检索结果-南通市图书馆

Reliable high temperature, high humidity flexible thin film encapsulation using Al2O3/MgO nanolaminates for flexible OLEDs

引用

Nano Research 2020年第10期13卷 2716-2725页

作者： Ki Suk Kang so yeong jeong Eun Gyo jeong Kyung Cheol Choi School of Eetrical Enginerng Korea Advanced lstute of Sciencp and Tchcnoloy(KAIST) 291 Daehak roYuscong guDaejeon 34141Republic of Korea Department of Clothing and Textiles Chormam National University77 Yongbong.roBuk guGwangjiu 61186Republic of Korea

Since most organic materials are very sensitive to moisture and oxygen, organic light emitting diodes (OLEDs) require an encapsulation layer to protect the active layer from these gases. Since light, flexible and portable OLEDs are being employed in more diverse climates and environmental conditions, the OLED encapsulation layer must retain robust mechanical properties and stability in high temperature/high humidity conditions. Al2O3 films have demonstrated excellent barrier performance, but they readily hydrolyze when exposed to prolonged harsh environments. In this study, we fabricated a thin film encapsulation (TFE) film that was resistant to hydrolysis, using Al2O3/MgO (AM) nanolaminates. MgO has superior resistance to harsh environments, and the aluminate phase generated by the chemical reaction of Al2O3 and MgO provided excellent barrier performance, even after storage in harsh conditions. A multi-barrier fabricated using the AM nanolaminate showed excellent barrier performance, close to the level required by OLEDs. It did not significantly deteriorate even after a bending test of 1,000 iterations at 0.63% strain. After 1,000 cycle of bending, the electrical properties of the passivated OLEDs were not significantly degraded at shelf-lifetime test where the fabricated device was stored for 50 days in a harsh environment of 60℃, 90% relative humidity. The multi-barrier shows the best performance compared to previous studies on flexible encapsulation that can be used in harsh environments.

关键词： thin film encapsulation nanolaminate structure Al2O3 MgO flexible organic light emitting diode(OLED)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Foldable and washable textile-based OLEDs with a multi-functional near-room-temperature encapsulation layer for smart e-textiles

引用

npj Flexible Electronics 2021年第1期5卷 123-131页

作者： so yeong jeong Hye Rin Shim Yunha Na Ki Suk Kang Yongmin Jeon Seungyeop Choi Eun Gyo jeong Yong Cheon Park Ha-Eun Cho Junwoo Lee jeong Hyun Kwon Sung Gap Im Kyung Cheol Choi School of Electrical Engineering Korea Advanced Institute of Science and Technology(KAIST)DaejeonRepublic of Korea Department of Chemical and Biomolecular Engineering Korea Advanced Institute of Science and Technology(KAIST)DaejeonRepublic of Korea Department of Clothing and Textiles Chonnam National UniversityGwangjuRepublic of Korea Department of Display and Semiconductor Engineering Sun Moon UniversityAsanRepublic of Korea Department of Chemical and Biomolecular Engineering and KI for the NanoCentury Korea Advanced Institute of Science and Technology(KAIST)DaejeonRepublic of Korea.

Wearable electronic devices are being developed because of their wide potential applications and user *** them,wearable organic light emitting diodes(OLEDs)play an important role in visualizing the data signal processed in wearable electronics to *** this study,textile-based OLEDs were fabricated and their practical utility was *** textilebased OLEDs exhibited a stable operating lifetime under ambient conditions,enough mechanical durability to endure the deformation by the movement of humans,and washability for maintaining its optoelectronic properties even in water condition such as rain,sweat,or *** this study,the main technology used to realize this textile-based OLED was multi-functional nearroom-temperature *** outstanding impermeability of TiO_(2)film deposited at near-room-temperature was *** internal residual stress in the encapsulation layer was controlled,and the device was capped by highly crosslinked hydrophobic polymer film,providing a highly impermeable,mechanically flexible,and waterproof encapsulation.

