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Plant based metabolomics:a future prospective and versatile tool for metabolite databases of Curcuma longa

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未来食品学报(英文) 2024年第1期4卷 37-47页

作者： Shuvendhu Gupta Amrat pal singh Gurpreet singh Xianting Ding Alok Sharma Department of Pharmacognosy ISF College of PharmacyMoga 142001India Department of Pharmaceutical Chemistry ISF College of PharmacyMoga 142001India School of Biomedical Engineering Med-X Research InstituteShanghai Jiao Tong UniversityShanghai 200030China

sophisticated analytical instruments are used for quality evaluation and scientific validation to compliance the sophisticated analytical instruments are used for quality evaluation and scientific validation to compliance the market ***,increase in demand of Curcuma longa has led to a high swing in small and medium food *** present review is devoted to an in-depth information on metabolite database of *** from different analytical techniques such as high-performance thin-layer chromatography(HPTLC),liquid chromatography-mass spectrometry,gas chromatography-mass spectrometry and nuclear magnetic *** work highlights different extraction methods,phytochemistry along with structure activity relationship,nutritional profiling,market viability and pharmacology of *** bioactives of *** depends on various factors such as plants growth,temperature,humidity,soil type,collection,drying and extraction *** factors can contribute in quality evaluation of the food supplements if need to be *** introduction of omics approaches can helpful to explore the quality and identification of potential lead of *** results could play an essential role in the area of food-phyto based ***,metabolomics techniques may provide a analytical platfom by combination of different"omics"data souces for future esearch to food sand herbal based products.

关键词： Curcuma longa Omics approaches Multidisciplinary method Quality control Metabolomics

Dust-Holding Capacity and Bio-Chemical Changes of Plant Species Growing in an Around Opencast Mining Area of Bundelkhand Region of Uttar Pradesh, India

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American Journal of Plant Sciences 2024年第8期15卷 677-698页

作者： Priyanka singh Amit pal Institute of Environment and Development Studies Bundelkhand University Jhansi India

The present study has been carried out on a total of 50 available plant species to assess their dust-capturing capacity and biochemical performances in and around open cast granite mine areas of Jhansi district and Bundelkhand University campus treated as control site. Plant species existing under a polluted environment for a long time may be considered as potentially resistant species and recommended for green belt design in mining areas, especially to cope with dust pollution. Results showed the pollution level, especially of mining-originated dust particles holding capacity of leaves and effects of different biochemical parameters (Total Chlorophyll, Protein and Carotenoid) of existing plant species both from mining areas as well as from Bundelkhand University campus. Based on their performances, Tectona grandis L., Ficus hispida L., Calotropis procera Aiton., Butea monosperma Lam. and Ficus benghalensis L., etc. are highly tolerant species while Ficus infectoria L., Artocarpus heterophyllus Lam., Ipomoea purpurea L., Allianthus excelsa Roxb. and Bauhinia variegata L. are intermediate tolerant species. T. grandis had shown the highest dust-holding capacity (2.566 ± 0.0004 mg/cm2) whereas Albizia procera (0.018 ± 0.0002 mg/cm2) was found to be the lowest dust-holding capacity. Our findings also showed that the T. grandis and F. hispida have significant dust deposition with minimal effect of dust on their leaf chlorophyll (17.447 ± 0.019 mg/g and 14.703 ± 0.201 mg/g), protein (0.699 ± 0.001 mg/g and 0.604 ± 0.002 mg/g) and carotenoid (0.372 ± 0.003 mg/g and 0.354 ± 0.003 mg/g) content respectively among all selected plant species. Therefore, in the present investigation, plant species with high tolerance to high dust-holding capacity on their leaf surfaces are preferable for green corridors as open cast granite mines and their adjacent areas.

关键词： Bundelkhand Region Biochemical Changes Dust-Holding Capacity Chlorophyll Content Open Cast Granite Mining

Systematic review with expert consensus on use of extracorporeal hemoadsorption in septic shock:An Indian perspective

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World Journal of Critical Care Medicine 2024年第1期13卷 65-75页

作者： Yatin Mehta Abdul Samad Ansari Amit Kumar Mandal Dipanjan Chatterjee Gauri Shankar Sharma Prachee Sathe Purvesh V Umraniya Rajib Paul Sachin Gupta Vinod singh Yogendra pal singh Institute of Critical Care and Anesthesiology Medanta The MedicityGurgaon 122001HaryanaIndia Department of Critical Care Nanavati Max Super Specialty HospitalMumbai 400065India Department of Pulmonology Sleep and Critical CareFortis HospitalMohaliPunjabMohali 160062PunjabIndia Department of Cardio-Puimonary Critical Care Medica Superspecialty HospitalKolkata 700099India Department of Critical Care Medicine Fortis HospitalNew Delhi 110070India Department of Critical Care Medicine D.Y.Patil Medical CollegeSant Tukaram NagarPimpri ColonyPimpri-ChinchwadPune 411018India Department of Critical Care Medicine Bhailal Amin General HospitalVadodara 390003GujaratIndia Department of Internal Medicine Apollo HospitalsJubilee HillsHyderabad 500033India Department of Anaesthesiology Narayana Superspeciality HospitalGurugram 122002India Department of Critical Care Medicine Institute of Critical Care MedicineHospital Name-Sir Ganga Ram HospitalNew Delhi 110001India Department of Critical Care Medicine Max Super Speciality HospitalDelhi 110092India

