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Nationwide retrospective study of hepatitis B virological response and liver stiffness improvement in 465 patients on nucleos(t)ide analogue

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World Journal of Gastroenterology 2022年第31期28卷 4390-4398页

作者： Alnoor ramji Karen Doucette Curtis Cooper Gerald Yosel Minuk Mang Ma Alexander Wong David Wong Edward Tam Brian Conway David Truong Philip Wong Lisa Barrett Hin Hin Ko Sarah Haylock-Jacobs Nishi patel Gilaad G Kaplan Scott Fung Carla S Coffin Department of Medicine University of British ColumbiaVancouver v6t 1z3Canada Department of Medicine University of AlbertaEdmonton t6g 2r7Canada Department of Medicine The Ottawa Hospital Research InstituteUniversity of OttawaOttawa ON K1H 8L6Canada Department of Medicine University of ManitobaWinnipeg r3e 3j7Canada Department of Medicine University of SaskatchewanSaskatoon s7n 5e5Canada Department of Medicine University Health NetworkToronto m5g 2c4Canada Pacific Gastroenterology Associates Vancouver v6z 2k5Canada Vancouver Infectious Disease Centre Vancouver v6z 2c7Canada Department of Medicine McGill UniversityMontreal h3a 0g4Canada Department of Microbiology and Immunology Dalhousie UniversityHalifax b3h 4r2Canada Cumming School of Medicine University of CalgaryCalgary t2n 1n4Canada

BACKGrOUND Hepatitis B virus(HBV)nucleos(t)ide analog(NA)therapy reduces liver disease but requires prolonged therapy to achieve hepatitis B surface antigen(HBsAg)*** is limited North American real-world data using non-invasive tools for fibrosis assessment and few have compared 1st generation NA or lamivudine(LAM)to tenofovir disoproxil fumarate(TDF).AIM To assess impact of NA on virological response and fibrosis regression using liver stiffness measurement(LSM)(i.e.,FibroScan®).METHODS retrospective,observational cohort study from the Canadian HBV *** collected included demographics,NA,HBV DNA,alanine aminotransferase(ALT),and *** were HBV monoinfected patients,treatment naïve,and received 1 NA with minimum 1 year *** In 465(median 49 years,37%female,35%hepatitis B e antigen+at baseline,84%Asian,6%White,and 9%Black).Percentage of 64(n=299)received TDF and 166 were LAM-treated with similar median duration of 3.9 and 3.7 years,*** mean baseline LSM was 11.2 kPa(TDF)vs 8.3 kPa(LAM)(P=0.003).At 5-year follow-up,the mean LSM was 7.0 kPa in TDF vs 6.7 kPa in LAM(P=0.83).There was a significant difference in fibrosis regression between groups(i.e.,mean-4.2 kPa change in TDF and-1.6 kPa in LAM,Preatment showed that all had normal ALT,but more TDF patients were virologically suppressed(reated(n=35/58,60%)(Pred *** In this real-world North American study,approximately 5 years of NA achieves liver fibrosis regression rarely leads to HBsAg loss.

关键词： Nucleos(t)ide analog therapy Functional cure Hepatitis B virus surface antigen loss Fibrosis regression Liver stiffness measurement Transient elastography

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Structure of Some 4f rare Earth Liquid Metals --A Charged Hard Sphere Approach

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Communications in Theoretical Physics 2006年第2X期46卷 337-342页

作者： P.B. Thakor P.N. Gajjar A.r. Jani Department of Physics Veer Nazmad South Gujarat University Udhana Magdalla Road Surat 395 007 Gujarat India Department of Physics Oujarat University Ahmedabd Oujarat India Department of Physics Sardar Patel University Vallabh Vidyanagar 388 120 Gujarat India

A well-established pseodopotential is used to study the structure of some 4f rare earth liquid metals （Ce, Pr, Eu, Gd, Tb, and Yb）. The structure factor S（q）, pair distribution function g（r）, interatomic distance r1, and coordination number n1 are calculated using Charged Hard Sphere （CHS） reference system. To introduce the exchange and correlation effects, the local field correction due to Sarkar et al. （S） is applied. The present investigation is successful in generating the structural information of Ce, Pr, Eu, Gd, Tb, and Yb 4f rare earth liquid metals.