关键词： OLEDs layer film

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Challenges to addressing the unmet medical needs for immunotherapy targeting cold colorectal cancer

引用

World Journal of Gastrointestinal Oncology 2023年第2期15卷 215-224页

作者： Keun-yeong jeong Research and Development Center PearlsinMiresSeoul 03690South Korea

With the establishment of the immune surveillance mechanism since the 1950s,attempts have been made to activate the immune system for cancer treatment through the discovery of various cytokines or the development of antibodies up to *** fruits of these efforts have contributed to the recognition of the 3rd generation of anticancer immunotherapy as the mainstream of cancer ***,the limitations of cancer immunotherapy are also being recognized through the conceptual establishment of cold tumors recently,and colorectal cancer(CRC)has become a major issue from this therapeutic point of ***,it is emphasized that non-clinical strategies to overcome the immunosuppressive environment and clinical trials based on these basic investigations are being made on the journey to achieve better treatment outcomes for the treatment of cold CRC.

关键词： Colorectal cancer Immunotherapy Cell therapy Checkpoint inhibitor Cancer vaccine Cytokine therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Poly adenosine diphosphate-ribosylation, a promising target for colorectal cancer treatment

引用

World Journal of Gastrointestinal Oncology 2021年第6期13卷 574-588页

作者： Keun-yeong jeong Minhee Park Research and Development Metimedi PharmaceuticalsIncheon 22006South Korea

The development of colorectal cancer(CRC)can result from changes in a variety of cellular systems within the tumor ***,it is primarily associated with genomic instability that is the gradual accumulation of genetic and epigenetic changes consisting of a characteristic set of mutations crucial for pathways in CRC *** on this background,the potential to focus on poly[adenosine diphosphate(ADP)-ribose]polymerase(PARP)-1 and poly-ADP ribosylation(PARylation)as the main causes of malignant formation of CRC may be *** of the important functions of PARP-1 and PARylation is its deoxyribonucleic acid(DNA)repair function,which plays a pivotal role in the DNA damage response and prevention of DNA damage maintaining the redox homeostasis involved in the regulation of oxidation and ***-1 and PARylation can also alter epigenetic markers and chromatin structure involved in transcriptional regulation for the oncogenes or tumor suppressor genes by remodeling histone and chromatin *** the high importance of these processes in CRC,it can be considered that PARP-1 and PARylation are at the forefront of the pathological changes required for CRC ***,this review addresses the current molecular biological features for understanding the multifactorial function of PARP-1 and PARylation in CRC related to the aforementioned roles;furthermore,it presents a summary of recent approaches with PARP-1 inhibition in non-clinical and clinical studies targeting *** understanding could help embrace the importance of targeting PARP-1 and PARylation in the treatment of CRC,which may present the potential to identify various research topics that can be challenged both nonclinically and clinically.

关键词： Colorectal cancer Poly adenosine diphosphate-ribose polymerase-1 Poly adenosine diphosphate-ribose Poly-adenosine diphosphate ribosylation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Inhibition of poly(ADP-Ribose)polymerase:A promising strategy targeting pancreatic cancer with BRCAness phenotype

引用

World Journal of Gastrointestinal Oncology 2021年第11期13卷 1544-1550页

作者： Keun-yeong jeong Haejun Lee R&D Center Metimedi PharmaceuticalsIncheon 22006South Korea Department of Nuclear Medicine Gil Medical CenterIncheon 21565South Korea

The use of chemotherapeutic regimens for the treatment of pancreatic cancer is still limited because pancreatic cancer is usually diagnosed at an advanced stage as a refractory disease in which symptoms are difficult to recognize in the early ***,at advanced stages,there are important challenges to achieve clinical benefit and symptom resolution,even with the use of an expanded spectrum of anticancer ***,a point of reduced susceptibility to conventional chemotherapies by breast cancer susceptibility gene(BRCA)mutations led to a new perspective for overcoming the resistance of pancreatic cancer within the framework of increased genome ***(ADP-Ribose)polymerase(PARP)-1 is an enzyme that can regulate intrinsic functions,such as response to DNA ***,in an environment where germline mutations in BRCAs(BRCAness)inhibit homologous recombination in DNA damage,resulting in a lack of DNA damage response,a key role of PARP-1 for the adaptation of the genome instability could be further ***,we summarized the key functional role of PARP-1 in genomic instability of pancreatic cancer with the BRCAness phenotype and listed clinical applications and outcomes of PARP-1 inhibitors to highlight the importance of targeting PARP-1 activity.

