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Sudden Cardiac Death with Myocardial Infarction after Free-flap Lower Extremity Reconstruction

Chinese Medical Journal 2017年第4期130卷 499-500页

作者： Won Ha Ky. nam kim soe Hee Ann Chi Sun Yoon Department of Plastic and Reconstructive Surgery Ulsan University Hospital University of Ulsan College of Medicine Utsan Korea Department of Plastic and Reconstructive Surgery Konyang University Hospital University of Konyang College of Medicine DaeJon Korea Department of Cardiology Ulsan University Hospital University of Ulsan College of Medicine Ulsan Korea

To the Editor： Free-flap reconstructions involve factors that can increase the risk of myocardial infarction （MI; e.g., the intraoperative use of a vasoactive agent, body temperature maintenance, and postoperative administration of fluid therapy and/or antithrombotic drugs）,MI has been observed after free-flap head and neck reconstruction although it has not been reported after free-flap lower extremity reconstruction. Thus, we report a rare case of sudden death from MI after free-flap foot reconstruction.

关键词：钙调蛋白结合蛋白质类颈磷蛋白磷酸酶类体温头部下肢心肌梗死猝死心脏

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Folate-targeted nanostructured chitosan/chondroitin sulfate complex carriers for enhanced delivery of bortezomib to colorectal cancer cells

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Asian Journal of Pharmaceutical Sciences 2019年第1期14卷 40-51页

作者： Zar Chi soe Bijay Kumar Poudel Hanh Thuy nguyen Raj Kumar Thapa Wenquan Ou Milan Gautam Kishwor Poudel Sung Giu Jin Jee-Heon Jeong Sae Kwang Ku Han-Gon Choi Chul Soon Yong Jong Oh kim College of Pharmacy Yeungnam University Department of Pharmaceutics University of Pharmacy (Yangon) Department of Pharmaceutical Engineering Dankook University College of Korean Medicine Haany University College of Pharmacy Hanyang University

Folate-targeting self-assembled nanoparticles(nPs) using biocompatible and biodegradable natural polymers chitosan(Cs) and chondroitin sulfate(Chs) were developed to address the major challenge in cancer treatment, the selective delivery of nanoparticles to the target site. In this study, we successfully incorporated a hydrophobic drug, bortezomib(Bor), into folic acid(FA)-conjugated Cs/Chs self-assembled nPs(Bor/Cs/Chs-FA) for colorectal cancer therapy. The particle size and polydispersity index of Bor/Cs/Chs-FA were196.5 ± 1.2 nm and0.21 ± 0.5, respectively. A pH-dependent release profile was observed, facilitating cancer cell-targeted drug release under an acidic tumor microenvironment. Moreover, in vitro data revealed enhanced cellular uptake and apoptosis in folate receptor-expressing colorectal cancer cells(HCT-116 and HT-29) as compared to that in lung cancer cells(A549), which do not express folate receptors. Furthermore, intravenous administration of Bor/Cs/Chs-FA in a HCT-116 bearing xenograft mouse model showed that the nPs were a safe and effective drug delivery system. The results suggest that folate-targeted nanoparticle can be effectively applied for efficient chemotherapy of colorectal cancer.

关键词： Bortezomib Chitosan chondroitin sulfate Colorectal cancer Folic acid

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Automated segmentation of optical coherence tomography images

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Chinese Optics Letters 2019年第1期17卷 66-71页

作者： C.Kharmyssov M.W.L.Ko J.R.kim School of Engineering Nazarbayev University The University of Hong Kong

We propose a fast and accurate automated algorithm to segment retinal pigment epithelium and internal limiting membrane layers from spectral domain optical coherence tomography(SDOCT) B-scan images. A hybrid algorithm, which combines intensity thresholding and graph-based algorithms, was used to process and analyze SDOCT radial scans(120 B scans) images obtained from twenty patients. The relative difference in position of the layers segmented by the proposed hybrid algorithm and by the clinical expert was 1.49% ± 0.01%. The processing time of the hybrid algorithm was 9.3 s for six B scans. Dice's coefficient of the hybrid algorithm was 96.7% ± 1.6%. The proposed hybrid algorithm for the segmentation of SDOCT images had good agreement with manual segmentation and reduced processing time.

关键词： Automated segmentation optical coherence tomography images

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