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Shockwave intravascular lithotripsy and drug-coated balloon angioplasty in calcified coronary arteries:preliminary experience in two cases

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Journal of Geriatric Cardiology 2021年第8期18卷 689-691页

作者： hee Hwa Ho Jin Hyun Lee Deanna Zhi Lin Khoo Ko Ko soe Hpone Ki Fung Cliff Li Department of Cardiology Tan Tock Seng Hospital

Heavily calcified coronary arteries are extremely difficult to treat as calcium deposits "hardens" the arteries and alter vascular compliance. Intravascular lithotripsy (IVL)is a new technology consisting of a balloon-based system with miniaturized lithotripsy emitters that create a localised field effect to crack calcium in the arterial wall. Drug-coated balloon (DCB) angioplasty is an alternative treatment option in percutaneous coronary intervention (PCI) with an attractive strategy of leaving nothing behind combined with local drug delivery. In this brief clinical report, we described our early experience of using a novel combination of IVL and DCB angioplasty in two elderly patients with good angiographic results.

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Development of annulus fibrosus tissue construct with hydrogel coils containing pre-conditioned mesenchymal stem cell

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Journal of Materials Science & Technology 2021年第4期63卷 27-34页

作者： Yon Jin Chuah Yingnan Wu Mei Ling Shirlynn Cheong Yan Qing Chia Ching ann Tee Hwan Tak hee Chenjie Xu Yuejun Kang Dong-An Wang School of Chemical and Biomedical Engineering Nanyang Technological University62 Nanyang Drive637459Singapore Lee Kong Chian School of Medicine Nanyang Technological University59 Nanyang Drive636921Singapore Pinnacle Spine&Scoliosis Centre 3 Mount ElizabethMount Elizabeth Medical Centre228510Singapore Faculty of Materials and Energy Institute for Clean Energy and Advanced MaterialsSouthwest UniversityChongqing 400715China Department of Biomedical Engineering City University of Hong Kong83 Tat Chee AvenueKowloonHong KongChina National Dental Centre of Singapore 5 Second Hospital Ave168938Singapore

Low back pain associated with degenerative disc diseases has been a major health concern that brings suffering to the patients physically and *** existing therapeutic strategies provide shortterm relief of symptoms rather than treatment of the underlying *** of an engineered tissue for disc regeneration is still in its infancy due to the limited autologous healthy disc cell source from the *** is also challenging to mimic the complexity of micro-architecture in the native disc tissue that determine their unique structural *** date,simple tissue models that mimic the annulus fibrosus(AF)micro-environment for understanding the potential of mesenchymal stem cells(MSCs)in AF tissue engineering are still *** this study,the assembly of a coiled hydrogel microfiber has shown its capability to encapsulate MSCs and create an engineered tissue model that mimics the multiple lamellae of native *** this model,we investigated the potential of MSCs that were previously induced by ascorbic acid(AA).Compared to non-induced MSCs,AA-induced MSCs exhibited significant increase in AF-associated biomarkers during later development in the engineered AF tissue model and also encouraged collagen accumulation through the down-regulated catabolic gene MMP1 and upregulated anti-catabolic gene ***,AA-induced MSCs exhibited a Col2/Col1 ratio closer to that of a native AF *** results suggested that AA-induced MSCs could be a potential cell source for AF tissue engineering and this established tissue model may provide a simple tool for successful AF tissue engineering strategies in the future.

关键词： closer stem strategies

Activation-Tagged Suppressors of a Weak Brassinosteroid Receptor Mutant

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Molecular Plant 2010年第1期3卷 260-268页

作者： Bin Kang Hao Wang Kyoung hee Nam Jiayang Li Jianming Li Department of Molecular Cellular and Developmental Biology University of Michigan 830 N. University Ann Arbor MI 48109-1048 USA Division of Biological Sciences Sookmyung Woman's University 52 Hyochangwon-gil Yongsan-gu Seoul 140-742 Korea State Key Laboratory of Plant Genomics and National Center for Plant Gene Research Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China

Brassinosteroids （BRs） are important plant hormones that act synergistically with auxin to regulate a variety of plant developmental and physiological processes. In the past decade, genetic and biochemical studies have revealed a linear signaling pathway that relies on protein phosphorylation to transmit the BR signal into the nucleus, altering ex- pression of hundreds of genes to promote plant growth. We conducted an activation-tagging based suppressor screen to look for Arabidopsis genes that, when overexpressed by inserted 35S enhancer elements, could suppress the dwarf phe- notype of a weak BR receptor mutant bril-301. This screen identified a total of six dominant activation-tagged bril sup- pressors （atbs-Ds）. Using a plasmid rescue approach, we discovered that the bril-301 suppression effect in four atbs-D mutants （atbs3-D to atbs6-D） was caused by overexpression of a YUCCA gene thought to be involved in tryptophan- dependent auxin biosynthesis. Interestingly, the three activation-tagged YUCCA genes belong to the YUCCA IIA subfamily that includes two other members out of 11 known Arabidopsis YUCCA genes. In addition, our molecular studies revealed a T-DNA insertion near a basic helix-loop-helix gene in atbsl-D and a T-DNA insertion in a region carrying a BR biosynthetic gene in atbs2-D. Further studies of these atbs-D mutants could lead to better understanding of the BR signaling process and the BR-auxin interaction.

