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International Journal of Organic Chemistry 2011年第4期1卷 250-256页

作者： Kamatala Chinna Rajanna Mukka Satish Kumar Purugula Venkanna soma ramgopal Marri Venkateswarlu 不详

Nitration of aromatic Compounds is triggered by Vilsmeier-Haack reagent (DMF/POCl3) or (DMF/SOCl2) in the presence of KNO3 or NaNO2 under conventional and non-conventional conditions. The reactions af- forded corresponding Nitro derivatives in very good yield with high regioselectivity. The results obtained in non-conventional methods (Micro wave irradiation, Grinding, Sonication) are comparable with those ob- tained under conventional conditions, but the reaction times of former conditions are substantially shorter than that of the latter.

关键词： Nitration KNO3 or NaNO2 Vilsmeier-Haack Reagent Microwave Irradiation (MWI) Grinding Sonication

Environmentally Benign Synthetic Protocol for O-Alkylation of β-Naphthols and Hydroxy Pyridines in Aqueous Micellar Media

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Green and Sustainable Chemistry 2012年第4期2卷 123-132页

作者： Kancharla Rajendar Reddy Kamatala Chinna Rajanna soma ramgopal Mukka Satish Kumar Sariah Sana Department of Chemistry Osmania University Hyderabad India

Ultrasonic and microwave-assisted practical methods have been developed for the O-alkylation of aryl (β-naphthols) and Heteroaryl (hydroxy pyridines) in aqueous surfactant media in good to excellent yields. The developed methods are simple, efficient, economical and environmentally safe. Our novel methods describe a set of green methods to Wil-liamson synthesis.

关键词： Ultrasonically Assisted Microwave Assisted Green Chemistry Micelles β-Naphthols Heteroaryl Hydroxy Compounds Alcohols

Socio-economic vulnerability level in the Jeneberang watershed in Gowa Regency,South Sulawesi Province,Indonesia

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Regional Sustainability 2024年第1期5卷 69-79页

作者： Andi Rachmat ARFADLY Hazairin ZUBAIR MAHYUDDIN Andang Suryana soma Graduate School Hasanuddin UniversityMakassar90245Indonesia Faculty of Agriculture Hasanuddin UniversityMakassar90245Indonesia

Jeneberang watershed is vital,particularly for people living in Gowa Regency(South Sulawesi Province,Indonesia),who benefit from its many *** and floods occur every year in the Jeneberang watershed,so it is imperative to understand the socio-economic vulnerability of this *** research aims to identify the vulnerability level of the Jeneberang watershed so that the government can prioritize areas with high vulnerability level and formulate effective strategies to reduce these the ***,this study was conducted in 12 districts located in the Jeneberang *** primary data were collected from questionnaires completed by community members,community leaders,and various stakeholders,and the secondary data were from the Landsat satellite imagery in 2020,the Badan Push Statistic of Gowa Regency,and some governmental *** socio-economic vulnerability variables were determined using the Multiple Criteria Decision Analysis(MCDA)method,and each variable was weighted and analyzed using the Geographical Information System(GIS).The study reveals that the levels of socio-economic vulnerability are affected by variables such as population density,vulnerable groups(disabled people,elderly people,and young people),road network and settlement,percentage of poor people,and productive land area in the Jeneberang ***,all of the 12 districts in the Jeneberang watershed are included in the medium vulnerability level,with the mean percentage of socio-economic vulnerability around 50.92%.The socio-economic vulnerability of Bajeng,Pallangga,and Somba Opu districts is categorized at high level,the socio-economic vulnerability of Bungaya,Parangloe,and Tombolo Pao districts is classified as medium level,and the remaining 6 districts(Barombong,Bontolempangan,Bontomarannu,Manuju,Parigi,and Tinggimoncong)are ranked as low socio-economic *** study can help policy-makers to formulate strategy that contributes t

关键词： Socio vulnerability Economic vulnerability Population density Vulnerable groups Road network and settlement Productive land area Jeneberang watershed

