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Phase-pure Na3V2(PO4)2F3 embedded in carbon matrix through a facile polyol synthesis as a potential cathode for high performance sodium-ion batteries

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Nano Research 2019年第4期12卷 911-917页

作者： sohyun Park Jinju Song Seyeon kim Balaji Sambandam Vinod Mathew Sungjin kim Jeonggeun Jo Seokhun kim Jaekook kim Department of Materials Science and Engineering Chonnam National University 300 Ybngbong-dong Buk-gu Gwangju 500-757 Republic of Korea Gwangju Bio/Energy R&D Center Korea Institute of Energy Research (KIER) 270-25 Samso-ro Buk-gu Gwangju 61003 Republic of Korea

In this study,a pseudo-layered Na super-ionic conductor of Na3V2(PO4)2F3 (NVPF)/C cathode for sodium-ion batteries is prepared successfully using a facile polyol refluxing process without any impurity *** X-ray diffraction and Rietveld refinement results confirm that NVPF possesses tetragonal NASICON-type lattice with a space group of P42/*** this preparative method,polyol is utilized as a solvent as well as a carbon *** presence of nanosized NVPF particles in the carbon network is confirmed by field-emission scanning electron microscopy (FE-SEM) and high-resolution transmission electron microscopy (HR-TEM).The existence of carbon is analyzed by Raman scattering and elemental *** applied as a Na-storage material in a potential window of 2.0-4.3 V,the electrode exhibits two flat voltage plateaus at 3.7 and 4.2 V with an electrochemically active V^3+/V^4+ redox *** addition,Na3V2(PO4)2F3/C composite achieved a retention capacity of ~ 88% even after 1,500 cycles at 15 ***,at high current densities of 30 and 50 C,Na3V2(PO4)2F3/C cathode retains the specific discharge capacities of 108.4 and 105.9 mAh·g-1,respectively,revealing the structural stability of the material prepared through a facile polyol refluxing method.

关键词： fluorophosphate Na3V2(PO4)2F3 polyol process sodium ion batteries long life stability

Identification of differentially expressed miRNAs associated with chronic kidney disease-mineral bone disorder

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Frontiers of Medicine 2017年第3期11卷 378-385页

作者： Kyung Im kim sohyun Jeong Nayoung Han Jung Mi Oh Kook-Hwan Oh In-Wha kim College of Pharmacy Korea University Sejong 30019 Republic of Korea College of Pharmacy and Research Institute of Pharmaceutical Sciences -Seoul National University Seoui 08826 Republic of Korea Divisionof-Nephrology Department of Internai Medicine Seoul National University Hospital Seoul 03080 Republic of Korea

The purpose of this study is to characterize a meta-signature of differentially expressed mRNA in chronic kidney disease （CKD） to predict putative microRNA （miRNA） in CKD-mineral bone disorder （CKD- MBD） and confirm the changes in these genes and miRNA expression under uremic conditions by using a cell culture system. PubMed searches using MeSH terms and keywords related to CKD, uremia, and mRNA arrays were conducted. Through a computational analysis, a meta-signature that characterizes the significant intersection of differentially expressed mRNA and expected miRNAs associated with CKD-MBD was determined. Additionally, changes in gene and miRNA expressions under uremic conditions were confirmed with human Saos-2 osteoblast-like cells. A statistically significant mRNA meta-signature of upregulated and downregulated mRNA levels was identified. Furthermore, miRNA expression profiles were inferred, and computational anaIyses were performed with the imputed mieroRNA regulation based on weighted ranked expression and putative microRNA targets （IMRE） method to identify miRNAs associated with CKD occurrence. TLR4 and miR-146b levels were significantly associated with CKD-MBD. TLR4 levels were significantly downregulated, whereas pri- miR-146b and miR-146b were upregulated in the presence of uremic toxins in human Saos-2 osteoblast-like cells. Differentially expressed miRNAs associated with CKD-MBD were identified through a computational analysis, and changes in gene and miRNA expressions were confirmed with an in vitro cell culture system.

关键词： chronic kidney disease microRNA mineral bone disorder uremia

Dramatic Response to Cabozantinib in a Patient with Refractory Hepatocellular Carcinoma with c-MET Amplification

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Journal of Clinical and Translational Hepatology 2023年第3期11卷 747-750页

作者： Yun Beom Sang Gwangil kim sohyun Hwang Haeyoun Kang Hong Jae Chon Department of Medical Oncology CHA Bundang Medical CenterCHA University School of MedicineSeongnam-siGyeonggi-doKorea Department of Pathology CHA Bundang Medical CenterCHA University School of MedicineSeongnam-siGyeo-nggi-doKorea CHA Future Medicine Research Institute CHA Bundang Medical CenterSeongnam-siGyeonggi-doKorea

We report a case of a patient with c-MET amplified hepato-cellular carcinoma (HCC) who had a dramatic response to cabozantinib despite being refractory to four previous lines of systemic therapy. The patient had previously received re-gorafenib plus nivolumab as first-line treatment, lenvatinib as second-line, sorafenib as third-line, and ipilimumab plus nivolumab as fourth-line treatment in sequence. However, all regimens showed early progression within 2 months. The pa-tient’s HCC was well-controlled, with a partial response (PR) of over 9 months after beginning cabozantinib treatment. Although there were mild adverse events such as diarrhea and elevated liver enzymes, they were tolerable. Next-gen-eration sequencing (NGS) of the patient’s previous surgical specimen indicated amplification of c-MET genes. Although it is well known that cabozantinib has excellent effectiveness for inhibiting c-MET at the preclinical level, to the best of our knowledge this is the first case of dramatic response to cabozantinib in a patient with advanced HCC with c-MET am-plification.

