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Tissue adhesive hemostatic microneedle arrays for rapid hemorrhage treatment

Bioactive Materials 2023年第5期23卷 314-327页

作者： Reihaneh Haghniaz Han-Jun Kim Hossein Montazerian Avijit Baidya Maryam Tavafoghi Yi Chen Yangzhi Zhu solmaz karamikamkar Amir Sheikhi Ali Khademhosseini Department of Bioengineering University of CaliforniaLos Angeles410 Westwood PlazaLos AngelesCA90095United States California NanoSystems Institute University of CaliforniaLos Angeles570 Westwood PlazaLos AngelesCA90095United States Terasaki Institute for Biomedical Innovation 11570 W Olympic BoulevardLos AngelesCA90024United States Department of Chemical Engineering The Pennsylvania State UniversityUniversity ParkPA16802United States Department of Biomedical Engineering The Pennsylvania State UniversityUniversity ParkPA16802United States

Blood loss by hemorrhaging wounds accounts for over one-third of~5 million trauma fatalities worldwide every *** not controlled in a timely manner,exsanguination can take lives within a few *** new biomaterials that are easy to use by non-expert patients and promote rapid blood coagulation is an unmet medical ***,biocompatible,and biodegradable microneedle arrays(MNAs)based on gelatin methacryloyl(GelMA)biomaterial hybridized with silicate nanoplatelets(SNs)are developed for hemorrhage *** SNs render the MNAs hemostatic,while the needle-shaped structure increases the contact area with blood,synergistically accelerating the clotting time from 11.5 min to 1.3 min in *** engineered MNAs reduce bleeding by~92%compared with the untreated injury group in a rat liver bleeding ***-containing MNAs outperform the hemostatic effect of needle-free patches and a commercial hemostat in vivo via combining micro-and nanoengineered ***,the tissue adhesive properties and mechanical interlocking support the suitability of MNAs for wound closure *** hemostatic MNAs may enable rapid hemorrhage control,particularly for patients in developing countries or remote areas with limited or no immediate access to hospitals.

关键词： Hemostat Microneedles Hemorrhage Bleeding Gelatin methacryloyl Silicate nanoplatelets

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Photonic control of ligand nanospacing in self-assembly regulates stem cell fate

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Bioactive Materials 2024年第4期34卷 164-180页

作者： Sungkyu Lee Jounghyun Yoo Gunhyu Bae Ramar Thangam Jeongyun Heo Jung Yeon Park Honghwan Choi Chowon Kim Jusung An Jungryun Kim Kwang Rok Mun Seungyong Shin Kunyu Zhang Pengchao Zhao Yuri Kim Nayeon Kang Seong-Beom Han Dahee Kim Jiwon Yoon Misun Kang Jihwan Kim Letao Yang solmaz karamikamkar Jinjoo Kim Yangzhi Zhu Alireza Hassani Najafabadi Guosheng Song Dong-Hwee Kim Ki-Bum Lee Soong Ju Oh Hyun-Do Jung Hyun-Cheol Song Woo Young Jang Liming Bian Zhiqin Chu Juyoung Yoon Jong Seung Kim Yu Shrike Zhang Yongju Kim Ho Seong Jang Sehoon Kim Heemin Kang Department of Materials Science and Engineering Korea UniversitySeoul02841Republic of Korea Chemical and Biological Integrative Research Center Korea Institute of Science and TechnologySeoul02792Republic of Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul02841Republic of Korea Department of Chemistry Korea UniversitySeoul02841Republic of Korea Materials Architecturing Research Center Korea Institute of Science and TechnologySeoul02792Republic of Korea School of Biomedical Sciences and Engineering Guangzhou International CampusSouth China University of TechnologyGuangzhou511442China Department of Chemistry and Chemical Biology Rutgers UniversityPiscatawayNJ08854USA Terasaki Institute for Biomedical Innovation Los AngelesCA90064USA State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha410082China Department of Biomedical-Chemical Engineering The Catholic University of KoreaGyeonggi-do14662Republic of Korea Electronic Materials Research Center Korea Institute of Science and TechnologySeoul02792Republic of Korea KIST-SKKU Carbon-Neutral Research Center Sungkyunkwan University(SKKU)Suwon16419Republic of Korea Department of Orthopedic Surgery Korea University Anam HospitalSeoul02841Republic of Korea Department of Electrical and Electronic Engineering and Joint Appointment with School of Biomedical Sciences The University of Hong KongHong Kong518057China Department of Chemistry and Nanoscience Ewha Womans UniversitySeoul03760Republic of Korea Division of Engineering in Medicine Department of MedicineBrigham and Women’s Hospital Harvard Medical SchoolCambridgeMA02139USA Division of Nano&Information Technology KIST SchoolKorea University of Science and Technology(UST)Seoul02792Republic of Korea College of Medicine Korea UniversitySeoul02841Republic of Korea Division of Materials Science and Engineering Hanyang UniversitySeoul04763Republic of Korea