Poly Ethylene Glycols as Efficient Media for the Synthesis of β-Nitro Styrenes from α, β-Unsaturated Carboxylic Acids and Metal Nitrates under Conventional and Non-Conventional Conditions

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Green and Sustainable Chemistry 2011年第4期1卷 132-148页

作者： Kamatala Chinna Rajanna Kola Ramesh soma ramgopal somannagari Shylaja Pochampally Giridhar Reddy Pondichery Kuppuswamy Saiprakash 不详

Poly ethylene glycols (PEG-200, 400, 600, 4000 and 6000) supported reactions were conducted with certain α, β-unsaturated acids in presence of metal nitrates under solvent free (solid state) and mineral acid free conditions. The reactants were ground in a mortar with a pestle for about 30 minutes. The aromatic acids underwent nitro decarboxylation and afforded β-nitro styrene derivatives in very good yield while α, β-unsaturated aliphatic carboxylic acids gave corresponding nitro derivatives. Addition of PEG accelerated rate of the reaction enormously. Reaction times substantially decreased from several hours to few minutes followed by highly significant increase in the product yield. Among the several PEGs PEG-300 has been found to be much more effective than other PEGs.

关键词： Poly Ethylene Glycols (PEG) Rate Accelerations α β-Unsaturated Acids Metal Nitrates Solvent Free (Solid State) β-Nitro Styrene Derivatives β-Unsaturated Aliphatic Acids Nitro Derivatives

Rate Enhancements in the Acetylation and Benzoylation of Certain Aromatic Compounds with Vilsmeier-Haack Reagents Using Acetamide, Benzamide and Oxychlorides under Non-Conventional Conditions

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International Journal of Organic Chemistry 2011年第4期1卷 233-241页

作者： Marri Venkateswarlu Kamatala Chinna Rajanna Mukka Satish Kumar Utkoor Umesh Kumar soma ramgopal Pondichery Kuppuswamy Saiprakash 不详

Acetylation and benzoylation reactions of certain aromatic aldehydes, ketones with Vilsmeier-Haack Re- agents using Acetamide and Oxychloride (SOCl2 or POCl3) under conventional (thermal) and non conven- tional [microwave irradiated (MIR), ultrasonic assisted and solvent free mortar pestle (grinding)] conditions. Reactions afforded good to excellent yields of products with both the VH reagents, reaction times were fairly less in the case of [amide/POCl3] than those of [amide/SOCl2] reagent. Reactions are dramatically acceler- ated in under sonicated and microwave irradiations with a trend: MIR (few seconds) >> Sonication (minutes) > Grinding (min) >> thermal (several hrs).

关键词： Acetylation Benzoylation Vilsmeier-Haack Reagent (VHR) Acetamide Benzamide Micro Wave Irradiation Grinding Sonication

Study of Hemorrhoid Disease in the Department of General Surgery of the Cs Ref of the Commune I Bamako

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Surgical Science 2024年第2期15卷 36-47页

作者： Tounkara Cheickna Diarra Issaka Sanogo Modibo Togola Modibo Camara Ladji soma Dembele Bakary Tientigui Traore Alhassane Togo Adégné Pierre Kante Lassana Ouattara Zanafon Diallo Gangaly Department of General Surgery The Reference Health Center in Commune I Bamako Mali Department of General Surgery The Gabriel Toure University Hospital Bamako Mali Department of Urology The Gabriel Toure University Hospital Bamako Mali

