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Can Fig and Olive Ameliorate the toxicity Induced by 2-nitropropane in some organs of mice? role of inflammatory versus anti-inflammatory genes

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Journal of Traditional Chinese Medicine 2021年第6期41卷 891-899页

作者： Elham A.Abd-allah Nouf S.al-Abbas Mona M.Atia Fawzia alzahrani El-Mokhtar M.Ahmed soad S.ali soad k.al jaouni Department of Zoology Faculty of Sciencethe New Valley UniversityEl-Kharga 72511Egypt Department of chemistry Al Leith University CollegeUmm Al-Qura UniversityMecca 21955Saudi Arabia Department of Zoology Faculty of ScienceAssiut UniversityAssiut 71684Egypt Anatomy Department(Cytology and Histology) Faculty of Medicine(FM)King Abdulaziz UniversityJeddah 21589Saudi Arabia(KAU) Department of Microbiology and Immunology Faculty of MedicineAssiut UniversityAssiut 71684Egypt Department of Histology and Yousef Abdulatif Jameel Scientific Chair of Prophetic Medicine Faculty of MedicineKing Abdul Aziz UniversityJeddah 21589Saudi Arabia Department of Hematology/Pediatric Oncology and Head of Yousef Abdulatif Jameel Scientific Chair of Prophetic Medicine Faculty of MedicineKing Abdul Aziz UniversityJeddah 21589Saudi Arabia

OBJECTIVE:To investigate the efficacy of Fig fruit powder and olive on hepatic,renal and splenic injury induced by 2-nitropropane(2-NP)in mice,especially if they were used in ***:A total of 40 adult BalB/c male mice weighting 25-30 g/*** were categorized into five groups(8 each).Group 1 as negative *** 2 as positive control group intraperitoneally injected with 2-NP(100 mg/kg b.w.)3 times/weekly for eight *** 3 injected with 2-NP and were orally supplemented with Fig(300 mg/kg).Group 4 injected with 2-NP and were orally supplemented with olive(100 mg/kg).Group 5 injected with 2-NP and were orally supplemented with mixture of Fig and olive(3∶1 respectively).RESULTS:Histopathological observation of liver in mice treated with 2-NP showed cellular degeneration,pyknosis,and congestion of the portal *** kidney there were disorganization of the cortical tissues,cellular necrosis and plenty of inflammatory lymphocytic *** elevations in liver function parameters(alanine aminotransferase and aspartate aminotransferase),m RNA expression levels of tumor necrosis factor-α,nicotinamide adenine dinucleotide phosphate oxidase and cyclooxygenase were detected as anti-inflammatory markers and 5-lipoxygenase,interleukin-1βand interleukin-6 as inflammatory biomarkers for liver and spleen,also significant elevations was detected in lipid peroxidation *** levels of antioxidants,glutathione,glutathione peroxidase,catalase and superoxide dismutase were significantly ***:our findings indicated that Fig fruit powder and olive protected against hepatic,renal and splenic injury induced with 2-NP in mice,especially if they were used in combination.

关键词： Ficus olea antioxidants toxicity tests 2-nitropropane inflammatory genes

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沙特阿拉伯鲜乳和发酵乳中乳酸菌的分离、分子特征和益生菌潜力的研究

沙特阿拉伯鲜乳和发酵乳中乳酸菌的分离、分子特征和益生菌潜力的...

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中国畜牧兽医学会动物微生态学分会第五届第十三次全国学术研讨会

作者： Maged S.Bin Masalam Ahmed Bahieldin Mona G.alharbi Saad al-Masaudi soad k.al-jaouni Steve M.Harakeh Rashad R.al-Hindi 白海武如娟香红星 Department of Biology Faculty of ScienceKing Abdulaziz University Department of Pediatric Hematology/Oncology Yousef Abdullatif Jameel Chair of Prophetic Medicine ApplicationKing Abdulaziz University HospitalFaculty of Medicine

益生菌对人体胃肠道有益,乳酸菌(LAB)广泛分布于自然界,并在食品工业中得到了充分利用,是益生菌的侯选细菌。本研究目的从沙特阿拉伯国家的某牧场生产的鲜乳和发酵乳中分离乳酸菌和研究其特征。结果,从13种不同的鲜乳和发酵乳分离得到9... 详细信息

益生菌对人体胃肠道有益,乳酸菌(LAB)广泛分布于自然界,并在食品工业中得到了充分利用,是益生菌的侯选细菌。本研究目的从沙特阿拉伯国家的某牧场生产的鲜乳和发酵乳中分离乳酸菌和研究其特征。结果,从13种不同的鲜乳和发酵乳分离得到93株疑似乳酸菌。基于16S rDNA基因序列比较并分析其遗传相关性,鉴定了46株乳酸菌。没有一株乳酸菌表现出对临床相关抗生素的抗性或有任何溶血活性,但它们的益生菌特性表现不一,即对pH的耐受性、对胆汁的抗性和抗菌活性。结果表明,分离得到的干酪乳杆菌MSJ1(Lactobacillus casei),干酪乳杆菌Dwan5,植物乳杆菌EyLan2(Lactobacillus plantarum)和屎肠球菌Gail-BawZir8(Enterococcus faecium)最有可能成为有益生菌潜力的最好菌株。我们推测菌种组合的协同作用可以发挥更有效的益生菌的潜力。来自沙特阿拉伯的生鲜乳和发酵乳产品,特别是由骆驼奶制成的发酵奶制品Laban,富含乳酸菌LAB,具有很好的益生菌潜力。