Extracellular matrix(ECM)undergoes dynamic inflation that dynamically changes ligand nanospacing but has not been *** we utilize ECM-mimicking photocontrolled supramolecular ligand-tunable Azo^(+)self-assembly composed of azobenzene derivatives(Azo^(+))stacked via cation-πinteractions and stabilized with RGD ligand-bearing poly(acrylic acid).Near-infrared-upconverted-ultraviolet light induces cis-Azo^(+)-mediated inflation that suppresses cation-πinteractions,thereby inflating liganded *** inflation increases nanospacing of“closely nanospaced”ligands from 1.8 nm to 2.6 nm and the surface area of liganded selfassembly that facilitate stem cell adhesion,mechanosensing,and differentiation both in vitro and in vivo,including the release of loaded molecules by destabilizing water bridges and hydrogen bonds between the Azo^(+)molecules and loaded ***,visible light induces trans-Azo^(+)formation that facilitates cation-πinteractions,thereby deflating self-assembly with“closely nanospaced”ligands that inhibits stem cell adhesion,mechanosensing,and *** stark contrast,when ligand nanospacing increases from 8.7 nm to 12.2 nm via the inflation of self-assembly,the surface area of“distantly nanospaced”ligands increases,thereby suppressing stem cell adhesion,mechanosensing,and ***-term in vivo stability of self-assembly via real-time tracking and upconversion are *** tuning of ligand nanospacing can unravel dynamic ligand-cell interactions for stem cell-regulated tissue regeneration.

关键词： Dynamic self-assembly Ligand nanospacing In vivo tracking Stem cell adhesion Stem cell fate

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Diagenetic Aspects of the Lower Paleocene Sachun Formation Carbonates,Zagros Basin,Southwestern Iran

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Journal of Earth Science 2014年第5期25卷 884-894页

作者： solmaz Arzaghi Massih Afghah Geology Department of Islamic Azad University Fars Science and Research Branch Iran Geology Department of Islamic Azad University Shiraz Branch Shiraz Iran

The Sachun Formation in the Zagros Mountains Ranges was sampled on the basis of changes in lithology and 150 vertically oriented thin-sections were prepared and subjected to detailed petrographic study. Evaporite, carbonate and shale/marl facies are identified here. These facies which have been laid in 4 facies belts of supratidal, intertidal, lagoon and barrier, deposited on a ramp platform. Petrographic studies showed that the Sachun Formation has had a complex diagenetic history. The following diagenetic events occurred in the carbonate microfacies： micritization, dissolution, silicification, dolomitization, hematitization, compaction, fracturing and stylolitization. The diagenetic features observed petrographically in the carbonate microfacies represent changes which took place under three diagenetic environments（eogenic, mesogenic, and telogenic） with three different marine, burial, and meteoric diagenetic conditions. The diagenetic sequence of events that affected the Sachun Formation includes micritization and micrite envelope features which have been reported from an eogenic/marine environment.

关键词： Iran Zagros Sachun Formation carbonate diagenesis petrography

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Characterization and corrosion studies of ternary Zn–Ni–Sn alloys

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International Journal of Minerals,Metallurgy and Materials 2020年第1期27卷 74-82页

作者： Reyhan solmaz B.Deniz Karahan Department of Metallurgical and Materials Engineering Istanbul Technical UniversityMaslakIstanbul 34469Turkey School of Engineering and Natural Sciences Istanbul Medipol UniversityBeykozIstanbul 34810Turkey

Nine distinct zinc-nickel-tin films with different compositions have been galvanostatically electrodeposited. The films have been characterized by scanning electron microscopy(SEM) and energy dispersive spectrometry(EDS). Their corrosion potentials and densities have been estimated using Tafel extrapolation. Next, the electrochemical behaviors of the films(deposited through the electrolytes containing 0, 6, 8, and10 g/L SnCl2?6H2O) have been examined based on cyclic voltammetry(CV) measurements. Further, these films have been immersed in 3.5 wt%Na Cl solution for 1 h, 1 d, 7 d, 14 d, 28 d, and 42 d followed by application of Tafel extrapolation and electrochemical impedance spectroscopy(EIS) tests on each aged sample. Finally, to analyze the morphologies and the compositions of the oxide films covering the surfaces of the 42-d aged films, FT-IR and SEM analyses have been performed. The results indicated that the Zn–Ni–Sn film produced through the bath including 6g/L SnCl2?6H2 O exhibits superior corrosion resistance because of the high Ni content in the presence of Sn that promotes the barrier protection capability of the deposit.

