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急性心源性肺水肿与心脏多支血管病变、传导异常以及无症状心肌缺血的关系

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世界核心医学期刊文摘（心脏病学分册） 2006年第1期2卷 56-57页

作者： Pena-Gil C. Figueras j. soler-soler j. 张宪伟 Unitat Coronria Servei de Cardiologa Universitat Autonoma de Barcelona P. Vall d’Hebron 119-129 08035 Barcelona Spain

The frequency distribution and severity of the cardiac disease underlying acute cardiogenic pulmonary edema(APE) to define appropriate subsequent diagnostic and management strategies were investigated in 216 consecutive patients. To this effect, the clinical, electrocardiographic, echocardiographic and angiographic characteristics were analyzed. Coronary artery disease was identified in 185 patients(86%)-146 with acute myocardial infarction-as the underlying cause, isolated valvular disease in 10(5%) and other causes in 21(11%). Most patients were elderly(≥70 years, 72%), hypertensive(71%)and diabetic(44%). Among coronary disease(CAD) patients, however, 105(57%) showed conduction disturbances in theECG(QRS >0.10 s) and 84(45%) had no anginal pain during pulmonary edema. A 2D echocardiogram showed a 30%incidence of moderate-severe mitral regurgitation in coronary disease and non-coronary disease patients, and a 67%incidence of reduced ej.ction fraction(< 50%), particularly in coronary disease patients(73%). A coronary angiography performed in 99 patients with coronary disease showed multivessel disease in 89(91%) with a 32%incidence of significant left main disease. Therefore, these findings demonstrate that coronary disease is the most common cause of acute pulmonary edema and it is associated with a distinctly high prevalence of multivessel and left main disease. This diagnosis, however, may often be overlooked if no serial enzymatic sampling is performed given the increased frequency of conduction abnormalities and lack of anginal pain.

关键词：急性心源性肺水肿无症状心肌缺血多支血管病变心脏病传导异常老年患者冠心病患者急性心肌梗死超声心动图心绞痛症状

Fusion and one-neutron stripping process for ^(6)Li+^(94)Zr system around the Coulomb Barrier

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Chinese Physics C 2024年第9期48卷 133-141页

作者： Xuedou Su Guangxin Zhang Shipeng Hu Peiwei Wen H.O.soler Gaolong Zhang Boshuai Cai Cenxi Yuan j.L.Ferreira Zhenwei j.ao Mingli Wang Xiaoyu Wang Zhen Huang Huanqiao Zhang Chunlei Zhang Xiaoguang Wu Yun Zheng Congbo Li Tianxiao Liand j.Lubian School of Physics Beihang UniversityBeijing 100191China Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China Institute for Advanced Study in Nuclear Energy&Safety Shenzhen UniversityShenzhen 518060China Shenzhen Key Laboratory of Research and Manufacture of High Purity Germanium Materials and Fetectors Shenzhen UniversityShenzhen 518060China China Institute of Atomic Energy Beijing 102413China Instituto de Física Universidade Federal FluminenseNiterói 24210-340Rio de JaneiroBrazil State Key Laboratory of Radiation Medicine and Protection School of Radiation Medicine and ProtectionSoochow UniversitySuzhou 215123China The Key Laboratory of Beam Technology and Material Modification of Ministry of Education College of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China

The complete and incomplete fusion cross section as well as one-neutron stripping process of ^(6)Li+^(94)Zr system were measured at the energies around the Coulomb barrier by onlineγ-ray *** addition to a 30%suppression factor when compared with the measured total fusion process,the complete fusion cross section in ^(6)Li+^(94)Zr system was observed to be significantly lower than those in the nearby ^(6)Li+^(90,96)Zr *** new experimental result implies that the coupling with breakup channel in the ^(6)Li-induced fusion processes can be affected by the inner structure of the target,which is still not clear in any available model *** the one-neutron stripping process,the direct production cross sections for each level in 95Zr were extracted and compared with the coupled reaction channel calculation,offering a unique opportunity to examine the single-particle nature of the produced excited *** the fact that an overall overestimation of the production cross section for 954-keV and1618-keV levels was observed in the comparison,further investigation is highly demanded in order to understand the full reaction mechanism for the one-neutron stripping process induced by ^(6)Li.

