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UV Spectroscopic Method for Optimization and Determination of Glibenclamide in Bulk,Pharmaceutical Dosage Form and its Application for In Vitro Interaction Studies

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Journal of Analysis and Testing 2020年第4期4卷 281-290页

作者： Faiza Akhtar somia gul Salman Ashfaq Iqra Rehman Agha Zeeshan Mirza Department of Pharmaceutical Chemistry Faculty of PharmacyJinnah University for WomenKarachi 74600Pakistan Department of Pharmaceutical Chemistry Faculty of PharmacyZiauddin UniversityKarachi 75600Pakistan Department of Pharmaceutics Faculty of PharmacyUniversity of KarachiKarachi 75270Pakistan Chemistry Department Faculty of Applied SciencesUmm Al-Qura UniversityMecca 21955Saudi Arabia

A simple,easy and cost-efficient UV spectroscopic method was developed and validated for glibenclamide,the second generation of sulfonylureas,using 0.1 N NaOH as a *** proposed method is linear(R^(2)>0.999)with the range 5-25μg mL^(−1),accurate(99.60%),precise(inter and intraday variation 0.241 and 0.019%,respectively)and robust(<1%).The quantification and detection limit were 1.46 and 0.48μg mL^(−1),*** validated method was applied for in vitro interaction studies of glibenclamide(GLB)with commonly prescribed quinolones(ciprofloxacin,levofloxacin,moxifloxacin,and gemifloxacin)and nonsteroidal anti-inflammatory drugs(NSAIDs)(diclofenac sodium,ibuprofen,mefenamic acid,and aspirin)using UV *** in vitro interaction studies were carried out in different artificially prepared physiological buffers at 37°C for 2 *** showed raised level of glibenclamide when interacted with gemifloxacin(pH 7.4),levofloxacin(pH 9),ciprofloxacin(pH 4.5)and with moxifloxacin(pH 4.5,7.4 and 9).Interaction with NSAIDs results in increased%availability of glibenclamide in the presence of diclofenac sodium,ibuprofen,and mefenamic acid at pH *** anticipated method can be successfully applied for the routine analysis and also for the interaction of glibenclamide with other drugs.

关键词： Glibenclamide Interaction Quinolones NSAIDS UV spectroscopy

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A novel HPTLC method for quantitative estimation of biomarkers in polyherbal formulation

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Asian Pacific Journal of Tropical Biomedicine 2015年第11期5卷 955-959页

作者： Zeeshan Ahmed Sheikh Sadia Shakeel somia gul Aqib Zahoor Saleha Suleman Khan Faisal Haider Zaidi Khan Usmanghani Herbion Pakistan (Pvt.) Ltd. Dow College of Pharmacy Dow University of Health Sciences Faculty of Pharmacy Jinnah University for Women Karachi Department of Basic Medical Sciences College of MedicineKing Saud bin Abdulaziz University of Health Sciences

Objective: To explore the quantitative estimation of biomarkers gallic acid and berberine in polyherbal formulation Entoban ***: High performance thin layer chromatography was performed to evaluate the presence of gallic acid and berberine employing toluene: ethyl acetate: formic acid:methanol 12:9:4:0.5(v/v/v/v) and ethanol: water: formic acid 90:9:1(v/v/v), as a mobile phase ***: The R f values(0.58) for gallic acid and(0.76) for berberine in both sample and reference standard were found comparable under UV light at 273 nm and 366 nm respectively. The high performance thin layer chromatography method developed for quantization was simple, accurate and ***: The present standardization provides specific and accurate tool to develop qualifications for identity, transparency and reproducibility of biomarkers in Entoban syrup.

关键词： Quantitative estimation Gallic acid Berberine Ento

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New Method for Optimization and Simultaneous Determination of Sparfloxacin and Non Steroidal Anti-Inflammatory Drugs: Its <i>In-Vitro</i>Application

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American Journal of Analytical Chemistry 2012年第4期3卷 328-337页

作者： somia gul Najma Sultana Muhammad Saeed Arayne Sana Shamim Mahwish Akhtar College of Pharmacy Dow University of Health Sciences Karachi Pakistan Faculty of Pharmacy Jinnah University for Women Karachi Pakistan United Biotech (Pvt) Ltd. Karachi Pakistan

A simple reversed phase HPLC method was developed and validated for the simultaneous determination of sparfloxacin (SPFX), diclofenac sodium, meloxicam, ibuprofen, flurbiprofen, naproxen and mefenemic acid in a relatively short time with high linearity in bulk material, pharmaceutical formulations and human serum. Purospher STAR C18 (250 × 4.6 mm, 5 μm) column was utilized with mobile phase, methanol and water (90:10, v/v pH 2.70 adjusted by phosphoric acid), was delivered at a flow rate of 1.5 ***–1. Eluent was monitored using UV detector at 240 nm. The proposed method is specific, accurate (98.42% - 102.75%), precise (intra-day and inter-day variation 0.011% - 1.85%) and linear (R2 > 0.999) with in the desired range 0.15 - 40 μ***–1 and the detection and quantification limit was 1.19E+08 – 0.150 μ***–1 and 3.62E+08 – 0.4574 μ***–1 respectively for SPFX and NSAIDs. The analysis of variance (ANOVA) and student’s t-test were applied to verify the results. The anticipated method is applicable to routine analysis of SPFX and NSAIDs in pharmaceutical formulations as well as in human serum samples. It has also applied on interaction of SPFX with NSAIDs.

关键词： Sparfloxacin NSAIDs HPLC Interactions ANOVA

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Determination of the heavy metal content of Entoban herbal medicinal product

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Journal of Chinese Pharmaceutical Sciences 2015年第11期24卷 764-769页

作者： Sadia Shakeel Zeeshan Ahmed Sheikh Khan Usmanghani Nadeem Khalid Zafar Ali somia gul Safila Naveed Faculty of Pharmacy Dow University of Health Sciences Herbion Pakistan (Pvt.) Ltd. Faculty of Pharmacy Jinnah University for Women Karachi.

The levels of As, Cd, Pb and Hg were investigated in the medicinal herbal syrup Entoban, which is widely used in the management of non-specific diarrhea and acute intestinal infections of various etiologies. The ingredients in Entoban syrup include 6 potent herbal drugs: Aegle marmelose, Berberis aristata, Butea frondosa, Holarrhena antidysenterica, Myrtus communis, and Quercus infectoria. Entoban medicinal plant syrup was analyzed for As, Cd, Pb and Hg by flame atomic absorption spectroscopy(FAAS). Contents of heavy metals in the examined samples were in the range: As(0.074–10.0 ppm); Cd(0.020–0.3 ppm); Pb(0.00–10.0 ppm) and Hg(0.00–1.0 ppm). Results were compared with permissible limit acceptability intake(AHPA). According to determined amounts of heavy metals, the investigated Entoban syrup samples were validated and considered safe for human consumption.

关键词： Heavy metals, Flame atomic absorption spectroscopy, Medicinal plants, Entoban syrup

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New Method for Optimization and Simultaneous Determination of Sparfloxacin and Non Steroidal Anti-Inflammatory Drugs: ItsIn-VitroApplication

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American Journal of Analytical Chemistry 2012年第4期

作者： somia gul Najma Sultana Muhammad SaeedArayne Sana Shamim Mahwish Akhtar

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