关键词： Hepatocellular carcinoma c-MET amplification Cabozantinib Dra-matic response Next-generation sequencing

WheatNet： a Genome-Scale Functional Network for Hexaploid Bread Wheat, Triticum aestivum

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Molecular Plant 2017年第8期10卷 1133-1136页

作者： Tak Lee sohyun Hwang Chan Yeong kim Hongseok Shim Hyojin kim Pamela C. Ronald EdwardM. Marcotte Insuk Lee Department of Biotechnology College of Life Science and Biotechnology Yonsei University Seou1120-749 Korea Center for Systems and Synthetic Biology Institute for Cellular and Molecular Biology University of Texas at Austin Austin TX 78712 USA Department of Biomedical Science College of Life Science CHA University Seongnam-si 13496 Korea Department of Plant Pathology University of California Davis CA 95616 USA Joint Bioenergy Institute Emeryville CA 94608 USA The Genome Center University of California Davis CA 95616 USA Department of Molecular Bioseiences University of Texas at Austin Austin TX 78712 USA

Dear Editor Gene networks provide a system-level overview of genetic organizations and enable the dissection of functional modules underlying complex traits. Integration of diverse genomics data based on the Bayesian statistics framework has been successfully applied to the construction of genome-scale functional networks for major crop species such as rice （Lee et al., 2011）, soybean （kim et al., 2017）, and tomato （kim et al.,

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TomatoNet A Genome-wide Co-functional Network for Unveiling Complex Traits of Tomato, a Model Crop for Fleshy Fruits

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Molecular Plant 2017年第4期10卷 652-655页

作者： Hyojin kim Bong Suk kim Jung Eun Shim sohyun Hwang Sunmo Yang Eiru kim Aniafi S. Iver-Pascuzzi2 Insuk Lee Department of Biotechnology College of Life Science and Biotechnology Yonsei University Seou1120-749 Korea Department of Botany and Plant Pathology Purdue University West Lafayette IN 47907 USA

Tomato （Solanum lycopersicum） is the second most important vegetable crop globally, with a total world production valued at over $74 billion （FAOSTAT Statistics Database, 2009）. Tomato is also an important model c... 详细信息

关键词： Genome-wide Co-functional Network Unveiling Complex Traits Tomato

Microwave Synthesis of Silver Nanoparticles Using Different Pentose Carbohydrates as Reducing Agents

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Journal of Chemistry and Chemical Engineering 2018年第1期12卷 1-10页

作者： David S. Chung Hanna kim Jonathan Ko Justine Lee Bryant Hwang sohyun Chang ByungJun kim Sung-Jae Chung Division of Biology and Medicine Brown University Providence R102912 USA Granada Hill Charter High School Granada Hills CA 91344 USA Thomas Jefferson High School for Science and Technology Alexandria VA 22312 USA Langley High School Mclean VA 2210 USA Department of Biology School of Arts & Sciences Johns Hopkins University Baltimore MD 21218 USA Biological Sciences Carnegie Mellon University Pittsburgh PA 15213 USA Marymount University School of Arts and Sciences 2807 N. Glebe Road Arlington VA 22302 USA

A fast, green and readily reproducible microwave-based method for the production of high quality silver nanoparticles （AgNPs） in high yield is presented. Starch is used as a stabilizing agent with few pentose different reducing carbohydrates as D-ribose, D-arabinose and L-arabinose. From the UV-vis peak profile spectra of the solutions of the silver nanoparticles, the authors have investigated the size of the NPs together with the average diameter, shape, and aggregation state of the colloidal AgNPs. TEM measurements and EDX analysis have confirmed the morphology of our AgNPs.

关键词： Microwave synthesis UV-vis spectroscopy Mie theory silver nanoparticles TEM and EDX.

