检索结果-南通市图书馆

Human Epididymis Protein-4 Gene Expression as a Biomarker in Patients with Ovarian Cancer in Iran

Open Journal of Clinical Diagnostics 2017年第3期7卷 83-90页

作者： Arezo Shahi Naghmeh Bahrami Atefeh Fakharian somayeh Sharifynia Elham Moslemi Amir Izadi Adnan Khosravi Hamidreza Jamaati Abdolreza Mohamadnia Department of Biology Faculty of Basic Sciences Islamic Azad University North Tehran Branch Tehran Iran Craniomaxillofacial Research center Tehran University of Medical Sciences Tehran Iran Oral and Maxillofacial Surgery Department School of Dentistry Tehran University of Medical Sciences Tehran Iran Chronic Respiratory Diseases Research Center National Research Institute of Tuberculosis and Lung Diseases (NRITLD) Shahid Beheshti University of Medical Sciences Tehran Iran Clinical Tuberculosis and Epidemiology Research Center National Research Institute of Tuberculosis and Lung Diseases (NRITLD) Shahid Beheshti University of Medical Sciences Tehran Iran Department of Biology Islamic Azad University Tehran East Tehran Iran Young Researchers and Scholars Club Islamic Azad University Tehran East Tehran Iran Bunge Oxir Research Institute Iran Tobacco Prevention and Control Research Center National Research Institute of Tuberculosis and Lung Diseases (NRITLD) Shahid Beheshti University of Medical Sciences Tehran Iran Virology Research Center National Research Institute of Tuberculosis and Lung Diseases (NRITLD) Shahid Beheshti University of Medical Sciences Tehran Iran Department of Biotechnology School of Advanced Technologies in Medicine Shahid Beheshti University of Medical Sciences Tehran Iran

Introduction: Ovarian cancer is one of the most common malignancies in women and the fifth cause of cancer-related deaths in women worldwide. Contrary to the challenges in developing new clinical markers using the conventional methods, recent advances in genomics and proteomics have led to identification of candidate and promising biomarkers for the diagnosis of ovarian cancer. Human epididymis protein 4 (HE4) is such a marker that has recently been reported to correlate with recurrence or progression of epithelial ovarian cancer. The purpose of this study was to measure the expression level of HE4 gene in women with ovarian cancer. Methodology: We evaluated and compared paraffin-embedded tissue samples of 20 ovarian cancer patients with 10 samples from healthy individuals. RNA was initially extracted from the samples and cDNA was synthetized. Gene expression level was then measured using real-time polymerase chain reaction (PCR). Results: Our results demonstrated that HE4 gene expression level was significantly higher in samples of patients with ovarian cancer compared with samples from healthy individuals. Moreover, higher levels of HE4 gene expression were associated with more advanced disease and larger tumor size. Conclusion: HE4 gene over-expression has the potential to be used as a biomarker for detecting early-stage ovarian cancer in women. Future more comprehensive studies are needed to confirm our findings.

关键词： Ovarian Neoplasms Genomics Tumor Biomarkers HE4 Protein

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Two Molecular Markers of Early Non-Small Cell Lung Carcinoma Based on Gene Expression in Peripheral Blood

引用

Open Journal of Clinical Diagnostics 2017年第3期7卷 91-102页

作者： Naghmeh Bahrami Hamidreza Jamaati Jalal Heshmat Nia Payam Tabarsi Atefeh Fakharian Habib Emami somayeh Sharifynia Masoum Abniki Abdolreza Mohamadnia Craniomaxillofacial Research center Tehran University of Medical Sciences Tehran Iran Oral and Maxillofacial Surgery Department School of Dentistry Tehran University of Medical Sciences Tehran Iran Chronic Respiratory Diseases Research Center National Research Institute of Tuberculosis and Lung Diseases (NRITLD) Shahid Beheshti University of Medical Sciences Tehran Iran Clinical Tuberculosis and Epidemiology Research Center National Research Institute of Tuberculosis and Lung Diseases (NRITLD) Shahid Beheshti University of Medical Sciences Tehran Iran Tobacco Prevention and Control Research Center National Research Institute of Tuberculosis and Lung Diseases (NRITLD) Shahid Beheshti University of Medical Sciences Tehran Iran Department of Biotechnology Faculty of Sciences Islamic Azad University Tehran Iran Virology Research Center National Research Institute of Tuberculosis and Lung Diseases (NRITLD) Shahid Beheshti University of Medical Sciences Tehran Iran Department of Biotechnology School of Advanced Technologies in Medicine Shahid Beheshti University of Medical Sciences Tehran Iran

