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Predicted pattern of Zika virus infection distribution with reference to rainfall in Thailand

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Asian Pacific Journal of Tropical Medicine 2016年第7期9卷 698-699页

作者： somsri wiwanitkit Viroj wiwanitkit wiwanitkit House Hainan Medical University

Zika virus infection is the present global medical *** disease appears in several countries around the *** relationship between rainfall and occurrence of Zika virus infection was previously ***,the authors use the mathematical modeling technique to reappraise on the previous data on immunoreactivity rate of Zika virus,dengue virus and Ckikungunya virus in Thailand and the reported interrelationship between arboviral infections and rainfall in Thailand for constructing of the predicted pattern of Zika virus distribution in *** data can be a useful tool for further disease surveillance in this area.

关键词： Zika virus Infection Rainfall

Change in molecular weight due to important pfatp6 and pfmdr1 polymorphisms and susceptibility to antimalarial drug:Possible role of epigenetic phenomenon

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Asian Pacific Journal of Tropical Biomedicine 2017年第3期7卷 181-182页

作者： somsri wiwanitkit Viroj wiwanitkit wiwanitkit House BangkhaeBangkokThailand Hainan Medical University HaikouHainanChina

Malaria is an important tropical mosquito borne infection. It is still the present global public health issue. The management of malaria requires antimalarial drugs. The resistance to antimalarial drugs is a very big problem. The genetic variant is proposed to be an important factor affecting susceptibility to antimalarial drug. Here, the authors studied the change in molecular weight due to important pfatp6 and pfmdr1 polymorphisms and further implied the interrelationship with susceptibility to antimalarial drug. The greatest change can be seen in case of G639D(of pfatp6 polymorphism) while the least change can be seen in the case of N1042D(of pfmdr1 polymorphism). The results from some studies imply that there must be other factors that affect the susceptibility to antimalarial drugs. Those factors might be protein conformation factors, epigenetic factors or environmental factors. Further studies on these aspects should be carried out. It is concluded for possible role of epigenetic phenomenon.

关键词： Polymorphism Malaria Drug Susceptibility Molecular weight

Anisakiasis in Southeast Asia: A story of new tropical disease?

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Asian Pacific Journal of Tropical Biomedicine 2016年第5期6卷 382-383页

作者： somsri wiwanitkit Viroj wiwanitkit wiwanitkit House Bangkhae Hainan Medical University Faculty of Medicine University of Nis Joseph Ayobabalola University Dr DY Patil Medical University

Anisakiasis is an important worm infestation. It is seen in some non-tropical countries and becomes an important issue in coastal medicine. However, in the few recent years, there are some reports on occurrence of anisakiasis in tropical countries. In this specific short article,the authors review and present the situation of anisakiasis in Southeast Asia. It can be said that anisakiasis becomes a new focused interest in tropical coastal medicine at present.

关键词： Anisakiasis Southeast Asia Infestation Tropical disease

Cleft analysis of Zika virus non-structural protein 1

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Asian Pacific Journal of Tropical Biomedicine 2017年第8期7卷 763-764页

作者： somsri wiwanitkit Viroj wiwanitkit wiwanitkit House Hainan Medical University

The non-strctural protein 1 is an important molecule of the viruses in flavivirus group including to Zika virus. Recently, the NS1 of Zika virus was *** is still no complete information of the molecular interaction of NS1 of Zika virus which can be the clue for explanation for its pathogenesis and further drug search. Here the authors report the cleft analysis of NS1 of Zika virus and the result can be useful for future development of good diagnostic tool and antiviral drug finding for management of Zika virus.

关键词： Zika 病毒非结构的蛋白质 1 劈开 Flavivirus

Cholera toxin A1 residues single alanine substitutional mutation and effect on activity with stimulatory G protein

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Asian Pacific Journal of Tropical Biomedicine 2017年第6期7卷 585-586页

作者： somsri wiwanitkit Viroj wiwanitkit wiwanitkit House Hainan Medical University Faculty of Medicine University of Nis Joseph Ayobabalola University Dr DY Patil Medical University

