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New insights on the role of chondroitin sulfate proteoglycans in neural stem cell–mediated repair in spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1699-1700页

作者： Seyed Mojtaba Hosseini soheila Karimi-Abdolrezaee Department of Physiology and Pathophysiology Spinal Cord Research CentreRady Faculty of Health SciencesUniversity of ManitobaWinnipegMBCanada Manitoba Multiple Sclerosis Research Center WinnipegMBCanada Children Hospital Research Institute of Manitoba WinnipegMBCanada

Extensive neurodegeneration is a hallmark of traumatic spinal cord injury (SCI) that underlies permanent sensorimotor and autonomic impairments (Alizadeh et al.,2019).Following the primary impact,the spinal cord undergoes a cascade of secondary injury mechanisms that are driven by disruption of the blood-spinal cord ba rrier,vascula r inju ry,glial reactivity,neu roinfla mmation,oxidative stress,lipid peroxidation,and glutamate excitotoxicity that culminate in neuronal and oligodendroglial cell death,demyelination,and axonal damage(Alizadeh et al.,2019).To achieve a meaningful functional recovery after SCI,regeneration of new neurons and oligodendrocytes and their successful growth and integration within the neural network are critical steps for reconstructing the damaged spinal cord tissue (Fischer et al.,2020).

关键词： peroxidation Fischer injury

ORGANOSOLUBLE AND THERMALLY STABLE POLYIMIDES DERIVED FROM A NEW DIAMINE CONTAINING BULKY-FLEXIBLE TRIARYL PYRIDINE PENDENT GROUP

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Chinese Journal of Polymer Science 2011年第4期29卷 465-474页

作者： Mousa Ghaemy soheila Khajeh Faculty of Chemistry University of MazandaranBabolsarIran

A novel kind of aromatic diamine, N-（4-（4-（2,6-diphenyl pyridine-4-yl） phenoxy） phenyl）-3,5-diaminobezamide （DPDAB）, was synthesized via aromatic nucleophilic substitution of 3,5-dinitrobenzoylchloride with 4-（4-（2,6- diphenylpyridine-4-yl）phenoxy）aniline （DPPA）, followed by palladium-catalyzed hydrazine reduction. This monomer was used to prepare polyimides （PIs） based on reaction with several commerically avaiable tetracarboxylic dianhydrides such as pyromellatic dianhydride （PMDA）, benzophenone tetracarboxylic acide dianhydride （BTDA） and bicycle [2.2.2] oct-7-ene- 2, 3,5,6-tetracarboxylic dianhydride （BCDA）. These PIs had inherent viscosity in the range of 0.34-0.76 dL/g and showed good solubility in various aprotic polar solvents. The glass-transition tempratures （Tgs） of the PIs were in the range of 184-302℃, and showed high thermal stability with 10% weight loss in the temperature range of 360-500℃ under nitrogen atmosphere.

关键词： Polyimides Inherent viscosity Solubility Thermal stability DSC.

Metal-organic framework-based materials as key components in electrocatalytic oxidation and reduction reactions

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Journal of Energy Chemistry 2023年第12期87卷 540-567,I0014页

作者： soheila Sanati Ali Morsali Hermenegildo García Department of Chemistry Faculty of Basic SciencesTarbiat Modares UniversityTehran 14115175Iran Instituto Universitario de Tecnología Química Universidad Politecnica de ValenciaConsejo Superior de Investigaciones CientíficaSUniversitat Politècnica de ValènciaValència 46022Spain

Studies have extensively addressed the development of electrocatalytic technologies for energy storage and conversion,fuel production,and environmental *** processes such as different oxidation and reduction reactions play a vital and significant role in these *** this regard,efficient,inexpensive,and stable electrocatalysts capable can significantly promote electrochemical *** features of metal–organic frameworks(MOFs)such as their high porosity,tunable structure,size,and pore shape,high surface area,and redox properties have introduced them as an ideal electrocatalyst *** review is thus aimed at elucidating the role of MOF-based materials(pristine,derivatives and composites)as efficient electrocatalysts in energy and sensing-related oxidation and reduction reactions such as oxygen reduction reaction(ORR),hydrogen oxidation reaction(HOR),carbon dioxide reduction reaction(CO_(2)RR),urea oxidation reaction(UOR),alcohol oxidation reaction(AOR),nitrogen reduction reaction(NRR),and glucose oxidation reaction(GOR)in advanced energy and sensing ***,the structure–property relationship of the electrocatalyst was elaborated for each electrocatalytic ***,perspectives on the potential research topics for practical use of MOF-based electrocatalysts are *** present review can improve the interest in MOF-based electrocatalysts to study different oxidation and reduction reactions in energy and sensing systems.