Background: Lung cancer is among the most common cancers. Search is ongoing to find biomarkers to improve the diagnosis lung cancer techniques in early stages. In this study we evaluate the sensitivity and specificity of the MUC1 and CEA gene expressions in the peripheral blood of non-small cell lung cancer (NSCLC). Material and Methods: This study was done in Masih Daneshvari Hospital, Tehran, Iran and was case/control study that conducted on 30 NSCLC patients and 30 healthy controls. Peripheral blood was collected and total RNA was extracted then cDNA was synthesized. Sample was separately assessed by real time PCR. Results: The expression of CEA gen was positive in 24 patients indicating 80% sensitivity for this marker. The expression of CEA gen was positive in 9 controls out of 30 each. A statistically significant difference was detected between patients and healthy controls with regard to CEA mRNA expression (P 0.001). The MUC1 gen expressed in 20 out of 30 patients, while it expressed in 3 controls. The difference in MUC1 mRNA expression was statistically significant between NSCLC patients and healthy controls (P 0.001). Conclusion: MUC1 and CEA are molecular biomarkers with relatively favorable sensitivity for primary diagnosis of NSCLC.

关键词： MUC1 mRNA CEA mRNA Non-Small Cell Lung Cancer Biomarker

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

<i>In Vitro</i>Studies of NIPAAM-MAA-VP Copolymer-Coated Magnetic Nanoparticles for Controlled Anticancer Drug Release

引用

Journal of Encapsulation and Adsorption Sciences 2013年第4期3卷 108-115页

作者： Soodabeh Davaran Abolfazl Akbarzadeh Kazem Nejati-Koshki somayeh Alimohammadi Mahmoud Farajpour Ghamari Mahsa Mahmoudi Soghrati Akbar Rezaei Amir Ahmad Khandaghi Department of Medical Nanotechnology Faculty of Advanced Medical Science Tabriz University of Medical Sciences Tabriz Iran Department of Medical Nanotechnology Faculty of Advanced Medical Science Tabriz University of Medical Sciences Tabriz Iran Drug Applied Research Center Tabriz University of Medical Sciences Tabriz Iran Department of Medical Physics and Biomedical Engineering Shahid Beheshti University of Medical Sciences Tehran Iran Department of Medicinal Chemistry Faculty of Pharmacy Drug Applied Research Center Tabriz University of Medical Sciences Tabriz Iran Department of Science Ahar Branch Islamic Azad University Ahar Iran Faculty of Medicine Tabriz University of Medical Sciences Tabriz Iran

Thermosensetive poly(N-isopropylacrylamide)-based magnetic nanoparticles were synthesized by free radical polymerization of N-isopropylacrylamide (NIPPAMs), methacrylic acid (MAA), and vinyl pyrrolidone (VP) in the presence of methylene-bis-acrylamide as cross linking agent. The Fe3O4 magnetic nanoparticls were prepared by chemical precipitation of Fe salts in the ratio of 1:2 under alkaline and inert condition. Thermosensitive crosslinked P (NI-PAAM-MAA-VP) copolymers were characterized by FT-IR and H-NMR. The pH and thermosensitive copolymer was used for preparation of drug loaded magnetic nanoparticles, and doxorubicin (DOX) was used as a typical anticancer drug. The amount of the loaded drug and drug release amount were determined by UV measurements. Scanning electron microscopy (SEM) and lower critical solution temperature (LCST) were used to determine the particle surface morphology and the phase transition temperature of the nanoparticles respectively. The release behavior of DOX at pH = 7.4 and 37°C was studied. The result indicated that this thermosensetive magnetic nanoparticle has a high drug loading capacity and favorable linear release property for DOX without initial burst release. Thus this system is promising for the application in targeted smart anticancer drug delivery.

关键词： Magnetic Nanoparticles Thermosensitive Copolymer Doxorubicin P(NIPAAM-MAA-VP) Copolymer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Differentiation of Menstrual Blood Derived Stem Cell (MensSCs) to Hepatocyte-Liked Cell on Three Dimensional Nanofiberscaffold: Poly Caprolacton (PCL)

引用

Journal of Biomedical Science and Engineering 2016年第4期9卷 216-225页

作者： Farnaz Sani Giti Borzooeian somayeh Kazemnejad Sepideh Ebrahimi Masoomeh Mohamadpour Sayeh Khanjani Mona Latifi Seyed Mojtaba Hosseini Mahin Salmannejad Fatemeh Aleahmad Hossein Mehraban Jahromi Mahsa Sani Laboratory for Stem Cell Research Anatomy Department Shiraz Medical School Shiraz University of Medical Sciences Shiraz Iran Student Research Committee Shiraz University of Medical Sciences Shiraz Iran Departments of Embryology and Stem Cells Reproductive Biotechnology Research Center Avicenna Research Institute ACECR Tehran Iran Department of Biochemistry Shiraz Medical School Shiraz University of Medical Sciences Shiraz Iran Anatomy Histomorphometry and Stereology Research Center Shiraz Medical School Shiraz University of Medical Sciences Shiraz Iran