关键词： Brassinosteroid BRI1 bril-301 auxin YUCCA.

Bioactivity‑Guided Isolation of Totarane‑Derived Diterpenes from Podocarpus neriifolius and Structure Revision of 3‑Deoxy‑2α‑hydroxynagilactone E

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Natural Products and Bioprospecting 2019年第2期9卷 157-163页

作者： P.annécie Benatrehina Wei-Lun Chen Austin A.Czarnecki Steven Kurina hee-Byung Chai Daniel D.Lantvit Tran N.Ninh Xiaoli Zhang Djaja D.soejarto Joanna E.Burdette A.Douglas Kinghorn L.Harinantenaina Rakotondraibe Division of Medicinal Chemistry and Pharmacognosy The Ohio State UniversityCollege of PharmacyColumbusOHUSA Center for Biostatistics The Ohio State UniversityColumbusOHUSA College of Pharmacy University of Illinois at ChicagoChicagoILUSA John G.Searle Herbarium of the Field Museum of Natural History ChicagoILUSA Institute of Ecology and Biological Resources Vietnam Academy of Science and Technology HanoiHanoiVietnam

Bioactivity-guided phytochemical investigation of Podocarpus neriifolius ***.(Podocarpaceae)has led to the isolation of one new(2)and three known(1,3,and 4)B-type podolactones,along with three totarane-type diterpenes(5-7).Their structures were determined by interpretation of High Resolution ElectroSpray Ionization Mass Spectrometry(HRESIMS)and 1D and 2D NMR data,and comparison with the values reported in the *** structure of compound 1,previously identifed as 3-deoxy-2α-hydroxynagilactone E(8),was revised as its 2β-epimer,which has been reported recently as a new *** of the isolates were evaluated for their antiproliferative activity against a panel of four human cancer cell lines,namely,ovarian(OVCAR3),breast(MDA-MB-231),colon(HT-29),and melanoma(MDA-MB-435),and compounds 1 and 3 were found to be cytotoxic with IC_(50) values in the low micromolar range for most of the cell lines *** major compound,inumakilactone A(3),was further tested in vivo using the HT-29,MDA-MB-435,and OVCAR3 cells in a murine hollow fber model,for the frst time.

关键词： Podocarpus neriifolius Nagilactone G-2β-O-β-d-glucoside Hollow fber assay 3-Deoxy-2αhydroxynagilactone E Antiproliferative B-type podolactone

MicroRNA therapeutics:principles,expectations,and challenges

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Chinese Journal of Cancer 2011年第6期30卷 368-370页

作者： Rajesha Rupaimoole hee-Dong Han Gabriel Lopez-Berestein Anil K.Sood Department of Gynecologic Oncology The University of Texas M.D.Anderson Cancer Center Department of Center for RNA Interference and Non-Coding RNA The University of Texas M.D.Anderson Cancer Center Department of Experimental Therapeutics The University of Texas M.D.Anderson Cancer Center Department of Department of Cancer Biology The University of Texas M.D.Anderson Cancer Center

MicroRNAs(miRNAs) are a class of highly abundant non-coding RNA molecules that are involved in several biological *** miRNAs are often deregulated in several diseases including *** is substantial interest in exploiting miRNAs for therapeutic *** this editorial,we briefly review current advances in the use of miRNAs or antisense oligonucleotides(antagomirs) for such *** of the key issues related to therapy using miRNAs is degradation of naked particles in *** overcome this limitation,delivery systems for miRNA-based therapeutic agents have been developed,which hold tremendous potential for improving therapeutic outcome of cancer patients.

关键词：微RNA 疗法 miRNAs 小分子RNA 治疗药物期望非编码RNA 反义寡核苷酸

Innate-like CD4 T cells selected by thymocytes suppress adaptive immune responses against bacterial infections

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Open Journal of Immunology 2012年第1期2卷 25-39页

作者： Yu Qiao Brian M. Gray Mohammed H. Sofi Laura D. Bauler Kathryn A. Eaton Mary X. D. O’Riordan Cheong-hee Chang Department of Microbiology and Immunology University of Michigan Ann Arbor USA Unit for Lab Animal Medicine Medical School University of Michigan Ann Arbor USA