关键词： Metal-organic frameworks Electrocatalyst Oxidation reaction Reduction reaction

SYNTHESIS AND CHARACTERIZATION OF POLYAMIDES DERIVED FROM(4-(4-(2,6-DIPHENYLPYRIDIN-4YL)PHENOXY)PHENYL)-3,5-DIAMINOBEZAMIDE

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Chinese Journal of Polymer Science 2012年第1期30卷 82-92页

作者： Mousa Ghaemy soheila Khajeh Faculty of Chemistry University of Mazandaran BabolsarIran

New types of polyamides containing pendent triaryl pyridine groups were successfully synthesized by direct polycondensation of a symmetry diamine,（4-（4-（2,6-diphenylpyridin-4yl）phenoxy）phenyl）-3,5-diaminobezamide（DPDAB）, and various aromatic and aliphatic dicarboxylic diacids in NMP using triphenyl phosphate（TPP） and pyridine as catalyst. The diamine and all the prepared polyamides were fully characterized by using FT-IR,~1H-NMR,UV-Vis spectroscopy, fluorimetry and elemental *** inherent viscosity of polyamides ranged from 0.45 dL/g to 0.68 dL/*** the polymers exhibited solubility in common polar aprotic solvents such as NMP,DMAc,DMF,DMSO,pyridine,HMPA,and even in less polar solvents such as THF and m-cresol at room *** properties of polyamides were evaluated by means of DSC,DMTA and *** polymers showed glass transition temperatures（T_g） in the range of 138-210℃. Their initial decomposition temperature（T_i） varied from 265℃to 310℃under N_*** dilute solution（0.2 g/dL） of polyamides in DMF exhibited fluorescence emission withλ_（max） in the range of 470-550 nm.

关键词： Polyamides Synthesis Direct polycondensation Solubility Thermal stability

Neuregulin-1:a novel regulator of glial response in spinal cord injury

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Neural Regeneration Research 2017年第10期12卷 1616-1617页

作者： Hardeep Kataria soheila Karimi-Abdolrezaee Regenerative Medicine Program Department of Physiology and PathophysiologySpinal Cord Research CentreRady Faculty of Health SciencesUniversity of ManitobaWinnipegManitobaCanada

Spinal cord injury （SCI） results in a dysregulated microenvi- ronment that is largely driven by the immediate and robust response of resident astrocytes and microglia （Filous and Silver, 2016）.

关键词： Neuregulin-1:a novel regulator of glial response in spinal cord injury SCI

Evaluating innovation ecosystem resiliency using agent-based modeling and systems dynamics

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Journal of Safety Science and Resilience 2024年第2期5卷 204-221页

作者： soheila Abdi Mehdi Yazdani Esmaeil Najafi Department of Industrial Engineering Science and Research BranchIslamic Azad UniversityTehranIran Department of Industrial Engineering Qazvin BranchIslamic Azad UniversityQazvinIran

Evaluating the resilience of the innovation ecosystem to maintain its performance,in the sense of resistance to disruption and recovery after it,has recently received more *** studies have been conducted to model different ecosystems and evaluate their ***,modeling the innovation ecosystem from a holistic perspective and performing a quantitative assessment of its resilience have received less *** paper models the innovation ecosystem holistically and evaluates its resilience index using a quantitative approach through five main *** the first step,a case study related to the innovation ecosystem of Iran's Ministry of Energy,called the Power Innovation Ecosystem,is modeled by combining system dynamics and agent-based *** validating the model in the second step,the disruption of the loss of experts is investigated in the third step,and all possible actions to recover each actor are *** the fourth step,the performance of the ecosystem is simulated before and after the disruption using the data gathered in the previous ***,resilience is calculated in two different ways in the fifth *** improvement solutions are also suggested when considering that the resilience index of the innovation ecosystem is at a medium *** research may assist policymakers in observing the resilience level of the innovation ecosystem based on the proposed *** applying strategic changes to this model,they can determine the effects of their policies and make the most appropriate decisions to increase the resilience of the innovation ecosystem.

