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Does granulocyte-colony stimulating factor administration induce damage or repair response in schistosomiasis?

World Journal of Hepatology 2010年第12期2卷 434-441页

作者： Lobna Y Ghanem Uta Dahmen Olaf Dirsch Mona MF Nosseir soheir s mahmoud.wafaa af mansour Department of Electron Microscope Theodor Bilharz Research Institute Department of General Visceral and Transplantation SurgeryUniversity Hospital Essen Division of Pathology German Heart Institute Department of Pathology Theodor Bilharz Research Institute Department of Parasitology Theodor Bilharz Research Institute Department of Immunology Theodor Bilharz Research Institute

AIM:To introduce Granulocyte-colony stimulating factor (G-CsF) as a new therapeutic modality for schistosomiasis through stem cell mobilization,immunomodulation or fibrosis remodeling. METHODs:In this study,a 5 d course of human recombinant G-CsF (100 μg/kg sc) was applied to schis-tosoma mansoni-infected mice at different stages of disease (5 d before infection as well as 3,5 and 7 wk post-infection). The animals were sacrificed at 10 d as well as 4,6 and 8 wk post infection. Mice were examined for:(1) Total leukocyte count which is an accepted surrogate marker for the stem cell mobilization into the circulation; (2) Egg count in intestine and liver tissue to assess the parasitic load; and (3) Histopathological changes in Hx/E and Masson trichrome stained sections as well as collagen content in sirius redstained liver sections to determine the severity of liver fibrosis. REsULTs:Mice developed leukocytosis. The egg load and the number of granulomas were not affected by the G-CsF treatment but there was an obvious change in the composition of granulomas towards an increased cellularity. Moreover,fibrosis was significantly decreased in treated groups compared to untreated animals (collagen content either preinfection or at 3 and 5 wk post infection:5.8 ± 0.5,4.7 ± 0.5,4.0 ± 0.7 vs 8.2 ± 0.9; P ≤ 0.01). CONCLUsION:Although G-CsF did not cause direct elimination of the parasite,it enhanced granulomatous reaction and reduced the fibrosis. Further investigation of the underlying mechanisms of these two actions is warranted.

关键词： schistosomiasis Granulocyte-colony stimulating factor Periovular granuloma Fibrosis Immunomodulation stem cell mobilization

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Atrial fibrillation in older adults with cancer

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Journal of Geriatric Cardiology 2022年第1期19卷 1-8页

作者： Manish Kumar Nerea Lopetegui-Lia Christina Al Malouf mansour Almnajam Patrick P.Coll Agnes s.Kim Department of Medicine Pat and Jim Calhoun Cardiology CenterUniversity of Connecticut School of MedicineFarmingtonCT 06030USA Department of Hematology and Oncology Cleveland ClinicOhio 44195USA De-partment of Cardiology Mount Sinai Hospital/Icahn School of MedicineNew York 10029USA Department of Fam-ily Medicine UConn Center of AgingUniversity of ConnecticutSchool of MedicineFarmingtonCT 06030USA

Cancer and atrial fibrillation(af)are common co-morbid conditions in older *** cancer and cancer treatment increase the risk of developing new af which increases morbidity and *** rate and rhythm control along with anticoagulation therapy remain the mainstay of treatment of af in older adults with both cancer and *** to the treatment may be necessary because of drug interactions with concurrent *** and old age increase the risk of both,thromboembolism and *** risk of these complications is further enhanced by concomitant cancer therapy,frailty,poor nutrition status and,coexisting geriatric ***,careful attention needs to be given to the risks and benefits of using anticoagulant *** review focuses on the management of af in older patients with cancer,including at the end-of-life care.

关键词： fibrillation Cancer chemotherapy

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Racial Differences Effects on Oral Health and Periodontal Diseases Extent, staging and Grading among the Multi-Ethnic Expatriates in Aseer Region, saudi Arabia

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International Journal of Clinical Medicine 2021年第4期12卷 145-164页

作者： Mohammed M. A. Abdullah Al-Abdaly sultan mansour A. Alqahtani shaker saleh M. Alosman Ghadah Ali saad Alqahtani Periodontics and Community Dental sciences Department College of Dentistry King Khalid University Abha Saudi Arabia College of Dentistry King Khalid University Abha Saudi Arabia

Background: Given the increase in the numbers of expatriates in saudi Arabia and the shortage of information about expatriates’ oral health and periodontal disease severity and progression. Objectives: This study aim... 详细信息

strong>Background: strong>Given the increase in the numbers of expatriates in saudi Arabia and the shortage of information about expatriates’ oral health and periodontal disease severity and progression. strong>Objectives: strong>This study aimed to evaluate the effects of the racial differences on oral health and periodontal disease extent, staging, and grading among the multi-ethnic expatriates in the Aseer region, saudi Arabia. strong>Materials and Methods:strong> This cross-sectional study was carried out on 300 expatriates in Aseer region, saudi Arabia. They were divided into three equal racial different groups (n = 100), Arabs (AR), Asians (As), and africans (af). The interviews of all participants were completed then the clinical examinations of periodontal diseases extent, staging, and grading parameters were performed. statistical analysis was done by ANOVA test, Tukey’s test, and Chi-square test. The statistical significance level was determined at p strong>Results: strong>There were statistically significant differences in the comparison between the three ethnic/racial groups in clinical parameters except in GBI, PCR, FI, TFO, and BC, where there were no statistically significant differences in the comparison between the three ethnic/racial groups. There were differences associated with age, gender, smoking, and diabetes, without statistically significant differences among the three racial groups.strong> Conclusion:strong> We concluded that most participants in this study had a generalized severe grade 4 plaque-induced gingivitis and localized periodontitis stage III grade B.

关键词： Multi-Ethnics Oral Health Periodontal Diseases Extent staging and Grading

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