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International Journal of Ophthalmology(English edition) 2022年第11期15卷 1837-1844页

作者： so min ahn Mihyun Choi Cheolmin Yun Seong-Woo Kim Jaeryung Oh Department of Ophthalmology Korea University College of MedicineSeoul 02841Republic of Korea

AIM:lo evaluate the changes on optical coherence tomography angiography(OCTA) and fluorescein angiography(FA) and their correlation in neovascular agerelated macular degeneration(nAMD) before and after intravitreal aflibercept injections(IAIs).METHODS:In 43 treatment-na?ve patients with nAMD,choroidal neovascularization(CNV) in OCTA were morphologically and quantitatively analyzed before and after IAIs to determine whether they are correlated with leakage on FA or *** combining CNV in OCTA and leakage in FA,lesions were characterized as three types:L+C+(with both CNV and leakage),L-C+(with CNV but without leakage),or L+C-lesion(with leakage outside CNV).RESULTS:Before IAI,while 27 eyes had L+C+lesion only,16 eyes had both L+C+and L-C+lesions *** capillaries and anastomosis in CNV were more developed in L+C+lesion,at 86.0% and58.1%,respectively,relative to 9.3% and 9.3% in L-C+lesions(Pso significantly ***:Leakage on FA is associated with CNV morphology in OCTA and remained so after ***,by carefully assessing the morphological and quantitative changes of CNV in OCTA before and after treatment,activity of nAMD is expected even though CNV on OCTA is not completely matched with fluorescein leakage.

关键词： choroidal neovascularization fluorescein angiography leakage neovascular age-related macular degeneration optical coherence tomography angiography

Transparent high-performance piezoceramics through pressureless sintering

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Journal of Advanced Ceramics 2024年第5期13卷 561-567页

作者： Hye-Lim Yu Woo-Seok Kang Ju-Hyeon Lee Temesgen Tadeyos Zate Young-Jin Lee Bo-Kun Koo Dong-Jin Shin min-soo Kim soon-Jong Jeong Young Ghyu ahn Wook Jo Department of Material Science and Engineering Ulsan National Institute of Science and TechnologyUlsan 44919Republic of Korea Energy Conversion Research Center Korea Electrotechnology Research InstituteChangwon 51543Republic of Korea MLCC Development Team Component Biz.UnitSamsung Electro-Mechanics Co.Ltd.Suwon 16674Republic of Korea

Piezoelectricity offers an electromechanical coupling that is widely utilized in transducer *** has been a consistent demand for transparent piezoelectric materials for optoelectrical ***,despite the inherent tradeoff between the transparency and the piezoelectricity,numerous strategies have been explored to develop the transparent piezoelectric ***,the most transparent piezoelectric materials developed to date is either a single crystal or materials that achieve transparency via hot-press sintering,limiting its industrial ***,we introduce a novel piezoelectric material that ensures transparency through co-doping and pressureless sintering of polycrystalline *** this study,we employed a compositional optimization approach to enhance the synergistic effect between the transparency and the piezoelectric properties of 0.71Pb(Mg_(1/3)Nb_(2/3))O_(3)–0.29PbTiO_(3)(PMN–0.29PT)*** utilizing the tape casting process for mass production and large-area manufacturing,our Pb_(0.913)La_(0.0145)Sm_(0.0145)(Mg_(1/3)Nb_(2/3))_(0.71)Ti_(0.29)O_(3)(TP2.9)ceramics exhibited over 60%transparency and large piezoelectric coefficient(d33)of 1104 pC/*** material holds considerable promise for a wide range of industrial applications in both the optical and electronic domains.