关键词： Resilience index innovation ecosystem System dynamics Agent-based modeling

Structural performance assessment of GFRP elastic gridshells by machine learning interpretability methods

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Frontiers of Structural and Civil Engineering 2022年第10期16卷 1249-1266页

作者： soheila KOOKALANI Bin CHENG Jose Luis Chavez TORRES Department of Civil Engineering Shanghai Jiao Tong UniversityShanghai 200240China Department of Civil Engineering Technical University of LojaLoja 110102Ecuador

The prediction of structural performance plays a significant role in damage assessment of glass fiber reinforcement polymer(GFRP)elastic gridshell *** learning(ML)approaches are implemented in this study,to predict maximum stress and displacement of GFRP elastic gridshell *** ML algorithms,including linear regression(LR),ridge regression(RR),support vector regression(SVR),K-nearest neighbors(KNN),decision tree(DT),random forest(RF),adaptive boosting(AdaBoost),extreme gradient boosting(XGBoost),category boosting(CatBoost),and light gradient boosting machine(LightGBM),are implemented in this *** features of structural performance considered in this study are the maximum stress as f1(x)and the maximum displacement to self-weight ratio as f2(x).A comparative study is conducted and the Catboost model presents the highest prediction ***,interpretable ML approaches,including shapely additive explanations(SHAP),partial dependence plot(PDP),and accumulated local effects(ALE),are applied to explain the *** is employed to describe the importance of each variable to structural performance both locally and *** results of sensitivity analysis(SA),feature importance of the CatBoost model and SHAP approach indicate the same parameters as the most significant variables for f1(x)and f2(x).

关键词： machine learning gridshell structure regression sensitivity analysis interpretability methods

Emerging role of neuregulin-1beta1 in pathogenesis and progression of multiple sclerosis

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Neural Regeneration Research 2023年第1期18卷 133-134页

作者： Seyyed Mohyeddin Ziaee soheila Karimi-Abdolrezaee Department of Physiology and Pathophysiology Spinal Cord Research CenterRady Faculty of Health SciencesUniversity of ManitobaChildren Hospital Research Institute of ManitobaWinnipegMBCanada

Multiple sclerosis(MS)is a chronic immune-mediated disorder of the central nervous system(CNS)that causes focal demyelinating lesions,followed by axonal and neuronal *** genetic and environmental factors are found to be associated with MS *** MS etiology seems to be multifactorial and needs further elucidation,it is understood that the response of an immune system to specific myelin antigens triggers the onset of MS(Dendrou et al.,2015).However,how the autoimmune response initiates against myelin,and the cellular and molecular mechanisms underpinning the development and progression of MS are not fully ***,deconstructing MS pathogenesis is of paramount importance for identifying novel diagnostic and therapeutic targets for this complex disease.

关键词： pathogenesis sclerosis degeneration

Temperature effect on performance of nanoparticle/surfactant flooding in enhanced heavy oil recovery

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Petroleum Science 2019年第6期16卷 1387-1402页

作者： Sajjad Mahmoudi Arezou Jafari soheila Javadian Department of Petroleum Engineering Faculty of Chemical EngineeringTarbiat Modares UniversityTehranIran Department of Physical Chemistry Faculty of Basic ScienceTarbiat Modares UniversityP.O.Box 14115-175TehranIran

Recently,nanoparticles have been used along with surfactants for enhancing oil *** the recent studies show that oil recovery is enhanced using nanoparticle/surfactant solutions,some effective parameters and mechanisms involved in the oil recovery have not yet been ***,the temperature effect on the stability of nanoparticle/surfactant solutions and ultimate oil recovery has been studied in this work,and the optimal concentrations of both SiO2 nanoparticle and surfactant(sodium dodecyl sulfate)have been determined by the Central Composite Design *** addition,the simultaneous effects of parameters and their interactions have been *** of the stability of the injected solutions indicates that the nanoparticle concentration is the most important factor affecting the solution *** surfactant makes the solution more stable if used in appropriate concentrations below the *** to the micromodel flooding results,the most effective factor for enhancing oil recovery is temperature compared to the nanoparticle and surfactant ***,in floodings with higher porous medium temperature,the oil viscosity reduction is considerable,and more oil is *** addition,the surfactant concentration plays a more effective role in reservoirs with higher *** other words,at a surfactant concentration of 250 ppm,the ultimate oil recovery is improved about 20%with a temperature increase of 20°***,when the surfactant concentration is equal to 750 ppm,the temperature increase enhances the ultimate oil recovery by only about 7%.Finally,the nanoparticle and surfactant optimum concentrations determined by Design-Expert software were equal to 46 and 159 ppm,*** is worthy to note that obtained results are validated by the confirmation test.

关键词： Enhanced heavy oil recovery Nanoparticle Surfactant Temperature High salinity brine Stability Micromodel Experimental design