This work was a retrospective prospective study carried out in the general surgery department of the Cs ref of commune I from January 2009 to December 2012. Our study aimed to determine the hospital frequency of hemorrhoidal disease, to identify the contributing factors, describe the clinical and therapeutic aspects and analyze the surgical consequences. We collected 73 patients with an average age of 37.8 years (range: 19 years and 77 years) with a sex ratio of 2.5 in favor of men. We operated on 49 patients or 67.1% of cases. 71.2% of our patients were married and lived in Bamako. Schoolchildren and middle managers made up 39.8% of cases. 82.2% of patients were seen in ordinary consultation and 69.9% complained of progressive anal pain in 66.7% of cases. This pain was triggered by defecation in 88.2% of our patients. The contributing factors were dominated by constipation (53.4%), working in a seated position (41.1%) and a sedentary lifestyle (16.4%) of cases. Stage IV external hemorrhoids and hemorrhoidal thrombosis represented 53.8% of surgical indications. The most used surgical technique was that of Milligan-Morgan, i.e. 51.9% of cases and 45.2% of patients treated medically received a combination of transit regulator, venotonics and analgesics. The surgical aftermath was marked by hemorrhage (3 cases), delayed healing (5 cases), urinary retention (1 case) and scarring anal stenosis (1 case). The morbidity rate was 5.48% of cases and a zero mortality rate. The average length of hospitalization was 2 days with extremes of 1 and 5 days.

关键词： Hemorrhoid Surgery Cs Ref C I Bamako Mali

The Entomological Efficacy of Piperonyl Butoxide (PBO) Combined with a Pyrethroid in Insecticide-Treated Nets for Malaria Prevention: A Village-Based Cohort Study Prior to Large-Scale Deployment of New Generation Mosquito Nets in Burkina Faso

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Advances in Entomology 2024年第3期12卷 224-248页

作者： Aristide S. Hien Samina Maiga Koama Bayili Adissa Y. Ouattara Dieudonné D. soma Richard Bationo Georges Benson Meda Delphine O. Karama Tiecoura Camara Georges Anicet Ouedraogo Roch K. Dabiré Abdoulaye Diabaté Malaria and Neglected Tropical Disease Department Institut de Recherche en Sciences de la Sant (IRSS) Bobo-Dioulasso Burkina Faso Sciences and Techniques Department Institut du Developpement Rural Universit Nazi Boni Bobo-Dioulasso Burkina Faso Vector Control Department Permanent Secretariat for Malaria Elimination Ouagadougou Burkina Faso

The efficacy of insecticide-treated nets (ITNs) is increasingly compromised by the prevalence of malaria vectors resistant to pyrethroids. In response to this issue, a new generation of ITNs has been developed that incorporate synergistic components, such as piperonyl butoxide (PBO). The purpose of this study is to provide entomological evidence for the efficacy of a PBO-based ITN brand at the village level, serving as a basis for decision-making before large-scale net deployment. During the high malaria transmission period, ITNs were distributed in each group and vector sampling was conducted biweekly in selected households. Bionomic data were collected to assess the resistance of wild An. gambiae populations to various chemical insecticides. There was a significant disparity in total An. gambiae sl. collected between the ITN arms, the intervention arm (ITN arms), and the control arm (P = 0.003). An. coluzzi was identified as the predominant species in the study area, as confirmed by PCR analysis. Analysis of the blood-feeding inhibition rate revealed that 100% permethrin + PBO ITN exhibited significantly greater inhibition than 66.81% permethrin only ITN. According to the log-time probit regression analysis, permethrin exhibited a knockdown time of 256 min without synergists, while it decreased to 139 min (P = 0.001) when pre-exposed to PBO. The evidence from this trial supports the use of PBO ITNs over standard ITNs for pyrethroids to combat pyrethroid resistance and improve protection against malaria for both individuals and communities, particularly in areas with high pyrethroid resistance.