关键词： weakly bound nuclei complete fusion incomplete fusion transfer reaction

Utilization of RNA sequencing to investigate olfactory dysfunction in chronic rhinosinusitis without nasal polyps:A pilot study

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World j.urnal of Otorhinolaryngology-Head and Neck Surgery 2024年第1期10卷 29-36页

作者： j.rge A.Gutierrez III j.remy L.Barth Rodney j.Schlosser Thomas S.Edwards Timothy L.Smith Zachary M.soler Department of Otolaryngology-Head and Neck Surgery Medical University of South CarolinaCharlestonSouth CarolinaUSA Department of Regenerative Medicine&Cell Biology Medical University of South CarolinaCharlestonSouth CarolinaUSA Department of Otolaryngology-Head and Neck Surgery Oregon Health&Science UniversityPortlandOregonUSA

Obj.ctives:Prior research on olfactory dysfunction in chronic rhinosinusitis(CRS)has focused on patients with polyps and suggests that direct inflammation of the olfactory cleft mucosa plays a contributory *** purpose of this study was to evaluate gene expression in superior turbinate mucosal specimens,comparing normosmic and dysosmic CRS patients without polyps(CRSsNP).Methods:Tissue samples were obtained from the superior turbinates of patients with CRSsNP at the time of endoscopic sinus *** subsequently underwent RNA sequencing and functional analysis to investigate biological pathways associated with differentially expressed genes between dysosmic(n=7)and normosmic(n=4)***:Differential gene expression analysis comparing dysosmic and normosmic CRSsNP patients showed upregulation of 563 genes and downregulation of 327 *** stringent criteria for multiple comparisons,one upregulated gene(Immediate Early Response 3[IER3])had an false discovery rate(FDR)correction adj.stedP value considered statistically significant(P<0.001,fold change 2.69).Reactome functional analysis revealed eight biological pathways significantly different between dysosmic and normosmic patients(P<0.05,FDR correction)including IL-4 and IL-13 signaling,IL-10 signaling,and rhodopsin-like ***:RNA sequencing of the superior turbinates in patients with CRSsNP can provide valuable information regarding biological pathways and genes involved in olfactory *** study supports literature suggesting that Type 2 inflammation may play a role in olfactory dysfunction in at least some patients with *** study also prompts questions regarding the role of IL-10,rhodopsin-like receptors,andIER3 in the pathogenesis of olfactory dysfunction.

关键词： chronic rhinosinusitis without nasal polyps olfactory dysfunction RNA sequencing

Comparison of trigeminal lateralization with differing stimulants

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World j.urnal of Otorhinolaryngology-Head and Neck Surgery 2024年第1期10卷 66-69页

作者： Tiffany Chen Nicolas S.Poupore Michael C.Shih Thomas S.Edwards Shaun A.Nguyen Zachary M.soler Rodney j.Schlosser Department of Otolaryngology‐Head and Neck Surgery Medical University of South CarolinaCharlestonSouth CarolinaUSA

Trigeminal-specific stimulants have been shown to activate different receptors preferentially and this likely accounts for variation in sensory *** is unclear whether trigeminal sensitivity is similar across different transient receptor potential(TRP)receptors or if dysfunction of different receptors results in differing patient ***,a prospective cohort study was conducted,consisting of trigeminal lateralization testing with three different stimulants(eucalyptol,isothiocyanate,acetic acid),olfaction testing with Sniffin'Sticks,and measurement of various patient‐reported outcome measures(PROMs).A total of 50 participants were enrolled across the olfactory *** TDI score was 27.1±8.3(range 7.0–39.5)with 38%normosmic and 62%*** trigeminal lateralization scores out of 20 in the overall cohort were 16.18(2.78)for eucalyptol,14.94(3.49)for mustard oil,and 15.28(3.68)for *** showed a significant correlation with threshold scores of Sniffin'Sticks.A significant correlation was found between acetic acid and various *** of the lateralization scores of the trigeminal stimulants correlated to each other significantly and there was no correlation to *** lack of correlation suggests that the measured sensitivity of one type of TRP receptor may not translate to similar sensitivity of the other *** investigations with TRPV1 and TRPA1 agonists are needed to corroborate our findings.