We have reported a new innate-like CD4 T cell population that expresses cell surface makers of effector/memory cells and produce Th1 and Th2 cytokines immediately upon activation. Unlike conventional CD4 T cells that are selected by thymic epithelial cells, these CD4 T cells, named T-CD4 T cells, are selected by MHC class II expressing thymocytes. Previously, we showed that the presence of T-CD4 T cells protected mice from airway inflammation suggesting an immune regulatory role of T-CD4 T cells. To further understand the function of T-CD4 T cells, we investigated immune responses mediated by T-CD4 T cells during bacterial infection because the generation of antigen specific CD4 T cells contributes to clearance of infection and for the development of immune memory. The current study shows a suppressive effect of T-CD4 T cells on both CD8 and CD4 T cell-mediated immune responses during Listeria and Helicobacter infections. In the mouse model of Listeria monocytogenes infection, T-CD4 T cells resulted in decreasedfrequency of Listeria-specific CD8 T cells and the killing activity of them. Furthermore, mice with T-CD4 T cells developed poor immune memory, demonstrated by reduced expansion of antigen-specific T cells and high bacterial burden upon re-infection. Similarly, the presence of T-CD4 T cells suppressed the generation of antigen-specific CD4 T cells in Helicobacter pylori infected mice. Thus, our studies reveal a novel function of T-CD4 T cells in sup-pressing anti-bacterial immunity.

关键词： Bacterial Infection Innate-Like CD4 T Cells Immune Suppression

Petawatt and exawatt class lasers worldwide

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High Power Laser Science and Engineering 2019年第3期7卷 168-221页

作者： Colin N.Danson Constantin Haefner Jake Bromage Thomas Butcher Jean-Christophe FChanteloup Enam A.Chowdhury Almantas Galvanauskas Leonida A.Gizzi Joachim Hein David I.Hillier Nicholas W.Hopps Yoshiaki Kato Efim A.Khazanov Ryosuke Kodama Georg Korn Ruxin Li Yutong Li Jens Limpert Jingui Ma Chang hee Nam David Neely Dimitrios Papadopoulos Rory R.Penman Liejia Qian Jorge J.Rocca andrey A.Shaykin Craig W.Siders Christopher Spindloe Sándor Szatmári Raoul M.G.M.Trines Jianqiang Zhu Ping Zhu Jonathan D.Zuegel AWE AldermastonReadingUK OxCHEDS Clarendon LaboratoryDepartment of PhysicsUniversity of OxfordOxfordUK CIFS Blackett LaboratoryImperial CollegeLondonUK NIF&Photon Science Directorate Lawrence Livermore National LaboratoryLivermoreUSA Fraunhofer Institute for Laser Technology(ILT) AachenGermany Chair for Laser Technology LLT RWTH Aachen UniversityAachenGermany University of Rochester Laboratory for Laser EnergeticsRochesterUSA Central Laser Facility STFC Rutherford Appleton LaboratoryChiltonDidcotUK LULI CNRSCEASorbonne UniversitesEcole PolytechniqueInstitut Polytechnique de ParisPalaiseauFrance Department of Physics The Ohio State UniversityColumbusUSA Centre for Ultrafast Optical Science University of MichiganAnn ArborUSA Intense Laser Irradiation Laboratory Istituto Nazionale di Ottica(INO)CNRPisaItaly Institute of Optics and Quantum Electronics Friedrich-Schiller-University Jena and Helmholtz InstituteJenaGermany The Graduate School for the Creation of New Photonics Industries NishikuHamamatsuJapan Institute of Applied Physics Russian Academy of SciencesNizhny NovgorodRussia Institute of Laser Engineering Osaka UniversitySuitaOsakaJapan ELI-Beamlines Institute of PhysicsCzech Academy of SciencesPragueCzech Republic State Key Laboratory of High Field Laser Physics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghai 201800China National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China Institute for Applied Physics(IAP)at Friedrich-Schiller-University Jena JenaGermany Helmholtz Institute Jena JenaGermany Fraunhofer Institute for Applied Optics and Precision Engineering(IOF) JenaGermany Key Laboratory for Laser Plasma(Ministry of Education) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Centre for Relativistic Laser Science(CoReLS) Institute for Basic ScienceDepartment of Physics and Photon ScienceGwangju Institute of Science and Techno

In the 2015 review paper‘Petawatt Class Lasers Worldwide’a comprehensive overview of the current status of highpower facilities of>200 TW was *** was largely based on facility specifications,with some description of their uses,for instance in fundamental ultra-high-intensity interactions,secondary source generation,and inertial confinement fusion(ICF).With the 2018 Nobel Prize in Physics being awarded to Professors Donna Strickland and Gerard Mourou for the development of the technique of chirped pulse amplification(CPA),which made these lasers possible,we celebrate by providing a comprehensive update of the current status of ultra-high-power lasers and demonstrate how the technology has *** are now in the era of multi-petawatt facilities coming online,with 100 PW lasers being proposed and even under *** addition to this there is a pull towards development of industrial and multi-disciplinary applications,which demands much higher repetition rates,delivering high-average powers with higher efficiencies and the use of alternative wavelengths:mid-IR *** apart from a comprehensive update of the current global status,we want to look at what technologies are to be deployed to get to these new regimes,and some of the critical issues facing their development.

关键词： exawatt lasers high-power lasers petawatt lasers ultra-high intensity