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Circulating hTERT mRNA as a tumor marker in cholangiocarcinoma patients

World Journal of Gastroenterology 2006年第26期12卷 4195-4198页

作者： Kawin Leelawat Surang Leelawat Thawee Ratanachu-Ek somboon trubwongchareon Jerasak Wannaprasert Saad Tripongkaruna Suchart Chantawibul Panadda Tepaksorn Department of Surgery Rajavithi Hospital Bangkok10400Thailand Department of BiochemistryFaculty of ScienceMahidol UniversityBangkok10400Thailand Faculty of Pharmacy Rangsit University Patumthani12000Thailand Department of Surgery Rajavithi Hospital Bangkok10400Thailand Medical Biotechnology Center National Institute of Health 13000Thailand

AIM： To investigate human telomerase reverse transcriptase （hTERT） mRNA in the serum of cholangiocarcinoma patients. METHODS： The serum of thirty three cholangiocarcinoma patients, forty one benign biliary tract disease patients and ten healthy volunteers were collected and analyzed for the expression of hTERT mRNA by real-time reverse transcriptase-polymerase chain reaction （RT-PCR）. We then examined the correlation between values of serum hTERT mRNA and the pathological staging of cholangiocarcinoma. RESULTS： hTERT mRNA was detected in 28 of 33 （84.85%） of serum obtained from cholangiocarcinoma patients and 9 of 41 （21.9%） of serum obtained from benign biliary tract disease patients, hTERT mRNA was not detected in any serum obtained from healthy volunteers, on the other hand the common tumor marker, CA19-9 was detected in 20 of 33 （60.6%） of serum obtained from cholangiocarcinoma patients and 8 of 41 （19.5%） of serum obtained from benign biliary tract disease patients. However, no correlation was found between the present of serum hTERT mRNA and tumor staging. CONCLUSION： These results indicate that the detection of circulating hTERT mRNA was identified in almost all cholangiocarcinoma patients. It offers a novel tumor marker, which can be used as a complementary study for diagnosis of cholangiocarcinoma .

关键词： Cholangiocarcinoma Telomerase hTERT Real-time reverse transcriptase-polymerase chain reaction

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