关键词： Pyrethroid Resistance Permethrin + PBO ITNs Permethrin ITN Bionomic Data Insecticide Susceptibility Data Burkina Faso

Identification of genes associated with gall bladder cell carcinogenesis:Implications in targeted therapy of gall bladder cancer

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World Journal of Gastrointestinal Oncology 2023年第12期15卷 2053-2063页

作者： Ishita Ghosh Ruma Dey Ghosh soma Mukhopadhyay Department of Molecular Biology Netaji Subhas Chandra Bose Cancer Research InstituteKolkata 700094India

Gall bladder cancer(GBC)is becoming a very devastating form of hepatobiliary cancer in *** year new cases of GBC are quite high in *** recent advanced multimodality treatment options,the survival of GBC patients is very *** the disease is diagnosed at the advanced stage(with local nodal metastasis or distant metastasis)or surgical resection is inoperable,the prognosis of those patients is very ***,perspectives of targeted therapy are being *** therapy includes hormone therapy,proteasome inhibitors,signal transduction and apoptosis inhibitors,angiogenesis inhibitors,and immunotherapeutic *** such signal transduction inhibitor is the specific short interfering RNA(siRNA)or short hairpin RNA(shRNA).For developing siRNAmediated therapy shRNA,although several preclinical studies to evaluate the efficacy of these key molecules have been performed using gall bladder cells,many more clinical trials are *** date,many such genes have been *** review will discuss the recently identified genes associated with GBC and those that have implications in its treatment by siRNA or shRNA.

关键词： Gall bladder cancer Gene biomarker Targeted therapy siRNA mediated therapy Prognosis Advanced therapy of gall bladder cancer

Forensic Identification of Four Indian Snake Species Using Single Multiplex Polymerase Chain Reaction

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Journal of Forensic Science and Medicine 2022年第3期8卷 81-87页

作者： Ishani Mitra soma Roy Ikramul Haque Division of Biology Central Forensic Science LaboratoryKolkataWest BengalIndia Office of Director Central Forensic Science LaboratoryChandigarhIndia

Among different endangered animal species,snakes are the most neglected creature looked at with apathy and therefore,are ruthlessly killed,illegally trafficked,and poached for their venom,lucrative skin,meat,and bones for manufacturing of medicines,accessories,and food *** the identity of the endangered snake species is important for punishing the offenders under Wildlife Protection Act(WPA)(1972)but morphological characters fail to establish identity as they are often *** technique of identification of snake species at molecular level holds very effective conclusion in punishing ***,we have constructed and demonstrated a novel multiplexing polymerase chain reaction technique,using 16S rRNA and C-mos gene for identification of four Indian snake species,namely Ptyas mucosa,Daboia russellii,Naja naja,and Xenochrophis *** are listed in Appendix-II and III of convention on international trade in endangered species of wild fauna and flora and Schedule II;Part II of Indian WPA,***,it may be considered a functional tool for establishing species-specific identity of four Indian snake species and promising to be useful for their conservation.

关键词： 16S rRNA C-mos forensic identification Indian snakes multiplex polymerase chain reaction amplification Wildlife Protection Act(1972)

Characteristics of inflammatory bowel diseases in patients with concurrent immune-mediated inflammatory diseases

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World Journal of Gastroenterology 2022年第25期28卷 2843-2853页

作者： Shintaro Akiyama soma Fukuda Joshua M Steinberg Hideo Suzuki Kiichiro Tsuchiya Department of Gastroenterology University of TsukubaTsukuba 305-8575IbarakiJapan Inflammatory Bowel Disease Gastroenterology of the RockiesDenverCO 80218United States

Patients with inflammatory bowel disease(IBD)are more likely to have concurrent immune-mediated inflammatory diseases(IMIDs)than those without *** have been observed to alter the phenotype and outcomes of IBD in recent *** studies have found that IBD patients with concurrent IMIDs may have more extensive or severe disease phenotypes,and are considered to be at increased risk of requiring biologics and IBD-related surgeries,suggesting that having multiple IMIDs is a poor prognostic factor for ***,IBD patients with primary sclerosing cholangitis and Takayasu arteritis are reported to have unique endoscopic phenotypes,suggesting concurrent IMIDs can influence IBD phenotype with specific intestinal inflammatory *** this review,we discuss the pathogenesis,disease phenotypes,and clinical outcomes in IBD patients with concomitant IMIDs.

关键词： Inflammatory bowel disease Phenotypes Outcomes Concurrent immunemediated inflammatory diseases