关键词：鲜乳发酵乳分离鉴定益生菌沙特阿拉伯

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Exploring the anti-inflammatory bioactive metabolites of some marine algae through integration of metabolomics,network pharmacology and molecular docking analyses

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Food Bioscience 2022年第6期50卷 861-874页

作者： Dina S.Ghallab Eman Shawky Doaa A.Ghareeb Shaymaa A.Abdulmalek soad M.Mohy El-Din Mohamed M.Mohyeldin Reham S.Ibrahim Department of Pharmacognosy Faculty of PharmacyAlexandria UniversityEgypt Center of Excellency for Preclinical Study (CE-PCS) Pharmaceutical and Fermentation Industries Development CentreCity of Scientific Research and Technological ApplicationsSRTA-CityNew Borg El-Arab CityAlexandriaEgypt Bio-screening and Preclinical Trial Lab Biochemistry DepartmentFaculty of ScienceAlexandria UniversityAlexandriaEgypt Biochemistry Department Faculty of ScienceAlexandria UniversityAlexandriaEgypt Botany and Microbiology Department Faculty of ScienceAlexandria UniversityAlexandria21511Egypt

Marine algae are well-acknowledged as a prime store of largely unexplored extraordinary chemical entities potentially ameliorating against inflammation however,the efficacy mechanism remains *** study offers an integrated strategy of several bioinformatics and computational tools as well as bio-guided fractionation,and multi-step experimental validations integrated with metabolomics to systematically provide a shortcut of potentially active anti-inflammatory biomarkers of ***,multi-level network model of“multi-components-multi-targets-multiple pathways”was ***,an in vitro anti-inflammatory testing was estimated via monitoring release of pro-inflammatory ***-guided fractionation of *** integrated with UPLC-MS analysis of the most promising enriched fractions in terms of anti-inflammatory efficacy were *** docking studies on the top enriched targets were ultimately ***-level network analysis illuminated that the intricate pharmacological mechanisms underlying inflammation mitigation was the knockout of the crucial targets of TLR2,AkT1 and PRkCA and further regulation of principal pathways as PI3k-Akt signaling pathway,arachidonic acid(AA)metabolism and Toll-like receptor signaling *** vitro testing,*** exhibited the greatest ***-MS analysis of Spirulina active fractions showed linolenic acid,hydroxy linolenic acid,eicosapentaenoic acid,catechin and carnosic acid were efficacy constituents for mitigating *** docking showed that eicosapentaenoic,hydroxy linolenic acid and carnosic acid displayed favorable molecular binding capacity to TLR2,AkT1 and *** rationally developed workflow offered the convincing evidence marine algae armed with an arsenal of weapons to regain the harmony disturbed in inflammatory disorders by multi-targeted synergistic functions.

关键词： Bioinformatics Seaweeds Network pharmacology Molecular docking Metabolomics

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Natural radioactivity levels and radiation hazards for gypsum materials used in Egypt

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Natural Science 2014年第1期6卷 5-13页

作者： Ahmed Hassan korna soad Saad Fares Magda Abd El-Rahman Department of Physics Faculty of Science Al Baha University Al Bahah KSA Department of Radiation Physics National Center of Radiation Research and Technology NCRRT Atomic Energy Authority Cairo Egypt

Radionuclides naturally occurring in building materials may significantly contribute to the annual doses to the public. For instance, familiar building materials such as the concrete and gypsum board have been reported to produce a dose of about 0.04 mSv per year for a typical person (NCRP 1987c). External as well as internal exposures are two pathways of radiation dose imparted to human beings from the building materials. As information on the radioactivity of such materials is lacking, the study of gypsum materials used in Egypt was carried out in order to estimate the annual dose to the Egyptian population due to natural radionuclides in building materials. During the study, 18 samples of commonly used gypsum raw materials were collected and measured. The activity concentrations were determined by gamma ray spectrometry. Their mean values were in the ranges of 499.29 ± 11.53 Bq·kg-1 for 40k, 91.97 ± 2.61 Bq·kg-1 for 226Ra, 37.62 ± 1.67 Bq·kg-1 for 238U and 42.27 ± 2.22 Bq·kg-1 for 232Th. The activity indexed Iγ for 18, different gypsum samples varied from 0.31 ± 0.03 to 2.3 ± 0.19 and the radium equivalent activity (Raeq), from 38.81 ± 1.68 to 324.7 ± 9.42. These values are lower than the limit of 370 Bq·kg-1 adopted by the Organization for Economic Cooperation and Development (OECD). The average indoor annual effective gamma dose rate (DE) in (mSv/y) for the people, caused by the building materials of dwellings, was assessed for most commonly gypsum materials. It was estimated to be in the range from 0.10 ± 0.003 mSv/y to 0.74 ± 0.08 mSv/y. The internal and external hazard indices (Hin, Hex) and the absorbed dose rate in air D in each sample were evaluated to assess the radiation hazard for people living in dwelling made of the studied materials. The absorbed dose rate of indoor air in samples G1, G2, G11, G17 and G18 is less than the international recommended value which is 55 nGyh-1. While the absorbed dose rate for samples G3, G4, G5, G6, G7, G8, G9, G10, G12

关键词： Gypsum Gamma Spectrometer Hazard Indices NORM Building Materials

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