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Client views,perception and satisfaction with immunisation services at Primary Health Care Facilities in Calabar,South-South Nigeria

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Asian Pacific Journal of Tropical Medicine 2010年第4期3卷 298-301页

作者： Udonwa ne Gyuse AN Etokidem AJ Ogaji DST Department of Family Medicine University of Calabar Teaching HospitalCalabarNigeria Department of Community Medicine University of Calabar Teaching HospitalCalabarNigeria

Objective:To determine the degree of client satisfaction with immunisation services at Primary Health facilities in Calabar,Cross River State,***:A semi-structured questionnaire was administered on 402 caregivers who were selected using systematic random sampling from four primary health *** four centres were randomly selected from the 19 health centres using the table of random *** obtained were analysed using Epi-Info s of tware version ***:The majority of clients were dissatisfied with most aspects of care given at the Health Care Centres including long waiting time,accessibility of immunisation services,poor respect for clients’ rights,especially to their dignity,health information and counseling on their medical ***:The study concludes that client satisfaction with immunization service in Calabar was low due to poor attitude of health care providers,long waiting time and lack of respect for clients’ rights.

关键词： Client satisfaction Immunisation services Primary health centres

Preparation and characterization of phosphate-modified mesoporous TiO2 incorporated in a silica matrix and their photocatalytic properties in the photodegradation of Congo red

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Frontiers of Materials Science 2017年第3期11卷 250-261页

作者： Alberto ESTRELLA GONZALEZ Maximiliano ASOMOZA Ulises ARELLANO Sandra CIPAGAUTA DiAZ Silvia solíS Department of Chemistry Metropolitan Autonomous University-lztapalapa P.O. Box 55-532 C.P. 09340 México City México

This study describes the development of mesostructured TiO2 photo- catalysts modified with PO4^3- to improve its specific surface area and reduce the recombination rate of the electron-hole pairs. The mesoporous photocatalyst was successfully incorporated into a high specific surface area silica matrix by the hydrolysis reaction of tetraethyl orthosilicate （TEOS）. Pluronic 123 and phosphoric acid were used as the directing agent for the structure of the mesoporous TiO2 and as a source of phosphorus, respectively, TiO2, P/TiO2, TiO2-SiO2 and P/TiO2-SiO2 materials were characterized by BET, XRD, TEM-EDS, FTIR and UV-vis DRS measurements. The photoactivity of TiO2-SiO2 nanocomposites containing 15 wt.% photocatalystJsilica was evaluated in the degradation reaction of anionic dyes with UV radiation. The proposed nanomaterials showed high potential for applications in the remediation of wastewater, being able to reuse in several cycles of reaction, maintaining its photoactivity and stability. The separation and recovery time of the material is reduced between cycles since no centrifugation or filtration processes are required after the photooxidation reaction.

关键词： photocatalysis phosphated TiO2 TiO2-SiO2 Congo red dye

G2/M inhibitors as pharmacotherapeutic opportunities for glioblastoma:the old,the new,and the future

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Cancer Biology & Medicine 2018年第4期15卷 354-374页

作者： Angel Mauricio Castro-Gamero Julia Alejandra Pezuk Maria sol Brassesco Luiz Gonzaga Tone Human Genetics Laboratory Institute of Natural SciencesFederal University of Alfenas(UNIFAL-MG)Alfenas 37130-001Brazil Biotechnology and Innovation in Health Program and Pharmacy Program Anhanguera University Sao Paulo(UNIANSP)Sao Paulo 05145-200Brazil Department of Biology Faculty of PhilosophySciences and Letters at Ribeirao PretoUniversity of Sao PauloRibeirao Preto 14040-901Brazil Department of Pediatrics Department of Genetics Ribeirao Preto School of MedicineUniversity of Sao PauloRibeirao Preto 14049-900Brazil

Glioblastoma(GBM) is one of the deadliest tumors and has a median survival of 3 months if left untreated. Despite advances in rationally targeted pharmacological approaches, the clinical care of GBM remains palliative in intent. Since the majority of altered signaling cascades involved in cancer establishment and progression eventually affect cell cycle progression, an alternative approach for cancer therapy is to develop innovative compounds that block the activity of crucial molecules needed by tumor cells to complete cell division. In this context, we review promising ongoing and future strategies for GBM therapeutics aimed towards G2/M inhibition such as anti-microtubule agents and targeted therapy against G2/M regulators like cyclin-dependent kinases,Aurora inhibitors, PLK1, BUB, 1, and BUBR1, and survivin. Moreover, we also include investigational agents in the preclinical and early clinical settings. Although several drugs were shown to be gliotoxic, most of them have not yet entered therapeutic trials. The use of either single exposure or a combination with novel compounds may lead to treatment alternatives for GBM patients in the near future.