关键词： chemosensory olfaction trigeminal TRP receptor

Genotypes and Phenotypes of Uygur Children with Xeroderma Pigmentosum: A Case Study in Xinj.ang, China

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International j.urnal of Dermatology and Venereology 2024年第3期7卷 144-149页

作者： Qiu Y. Wang W.-j. Liang j.-Q. Yakeya B. Wang P. Zhang j.-Z. Kang X.-j. Department of Dermatology and Venereology People's Hospital of Xinjiang Uygur Autonomous Region Xinjiang Uygur Autonomous Region Urumqi 830001 China Xinj.ang Clinical Research Center for Dermatologic Diseases Xinjiang Uygur Autonomous Region Urumqi 830001 China Xinj.ang Key Laboratory of Dermatology Research (Xj.S1707) Xinjiang Uygur Autonomous Region Urumqi 830001 China

Obj.ctive: Xeroderma pigmentosum (XP) is a rare autosomal recessive dermatosis caused by genetic defects of DNA repair. This study was performed to detect and analyze the genes of 2 Uygur patients with XP and their families and assess the patients' phenotypes, which may enrich the understanding of the genetic skin disorder spectrum in Xinj.ang area. Methods: We collected the clinical data from 2 patients with XP and peripheral blood samples from the patients and their family members. The patients' DNA was sequenced and detected by Sanger sequencing, and gene mutations were screened. Results: The proband in family 1 presented with brown maculae at the exposure site and squamous cell carcinoma secondary to a facial rash. The proband had a homozygous nucleotide variation of XPC c.2251-2A> G (A change from A to G in the penultimate position of the intron before the 2251 position in the coding region), which was a shear mutation. In this family, both parents were heterozygous, and no similar mutation detected in the sister. In family 2, the proband had scattered black brown spots and papules on the trunk and limbs. and his younger sister was also a patient. The proband and his younger sister had homonucleotide variation of XPA c.631C> T, which was nonsense mutation, resulting in the codon for Arg No.211 being changed into termination codon (***211X), thus terminating the peptide chain synthesis prematurely. All the normal individuals in the two families were heterozygotes, and homozygous mutations occurred in all the patients, which was consistent with the autosomal recessive inheritance. Conclusion: XP is rare in Uygur population. This study expanded the mutation spectrum of XP and provided a basis for early diagnosis, treatment, prognostic prediction, and prenatal genetic consultation. © 2022 Hospital for Skin Diseases (Institute of Dermatology), Chinese Academy of Medical Sciences, and Chinese Medical Association, published by Wolters Kluwer, Inc.

关键词： gene mutation xeroderma pigmentosum XPA gene XPC gene

Wind power potential over northern South America using ERA5-Land global reanalysis

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CLEAN ENERGY 2024年第2期8卷 104-112页

作者： Arregoces, Heli A. Bonivento, Guillermo j. Roj.no, Roberto Univ Guaj.ra Fac Ingn Grp Invest GISA Riohacha Colombia Univ Antioquia UdeA Fac Ingn SIU Grp Proc Fisicoquim Aplicados Calle 70 52-21 Medellin Colombia

The northernmost region of South America has great potential for wind energy production and is a strategic area for the energy transition. We analysed data from ERA5-Land global reanalysis from 1980 to 2020 to determine the wind power potential in this area. Our aim was to identify areas with a high potential for wind energy that could be used to supply energy in case of drought in the region or increases in fuel prices. We compared data from 19 meteorological stations located in Colombia with ERA5-Land reanalysis data to generate reliable information for the feasibility and operation of wind farms. According to our analysis, the Colombian Caribbean and Coastal Plain have monthly average wind speeds at 90 m ranging from 4.85 to 10.34 m/s and 3.79 to 6.62 m/s, respectively. Based on wind power density calculations, these regions have the highest wind power density in our study, with a monthly average of between 250 and 399 W/m2. The Caribbean Region had a 69% increase in wind power density from j.nuary to j.ly compared with the annual average. The wind power density in the plains increased from j.nuary to March, while the Mountain Region had higher anomalies from May to October. The Alta Guaj.ra and Paraguana Peninsula have great potential to generate wind energy due to their privileged geographical location. Although ERA5 offers valuable information about wind availability in time and space, it cannot represent the influence of local effects on wind patterns for the Mountain Region. Data from ERA5-Land global reanalysis (1980-2020) are used to determine the wind power potential in the northernmost region of South America to identify areas with a high potential for wind energy, which could be used to supply energy in case of drought or increases in fuel prices. Graphical Abstract

