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Exercise intervention under hypoxic condition as a new therapeutic paradigm for type 2 diabetes mellitus:A narrative review

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World Journal of Diabetes 2021年第4期12卷 331-343页

作者： Sung-Woo Kim Won-Sang Jung sochung chung Hun-Young Park Physical Activity and Performance Institute(PAPI) Konkuk UniversitySeoul 05029South Korea Department of Pediatrics Konkuk University Medical CenterResearch Institute of Medical ScienceKonkuk UniversitySchool of MedicineSeoul 05029South Korea Department of Sports Science and Medicine Konkuk UniversitySeoul 05029South Korea

This review aims to summarize the health benefits of exposure to hypoxic conditions during exercise in patients with type 2 diabetes mellitus(T2 DM).Exposure to hypoxic conditions during exercise training positively changes the physiological response in healthy *** to hypoxic conditions during exercise could markedly increase skeletal muscle glucose uptake compared to that in normoxic ***,post-exercise insulin sensitivity of T2 DM patients increases more when exercising under hypoxic than under normoxic *** exercise under short-term hypoxic conditions can improve blood glucose control at lower workloads than in normoxic ***,exercise training under short-term hypoxic conditions can maximize weight loss in overweight and obese *** studies on healthy subjects have reported that regular exercise under hypoxic conditions had a more positive effect on vascular health than exercising under normoxic ***,currently,evidence indicating that exposure to hypoxic conditions could positively affect T2 DM patients in the long-term is ***,further evaluations of the beneficial effects of exercise under hypoxic conditions on the human body,considering different cycle lengths,duration of exposures,sessions per day,and the number of days,are *** this review,we conclude that there is evidence that exercise under hypoxic conditions can yield health benefits,which is potentially valuable in terms of clinical care as a new intervention for T2 DM patients.

关键词： Exercise Hypoxia Insulin-resistance Metabolism Type 2 diabetes mellitus Weight loss

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