BACKGROUND Septic shock is a severe form of sepsis characterised by deterioration in circulatory and cellular-metabolic *** standard therapy,the outcomes are *** adjuvant therapy,such as Cytosorb®extracorporeal haemoadsorption device,has been investigated and shown promising ***,there is a lack of some guidance to make clinical decisions on the use of Cytosorb®haemoadsorption as an adjuvant therapy in septic shock in Indian ***,this expert consensus was *** To formulate/establish specific consensus statements on the use of Cytosorb®haemoadsorption treatment based on the best available evidence and contextualised to the Indian *** We performed a comprehensive literature on Cytosorb®haemoadsorption in sepsis,septic shock in PubMed selecting papers published between January 2011 and March 20232021 in English *** statements for a consensus document were developed based on the summarised literature analysis and identification of knowledge *** a modified Delphi approach combining evidence appraisal and expert opinion,the following topics related to Cytosorb®in septic shock were addressed:need for adjuvant therapy,initiation timeline,need for Interleukin-6 levels,duration of therapy,change of adsorbers,safety,prerequisite condition,efficacy endpoints and management *** expert members from critical care,emergency medicine,and the intensive care participated and voted on nine statements and one open-ended *** Eleven expert members from critical care,emergency medicine,and the intensive care participated and voted on nine statements and one open-ended *** 11 experts in the consensus group(100%)participated in the first,second and third round of *** three iterative voting rounds and adapting two statements,consensus was achieved on nine statements out of nine *** consensus expert panel also recognised the necessity to form an associatio

关键词： Consensus Cytosorb Cytokine Hemoadsorption Refractory Sepsis Septic shock

Fabrication of core-shell PLGA/PLA-pNIPAM nanocomposites for improved entrapment and release kinetics of antihypertensive drugs

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Particuology 2018年第5期16卷 169-176页

作者： Tanushree Basu Bonamali pal Satnam singh School of Chemistry and Biochemistry Thapar lnstitute of Engineering and TechnologyPatiala 147004Punjablndia

Polylactic acid (PLA)and poly(lactic-co-glycolic)acid (PLGA)are two commonly applied biodegrad- able polymers for the preparation of nanocomposites used in drug-delivery ***,these polymers lack desirable attributes such as resistance to aggregation during long-term storage due to *** improve their efficacy,in this work,PLA and PLGA were encapsulated within a shell of poly(N-isopropylacrylamide)(pNIPAM)using a single emulsion technique followed by an aqueous free radical precipitation polymerisation process,yielding core-shell PLA/PLGA-pNIPAM nanocomposites. The nanocomposites were cbaracterised using zeta potential,dynamic light scattering,and transmission electron microscopy analyses and were further applied as a delivery system for ramipril,an antihypertensive *** drug-loaded PLGA-pNIPAM core-shell nanoparticles exhibited a higher drug content (91%)and entrapment efficiency (78%)than their PLA *** in vitro release study of the formulations at pH 7.3in phosphate-buffered saline indicated that PLGA was more efficient than PLA with a sustained release of 86% of ramipril from the polymer matrix within ***,to determine the release kinetics,the data were fitted to Korsmeyer-Peppas and Higuchi models;the release of ramipril from the polymer matrix followed zero-order rate kinetics and an anomalous (non-Fickian)diffusion mechanism.

关键词： Poly(lactic-co-glycolic)acid Polylactic acid Poly(N-isopropylacrylamide) Antihypertensive drug Entrapment efficiency Drug release

Joint routing and rate allocation for multiple video streams in ad-hoc wireless networks

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第5期7卷 727-736页

作者： singh Jatinder pal GIROD Bernd Deutsche Telekom Laboratories Ernst-Reuter-Platz 7 Berlin 10587 Germany Information System Laboratory Stanford University California 94305 USA

The support for multiple video streams in an ad-hoc wireless network requires appropriate routing and rate allocation measures ascertaining the set of links for transmitting each stream and the encoding rate of the video to be delivered over the chosen links. The routing and rate allocation procedures impact the sustained quality of each video stream measured as the mean squared error (MSE) distortion at the receiver, and the overall network congestion in terms of queuing delay per link. We study the trade-off between these two competing objectives in a convex optimization formulation, and discuss both centralized and dis- tributed solutions for joint routing and rate allocation for multiple streams. For each stream, the optimal allocated rate strikes a balance between the selfish motive of minimizing video distortion and the global good of minimizing network congestions, while the routes are chosen over the least-congested links in the network. In addition to detailed analysis, network simulation results using ns-2 are presented for studying the optimal choice of parameters and to confirm the effectiveness of the proposed measures.

