 888-896页

作者： Carlos García-Gutiérrez Fernando san José martínez J.Caniego Dpto.Matemática Aplicada E.T.S.I.Navales Universidad Politécnica de Madrid Dpto.Matemática Aplicada E.T.S.I.Agrónomos Universidad Politécnica de Madrid

A protocol for obtaining digital images from natural porous media with a wide range of pore sizes, intended for fractal studies of the porosity, is proposed. Soil porosity is used as para- digm of complex natural porous media in this study. The use of several imaging devices and fluores- cent compounds to enhance the contrast between the solid and the pore phase is tested. Finally a protocol is reached using a photo camera and a confocal microscope. It is the first time that confocal microscopy is used for this purpose. Artificial porous images are created through random Sierpinski carpet fractals and the statistical information of real soil images. These ground truth images are used in an objective comparison of automatic segmentation algorithms for the obtained images. A statistical classification on the performance of several automatic segmentation algorithms for this tv^e of images is reached.

关键词： porous media micromorphology image segmentation confocal microscope fractal,porosity photography.

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Evaluating methods to quantify sediment volumes trapped behind check dams,Saldana badlands(Spain)

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International Journal of Sediment Research 2017年第1期32卷 1-11页

作者： Iván Ramos-Diez Joaquín navarro-Hevia Roberto san martín Fernández Virginia Díaz-Gutiérrez Jorge Mongil-Manso Department of Agricultural and Forestry Engineering University of Valladolid Sustainable Forest Management Research Institute Department of Statistics and Operations Research.University of Valladolid Hydrology and Conservation Research Group.Catholic University of vila

The determination of sediment yield in catchments based on the sediment trapped by check dams is becoming a subject of *** fact,several methods have been developed in recent years to estimate the sediment retained by check *** complexity,precision and accuracy of each method vary *** this study,we evaluate the sediment trapped by check dams comparing the Sections method respect to the Prism,Pyramid,DTMs and Trapezoid *** analyzed a sample of 25 check dams(α-1=90%;ε=10%) in the Saldana badlands(Spain).The results showed that the Sections method offered a volume of retained sediment between the others,which gave an absolute variation from 22%to40%.The high variability of the check dam and sediment wedge sizes made necessary to compare methods in groups combining both *** significant differences in sediment volumes could be found between the methods for very small(height(h):1.8-2.3 m;trapped volume(V):6-102 m3) or large check dams(h > 2.3 m;V:165-387 m3),while significant differences are found for small(h nevertheless,volume differences between groups ranged up to + 25%.For these reason,the size of the check dam,the shape of the sediment wedge and the accuracy of the measure methods must considered when selecting an appropriate method to obtain the volume of retained sediment by check dams.A correct estimation of the sediment retention is needed to evaluate the role and efficiency of check dams in restoration projects or to estimate sediment yields.

关键词： Erosion Gullies Check dam construction Sediment retention Erosion models Topographic survey

Chemotherapy induces cell plasticity;controlling plasticity increases therapeutic response

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Signal Transduction and Targeted Therapy 2023年第8期8卷 3563-3566页

作者： Francisco J.Iborra Cristina martí Virtu Calabuig-navarro Petros Papadopoulos Salvador Meseguer Pedro M.Iborra Francisco García Antonio martínez-Lorente Fernando Almazán Juana Calabuig Centro de Investigación Príncipe Felípe(Associated Unit to Instituto de Biomedicína de Valencia) ValenciaSpain Pathology and Molecular Therapy Department Instituto de Biomedicína de Valencia(IBV)CSICValenciaSpain Molecular and Cellular Biology Department Centro Nacional de Biotecnología(CNB)CSICMadridSpain Hematology Department Hospital Clínico San CarlosMadridSpain Medical Systems Biology Faculty of MedicineUniversity of HelsinkiHelsinkiFinland IC Biomed AlicanteSpain VinalopóHospitals Elcheand Biotechnology DepartmentUniversidad de AlicanteAlicanteSpain

Dear Editor,One of the most serious issues in modern oncology is the ineffectiveness of treatments in destroying tumours,which leads to tumour recurrence and,ultimately,patient *** phenomenon is caused by conventional therapies’fractional killing of tumour cells,which can also cause resistant cells to spread.1 We analysed chemotherapy-resistant cells and discovered that they are smaller than untreated cells(Fig.1a).The fact that this phenomenon occurs in all tested cell types(Hela,A549,Huh7,and MCF7)and regardless of the chemotherapy regimen(TRAIL,Camptothecin,Doxorubicin)suggests that it is a widespread phenomenon(Fig.1a,Supplementary Fig.S1).