关键词： ternary alloys corrosion electro galvanizing anomalous deposition Tafel

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Cycle Flow Formulation of Optimal Network Flow Problems and Respective Distributed Solutions

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IEEE/CAA Journal of Automatica Sinica 2019年第5期6卷 1251-1260页

作者： Reza Asadi solmaz S.Kia the Computer Science Department University of CaliforniaIrvineCA 92697 USA the Mechanical and Aerospace Engineering Department University of CaliforniaIrvineCA 92697 USA

In this paper, we use the cycle basis from graph theory to reduce the size of the decision variable space of optimal network flow problems by eliminating the aggregated flow conservation constraint. We use a minimum cost flow problem and an optimal power flow problem with generation and storage at the nodes to demonstrate our decision variable reduction *** main advantage of the proposed technique is that it retains the natural sparse/decomposable structure of network flow problems. As such, the reformulated problems are still amenable to distributed solutions. We demonstrate this by proposing a distributed alternating direction method of multipliers(ADMM)solution for a minimum cost flow problem. We also show that the communication cost of the distributed ADMM algorithm for our proposed cycle-based formulation of the minimum cost flow problem is lower than that of a distributed ADMM algorithm for the original arc-based formulation.

关键词： ADMM cycle basis distributed optimization optima network Flow

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Human microbiome and prostate cancer development:current insights into the prevention and treatment

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Frontiers of Medicine 2021年第1期15卷 11-32页

作者： solmaz Ohadian Moghadam Seyed Ali Momeni Uro-Oncology Research Center Tehran University of Medical SciencesTehranIran

The huge communities of microorganisms that symbiotically colonize humans are recognized as significant players in health and *** human microbiome may influence prostate cancer *** date,several studies have focused on the effect of prostate infections as well as the composition of the human microbiome in relation to prostate cancer *** studies suggest that the microbiota of men with prostate cancer significantly differs from that of healthy men,demonstrating that certain bacteria could be associated with cancer development as well as altered responses to *** healthy individuals,the microbiome plays a crucial role in the maintenance of homeostasis of body *** may contribute to the emergence of health problems,including malignancy through affecting systemic immune responses and creating systemic inflammation,and changing serum hormone *** this review,we discuss recent data about how the microbes colonizing different parts of the human body including urinary tract,gastrointestinal tract,oral cavity,and skin might affect the risk of developing prostate ***,we discuss strategies to target the microbiome for risk assessment,prevention,and treatment of prostate cancer.

关键词： microbiome prostate cancer prevention treatment molecular pathological epidemiology(MPE) biomarker

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Potential role of Müller cells in the pathogenesis of macropsia associated with epiretinal membrane:a hypothesis revisited

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International Journal of Ophthalmology(English edition) 2017年第11期10卷 1759-1767页

作者： Ahmet Colakoglu solmaz Balci Aka Department of Ophthalmology Acibadem University Schoolof MedicineIstanbul 34752Turkey Department of Ophthalmology Istanbul University CerrahpasaSchool of MedicineIstanbul 34098Turkey

Pathophysiological explanations for metamorphopsia associated with retinal pathologies generally focus on photoreceptor organization disruption. However, the retinal microarchitecture is complicated, and we hypothesize that other retinal cells may also be involved. Metamorphopsia has been widely studied in eyes with epiretinal membranes and we revisit the idea that Müller cell displacement causes retinal macropsia. A Pub Med query and related article search for the macula ultrastructure under normal and pathological conditions revealed an enormous amount of information, particularly ultrahigh definition optical coherence tomography and other retinal imaging modality studies. Findings of these imaging studies support our hypothesis that Müller cells, and not cone photoreceptors, are primarily responsible for macropsia in eyes with epiretinal membranes. More specifically, we conclude that displacement of Müller cell endfeet, and not photoreceptor cones, is a more likely the explanation for retinal macropsia associated with epiretinal membranes.

关键词： macropsia metamorphopsia epiretinal membrane Müller cells

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Reflections on the past and future of urban conservation in Iran

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Built Heritage 2020年第4期4卷 1-13页

作者： solmaz Yadollahi Chair of Urban Management Faculty 6Brandenburg University of Technology Cottbus-Senftenberg Gebäude 2ARaum A1.01Konrad-Wachsmann-Allee 203046 CottbusGermany

The material authenticity of cultural heritage has been questioned by societies in which the modern paradigm of conservation has not developed from within the native *** paper examines the philosophical and practical traditions in Iran regarding the materiality and authenticity of past *** reviewing the emergence of the Western conservation paradigm in Iran,this paper highlights two key factors:the rapidness of this paradigm shift and the remarkable contradiction between the new and old *** borrowing the Deleuzo-Guattarian concept of a‘body without organs’(BwO),this paper problematises the rapidness and radicality of the paradigm shift in *** suggests exploring the under-investigated possibilities between the pre-modern and modern paradigms to address the gap between native circumstances and Western standards.