Cholera is a well-known gastrointestinal *** cholera toxin is an important pathological substance in pathogenesis of cholera *** toxin is composed of catalytic A1 subunit,an A2 linker,and a homopentameric cell-binding B *** enterocyte,cholera toxin will attach to GM1 ganglioside receptors on the apical membrane and causes retrograde vesicular trafficking to endoplasmic *** endoplasmic reticulum,cholera toxin A1 is released from the rest of the toxin into *** cholera toxin A1 interacts will catalyze ADP ribosylation of subunits of stimulatory G protein resulting a persistent activation of adenylate cyclase and an elevation of intracellular c AMP which further result in *** single alanine substitutional mutation can result in the reduction of the interaction activity between cholera toxin A1 and stimulatory G *** this study,the four well-known mutations,H55,R67,L71,S78,or D109,of cholera toxin A1 is *** author hereby calculates for the reaction energy for the reaction between cholera toxin A1 and stimulatory G protein in na¨?ve case and mutated *** calculate,the standard bonding energy calculation technique in mutation analysis was *** can be seen that aberrant in reaction energy in each studied mutation is different and can imply the different effect on activity with stimulatory G protein.

关键词： Cholera Toxin Mutation

Doubled dosage of sofosbuviris expected for inhibiting Zika virus infection

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Asian Pacific Journal of Tropical Medicine 2017年第6期10卷 682-683页

作者： somsri wiwanitkit Viroj wiwanitkit wiwanitkit House BangkhaeBangkok Thailand Hainan Medical University China Dr DY Patil University India Faculty of Medicine University of NisSerbia Joseph Ayobabalola University Nigeria

Sofosbuvir is a new antiviral drug that has been recommended for management of hepatitis C virus(HCV) for a few years. New researches support that sofosbuvir might be useful for the management of Zika virus infection. Based on the pharmacological activity, inhibiting the HCV RNA-dependent RNA polymerase(RdR p or NS5 protein), sofosbuvir is proposed for its effectiveness against Zika virus infection. Here, the authors used a mathematical modelling theoretical approach to predict the expected dosage of sofosbuvir for inhibiting Zika virus infection. Based on the modeling study, if sofosbuvir is assigned for management of Zika virus infection, doubled dosage of the present dosage for hepatitis C management is recommended.

关键词： Sofosbuvir 禁止 Zika 病毒剂量

Computational intelligence in tropical medicine

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Asian Pacific Journal of Tropical Biomedicine 2016年第4期6卷 350-352页

作者： somsri wiwanitkit Viroj wiwanitkit wiwanitkit House Hainan Medical University Faculty of Medicine University of Nis Joseph Ayobabalola University Dr DY Patil Medical University

The application of computational technology for medical purpose is a very interesting *** content development and new technology search using computational technology becomes the newest approach in *** advanced computational technology,several omics sciences are available for clarification and prediction in *** computational intelligence is an important application that should be ***,the author details and discusses on computational intelligence in tropical medicine.

关键词： Computer Tropical medicine Computational intelligence Application

Based on the risk of dengue virus transmission via blood transfusion:What about the risk in case of Zika virus?

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Asian Pacific Journal of Tropical Medicine 2016年第11期9卷 1099-1100页

作者： somsri wiwanitkit Viroj wiwanitkit Wiwanitit House Bangkhae Hainan Medical University

The risk of dengue virus transmission via blood transfusion is *** a similar virus,the risk for the case of Zika virus should be ***,the authors calculated for the risk of Zika virus transmission via blood transmissio... 详细信息

关键词： Zika virus Blood Transfusion Transmission

ZIka virus infection in Asia: reappraisal on phylogenetic data of Asian lineage

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Asian Pacific Journal of Tropical Medicine 2016年第6期9卷 595-596页

作者： somsri wiwanitkit Viroj wiwanitkit wiwanitkit House Hainan Medical University Visiting professor University of Nis visiting professor Joseph Ayobabalola University adjunct professor DY Patil Medical University

Zika virus infection becomes the important global problem in the present day. The worldwide distribution of the infection can be seen. The genetic epidemiology study shows that the infection has subgroups of outbreaks. The Asian lineage is an interesting group that can be seen in a wide area. In this short article, the authors reappraises on the phylogenetic data of Asian lineage. The study on period, distance and phylogenetic parameter differences among isolated from several countries in the Asia lineage group is done. Based on the present study, the time and place dimnensional analysis can show that the disease distribution should be mainly induced by the international traveling.

关键词： Zika Virus Asia Phylogenetic