关键词： chemotherapy tumour plasticity

Repellent and Insecticidal Activity of naphthoquinones from the Heartwood of Tectona grandis on Incisitermes marginipennis(Latreille)

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Phyton-International Journal of Experimental Botany 2023年第7期92卷 2165-2181页

作者： Crisanto Velázquez-Becerra Gu Yen Ambriz-Ortiz Rafael Torres-martínez Mauro Manuel martínez-Pacheco Facultad de Ingeniería en Tecnología de la Madera Universidad Michoacana de San Nicolás de HidalgoMoreliaMéxico Escuela nacional de Estudios Superiores Unidad MoreliaMoreliaMéxico Instituto de Investigaciones Químico-Biológicas Universidad Michoacana de San Nicolás de HidalgoMoreliaMéxico

Wood is a lignocellulosic material that,because of its organic nature,is a source of nutrients for bacteria,fungi,and *** marginipennis(Latreille)is an interesting dry wood-boring *** it is an extremely destructive pest,difficult to control due to its cryptic lifestyle,and for its role in the biogeochemical cycle of carbon and other elements;it is a fundamental *** use of less toxic and eco-friendly substances is important for protecting domestic,cultural,and historical heritage made of wood or lignocellulosic *** aim of this study was to evaluate the biological activity of various naphthoquinones extracted from the heartwood of *** on ***,heartwood flour was used for Soxhlet-type extractions to isolate and characterize the heartwood compounds by thin-layer *** identify the heartwood compounds,nuclear magnetic resonance and gas chromatography coupled to a mass spectrometer were *** information obtained was supported using the Interactive Spectroscopy *** identified heartwood compounds were lapachol,tectoquinone,deoxylapachol,dehydro-α-lapachone,tectol and *** nymphal termites of *** as a biological model,the isolated and identified molecules were under three different tests(repellent,insecticide and protective)and their biological activity was individually *** results showed that the molecules obtained have a repellent-protective effect against ***,although not in all cases,these molecules have high percentages of mortality and decreased the weight loss of the treated material exposed to ***.

关键词： naphthoquinones dry wood termite Incisitermes marginipennis wood preservatives

Classification of anemia for gastroenterologists

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World Journal of Gastroenterology 2009年第37期15卷 4627-4637页

作者： Jose Antonio Moreno Chulilla Maria Soledad Romero Colás martín Gutiérrez martín Department of Hematology University Hospital "Lozano Blesa" University of Zaragoza C/San Juan Bosco 15 Zaragoza 50009 Spain

Most anemia is related to the digestive system by dietary deficiency, malabsorption, or chronic bleeding. We review the World Health Organization definition of anemia, its morphological classifi cation (microcytic, macrocytic and normocytic) and pathogenic classi-fication (regenerative and hypo regenerative), and integration of these classifications. Interpretation of laboratory tests is included, from the simplest (blood count, routine biochemistry) to the more specific (iron metabolism, vitamin B12, folic acid, reticulocytes, erythropoietin, bone marrow examination and Schilling test). In the text and various algorithms, we propose a hierarchical and logical way to reach a diagnosis as quickly as possible, by properly managing the medical interview, physical examination, appropriate laboratory tests, bone marrow examination, and other comple-mentary tests. The prevalence is emphasized in all sections so that the gastroenterologist can direct the diagnosis to the most common diseases, although the tables also include rare diseases. Digestive diseases potentially causing anemia have been studied in preference, but other causes of anemia have been included in the text and tables. Primitive hematological diseases that cause anemia are only listed, but are not discussed in depth. The last section is dedicated to simplifying all items discussed above, using practical rules to guide diagnosis and medical care with the greatest economy of resources and time.

关键词：形态分类贫血症胃肠病消化系统疾病网织红细胞维生素B12 红细胞生成素身体检查