关键词： Conservation Authenticity Materiality Cities Iran Body without organs(BwO)

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Facies analysis and depositional environments of the OligoceneeMiocene Asmari Formation, Zagros Basin, Iran

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Geoscience Frontiers 2014年第1期5卷 103-112页

作者： Mohammad Sahraeyan Mohammad Bahrami solmaz Arzaghi Department of Geology Khorasgan (Esfahan) Branch Islamic Azad UniversityEsfahan Iran Department of Geology Fars Science and Research Branch Islamic Azad UniversityShiraz Iran

The Asmari Formation （a giant hydrocarbon reservoir） is a thick carbonate sequence of the Oligocene Miocene in the Zagros Basin, southwest of h＇an. This formation is exposed at Tang-e-Lendeh in the Fars interior zone with a thickness of 190 m comprising medium and thick to massive bedded carbonates. The age of the Asmari Formation in the study area is the late Oligocene （Chattian）-early Miocene （Burdigalian）. Ten microfacies are defined, characterizing a gradual shallowing upward trend; the related environments are as follows： open marine （MF 8-10）, restricted lagoon （MF 6-7）, shoal （MF 3 5）, lagoon （MF 2）, and tidal fiat （MF 1 ）. Based on the environmental interpretations, a homoclinal ramp consisting of inner and middle parts prevails. MF 3-7 are characterized by the occmrence of large and small porcelaneous benthic foraminifera representing a shallow-water setting of an inner ramp, influenced by wave and tidal pro- cesses. MF 8-10, with large particles of coral and algae, represent a deeper fair weather wave base of a middle ramp setting.

关键词： Asmari Formation Tang-e-Lendeh Benthic foraminifera Carbonate ramp

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Discriminating performance of macular ganglion cellinner plexiform layer thicknesses at different stages of glaucoma

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International Journal of Ophthalmology(English edition) 2019年第3期12卷 464-471页

作者： Melih Ustaoglu Nilgun solmaz Feyza Onder Glaucoma Research Center Wills Eye Hospital Ophthalmology Clinic Sisli Hamidiye Etfal Training and Research Hospital Ophthalmology Clinic Haseki Training and Research Hospital

AIM: To determine the discriminating performance of the macular ganglion cell-inner plexiform layer(GCIPL) parameters between all the consecutive stages of glaucoma(from healthy to moderate-to-severe glaucoma), and to compare it with the discriminating performances of the peripapillary retinal nerve fiber layer(RNFL) parameters and optic nerve head(ONH) ***: Totally 147 eyes(40 healthy, 40 glaucoma suspects, 40 early glaucoma, and 27 moderate-to-severe glaucoma) of 133 subjects were included. Optical coherence tomography(OCT) was obtained using Cirrus HD-OCT 5000. The diagnostic performances of GC-IPL, RNFL, and ONH parameters were evaluated by determining the area under the curve(AUC) of the receiver operating characteristics. RESULTS: All GC-IPL parameters discriminated glaucoma suspect patients from subjects with healthy eyes and moderate-to-severe glaucoma from early glaucoma patients(P<0.017, for all). Also, minimum, inferotemporal and inferonasal GC-IPL parameters discriminated early glaucoma patients from glaucoma suspects, whereas no RNFL or ONH parameter could discriminate between the two. The best parameters to discriminate glaucoma suspects from subjects with healthy eyes were superonasal GC-IPL, superior RNFL and average c/d ratio(AUC=0.746, 0.810 and 0.746, respectively). Discriminating performances of all the parameters for early glaucoma vs glaucoma suspect comparison were lower than that of the other consecutive group comparisons, with the bestGC-IPL parameters being minimum and inferotemporal(AUC=0.669 and 0.662, respectively). Moreover, minimum GC-IPL, average RNFL, and rim area(AUC=0.900, 0.858, 0.768, respectively) were the best parameters for discriminating moderate-to-severe glaucoma patients from early glaucoma ***: GC-IPL parameters can discriminate glaucoma suspect patients from subjects with healthy eyes, and also all the consecutive stages of glaucoma from each other(from glaucoma suspect to moderate-tosevere

关键词： retinal nerve fiber layer optic nerve head cirrus HD-OCT ganglion cell-inner plexiform layer glaucoma suspect

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