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Marfan Syndrome Complicated by Aortic Arch Aneurysm and Aortic Dissection: A Case Report from Congo

World Journal of Cardiovascular Diseases 2022年第10期12卷 463-471页

作者： solange flore ngamami mongo Christian Michel Kouala Landa Franck Yannis Kouikani Kivié Mou-Moué Ngolo Letomo Rogue Pattern Bakekolo Bertrand Fikahem Ellenga Mbolla Department of Cardiology University Hospital of Brazzaville Brazzaville Republic of the Congo Department of Doctoral Studies Faculty of Health Sciences Marien Ngouabi University Brazzaville Republic of the Congo

Context and Aim: Marfan syndrome is a transmissible genetic disease of the connective tissue that is rarely encountered in Congo and in sub-Saharan African countries. Its cardiovascular complications can be life frightening. The management of that disease is still limited in our country because of a lack of technical capacity in cardiovascular surgery. The aim of this clinical report is to show the interest of echocardiography and especially angioscanner as the main technique in the diagnosis of the severity of this disease, elaborate a literature review, but also to highlight the difficulties encountered in the management of that affection in our countries. Observation: The authors report the medical observation of a 48-year-old adult with a history of cataract of the left eye and a subluxation of the lens for which he underwent surgery in 2016, without any etiology being found. He is a smoker at a rate of 6 packs yearly. He consulted for progressively worsening dyspnea and constrictive mediosternal pain. The clinical examination revealed a moderate alteration of the general state, apyrexia, a blood pressure of 140/90 mmHg, a SPO2 of 97% in ambient air, a respiratory frequency of 32 cycles/min, signs of left ventricular insufficiency, a diastolic murmur of aortic insufficiency of intensity 4/6th, a long-limbed morphotype with a wingspan superior to the height and a kyphoscoliosis. Chest X-ray showed cardiomegaly with a cardiothoracic ratio of 58%, a highly dilated and uncoiled aorta, convexity of the left inferior arch, and venocapillary hypertension and a quiet alveolar-interstitial pulmonary oedema. The ECG was in sinus rhythm and showed a poor R-wave progression in anteroseptal leads. Echocardiography showed significant aortic root dilatation up to 72.6 mm and aortic regurgitation grade IV. Angioscanner showed a dissected aortic aneurysm and areas of emphysema located in the lungs. The medical treatment was palliative with beta blocker and angiotensin

关键词： Marfan Syndrome Heart Failure Aortic Aneurysm Aortic Dissection Congo

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Papulosa Nigra Dermatosis Another Factor Associated with Cardio-Vascular Diseases?

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World Journal of Cardiovascular Diseases 2023年第12期13卷 819-826页

作者： solange flore ngamami mongo Bani Aloise Macaire Franck Yannis Kouikani Kivié Mou-Moué Ngolo Letomo Bayonne S. E. Kombo Bertrand Fikahem Ellenga Mbolla Department of Cardiology B University Hospital of Brazzaville Brazzaville Republic of Congo Departement of Medecine Faculty of Health Sciences Marien Ngouabi University Brazzaville Republic of Congo General Hospital of Loandjili Pointe Noire Republic of Congo

Objectives: To determine the correlation between dermatosis papulosa nigra (DPN) and cardiovascular disease (CVD). Patients and Method: A retrospective study was conducted between April 2022 and March 2023 in cardiology at Loandjili General Hospital. Were included all adult patients older than 18 years of age presenting with DPN, and divided into two groups according to the presence of CVD. Hypertension (HT), endomyocardial fibrosis, dilated and restrictive cardiomyopathy, chronic pulmonary heart, ischemic heart disease, stroke, and valvular heart disease were retained as CVD. Pregnant women, Peutz Jeghers syndrome and all dermatosis with cardiovascular manifestations were excluded. Studied variables were clinico-demographic, hereditary and behavioral. Results: A total of 55 patients were selected. There were 40 patients with CVD, 15 patients without CVD, 43 women (78.1%) and 12 men (21.8%). Mean age was 52 ± 12.6 years (extremes: 22 - 85 years). There was a significant difference between age and sex (P 0.05). There were 34 hypertensive patients, 10 patients with diabetes mellitus, 7 strokes, 2 endomyocardial fibrosis and 2 ischemic heart diseases. Periorbital location was representative was frequently found in the group with CVD. Hereditary and behavioral factors were involved in the development of DPN and CVD. There was a significant correlation between DPN and onset in childhood (P 0.05), between hypertension and use of medication (P 0.05), and between onset in childhood (P 0.05) and use of mercury containing soap (P 0.05). Conclusion: DPN predominates in young women. The occurrence of CVD depends on DPN location. Hereditary and behavioral factors associated with development of DPN are CVD factor risks.