关键词： piezoelectric ceramics transparency pressureless sintering co-doping tape casting

1.45 GPa ultrastrong cryogenic strength with superior impact toughness in the in-situ nano oxide reinforced CrMnFeCoNi high-entropy alloy matrix nanocomposite manufactured by laser powder bed fusion

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Journal of Materials Science & Technology 2022年第2期97卷 10-19页

作者： Young-Kyun Kim min-Chul Kim Kee-ahn Lee Department of Materials Science and Engineering Inha UniversityIncheon 22212Republic of Korea Korea Atomic Energy Research Institute(KAERI) Daejeon 34057Republic of Korea

CrMnFeCoNi high-entropy alloys(HEAs)exhibit an excellent combination of tensile strength and ductility at cryogenic *** study led to the introduction of a new method for the development of high-performance CrMnFeCoNi HEAs at cryogenic temperatures by jointly utilizing additive manufacturing(AM)and the addition of interstitial *** interstitial oxygen present in the powder feedstock was transformed into beneficial nano-sized oxides during AM *** HEA nanocomposite fabricated using laser powder bed fusion(L-PBF)not only contains heterogeneous grains and substructures but also a high number density of nano-sized *** tensile results revealed that the L-PBF HEA nanocomposite has superior yield strengths of 0.77 GPa and 1.15 GPa,and tensile strengths of 0.92 GPa and 1.45 GPa at 298 K and 77 K,*** addition,the Charpy impact energies of the samples tested at 298 K and 77 K were measured as 176.2 J and 103.7 J,*** results indicate that the L-PBF HEA nanocomposite successfully overcomes the well-known strength-toughness *** tensile deformation microstructure contained a relatively large number of deformation twins(DTs)at cryogenic temperature,a possible consequence of the decrease in the stacking fault energy with decreasing *** the other hand,cracks were found to propagate along the grain boundaries at room temperature,whereas a transgranular crack was observed at cryogenic temperature in the specimens fractured as a result of the Charpy impact.

关键词： Laser powder bed fusion High-entropy alloy matrix nanocomposite Nano-oxide:cryogenic Tensile Impact toughness

PUB22 and PUB23 U-box E3 ubiquitin ligases negatively regulate 26S proteasome activity under proteotoxic stress conditions

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Journal of Integrative Plant Biology 2022年第3期64卷 625-631页

作者： min Yong ahn Dong Hye Seo Woo Taek Kim Department of Systems Biology Division of Life ScienceYonsei UniversitySeoul 03722Korea Institute of Life Science and Biotechnology Yonsei UniversitySeoul 03722Korea

The mechanism regulating proteasomal activity under proteotoxic stress conditions remains ***,we showed that arsenite-induced proteotoxic stress resulted in upregulation of Arabidopsis homologous PUB22 and PUB23 U-boxE3 ubiquitin ligases and that pub22 pub23 double mutants displayed arsenite-insensitive seed germination and root growth ***22/PUB23 downregulated 26 S proteasome activity by promoting the dissociation of the 19 S regulatory particle from the holo-proteasome complex,resulting in intracellular accumulation of UbG76 VGFP,an artificial substrate of the proteasome complex,and insoluble poly-ubiquitinated *** results suggest that PUB22/PUB23 play a critical role in arsenite-induced proteotoxic stress response via negative regulation of 26 S proteasome integrity.

关键词： Arabidopsis thaliana proteotoxic stress sodium arsenite U-box E3 ligases PUB22/23 26S proteasome complex

Intelligent Risk-Identification Algorithm with Vision and 3D LiDAR Patterns at Damaged Buildings

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Intelligent Automation & soft Computing 2023年第5期36卷 2315-2331页

作者： Dahyeon Kim Jiyoung min Yongwoo song Chulsu Kim Junho ahn Computer Information Technology Korea National University of TransportationChungju27469Korea Department of Railway Vehicle System Engineering Korea National University of TransportationUiwang16106Korea