关键词： onshore wind power wind power potential ERA5-Land global reanalysis wind speed ENERGY COLOMBIA REGION ERA5

Editorial for the Special Issue on Emerging Technology and Advanced Application of Nondestructive Detection for Power Equipment

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Chinese j.urnal of Electrical Engineering 2024年第1期10卷 1-2页

作者： Li j. Mei H. Li S. Tianj.n University China Tsinghua Shenzhen International Graduate School China Lanzhou j.aotong University China

The rapid development of clean and renewable energy technologies represented by wind and solar energy,as well as the continuous growth of load demand,have put forward higher requirements for the safe operation of the power *** performance of power equipment based on traditional dielectric materials is often limited by various defects generated during molding,transportation,assembly,and operation,which cannot meet the reliability requirements of power systems in the new *** detection is an essential technical method in industrial development,which can detect and evaluate the defect and damage status of in-service equipment,key components,and materials without damaging the obj.ct.

关键词： service Application operation

Exploring public perception and willingness to pay for a renewable source of energy: evidence from an emerging economy of renewable-energy development

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CLEAN ENERGY 2024年第2期8卷 177-188页

作者： Bashir, Mohammed j. K. Abdelhak, Senadj.i Salah, Wael A. Abuhelwa, Mai Cent Queensland Univ Sch Engn & Technol 120 Spencer St Melbourne Qld 3000 Australia Univ Tunku Abdul Rahman Fac Business & Finance Kampar Perak Malaysia Palestine Tech Univ Kadoorie Coll Engn & Technol Dept Elect Engn POB 7 Yafa St Tulkarm Palestine Univ Missouri Dept Elect Engn & Comp Sci Columbia MO 65211 USA

The study focuses on the transition from conventional energy sources to sustainable renewable energy (RE) in Palestine, particularly in the West Bank and Gaza Strip. The research aims to understand the relationship between key factors and residents' willingness to invest in the RE sector, with a specific focus on the impact of education. Using the unified theory of acceptance and use of technology, the study analyzes data from 400 residents through a questionnaire and employs ordinary least-squares regression analysis with Eviews 12. The key findings indicate that residents' inclination to invest in RE is significantly influenced by factors such as resource availability, knowledge level and power outages. Moreover, the study suggests that educated residents are more likely to invest in RE when factors such as knowledge, effort expectation, enabling conditions and resource availability are relatively high. The conclusion emphasizes the importance of policymakers' allocating sufficient funds to research and development to promote technological innovation in RE sources, thereby enhancing the population's energy efficiency. The study focuses on the transition from conventional energy to sustainable renewable energy in Palestine, particularly in the West Bank and Gaza Strip, to understand the relationship between key factors and residents' willingness to invest in the RE sector, with a specific focus on the impact of education. Graphical Abstract

关键词： renewable energy technology energy security public perceptions sustainable development UNIFIED THEORY RURAL-AREAS TECHNOLOGY ACCEPTANCE DETERMINANTS INTENTION RELIABILITY SERVICES SYSTEM ERRORS

Use of ketamine for severe asthma exacerbation in a pregnant patient with persistent bronchospasm: A case report

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Emergency and Critical Care Medicine 2024年第3期4卷 130-133页

作者： j.hnson M. Abbas M. Abdo j. Mansour M. j.nes j. Pharmacy Department Beaumont Health Dearborn MI United States Emergency Center Beaumont Health Dearborn MI United States

Background Estimated 4%-8% of pregnancies are complicated by asthma. Adequate management in this population is critical to minimize complications. Patients presenting with asthma exacerbation are typically managed with standard bronchodilators and systemic corticosteroids. However, additional agents may be used in patients with refractory asthma exacerbation. Ketamine has been used in refractory bronchospasm, although its efficacy in published literature is heterogeneous. Case Presentation We present a case of a pregnant patient with severe asthma exacerbation refractory to standard and salvage treatment who achieved termination of bronchospasm with ketamine infusion. Conclusion After receiving ketamine infusion for several days, the patient had improved air flow and achieved successful extubation, without experiencing rebound bronchospasm. Although this individual clinical case alone cannot change guidelines or directives to use in refractory asthma exacerbations, it offers a possible treatment option to patients and providers in unusually severe cases with extenuating risk factors. © Wolters Kluwer Health, Inc. All rights reserved.

关键词： Asthma Bronchospasms Case Report Ketamine Pregnancy