关键词： Chemotherapy PLK1 AURK survivin BUB BUR1

Effect of soluble Components From Plant Aggregates on the Setting of the Lime-Based Binder

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Journal of Renewable Materials 2019年第9期7卷 903-913页

作者： Lepeng Wang Hélène Lenormand Hafida Zmamou Nathalie Leblanc UniLaSalle Transformations&Agro-Resources Research UnitVAM²IN(EA 7519 UniLaSalle-Universitéd’Artois)3 rue du Tronquet76130 Mont-Saint-AignanFrance

Plant aggregate-based building materials are a viable solution for reducing greenhouse gas emissions and providing good thermal and acoustic *** this study,the investigated lightweight mortars require a hydraulic *** and on-site empirical observations about plant aggregate-based materials indicate a delay in setting time and a decrease in the mechanical performances of concretes based on plant *** natural origin of plant-aggregates causes a lot of variability in their *** studies have shown that the incompatibility between plant aggregates and cement is mainly caused by the dissolved and decomposed components of plant aggregates in alkaline ***,no research on the specific impact of each component on the setting time of lime-based binder *** this work,the impact of some soluble compounds(e.g.,sucrose,glucose,fructose,pectin)on the setting reaction of the lime matrix was studied using Vicat test,thermogravimetric analysis(TGA)and FT-IR *** results showed that carbohydrates such as glucose and sucrose not only affect the setting time but also have a long-term impact on the carbonation of *** measure of the setting time by Vicat test appears as a possible indicator to predict the compatibility between the matrix and plant aggregates.

关键词： Plant aggregates setting time lime-based binder carbohydrates hydration

Innovation Analysis Approach to Design Parameters of High Speed Train Carriage and Their Intrinsic Complexity Relationships

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Chinese Journal of Mechanical Engineering 2017年第5期30卷 1091-1100页

作者： Shou-ne Xiao Ming-Meng Wang Guang-Zhong Hu Guang-Wu Yang State Key Laboratory of Traction Power Southwest Jiaotong University School of Mechanical Engineering Sichuan University of Science & Engineering

In view of the problem that it＇s difficult to accurately grasp the influence range and transmission path of the vehicle top design requirements on the underlying design parameters. Applying directed-weighted complex network to product parameter model is an important method that can clarify the relationships between product parameters and establish the top-down design of a product. The relationships of the product parameters of each node are calculated via a simple path searching algorithm, and the main design parameters are extracted by analysis and comparison. A uniform definition of the index formula for out-in degree can be provided based on the analysis of out- in-degree width and depth and control strength of train carriage body parameters. Vehicle gauge, axle load, crosswind and other parameters with higher values of the out-degree index are the most important boundary condi- tions; the most considerable performance indices are the parameters that have higher values of the out-in-degree index including torsional stiffness, maximum testing speed, service life of the vehicle, and so on; the main design parameters contain train carriage body weight, train weight per extended metre, train height and other parameters with higher values of the in-degree index. The network not only provides theoretical guidance for exploring the relationship of design parameters, but also further enriches the appli- cation of forward design method to high-speed trains.

关键词： Train carriage body parameters Complexnetwork Width influence Depth influence Parametercontrol strength

Natural stilbenes effects in animal models of Alzheimer’s disease

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neural Regeneration Research 2020年第5期15卷 843-849页

作者： Aline Freyssin Guylène Page Bernard Fauconneau Agnès Rioux Bilan University of Poitiers EA3808 NEUVACOD (Neurovascular Unit and Cognitive Disorders)P?le Biologie Santé

Alzheimer’s disease is one of the most frequent neurodegenerative *** pathology is characterized by protein aggregates,mainly constituted by amyloid peptide and tau,leading to neuronal death and cognitive *** currently proposed to treat this pathology do not prevent neurodegenerative processes and are mainly symptomatic ***,stilbenes presenting multiple pharmacological effects could be good potential therapeutic *** aim of this review is to gather the more significant papers among the broad literature on this topic,concerning the beneficial effects of stilbenes (resveratrol derivatives) in animal models of Alzheimer’s ***,numerous studies focus on cellular models,but an in vivo approach remains of primary importance since in animals (mice or rats,generally),bioavailability and metabolism are taken into account,which is not the case in in vitro ***,examination of memory ability is feasible in animal models,which strengthens the relevance of a compound with a view to future therapy in *** paper is addressed to any researcher who needs to study untested natural stilbenes or who wants to experiment the most effective natural stilbenes in largest animals or in *** review shows that resveratrol,the reference polyphenol,is largely studied and seems to have interesting properties on amyloid plaques,and cognitive ***,some resveratrol derivatives such as gnetin C,trans-piceid,or astringin have never been tested on ***,pterostilbene is of particular interest,by its improvement of cognitive disorders and its neuroprotective *** could be relevant to evaluate this molecule in clinical trials.