Existingﬁreﬁghting robots are focused on simple storage orﬁre sup-pression outside buildings rather than detection or *** a large number of robots using expensive equipment is *** study aims to increase the efﬁciency of search and rescue operations and the safety ofﬁreﬁgh-ters by detecting and identifying the disaster site by recognizing collapsed areas,obstacles,and rescuers on-site.A fusion algorithm combining a camera and three-dimension light detection and ranging(3D LiDAR)is proposed to detect and loca-lize the interiors of disaster *** algorithm detects obstacles by analyzingﬂoor segmentation and edge patterns using a mask regional convolutional neural network(mask R-CNN)features model based on the visual data collected from a parallelly connected camera and 3D *** as objects are detected using you only look once version 4(YOLOv4)in the image data to localize persons requiring *** point cloud data based on 3D LiDAR cluster the objects using the density-based spatial clustering of applications with noise(DBSCAN)clustering algorithm and estimate the distance to the actual object using the center point of the clustering *** proposed artiﬁcial intelligence(AI)algorithm was veriﬁed based on individual sensors using a sensor-mounted robot in an actual building to detectﬂoor surfaces,atypical obstacles,and persons requiring ***,the fused AI algorithm was comparatively veriﬁed.

关键词： Three-dimension light detection and ranging vision risk identiﬁcation damaged building robot

Pathologic etiology and predictors of malignancy in children with cervical lymphadenopathy

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World Journal of Pediatrics 2023年第3期19卷 283-287页

作者： Jee Woo Kim Jee Yeon Baek Ji Young Lee Sung min Lim Ji-Man Kang Won Kee ahn Seung min Hahn Jung Woo Han Chuh Joo Lyu Jong Gyun ahn Department of Pediatrics Severance Children's HospitalYonsei University College of Medicine50-1 Yonsei-RoSeodaemun-guSeoul 03722South Korea Institute for Immunology and Immunological Diseases Yonsei University College of MedicineSeoulSouth Korea Division of Pediatric Hematology and Oncology Department of PediatricsYonsei University College of MedicineYonsei University Health SystemSeoulSouth Korea Department of Pediatric Hemato-Oncology Yonsei Cancer CenterYonsei University Health SystemSeoulSouth Korea

Cervical lymphadenopathy in children is a common disease entity that is accompanied by a variety of processes,ranging from benign disease to *** the cause of cer-vical lymphadenopathy in children is often benign[1-4],the presence of enlarged lymph nodes can cause anxiety to parents because of its association with *** should be considered for the histologic diagnosis of persistent or unex-plained cervical lymphadenopathy in ***,biopsy is an invasive examination method,and it is difficult to clinically determine whether biopsy is needed in children with unexplained cervical ***,clini-cians should be aware of the differential diagnosis of lymph node enlargement in children and should identify situations in which malignancy may be *** this study,we aimed to identify the etiology of pediatric cervical lymphadenopathy using biopsy and to analyze the risk factors associated with malignancy in children with cervical lymphadenopathy.

关键词： malignancy cervical diagnosis

Superior electrocatalytic negative electrode with tailored nitrogen functional group for vanadium redox flow battery

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Journal of Energy Chemistry 2023年第3期78卷 148-157,I0005页

作者： min Gu Kang Wook ahn Joonhee Kang Shin Ae song Kiyoung Kim Ju Young Woo Yong-Cheol Jeong Bonwook Koo Dae soo Jung Sung Nam Lim Micro/Nano Scale Manufacturing Group Korea Institute of Industrial Technology143 HanggaulroSangrok-guAnsan-siGyeonggi-do 15588Republic of Korea Department of Energy Systems Engineering Soonchunhyang University22 Soonchunhyang-roShinchang-myeonAsan-siChungcheongnam-do 31538Republic of Korea Department of Nanoenergy Engineering Pusan National UniversityBusan 46241Republic of Korea Department of Nano Fusion Technology Pusan National UniversityBusan 46241Republic of Korea Energy Storage Materials Center Energy&Environmental DivisionKorea Institute of Ceramic Engineering&Technology(KICET)101 Soho-roJinju-siGyeongsangnam-doRepublic of Korea