关键词： Papulosa Nigra Cardiovascular Disease Correlation Pointe Noire

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Epidemiological and Clinical Profile of Hypertensive Patients with Obstructive Sleep Apnea at CHU-B

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World Journal of Cardiovascular Diseases 2023年第10期13卷 664-673页

作者： solange flore ngamami mongo Kivie Mou-Moue Ngolo Letomo Arnold Sem Nguia Vel Christian Kouala Landa Franck Yannis Kouikani Rogue Pattern Bakekolo Bertrand Fikahem Ellenga Mbolla Department of Cardiology B University Hospital of Brazzaville Brazzaville Republic of Congo Departement of Medecine Faculty of Health Sciences Marien Ngouabi University Brazzaville Republic of Congo Adolphe Cissé Emergency Department Pointe Noire Republic of Congo

Objectives: To detect obstructive sleep apnea syndrome (OSAS) in a population of hypertensive patients, using the Berlin questionnaire and to establish the epidemiological and clinical profile of patients. Patients and Method: This was a cross-sectional and analytical study, carried out from March to August 2019 at the CHU Brazzaville. Included are hypertensive patients followed as outpatients. The diagnosis of the OSAS was based on the answers to the Berlin questionnaire. Results: A total of 315 patients were included, including 210 women (64.9%). Prevalence of OSAS was 75.8% (n = 239). The average age of patients with sleep apnea was 58.5 ± 12.4 years with female predominance (64.9%). In the mixed analysis, the factors associated with (OSAS) were: occupation OR (2.56) 95% CI (1.15 - 5.69), obesity OR 7.50 (1.60 - 35.1) and abdominal obesity OR 2.36 CI 95% (1.36 - 4.08). Living standards were high in 59 cases (18.7 per cent). The medical history of previous hospitalization was present in 209 cases (66.3%), diabetes 95 (30.2%), and heart failure 57 cases (18.1%). Lifestyle patterns were: sedentary (n = 181;57.5%) alcohol consumption (n = 97;30.8%). On physical examination, overweight was noted in 96 cases (30.5%) and obesity in 91 cases (28.8%). The anomalies in the Berlin questionnaire were: snoring (n = 197;62.5%), waking fatigue (n = 127;40.3%), fatigue during the day (n = 97;30.8%). Conclusion: The prevalence of obstructive sleep apnea syndrome is high during arterial hypertension in our setting. Hence the need for sleep exploration through polysomnography, and prevention through the fight against the associated risk factors.

关键词： Hypertension Obstructive Sleep Apnea Syndrome Brazzaville

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Arterial Hypertension and Pregnancy about 72 Cases

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World Journal of Cardiovascular Diseases 2023年第12期13卷 870-878页

作者： solange flore ngamami mongo Kivié Mou-Moué Ngolo Letomo Christian Michel Kouala Landa Rode Vaclair Kibongui Massinssa Rogue Pattern Bakekolo Franck Yannis Kouikani Bani Aloise Macaire Bertrand Fikahem Ellenga Mbolla Department of Cardiology B University Hospital of Brazzaville Brazzaville Republic of Congo Departement of Medecine Faculty of Health Sciences Marien Ngouabi University Brazzaville Republic of Congo Hô pital général de Loandjili Pointe Noire République du Congo

Background: Hypertension is the leading cause of cardiovascular disease worldwide. Hypertensive disorders in pregnancy also constitute a major global health threat. There are different types of hypertension that can occur during pregnancy;with different mechanisms and consequences for mother and fetus. Objectives: To determine the frequency of hypertension (hypertension) during pregnancy. Document the risk factors for pregnancy-related hypertension. Review the material and fetal complications which determine the prognosis. Methods and Patients: This was a retrospective cross-sectional study from January 1 to June 30, 2022 in the Obstetrics and Gynecology Department of the Brazzaville Hospital and University Center. We noted 72 cases of hypertension among 1188 births admitted during the reference period. Hypertension was defined as blood pressure 40/90mmHg. Results: Hypertension was observed in 6% of those giving birth. The average age of the patients was 28 ± 8 years (range 15 to 39 years). The age group of 15 to 34 years was the most affected, 56 cases (778%). The risk factors were young age (15 - 34 years), late transfer of women in labor, 49 cases (68%). Primiparity, 33 cases (45.8%), absence of prenatal consultation, 7 cases (9.7%), hypertension, 8 cases (11%), twinning, 4 cases (5%), fetal macrosomia, one case (1.3%). Maternal complications recorded were: 21 cases of eclampsia (29%), 6 cases of left ventricular failure (8.3%), 5 cases of anemia (6.9%), 2 cases of retroplacental hematoma (2.8%), 1 case of HELLP syndrome, as much renal failure. Fetal and neonatal complications were 23 cases of prematurity (32%), 10 cases of acute fetal distress (14%), 4 cases of hypotrophy (5.6%). Eleven cases of death (15.3%) were: 3 in utero. B in the neonatal period.

