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Journal of Biosafety and Biosecurity 2024年第3期6卷 157-169页

作者： Ranjan K.mohapatra Ahmed mahal Pranab K.mohapatra Ashish K.Sarangi snehasish m..hra meshari A.Alsuwat Nada N.Alshehri Sozan m.Abdelkhalig mohammed Garout mohammed Aljeldah Ahmad A.Alshehri Ahmed Saif mohammed Abdulrahman Alshahrani Ali S.Alqahtani Yahya A.Almutawif Hamza m.A.Eid Faisal m Albaqami mohnad Abdalla Ali A.Rabaan Department of Chemistry Government College of EngineeringKeonjhar 758002OdishaIndia Department of medical Biochemical Analysis College of Health TechnologyCihan University–ErbilErbilKurdistan RegionIraq Department of Chemistry CV Raman Global UniversityBhubaneswarOdishaIndia Department of Chemistry School of Applied SciencesCenturion University of Technology and ManagementBalangirOdishaIndia School of Biotechnology Campus-11KIIT Deemed-to-be-UniversityBhubaneswar 751024OdishaIndia Clinical Laboratory Sciences Department College of Applied Medical SciencesTaif UniversityAl-Taif 21974Saudi Arabia Internal medicine Department King Khalid University Medical CityCollege of MedicineAbha 61481Saudi Arabia Department of Basic medical Sciences College of MedicineAlMaarefa UniversityRiyadhSaudi Arabia Department of Community medicine and Health Care for Pilgrims Faculty of MedicineUmm Al-Qura UniversityMakkah 21955Saudi Arabia Department of Clinical Laboratory Sciences College of Applied Medical SciencesUniversity of Hafr Al BatinHafr Al Batin 39831Saudi Arabia Department of Clinical Laboratory Sciences Faculty of Applied Medical SciencesNajran UniversityNajran 61441Saudi Arabia Department of medical Laboratory Sciences Faculty of Applied Medical SciencesKing Khalid UniversityAbha 61481Saudi Arabia mDepartment of medical Laboratories Technology College of Applied Medical SciencesTaibah UniversityMadinah 41411Saudi Arabia Biology Department College of ScienceIslamic University of MadinahMadinah 42351Saudi Arabia Pediatric Research Institute Children’s Hospital Affiliated to Shandong UniversityJinanShandong 250022China molecular Diagnostic Laboratory Johns Hopkins Aramco HealthcareDhahran 31311Saudi Arabia College of medicine Alfaisal UniversityRiyadh 11533Saudi Arabia Department of Public Health and Nutrition The University of HaripurHaripur 22610Pakistan

Outbreaks of monkeypox(mpox)in over 100 non-endemic countries in 2022 represented a serious global health *** a neglected disease,mpox has become a global public health issue.A42R profilinlike protein from mpox(PDB ID:4QWO)represents a potential new lead for drug development and may interact with various synthetic and natural *** this report,the interaction of A42R profilinlike protein with six phytochemicals found in the medicinal plant Ficus religiosa(abundant in India)was *** on the predicted and compared protein–ligand binding energies,biological properties,IC_(50) values and toxicity,two compounds,kaempferol(C-1)and piperine(C-4),were *** characteristics and quantitative structure–activity relationship(QSAR)of these two compounds were determined,and molecular dynamics(mD)simulations were *** silico examination of the kaempferol(C-1)and piperine(C-4)interactions with A42R profilin-like protein gave best-pose ligandbinding energies of–6.98 and–5.57 kcal/mol,*** predicted IC_(50) of C-1 was 7.63 lm and 82 lm for *** data indicated that kaempferol and piperine are non-mutagenic,and the QSAR data revealed that piperlongumine(5.92)and piperine(5.25)had higher log P values than the other compounds *** simulations of A42R profilin-like protein in complex with C-1 and C-4 were performed to examine the stability of the ligand–protein ***/C and C-4 showed the highest affinity and activities,they may be suitable lead candidates for developing mpox therapeutic *** study should facilitate discovering and synthesizing innovative therapeutics to address other infectious diseases.

关键词： monkeypox mpox Phytochemical molecular docking mD simulation ADmET QSAR

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Phenomenological modelling of flow behaviour of 20mnmoNi55 reactor pressure vessel steel at cryogenic temperature with different strain rates

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Defence Technology（防务技术） 2019年第3期15卷 326-337页

作者： Swagatam Paul Partha Dey snehasish Bhattacharjee Sanjib Kumar Acharyya Prasanta Sahoo Jayanta Chattopadhyay Department of mechanical Engineering Jadavpur University Kolkata India Department of mechanical Engineering Academy of Technology Hooghly West Bengal India Bhaba Atomic Research Centre Mumbai India

In the present study a phenomenological constitutive model is developed to describe the flow behaviour of 20mnmoNi55 low carbon reactor pressure vessel (RPV) steel at sub-zero temperature under different strain rates. A set of uniaxial tensile tests is done with the variation of strain rates and temperature ranging from 10^-4s^-1 to 10^-1s^-1 and -80℃ to 140℃ respectively. From the experimental data, family of flow curves at different temperatures and strain rates are generated and fitted exponentially. The strain rate and temperature dependence of the coefficients of the exponential flow curves are extracted from these curves and characterised through a general phenomenological constitutive coupled equation. The coefficients of this coupled equation are optimised using genetic algorithm. Finite element simulation of tensile tests at different strain rates and temperatures are done using this coupled equation in material model of Abaqus FEA software and validated with experimental results. The novelties of proposed model are:(a) it can predict precisely the flow behaviour of tensile tests (b) it is a simple form of equation where fitting parameters are both function of strain rate ratio and temperature ratio,(c) it has ability to characterize flow behaviour with decreasing subzero temperatures and increasing strain rates.

关键词： Flow behaviour RPV steel Cryogenic temperature Strain rate

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Analysis of community question-answering issues via machine learning and deep learning:State-of-the-art review

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CAAI Transactions on Intelligence Technology 2023年第1期8卷 95-117页

作者： Pradeep Kumar Roy Sunil Saumya Jyoti Prakash Singh snehasish Banerjee Adnan Gutub Department of Computer Science and Engineering Indian Institute of Information TechnologySuratIndia Indian Institute of Information Technology DharwadIndia Department of Computer Science and Engineering National Institute of TechnologyPatnaIndia The York management School University of YorkYorkUK Computer Engineering Department College of Computer&Information SystemsUmm Al-Qura UniversityMakkahSaudi Arabia

Over the last couple of decades,community question-answering sites(CQAs)have been a topic of much academic *** have often leveraged traditional machine learning(mL)and deep learning(DL)to explore the ever-growing volume of content that CQAs *** clarify the current state of the CQA literature that has used mL and DL,this paper reports a systematic literature *** goal is to summarise and synthesise the major themes of CQA research related to(i)questions,(ii)answers and(iii)*** final review included 133 *** research themes include question quality,answer quality,and expert *** terms of dataset,some of the most widely studied platforms include Yahoo!Answers,Stack Exchange and Stack *** scope of most articles was confined to just one platform with few cross-platform *** with mL outnumber those with ***,the use of DL in CQA research is on an upward trajectory.A number of research directions are proposed.

关键词： answer quality community question answering deep learning expert user machine learning question quality

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