Development of electrodes with high electrocatalytic activity and stability is essential for solving problems that still restrict the extensive application of vanadium redox flow batteries(VRFBs).Here,we designed a novel negative electrode with superior electrocatalytic activity by tailoring nitrogen functional groups,such as newly formed nitro and pyridinic-N transformed to pyridonic-N,from the prenitrogen-doped *** was experimentally confirmed that an electrode with pyridonic-N and nitro fuctional groups(tailored nitrogen-doped graphite felt,TNGF) has superior electrocatalytic acivity with enhanced electron and mass *** functional theory calulations demonstrated the pyridonic-N and nitro functional groups promoted the adsorption,charge transfer,and bond formation with the vanadium species,which is consistent with expermental *** addition,the V2+/V3+redox reaction mechanism on pyridonic-N and nitro functional groups was estabilised based on density functional theory(DFT) *** TNGF was applied to a VRFB,it enabled enhanced-electrolyte utilization and energy efficiencies(EE) of 57.9% and 64.6%,respectively,at a current density of 250 mA cm^(-2).These results are 18.6% and 8.9% higher than those of VRFB with electrode containing graphitic-N and pyridinicN ***,TNGF-based VRFB still operated with an EE of 59% at a high current density of300 mA cm^(-2).The TNGF-based VRFB exhibited stable cycling performance without noticeable decay of EE over 450 charge-discharge cycles at a current density of 250 mA cm^(-2).The results of this study suggest that introducing pyridonic-N and nitro groups on the electrode is effective for improving the electrochemical performance of VRFBs.

关键词： Tailored nitrogen functional group Pyridonic-N Nitro Negative electrode Density functional theory Vanadium redoxﬂow batteries

Quantification of HBsAg:Basic virology for clinical practice

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World Journal of Gastroenterology 2011年第3期17卷 283-289页

作者： Jung min Lee Sang Hoon ahn Department of Internal Medicine Yonsei University College of Medicine Department of Internal Medicine Institute of GastroenterologyYonsei University College of Medicine Liver Cirrhosis Clinical Research Center

Hepatitis B surface antigen (HBsAg) is produced and secreted through a complex mechanism that is still not fully understood. In clinical fields, HBsAg has long served as a qualitative diagnostic marker for hepatitis B virus infection. Notably, advances have been made in the development of quantitative HBsAg assays, which have allowed viral replication monitoring, and there is an opportunity to make maximal use of quantitative HBsAg to elucidate its role in clinical fields. Yet, it needs to be underscored that a further understanding of HBsAg, not only from clinical point of view but also from a virologic point of view, would enable us to deepen our insights, so that we could more widely expand and apply its utility. It is also important to be familiar with HBsAg variants and their clinical consequences in terms of immune escape mutants, issues resulting from overlap with corresponding mutation in the P gene, and detection problems for the HBsAg variants. In this article, we review current concepts and issues on the quantification of HBsAg titers with respect to their biologic nature, method principles, and clinically relevant topics.

关键词：乙肝表面抗原临床实践病毒学乙型肝炎表面抗原 HBsAg 基因突变生物学特性病毒感染

Application of extracellular vesicles from mesenchymal stem cells promotes hair growth by regulating human dermal cells and follicles

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World Journal of Stem Cells 2022年第7期14卷 527-538页

作者： Ramya Lakshmi Rajendran Prakash Gangadaran Mi Hee Kwack Ji min Oh Chae Moon Hong Young KwanSung Jaetae Lee Byeong-Cheol ahn Department of Nuclear Medicine School of MedicineKyungpook National UniversityDaegu 41944South Korea BK21 FOUR KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents Department of Biomedical SciencesSchool of MedicineKyungpook National UniversityDaegu 41944South Korea Department of Immunology School of MedicineKyungpook National UniversityDaegu 41944South Korea Department of Nuclear Medicine Kyungpook National University HospitalDaegu 41944South Korea