关键词： Hypertension Pregnancy Pre-Eclampsia Complications

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Peri-Annular and Septal Abscesses in Infectious Endocarditis. About 3 Cases Observed at the University Hospital of Brazzaville

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World Journal of Cardiovascular Diseases 2022年第2期12卷 94-110页

作者： solange flore mongo ngamami Armel Landry Batchi-Bouyou Trésor Mavie Eouolo Ndona Christian Michel Kouala Landa Eric Gibrel Kimbally Kaky Jean Joseph Ekwa Sima Bertrand Fikahem Ellenga Mbolla Méo Stéphane Ikama Department of Cardiology University Hospital of Brazzaville Brazzaville Republic of the Congo Department of Doctoral Studies Faculty of Health Sciences Marien Ngouabi University Brazzaville Republic of the Congo

Infectious endocarditis (IE) is a relatively rare but serious condition. We report 3 cases of infectious endocarditis complicated by peri-annular and/or septal abscess. The patients aged 24, 25 and 28 were all male. Global heart failure was observed in 2 cases. Atrioventricular block was noted in 2 cases (complete syncopation: 1 time;2nd degree Mobitz 2 1 time). Transthoracic echocardiography made it possible to diagnose abscess in all cases (aortic and septal peri-annulus: once, septal only: twice). The aortic insufficiency was grade 2 in all cases, mitral insufficiency grade 2 in 1. The front door was found once, with a dental location. Blood cultures were negative in all cases. A bi-probabilistic antibiotic therapy made it possible to control the infectious process in all the patients. Cardiac surgery, indicated in all cases, was performed in 1 case, consisting of flattening the abscesses and then placing a pacemaker in the patient with complete syncopal atrioventricular block. The outcome of all patients was favorable. Return to permanent sinus rhythm, associated with complete left bundle branch block, was noted at the 4th year of development in the pacemaker wearer. The other 2 patients are still awaiting medical evacuation.

关键词： Infectious Endocarditis Peri-Annular and Septal Abscess Echocardiography Treatment

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Cardiac Tamponade: Epidemioclinical, Therapeutic and Evolutionary Aspects at the University Hospital of Brazzaville

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World Journal of Cardiovascular Diseases 2021年第12期11卷 572-582页

作者： solange flore mongo ngamami Armel Landry Batchi-Bouyou Evariste Pabingui Christian Michel Kouala Landa Bertrand Fikahem Ellenga Mbolla Jean Joseph Ekwa Sima Méo Stéphane Ikama Suzy-Gisèle Kimbally Kaky Department of Cardiology University Hospital of Brazzaville Brazzaville Republic of the Congo Department of Doctoral Studies Faculty of Health Sciences Marien Ngouabi University Brazzaville Republic of the Congo

Objectives: Contribute to improving the management of cardiac tamponade in Congo. Background: Cardiac tamponade is an acute or subacute compression of the heart chambers by pericardial effusion responsible for uncertain prognosis for patients. The objective of this study is to help improve the management of patients with cardiac tamponade. Patients and Methods: We conducted a retrospective and descriptive study at the University Hospital of Brazzaville, from January 2015 to December 31, 2019. Included were all patients hospitalized for cardiac tamponade. Epidemioclinical, therapeutic and evolutionary data were analyzed. Results: An overall of 14 patients were divided into 9 men (64.2%) and 5 women (35.7%), i.e. a sex ratio of 1.8. The mean age of patients was 34.2 ± 15.1 years old (18 years to 64). The most represented comorbidity was hypertension (n = 2;14.3%). The most frequent clinical sign was dyspnea (n = 14;100%). The ECG showed diffuse and concordant repolarization disturbances (n = 14;100%), sinus tachycardia (n = 13;92.8%), microvoltage (n = 12;85.7%). Cardiomegaly was constant (n = 14;100%). In terms of transthoracic ultrasound, we found: diastolic compression of the right ventricle (RV) (n = 12;85.7%), dilation of the inferior vena cava (IVC) (n = 12;85.7%). Treatment consisted of crystalloid vascular filling in all patients, pericardial punc