关键词： Pancreatic cancer BRCAness Poly(ADP-Ribose)polymerase-1 PARylation Poly(ADP-Ribose)polymerase-1 inhibitor

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer-specific metabolism:Promising approaches for colorectal cancer treatment

引用

World Journal of Gastrointestinal Oncology 2019年第10期11卷 768-772页

作者： Keun-yeong jeong The Research Center Metimedi Pharmaceuticals

Investigation of cancer-specific metabolism has made it possible to establish the principle that atypically reconstituted metabolism is considered a hallmark of cancer due to changes in physiological ***,a variety of targets depending on the prompted aerobic glycolysis process,starting from the abnormal uptake of glucose,and cancer-specific metabolism due to impaired mitochondrial function and abnormal expression of drug-metabolizing enzymes have been investigated and *** that most solid cancers rely on cancer-specific metabolism to support their growth,it is necessary to examine closely the specific processes of cancer metabolism and have a detailed understanding of how cellular metabolism is altered in colorectal cancer(CRC)related to CRC survival and *** development of key methods to regulate efficiently cancer-specific metabolism in CRC is still in the initial ***,targeting cancer-specific metabolism will yield treatable methods that are critical as a new area of development strategies for CRC treatment.

关键词： Colorectal cancer Cancer metabolism Warburg effect Aerobic glycolysis Mitochondria metabolism

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Inhibiting focal adhesion kinase:A potential target for enhancing therapeutic efficacy in colorectal cancer therapy

引用

World Journal of Gastrointestinal Oncology 2018年第10期10卷 290-292页

作者： Keun--yeong jeong Division of Research and Development Metimedi Pharmaceuticals

Focal adhesion kinase(FAK) is a major integrin- dep-endent tyrosine phosphorylated protein, recently, FAK association with colorectal cancer(CRC) has gained at-tention. The various cancer-promoting mechanisms that associated with FAK can be implicated in the progression of CRC. The interactions between structural features of FAK and various kinases could be closely related to growth, survival, and metastasis in CRC cells. These interactions include human epithelial growth factor re-ceptor, c-Met, platelet-derived growth factor receptor, vascular endothelial growth factor receptor, and Src. Such interactions can trigger the survival signaling of CRC cells and are also involved signaling downstream of phosphatidylinositol 3-kinase, AKT, and the extracellular regulated kinase. Based on this scientific background, many pharmaceutical companies are taking efforts to develop FAK inhibitors to treat solid cancer including CRC. Although the anti-cancer efficacies have been noted in many studies, the commercial drugs have not been deve-loped yet. Therefore, the FAK research on CRC is expec-ted to gain momentum and be highly appreciated as a potential field for developing the new drugs. Therefore, the studies on FAK that effect on the progression of human CRC s would be possible to suggest various app-roaches to CRC treatment, and FAK could be a potential target as an anticancer candidate for CRC therapies.

关键词： Colorectal cancer Focal adhesion kinase Focal adhesion kinase inhibitor Anticancer effect

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Paleo-shoreline changes in moraine dammed lake Khagiin Khar, Khentey Mountains, Central Mongolia

引用

Journal of Mountain Science 2019年第6期16卷 1215-1230页

作者： OH jeong-Sik SEONG yeong Bae HONG Seongchan YU Byung Yong Department of Geography Education Korea UniversityAnam-Ro 145Seongbuk-GuSeoul 02841Korea AMS Laboratory Advanced Analysis CenterKorea Institute of Science and TechnologySeoul 02791Korea

The formation and evolution of glacier moraine-dammed lakes are closely related to past glacier expansion and retreat. Geomorphic markers such as lacustrine terraces and beach ridges observed in these lakes provide important evidence for regional paleoenvironment reconstruction. We document the magnitude of paleo-shoreline fluctuations and timings of highstands of lake water by using cosmogenic 10Be surface exposure dating and optically stimulated luminescence(OSL) dating on samples collected from lacustrine sediment and bedrock strath in Lake Khagiin Khar. The lake was initially impounded by glacier moraine at the Global Last Glacial maximum(gLGM;21–19 ka), and the lake reached its maximum paleo-shoreline level of 1840 m at sea level(a.s.l.). At that time, the stored lake water amount was up to seven times greater and the surface area was three times larger than the present values. The paleolake experienced higher shoreline levels at 1832, 1822, and 1817 m a.s.l. and reached the present lake level after 0.4 ka. We interpret that decrease in the paleolake level was caused by spillover. The increase in melt water after the gLGM and the Late Glacial exceeded the storage threshold of the lake, and the paleolake water overflowed across the lowest drainage divides. The lake spilled over across the lowest bedrock ridge at 15.9 ± 0.6 ka, and the outlet was incised since that time at a rate of 3.72 ± 0.15 mm/yr. The initial stream of the Khiidiin Pass River was disturbed by LGM moraine damming and was rerouted into the present course running through moraine after the spillover at 15.9 ± 0.6 ka.