关键词： Ad-hoc wireless networks, Video streaming, Rate allocation, Multi-path routing

SiO2-coated pure anatase TiO2 catalysts for enhanced photo-oxidation of naphthalene and anthracene

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Particuology 2017年第5期15卷 156-161页

作者： Inderpreet singh Grover Roop Chand Prajapat Satnam singh Bonamali pal Department of Chemistry Public College Samana 147101 Punjab India School of Chemistry and Biochemistry Thapar University Putiala 147004 Punjab India

Our current efforts reveal the preparation of SiO2@TiO2 nanocomposites having different thicknesses of silica shell and the relationship to photocatalytic activity （PCA） for the photo-oxidation of naph-thalene and anthracene. The presence of SiO2 coating over TiO2 surface was demonstrated by FT-IR analysis, with peaks corresponding to Si-O-Si （1081 cm 1） and Si-O-Ti （950 cm-1） bonds observed. High-resolution transmission electron microscopy analysis confirmed the presence of SiO2 in the as- prepared nanocomposites and the amount of Si, Ti, and O was determined by energy dispersive X-ray spectroscopy analysis. Increasing the Si02 shell thickness increases the surface area of the nanocompos- ites （69-235 m2/g）, which enhances naphthalene/anthracene adsorption. However, the observed PCA trend presents an inverse correlation to the adsorption studies, where the as-prepared samples possess- ing the highest surface areas exhibited the least PCA, while catalysts having lower surface areas （among silica coated samples） displayed the highest PCA in the degradation of naphthalene and anthracene to CO2. Despite complete degradation of naphthalene and anthracene, incomplete mineralization occurred, ascribed to the formation of various intermediates, identified by GC-MS analysis.

关键词： Silica coating Naphthalene Anthracene Photo-oxidation TiO2 nanoparticles

Modeling oblique load carrying capacity of batter pile groups using neural network,random forest regression and M5 model tree

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Frontiers of Structural and Civil Engineering 2019年第3期13卷 674-685页

作者： Tanvi singh Mahesh pal V.K.ARORA Department of Civil Engineering National Institute of TechnologyKurukshetraHaryana 136119India

M5 model tree,random forest regression(RF)and neural network(NN)based modelling approaches were used to predict oblique load carrying capacity of batter pile groups using 247 laboratory experiments with smooth and rough pile *** length(L),angle of oblique load(a),sand density(ρ),number of batter piles(B),and number of vertical piles(V)as input and oblique load(Q)as output was *** suggest improved performance by RF regression for both pile groups.M5 model tree provides simple linear relation which can be used for the prediction of oblique load for field data *** developed using RF regression approach with smooth pile group data was found to be in good agreement for rough piles *** based approach was found performing equally well with both smooth and rough *** analysis using all three modelling approaches suggest angle of oblique load(a)and number of batter pile(B)affect the oblique load capacity for both smooth and rough pile groups.

关键词： batter piles oblique load test neural network M5 model tree random forest regression ANOVA

EFFECTS OF DELAY AND SEAsoNALITY ON TOXIN PRODUCING PHYTOPLANKTON-ZOOPLANKTON SYSTEM

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International Journal of Biomathematics 2012年第5期5卷 239-259页

作者： SUNITA GAKKHAR ANURAJ singh BRAHAM pal singh Department of MathematicsIndian Institute of Technology Roorkee Roorkee 247667 Uttarakhand India Department of Mathematics J. V. Jain Degree CollegeSaharanpur 2~001 U.P. India

A dynamical model for toxin producing phytoplankton and zooplankton has been formu- lated and analyzed. Due to gestation of prey, a discrete time delay is incorporated in the predator dynamics. The stability of the delay model is discussed and Hopf bifurcation to a periodic orbit is established. Stability and direction of bifurcating periodic orbits are investigated using normal form theory and center manifold arguments. Global existence of periodic orbits is also established. To substantiate analytical findings, numerical simu- lations are performed. The system shows rich dynamic behavior including chaos and limit cycles. The influence of seasonality in intrinsic growth parameter of the phytoplankton population is also investigated. Seasonality leads to complexity in the system.

关键词： Time delay stability Hopf bifurcation period chaos.

Pipes with Trapezoidal Cut Twisted Tape Inserts in the Laminar Flow Regime:Nusselt Number and Friction Coefficient Analysis

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Fluid Dynamics & Materials Processing 2023年第2期19卷 501-511页

作者： Shrikant Arunrao Thote Netra pal singh Department of Mechanical Engineering Oriental UniversityIndore453555India

The thermal behavior of pipes with a twisted tape inside(used to enhance heat transfer through the tube wall)is studied in the laminar flow *** is used as the work fluid with the corresponding Reynolds Number spanning the interval 200–*** is found that in such conditions the‘Nusselt Number’(Nu)gradually increases with reducing the tape twist ratio,whereas the friction factor is detrimentally affected by the presence of the tape(as witnessed by the comparison with the companion case where a plain tube is considered).In particular,it is shown that the heat transfer efficiency can be improved by nearly 69%if tape inserts with a relatively low twist ratio are *** the basis of these findings,it is concluded that loose fit tape inserts are superior to tight fit tapes in terms of heat transfer and ease of replacement.

关键词： Friction factor laminar flow Nusselt Number trapezoidal-cut twisted tape