Menstrual blood stem cells (MensSCs) have enormous potential as a source for cell replacement therapies. Since there is a major concern in utilization of nanofibers in tissue engineering of stem cells, we examined the potential of MensSCs to differentiate into hepatocytes, using different protocols and compare cells, with two-dimensional (2D) and three-dimensional (3D) culture systems. Cell characterization experiments of MensSCs have demonstrated that they are multipotent stem cells similar to mesenchymal stem cells, which can successfully differentiate into osteogenic and adipogenic lineages. The efficiency of the cells on the scaffold was appraised by scanning electron microscopy (SEM), MTT assay, and hematoxylin and eosin (H&E) staining. Thereafter, the differentiation protocols were developed by hepatocyte growth factor (HGF) and oncostatin M (OSM) with serum-supplemented or serum-free culture media up to 30 days. Immunofluorescence analysis and ELISA assay revealed the expression of albumin (ALB) in differentiated cells. Hepatocyte-like cells expressed liver-specific gene such as albumin(ALB), α-fetoprotein (AFP), tyrosine aminotransferase (TAT) and cytochrome P450 subunit 7a1 (Cyp7a1) at mRNA levels. In conclusion, the evidences presented in this study show that the nanofiber scaffold and MensSCs may provide a source of differentiated cells for treatment of liver diseases.

关键词： Differentiation Hepatocyte Menstrual Blood Stem Cell 3D Cultures

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Role of Cyberspace in Learning the Persian Language

引用

Sino-US English Teaching 2018年第9期15卷 445-453页

作者： somayeh Aghajani Kalkhoran Hankuk University of Foreign Studies SeoulSouth Korea

In today's modern world there is an important issue which is how media especially,the internet threatens our *** is undoubtedly true that media directly or not,has a substantial influence on *** paper focuses on how this menace,"Cyberspace",makes opportunities for languages to be learned in all over the *** seems that although cyberspace and especially the internet have some unfavorable effects on languages,they offer a big help in several ways to language learners easily become familiar with all aspects of the new *** paper tried to find opportunities and threats which the internet brings about to learning Persian language and how they affect learning this language as a new *** seems that albeit there are many threats to Persian language and its learning on the internet such as existence of writing-speaking mixture of Persian language,decreasing the attention to resource books and so on,the opportunities which caused by the internet,such as avalable resource everywher for everyone in anytime,cheeper or free education and so on,outweigh the negative effects and it is generally accepted we cannot omit cyberspace especially the internet from people's ***,experts have to use the advantages of the internet and technology to sustain and develop languages.

关键词： cyberspace internet threats and opportunities learning Persian language

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mortality and Morbidity among COVID-19-Associated Mucormycosis Patients in Iran: A Prospective Cohort Study

引用

Advances in Infectious Diseases 2023年第3期13卷 407-423页

作者： somayeh Dolatabadi Mehdi Bakhshaee Masoumeh Hosseinpoor Ali Alizadeh Noghani Mohammadreza Afzalzadeh Imaneh Roshanzamir Bashir Rasoulian Zahra Eslami Mohammadie Alireza Ghodsi Nazanin Forghani Parisa Arjmand Zahra Valipour Nima Ameli Department of Biology Hakim Sabzevari University Sabzevar Iran Sinus and Surgical Endoscopic Research Center Mashhad University of Medical Sciences Mashhad Iran Student Research Committee Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran Student Research Committee Faculty of Paramedical Sciences Mashhad University of Medical Sciences Mashhad Iran Department of Otolaryngology Mashhad University of Medical Sciences Mashhad Iran

Background: The key contribution of this paper is from investigating the mortality and morbidity rates and related factors associated with COVID-19-associated-mucormycosis among Iranian patients. The existing literature is scarce on this topic, particularly in the context of Iran. The present study investigates mortality and morbidity among 62 confirmed COVID-19-associated-mucormycosis Iranian patients in relation to their demographic characteristics, laboratory test results, predisposing factors, and COVID-related factors. Material and Methods: In this prospective cohort study, the patients were identified in the fifth wave of the disease, between 1st August and 15th October 2021, with data collected at baseline with a three-week follow-up. This was a multicenter investigation with patients admitted to two clinics in Iran. 62 participants were admitted, with the key criteria of them being COVID-19-associated-mucormycosis patients. 53 out of 60 patients underwent corticosteroid therapy and debridement surgery. Intravenous remdesivir (200 mg/ kg/day at day 1, 100 mg/kg/day in following days for up to 5 days) and corticosteroids were administered for 53 out 54 patients. Oxygen therapy was only needed for 30% (n = 19) of the patients. Results: A 40% mortality rate was observed within the three-week follow-up, with deaths concentrated among those with controlled diabetes mellitus (61%) and long-term diabetes mellitus patients (an average of eight versus four years). Higher mortality was also observed in patients with higher leucocytes and those with rhino-orbital-cerebral (59%), followed by nasal (55.6%) mucormycosis. Among survivors, 32% were reinfected, and 56% suffered from loss of vision. Conclusion: The study concludes that mucormycosis is associated with a higher mortality rate among COVID-19 patients with diabetes mellitus, particularly corticosteroid recipients. Thus, urgent attention to this coinfection is warranted in Iran.