关键词： Cardiac Tamponade Clinical Presentation Treatment Congo

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Hyperuricemia and Associated Factors during Arterial Hypertension in Brazzaville (Congo)

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World Journal of Cardiovascular Diseases 2019年第3期9卷 236-244页

作者： Stéphane Méo Ikama Amorce Rolles Matingou Jospin Makani Norbert Lamini Nsounda solange flore mongo-ngamami Bertrand Fikhaem Ellenga-Mbolla Louis Igor Ondze-Kafata Thierry Raoul Gombet Suzy Gisèle Kimbally-Kaky Department of Cardiology Brazzaville University Hospital Center Brazzaville Congo Department of Rhumatolology Brazzaville University Hospital Center Brazzaville Congo

A longitudinal analytical and comparative study including outpatients was carried between June 1st?and December 31st?2017. The objectives were to determine the hyperuricemia frequency during arterial hypertension, to identify associated factors, and to evaluate its impact on the blood pressure control. We have included, hypertensive patients having a minimum blood test including at least an uricemia. They were divided into two groups according to?whether they have presented a?hyperuricemia (HU) or a normouricemia (NU).?Among?these 202 patients included, 61 (30.2%) presented a hyperuricemia.?The mean age in HU group was 54.6 ± 11.6 years vs 53.6 ± 11 years for NU group (p = 0.573). Following cardiovascular risk factors were more found in the HU group than NU group: overweight/obesity (68.8% vs 46.1%;p = 0.003), metabolic syndrome (42.6% vs 39%;p = 0.021). Diuretics were used in 72.1% of patients in HU group vs 47.5% in NU group (p = 0.002).?Bitherapy was used in 56% of the patients of HU group vs 69% in the NU group (p = 0.295), and the quadritherapy?in 8% and 1% of the patients respectively (p = 0.049). Blood pressure was not controlled in 68.8% of HU group vs 48.9% in the NU group (p = 0.014). In multivariate analysis after logistic regression, factors associated with hyperuricemia were: glucose intolerance or diabetes (p = 0.004;OR = 1.35) and uncontrolled blood pressure (p = 0.006;OR = 2.51). This preliminary study showed that hyperuricemia is commonly found in hypertensive patients and has negative impact on blood pressure control.

关键词： Hypertension Hyperuricemia Frequency Blood Pressure Control Congo

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Hypertension, diabetes mellitus, overweight and obesity in employees under health transition at the railways company in Congo-Brazzaville

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World Journal of Cardiovascular Diseases 2014年第2期4卷 45-49页

作者： Bertrand Fikahem Ellenga Mbolla Thierry Raoul Alexis Gombet Henri Germain Monabeka Paul Macaire Ossou-Nguiet solange flore mongo-ngamami Christian Michel Kouala Landa Suzy-Gisèle Kimbally-Kaky Benjamin Longo-Mbenza Department of Cardiology University Hospital of Brazzaville Brazzaville Congo Department of Cardiology University Hospital of Brazzaville Brazzaville Congo Department of Medicine Faculty of Health Sciences Marien Ngouabi University Brazzaville Congo Department of Medicine Faculty of Health Sciences Marien Ngouabi University Brazzaville Congo Faculty of Health Sciences Walter Sisulu University Mthatha South Africa