Protein interaction network related to Helicobacter pylori infection response

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World Journal of Gastroenterology 2009年第36期15卷 4518-4528页

作者： Kyu Kwang kim Han Bok kim Daeil Foreign Language High School Seoul 136-100South Korea Department of Biotechnology The Research Institute for Basic SciencesHoseo UniversityAsan 336-795 South Korea

AIM:To understand the complex reaction of gastric inflammation induced by Helicobacter pylori(H pylori) in a systematic manner using a protein interaction network. METHODS:The expression of genes significantly changed on microarray during H pylori infection was scanned from the web literary database and translated into proteins.A network of protein interactions was constructed by searching the primary interactions of selected *** constructed network was mathematically analyzed and its biological function was *** addition,the nodes on the network were checked to determine if they had any further functional importance or relation to other proteins by extending them. RESULTS:The scale-free network showing the relationship between inflammation and carcinogenesis was *** analysis showed hub and bottleneck proteins,and these proteins were mostly related to immune *** network contained pathways and proteins related to H pylori infection,such as the JAK-STAT pathway triggered by *** of nuclear factor (NF)-κB,TLR4,and other proteins known to function as core proteins of immune response were also found. These immune-related proteins interacted on the network with pathways and proteins related to the cell cycle,cell maintenance and proliferation,andtranscription regulators such as BRCA1,FOS,REL,and zinc finger *** extension of nodes showed interactions of the immune proteins with cancer- related *** extended network,the core network,a summarized form of the extended network, and cell pathway model were constructed. CONCLUSION:Immune-related proteins activated by H pylori infection interact with proto-oncogene *** hub and bottleneck proteins are potential drug targets for gastric inflammation and cancer.

关键词： Gastric cancer Helicobacter pylori Inflammation Pathway Protein interaction network

Influence of Red Pepper (<i>Capsicum annuum</i>) Addition on Bioenergy Production in Microbial Fuel Cells

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Journal of Sustainable Bioenergy Systems 2019年第4期9卷 179-188页

作者： sohyun Chang Min Jae Shin Yujin kim Sung Jun Jang Seog In Moon Seoyeon Jeong Richard Shim Fengjun Shen Sara Kang Paul S. Chung School of Arts & Sciences Johns Hopkins University Baltimore MD USA Fuzbien Technology Institute Rockville MD USA Youth with Talents Fairfax VA USA

The current study was performed to evaluate the beneficial effect in the power output of microbial fuel cells (MFCs) through supplementation of dried red pepper (Capsicum annuum) powder into the anodic chamber. Mediator-less H-type MFCs were set up where the anode chamber contained rumen microorganisms as inocula on cellulose (Avicel) and the cathode chamber of phosphate buffered saline (pH 7.4), both separated by cation exchange membrane. Electrical power generation in MFC was monitored daily over a 10-day period and the accumulated amounts and components of gaseous byproducts were measured at the end of 10 d operation of MFC. For both groups of MFCs with red pepper and the control, the head space gases collected were methane and CO2, and its volume and composition were similar between treatments. Methane and CO2 produced for 10 d operation were 210.7 and 106.5 mL, respectively, in MFC. The addition of red pepper powder caused an average power density to increase from 24.0 mW/m2 to 39.6 mW/m2 (P 2 for control and bellflower, respectively. This study provides the strong evidence that red pepper (Capsicum annuum) supplementation might modify the anaerobic fermentation characteristics of rumen microorganisms in anode chamber and improve the cellulosic bioenergy production in MFC.

关键词： MFC Capsicum annuum Bioenergy Production

Patterns of Pediatric Malaria Incidence and Outcomes in Kasungu, Malawi in 2016

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Advances in Infectious Diseases 2019年第4期9卷 277-284页

作者： Byungchan kim sohyun Chang Min Jae Shin Prescott Hong George Lee Min Jung Koh Immanuel H. Anaborne Donghoon Lee Paul S. Chung George Talama Thomas Nyirenda Department of Radiology Washington University St. Louis MO USA Department of Art & Science Biology Johns Hopkins University Baltimore MD USA Youth with Talents Fairfax VA USA Kasungu District Hospital Kasungu District Malawi Clinical Research Education and Management Service Lilongwe Malawi

Malawi is resource poor country in Africa with one of the highest infant and child mortality rates in the world. Malaria is one of the major causes of morbidity and mortality among children in Malawi. Studies have shown barriers to care of sick children and the formal health sector has shown sub-optimal patient assessments and overreliance on antibiotic treatment of a child with fever. In 2017, a team of students from Korea and USA audited clinic registers of six health centres under the hospital’s administration of Kasungu District in Malawi for the year of 2016. The clinics were included in the study were those that contributed to the largest number of patients in the district annually. The aim of the audit was to examine treatment outcomes of all children presenting with fever and on whom a definitive diagnosis or presumptive diagnosis of malaria was made at the 6 chosen clinics in Kasungu for improvement of health information system for the district health office. The number of children with malaria ranged between 80 and 440 per month, with the peak occurring between the rainy months of February to May. Peak mortality rate occurred in September and November at 21%. Patients presented with multiple symptoms of fever, convulsion, pallor, vomiting, cough, diarrhea, abdominal pain and headache. Average mortality rate differed between traditional authorities, ranging from 4% to 15%. Off-season high mortality finding promotes more studies looking into socioeconomic and hospital support. Multiple symptoms among patients treated for malaria is a common finding emphasizing the need to integrate household practices for malaria prevention, good malaria case management and linkage with community care of childhood illness (CCM) programs at the clinics in the district.

关键词： Case Management Childhood Fever Kasungu Malawi Mortality Pediatric Malaria