关键词： Mucorales COVID-19 Mucormycosis Coinfection Dexamethasone Diabetes Mellitus

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Representation of BesilāLand in Kush-Nāme

引用

Sino-US English Teaching 2023年第6期20卷 203-216页

作者： somayeh Aghajani Kalkhoran Vahid Reza Nasrollahi Hankuk University of Foreign Studies SeoulSouth Korea Seoul National University SeoulSouth Korea

Kush-Nāme,authored by Hakim Iranshan Ibn Abi al-Khair,offers information on Iran,its features,and even its neighbors,as other classical Persian literary works *** some of this historical information may need to be more accurate due to the legendary nature of the work,it is important and worth *** from China,lands such as Makrān,Saqlab,Māchin,Besilā,and others are mentioned in Kush-Nā***āis the same as Korea based on the dynasty’s name,other details,and other *** translation of Kush-Nāme into Korean has piqued the interest of many South *** study seeks to extract and,to some extent,examine Besilā’s many political,economic,geographical,and cultural representations in Kush-Nāme,not just to gain a better understanding of this country but this study serves as a foundation for future *** to the research,Besilāwas a remote and prosperous land with a monotheistic people and kingdom,a profitable and prosperous business,a huge army,and beautiful people who sheltered Abtin from the Chinese army and later married Abtin and Farārang,the daughter of BesilāKing and mother of Fereidun,and were somehow involved in Fereidun’s killing of Zahhāk.

关键词： Kush-Nāme Besilā Korea Fereidun Teihur Abtin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

肉鸡接种IBD免疫复合物疫苗对伊朗地区野毒感染的保护力

肉鸡接种IBD免疫复合物疫苗对伊朗地区野毒感染的保护力

引用

第15届世界禽病大会、中国畜牧兽医学会2007年学术年会

作者： Mansour Mayahi Ramazan Ali Jafari somayeh Mohamadzadeh 周宏专 Faculty of Veterinary Medicine Shahid Chamran University Ahvaz-Iran.P.O.Box:61355-145 Faculty of Veterinary Medicine Shahid Chamran University Faculty of Veterinary Medicine Shahid Chamran University

简介：传染性法氏囊病(IBD)是由 Bimaviridae 科一种双链 RNA 病毒引起的鸡的传染病。传染性法氏囊病病毒(IBDV)毒力可在易感鸡中引发许多免疫抑制反应。因此,日常使用的家禽疫苗很难达到最佳效果

关键词：免疫复合物疫苗 IBD 野毒感染保护力

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Evaluation of the effectiveness of sexual skills training on increasing marital satisfaction

引用

Advances in Health and Behavior 2019年第1期2卷 34-40页

作者： somayeh Naderi Ali Delavar Fariborz Dortaj Faculty of Psychology and Educational Sciences Allameh Tabatabai University Tehran Iran

Background and Aims: Dissatisfaction with sexual relationships can influence the marital life of people and have negative psychological effects on them. Hence, the current research was conducted to evaluate the effectiveness of sexual skills training on marital satisfaction. Methods: The study design was quasiexperimental with pre-test and post-test type along with a control group. The research samples included 14 couples (28 people) who were randomly divided into experimental and control groups to evaluate the effect of sexual medicine intervention. Interventions were provided to the experimental group during 9 sessions. Control group did not receive any interventions during this time. Enrich Marital Satisfaction Questionnaire (short form) was used to collect the data. Data were analyzed using SPSS, version 19, software. Results and Conclusion: The results revealed that sexual skills training increased marital satisfaction (p<0.01). Thus, based on the results obtained and the importance of sexual skills training in increasing marital satisfaction, psychotherapists and counselors are recommended to use this intervention to reduce marital problems and increase satisfaction in couples.

关键词： sexual skills training sexual knowledge and attitude sexual satisfaction marital satisfaction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Study Coefficient and Optical Application of KCI Single Crystal with Sn Impurity Growth on Czochralski Method under Visible Radiation

引用

材料科学与工程（中英文A版） 2012年第12期2卷 799-802页

作者： Feridoun Samavat Ebrahim Haji Ali somayeh Solgi Physics Department Faculty of Science Bu-Ali-Sina University Hamedan Iran Physics Department Faculty of Science lmam Hossein University Tehran 1ran

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：