Background and Aim: Cardiovascular risk (CVR) factors, namely hypertension (HT), diabetes mellitus and obesity, are a public health problem in sub-Saharan Africa because of health transition. The additional effect of the social gradient within the railway companies in Congo-Brazzaville on high CVR is not yet established. The aim of this study was to determine the extent of hypertension, diabetes mellitus, overweight, and obesity and to identify the contributing factors of fatness and hypertension. Methods: This was a cross-sectional study conducted in April 2013. A simple random sample of 255 out of all 2550 workers from the railway companies of Congo was examined for epidemiological, clinical and biological variables. Results: Out of the study sample, 231 (90.6%), 79 (31%), and 52 (20.4%) were men, rural dwellers, and senior executives, respectively. The mean age was 45 ± 13 years (range 19 to 63 years). The rates of overweight, hypertension, obesity, and diabetes mellitus were 40.3% (n = 103), 29.4% (n = 75), 7.5% (n = 19), and 3.5% (n = 9), respectively. In univariate analysis, female sex (OR 2.7, 95% CI 1.13 - 6.45, p = 0.01), senior executive (OR 2.4;95% CI: 1.3 - 4.5;p = 0.003) and physical inactivity (OR 2.5;95% CI: 1.5 - 4.2;p < 0.001) were significantly associated with overweight. Female sex (OR 7.5, 95% CI: 2.6 - 21;p < 0.001) and senior executive (OR 3.17;95% CI: 1.2 - 8.3) were also significantly associated with obesity. In logistic regression, overweight (OR = 4.8, 95% CI 2.8 - 11, p < 0.0001), and obesity (OR = 6.8, 95%CI 2.1 - 22, p = 0.01) were identified as the most important and independent determinants of hypertension. Conclusions: Fatness is emerging and it is the most contributing factor of hypertension among workers at the Congolese railway companies. There is also a significant interaction between non-modifiable factors (genetic: females and family history) and modifiable factors (inactivity, fatness) for higher risk of hypertension. Health pr

关键词： Hypertension Diabetes Mellitus Overweight Obesity Workplace Congo Sub-Saharan Africa

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Hypertensive Emergencies in the Department of Cardiology at the Teaching University Hospital of Brazzaville (Republic of the Congo): Preliminary Study

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World Journal of Cardiovascular Diseases 2019年第1期9卷 1-8页

作者： solange flore mongo ngamami Bertrand Fikahem Ellenga Mbolla Guénol Barthel Ebinda Christian Michel Kouala Landa Louis I. Ondze Kafata Méo S. Ikama Thierry Raoul Gombet Suzy-Gisèle Kimbally Kaky Department of Cardiology Teaching University Hospital Brazzaville Republic of the Congo Department of Doctoral Studies Faculty of Health Sciences Marien Ngouabi University Brazzaville Republic of the Congo

Background: Hypertensive emergencies are still a common mode of finding hypertension.?Objective: to determine the epidemiological, clinical and paraclinical characteristics of the hypertensive emergency, and to evaluate the factors associated with poor blood pressure control. Patients and method: cross-sectional and analytical study, conducted from July 2010 to June 2014 (4 years), in the cardiology department of the Brazzaville University Hospital. Included, patients admitted were those systolic blood pressure (BP)?≥ 180 mm Hg, and diastolic BP ≥ 110 mm Hg, with target organ involvement. A minimum biological assessment, an ECG, a chest X-ray, a brain CT-scan and a cardiac ultrasound were required.?Results: Fifty patients were included, including 31 women (62%). The mean age was 53.8?±?13.7 years old, age;?68%), low income?population (n = 23;?46%). Hypertension was often known (n = 49;98%), and poor compliance?(n = 33;67.4%). Associated risk factors were: obesity (n = 13),?and?diabetes (n = 7). The average consultation time was 4.1?±?3.7 days. The reasons for hospitalization were: dyspnea (n = 24;?48%), neuro-sensory signs (n = 24;?48%),?and?functional limb impotence (n = 15;?30%). The major laboratory abnormalities were hyperuricemia (n = 16;?32%) and hyperglycemia (n = 16). Left ventricular hypertrophy was noted at the ECG (n = 29;?58%). Cardiac ultrasound showed a LVEF ?40% (n = 8). The main hypertensive emergencies were: heart failure (n = 23;?46%), stroke (n = 23;?46%), severe renal failure (n = 10;20%), and malignant hypertension (n = 23;46%). The average hospital stay was 11.4?±?5.5 days, and 1 death was recorded. BP was uncontrolled in 38 cases (76%). Factors associated with uncontrolled blood pressure were: female sex (OR 3;?95% CI 0.8 - 11.5) and low-income patient (OR 1.26;?95% CI 0.34 - 4.68).?Conclusion: organs affected during hypertensive emergencies are most often the heart, the brain and the kidney in our context. Early management of hypertension wil

关键词： Emergencies High Blood Pressure Stroke Heart Failure Black African

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Marfan Syndrome Complicated by Aortic Arch Aneurysm and Aortic Dissection:A Case Report from Congo

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World Journal of Cardiovascular Diseases（心血管病） 2022年第10期

作者： solange flore ngamami mongo christian michel kouala landa franck yannis kouikani kivié mou-moué ngolo letomo rogue pattern bakekolo bertrand fikahem ellenga mbolla

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