关键词： Moraine-dammed lake Lake Khagiin Khar Shoreline Spillover 10Be exposure dating

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Accumulation of poly(adenosine diphosphate-ribose)by sustained supply of calcium inducing mitochondrial stress in pancreatic cancer cells

引用

World Journal of Gastroenterology 2022年第27期28卷 3422-3434页

作者： Keun-yeong jeong Jae Jun Sim Minhee Park Hwan Mook Kim Research and Development Metimedi PharmaceuticalsIncheon 22006South Korea

BACKGROUND The biochemical phenomenon defined as poly adenosine diphosphate(ADP)-ribosylation(PARylation)is essential for the progression of pancreatic ***,the excessive accumulation of poly ADP-ribose(PAR)induces apoptosis-inducing factor(AIF)release from mitochondria and energy deprivation resulting in the caspase-independent death of cancer *** To investigate whether sustained calcium supply could induce an anticancer effect on pancreatic cancer by PAR *** Two pancreatic cancer cell lines,AsPC-1 and CFPAC-1 were used for the *** influx and mitochondrial reactive oxygen species(ROS)were observed by fluorescence *** in enzyme levels,as well as PAR accumulation and energy metabolism,were measured using assay ***-dependent cell death was investigated followed by confirming in vivo anticancer effects by sustained calcium *** Mitochondrial ROS levels were elevated with increasing calcium influx into pancreatic cancer ***,excess PAR accumulation,decreased PAR glycohydrolase and ADP-ribosyl hydrolase 3 levels,and energy deprivation were *** vitro and in vivo antitumor effects were confirmed to accompany elevated AIF *** This study visualized the potential anticancer effects of excessive PAR accumulation by sustained calcium supply on pancreatic cancer,however elucidating a clear mode of action remains a challenge,and it should be accompanied by further studies to assess its potential for clinical application.

关键词： Pancreatic cancer Calcium Reactive oxygen species Poly adenosine diphosphate-ribose Poly adenosine diphosphate-ribosylation Poly adenosine diphosphate-ribose polymerase Apoptosis-inducing factor Nicotinamide adenine dinucleotide Anticancer effect

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Surface characteristics of HA coated Ti-Hf binary alloys after nanotube formation

引用

中国有色金属学会会刊：英文版 2009年第4期19卷 852-856页

作者： Yong-Hoon jeong Won-Gi KIM Geun-Hyeong PARK Han-Cheol CHOE yeong-Mu KO Department of Dental Materials & Research Center of Nano-Interface Activation for Biomaterials College of DentistryChosun University Research Center for Oral Disease Regulation of the Aged College of DentistryChosun University

Ti-Hf binary alloys contained 10%,20%,30% and 40%(mass fraction)Hf were manufactured in the vacuum furnace *** then,specimens were homogenized for 24 h at 1 000 ℃ in argon *** formation of oxide nanotubes was conducted by anodic oxidation on the Ti-Hf alloy in 1 mol/L H3PO4 electrolytes containing small amounts of NaF at room *** hydroxyapatite(HA) coating made of tooth ash prepared by electron-beam physical vapor deposition(EB-PVD) *** corrosion behaviors of the specimens were examined through potentiodynamic test in 0.9% NaCl solution by *** microstructures of the alloys were examined by field emission scanning electron microscopy(FE-SEM) and x-ray diffractometer(XRD).It was observed that the lamellar structure translated to needle-like structure with Hf *** formed and HA coated Ti-xHf alloys had a good corrosion resistance.

关键词：二元合金 HA涂层纳米管表面特性管形 0.9%NaCl溶液物理气相沉积铪

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：