关键词： Alzheimer's disease amyloid animal models cognitive impairment inflammation natural stilbenes neuroprotection resveratrol tau

A hybrid method to select morphometric features using tensor completion and F-score rank for gifted children identification

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Science China(Technological Sciences) 2021年第9期64卷 1863-1871页

作者： ZHANG Jin FENG Fan HAN TianYi DUAN Feng SUN Zhe CAIAFA Cesar F. solÉ-CASALS Jordi College of Computer Science Nankai UniversityTianjin 300350China Department of Artificial Intelligence Nankai UniversityTianjin 300350China Computational Engineering Applications Unit Head Office for Information Systems and CybersecurityRIKEN351-0198 SaitamaJapan Instituto Argentino de Radioastronomía-CCT La Plata CONICET/CIC-PBA/UNLP1894 V.ElisaArgentina Department of Psychiatry University of CambridgeCambridge CB20SZUnited Kingdom Data and Signal Processing Group University of Vic-Central University of Catalonia08500 VicCataloniaSpain

Gifted children are able to learn in a more advanced way than others, probably due to neurophysiological differences in the communication efficiency in neural pathways. Topological features contribute to understanding the correlation between the brain structure and intelligence. Despite decades of neuroscience research using MRI, methods based on brain region connectivity patterns are limited by MRI artifacts, which therefore leads to revisiting MRI morphometric features, with the aim of using them to directly identify gifted children instead of using brain connectivity. However, the small, high-dimensional morphometric feature dataset with outliers makes the task of finding good classification models challenging. To this end, a hybrid method is proposed that combines tensor completion and feature selection methods to handle outliers and then select the discriminative features. The proposed method can achieve a classification accuracy of 93.1%, higher than other existing algorithms, which is thus suitable for the small MRI datasets with outliers in supervised classification scenarios.

关键词： gifted children identification morphometric features tensor completion feature selection

A Numerical Study Comparing the Effect on Residual Stresses of Two Different Types of Projectiles During Shot Peening

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Computers, Materials & Continua 2016年第3期51卷 203-215页

作者： J.solórzano-López F.A.García-Pastor Angélica Flores-Luna UNAM Facultad de QuímicaCiudad de MéxicoMéxico Cinvestav Unidad Saltillo CoahuilaMéxico TecNM Instituto Tecnológico de Tláhuac IIICiudad de MéxicoMéxico

Shot peening is a widely used technique to improve fatigue life in metallic *** processing technique introduces a subsurface compressive residual stress field through a plastic deformation of the surface caused by the impact of a large number of high-speed *** are a number of parameters that affect the residual stress field depth and *** effects of the impact angle,shot speed and shot geometry are currently being *** particular,substituting spherical cast shots by cylindrical cut wire shots is an attractive option,especially in terms of *** effect of shot geometry on residual stresses,however,needs to be further *** industrial-scale experimentation is costly and cumbersome,mathematical modeling offers a convenient alternative to carry out this type of *** present work shows a comparison between the residual stresses generated by the impact of spherical and cylindrical projectiles on a steel *** threedimensional model was developed using ABAQUS finite element commercial software(Release 6.12,Dassault Systémes,France).The results show that cylindrical shots generate residual stress fields t hat a re higher in magnitude than t hose generated by a spherical ***,the residual stress field of cylindrical shots impacting the surface at an oblique angle shows an important degree of *** effect is not found when spherical shots impact the surface at the same oblique angle.

关键词： Shot Peening Finite element method Residual Stresses

Mechanisms of retinal neuroprotection of calcium dobesilate：therapeutic implications

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neural Regeneration Research 2017年第10期12卷 1620-1622页

作者： Olga Simó-Servat Cristina solà-Adell Patricia Bogdanov Cristina Hernández Rafael Simó Diabetes and Metabolism Research Unit Vall d'Hebron Research InstituteCIBERDEM(Instituto de Salud CarlosⅢ)BarcelonaSpain

Current treatments for diabetic retinopathy （DR） are based on laser photocoagulation and intravitreal injections of corti- costeroids or anti-vascular endothelial growth factor （VEGF） agents. These treatments are applicable only at advanced stages of the disease. In addition, they are expensive, require a vitreo- retinal specialist and are associated with significant adverse ef- fects. Therefore, new pharmacological treatments for the early stages of the disease are needed.

关键词： Ca Mechanisms of retinal neuroprotection of calcium dobesilate:therapeutic implications