BACKGROUND Dermal papillae(DP)and outer root sheath(ORS)cells play important roles in hair growth and regeneration by regulating the activity of hair follicle(HF)*** To investigate the effects of human mesenchymal stem cell-derived extracellular vesicles(hMSC-EVs)on DP and ORS cells as well as *** are known to regulate various cellular ***,the effects of hMSC-EVs on hair growth,particularly on human-derived HF cells(DP and ORS cells),and the possible mechanisms underlying these effects are *** hMSC-EVs were isolated and characterized using transmission electron microscopy,nanoparticle tracking analysis,western blotting,and flow *** activation of DP and ORS cells was analyzed using cellular proliferation,migration,western blotting,and real-time polymerase chain *** growth was evaluated ex vivo using human *** Wnt3a is present in a class of hMSC-EVs and associated with the EV ***-EVs promote the proliferation of DP and ORS ***,they translocateβ-catenin into the nucleus of DP cells by increasing the expression ofβ-catenin target transcription factors(Axin2,EP2 and LEF1)in DP *** with hMSC-EVs also promoted the migration of ORS cells and enhanced the expression of keratin(K)differentiation markers(K6,K16,K17,and K75)in ORS ***,treatment with hMSC-EVs increases hair shaft elongation in cultured human *** These findings suggest that hMSC-EVs are potential candidates for further preclinical and clinical studies on hair loss treatment.

关键词： Mesenchymal stem cells Extracellular vesicles Hair growth Dermal papillae Outer root sheath cells

Utilizing hybrid faradaic mechanism via catalytic and surface interactions for high-performance flexible energy storage system

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能源化学:英文版 2023年第8期83卷 541-548,I0013页

作者： Dong-Gyu Lee Hyeonggeun Choi Yeonsu Park min-Cheol Kim Jong Bae Park Suok Lee Younghyun Cho Wook ahn A-Rang Jang Jung Inn sohn John Hong Young-Woo Lee Department of Energy Engineering Soonchunhyang UniversityAsan 31538Republic of Korea Division of Physics and Semiconductor Science Dongguk University-SeoulSeoul 04620Republic of Korea Jeonju Centre Korea Basic Science InstituteJeonju 54907Republic of Korea Division of Electrical Electronic and Control EngineeringKongju National UniversityCheonan 31080Republic of Korea School of Materials Science and Engineering Kookmin UniversitySeoul 02707Republic of Korea

Improving the capacitance and energy density is a significant challenge while developing practical and flexible energy storage system(ESS).Redox mediators(RMs),as redox-active electrolyte additives,can provide additional energy storing capability via electrochemical faradaic contribution on electrodes for high-performance flexible ***,determining effective material combinations between electrodes and RMs is essential for maximizing surface faradaic redox reactions for energy-storage *** this study,an electrode-RM system comprising heterostructured hybrid(carbon fiber(CF)/MnO_(2)) faradaic electrodes and iodine RMs(I-RMs) in a redox-active electrolyte is *** CF/MnO_(2)with the 1-RMs(CF/MnO_(2)-I) induces dominant catalytic faradaic interaction with the I-RMs,significantly enhancing the surface faradaic kinetics and increasing the overall energy-storage *** CF/MnO_(2)-I ESSs show a 12.6-fold(or higher) increased volumetric energy density of 793.81 mWh L^(-1)at a current of 10 μA relative to ESSs using CF/MnO_(2)without I-RMs(CF/MnO_(2)).Moreover,the CF/MnO_(2)-I retains 93.1% of its initial capacitance after 10,000 cycles,validating the excellent ***,the flexibility of the ESSs is tested at different bending angles(180° to 0°),demonstrating its feasibility for flexible and high-wear ***,CF/MnO_(2)electrodes present a practical material combination for high-performance flexible energy-storage devices owing to the catalytic faradaic interaction with I-RMs.

关键词： Energy storage system Redox mediators Faradaic electrodes Catalytic interactions Mechanical stability