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Anti-adipogenic effects of extracts of Ficus deitoidea var. deltoidea and var. angustifolia on 3T3-L1 adipocytes

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2014年第3期15卷 295-302页

作者： Shiau Mei WOON Yew Wei SENG Anna Pick Kiong LING soi moi chye Rhun Yian KOH School of Pharmacy International Medical University Bukit Jalil 57000 Kuala Lumpur Malaysia Department of Human Biology International Medical University Bukit Jalil 57000 Kuala Lumpur Malaysia

Objective： This study examined the anti-adipogenic effects of extracts of Ficus deltoidea var. deltoidia and var. angustifolia, a natural slimming aid, on 3T3-L1 adipocytes. Methods： Methanol and water extracts of leaves of the F. deltoidea varieties were analyzed to determine their total flavonoid content （TFC） and total phenolic content （TPC）, respectively. The study was initiated by determining the maximum non-toxic dose （MNTD） of the methanol and water extracts for 3T3-L1 preadipocytes. Possible anti-adipogenic effects were then examined by treating 2-d post confluent 3T3-L1 preadipocytes with either methanol extract or water extract at MNTD and half MNTD （1/2MNTD）, after which the preadipocytces were induced to form mature adipocytes. Visualisation and quantification of lipid content in mature adipocytes were carried out through oil red O staining and measurement of optical density （OD） at 520 nm, respec- tively. Results： The TFCs of the methanol extracts were 1.36 and 1.97 g quercetin equivalents （QE）/100 g dry weight （DW）, while the TPCs of the water extracts were 5.61 and 2.73 g gallic acid equivalents （GAE）/100 g DW for var. deltoidea and var. angustilofia, respectively. The MNTDs determined for methanol and water extracts were （300.0±28.3） and （225.0±21.2） μg/ml, respectively, for var. deltoidea, while much lower MNTDs [（60.0±2.0） IJg/ml for methanol extracts and （8.0＋1.0） μg/ml for water extracts] were recorded for var. angustifolia. Studies revealed that the methanol extracts of both varieties and the water extracts of var. angustifolia at either MNTD or 1/2MNTD significantly inhibited the maturation of preadipocytes. Conclusions： The inhibition of the formation of mature adipocytes indicated that leaf extracts of F. deltoidea could have potential anti-obesity effects.

关键词： Ad Dogenesis Ficus deltoidea Flavonoids Natural products Obesity

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Pteropine Orthoreovirus(PRV7S)does not Establish Persistent Infection in NP460 Cells but with Inflammatory Response Triggered

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生物医学与环境科学:英文版 2023年第9期36卷 886-891页

作者： LOH Mun Khin Alson SIEW Zhen Yun LEONG Pooi Pooi KOH Rhun Yian chye soi moi WONG Siew Tung VOON Kenny School of Postgraduate Studies International Medical University57000 Kuala LumpurMalaysia School of Pharmacy University of Nottingham Malaysia43500 SemenyihMalaysia Faculty of Medicine and Health Sciences Universiti of Tunku Abdul Rahman43000 KajangMalaysia School of Health Sciences International Medical University57000 Kuala Lumpur Malaysia School of MedicineInternational Medical University57000 Kuala LumpurMalaysia

Pteropine orthoreovirus(PRV)is a nonenveloped double-stranded RNA(dsRNA)virus of the genus Orthoreovirus under the family *** PRV genome is composed of 10 dsRNA segments,including three large(L)segments,three medium(M... 详细信息

关键词： PRV pine reovirus

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