关键词： pseudopotential structure factor pair distribution function interatomic distance

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re-re-treatment of hepatitis C virus: Eight patients who relapsed twice after direct-acting-antiviral drugs

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World Journal of Gastroenterology 2015年第43期21卷 12430-12438页

作者： Joshua Hartman Kian Bichoupan Neal patel Sweta Chekuri Alyson Harty Douglas Dieterich Ponni Perumalswami Andrea D Branch Department of Medicine Icahn School of Medicine at the Mount Sinai Medical Center Division of Liver Disease Icahn School of Medicine at the Mount Sinai Medical Center

AIM: To determine risk factors associated with hepatitis C virus(HCV) treatment failure after direct acting antivirals in patients with complex treatment ***: All HCV mono-infected patients who received treatment at our institution were *** was restricted to patients who previously failed treatment with boceprevir(BOC) or telaprevir(TVr) and started simeprevir(SMV) and sofosbuvir(SOF) ± ribavirin(rBV) between December 2013 and June 2014. Patients with human immunodeficiency virus(HIV)/HCV co-infection or patients who received a liver transplant in the past were excluded. Viral loads were recorded while on treatment and after treatment. Data collection continued until December,31 st 2014 when data analysis was initiated. Patients missing virologic outcomes data were not included in the analysis. Analysis of 35 patients who had virologic outcome data available resulted in eight patients who were viral load negative at the end of treatment with SMF/SOF but later relapsed. Data related to patient demographics,HCV infection,and treatment history was collected in order to identify risk factors shared among patients who failed treatment with SMF/***: Eight patients who were treated with the first generation HCV protease inhibitors BOC or TVr in combination with pegylated-interferon(PEG) and rBV who failed this triple therapy were subsequently retreated with an off-label all-oral regimen of SMV and SOF for 12 wk,with rBV in seven cases. Treatment was initiated before the Food and Drug Administration approved a 24-wk SMV/SOF regimen for patients with liver cirrhosis. All eight patients had an end of treatment response,but later relapsed. Eight(100%) patients were male. Mean age was 56(range,49-64). Eight(100%) patients had previously failed PEG/rBV dual therapy at least once in addition to prior failure with triple therapy. Total number of times treated ranged from 3-6(mean 3.8). Eight(100%) patients were male had liver cirrhosis as determi

关键词： Hepatitis C Protease inhibitor relapse Simeprevir

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12月份住院的急性心肌梗死患者的循证治疗和死亡率

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世界核心医学期刊文摘(心脏病学分册) 2006年第3期 18-19页

作者： Meine T. J. patel M. r. DePuy V. 王亭忠 877-B West Faris road Greenville SC 29605 United States Dr.

Background: Previous studies suggest that patients hospitalized with acute myocardial infarction(MI) in December have poor outcomes, and some studies have hypothesized that the cause may be the infrequent use of evidence-based therapies during the December holiday season. Objective: To compare the care and outcomes of patients with acute MI hospitalized in December and patients hospitalized during other months. Design: retrospective analysis of data from the Cooperative Cardiovascular Project. Setting: Nonfederal, acute care hospitals in the United States. Patients: 127 959 Medicare beneficiaries hospitalized between January 1994 and February 1996 with confirmed acute MI. Measurements: Use of aspirin, β -blockers, and reperfusion therapy(thrombolytic therapy or percutaneous coronary intervention), and 30-day mortality. results: When the authors controlled for patient, hospital, and physician characteristics, the use of evidence-based therapies was not significantly lower but 30-day mortality was higher(21.7% vs. 20.1% ; adjusted odds ratio, 1.07 95% CI, 1.02 to 1.12 ) among patients hospitalized in December. Limitations: This was a nonrandomized, observational study. Unmeasured characteristics may have contributed to outcome differences. Conclusions: Thirty-day mortality rates were higher for Medicare patients hospitalized with acute MI in December than in other months, although the use of evidence-based therapies was not significantly lower.

关键词：死亡率患者 AM 循证治疗

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Utilizing the Illumina deep sequencing technique to define the maize transcriptome

Utilizing the Illumina deep sequencing technique to define t...

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第十三届全国植物基因组学大会

作者： Tesfamichael Kebrom Thomas P.Brutnell Christopher r.Myers Lalit Ponnala Neeru Gandotra S.Lori Tausta Timothy Nelson Nicholas Provart rohan patel Edwin reidel robert Turgeon Boyce Thompson Institute Cornell UniversityIthacaNew York 14853USA Bovce Thompson Institute Cornell UniversityIthacaNew York 14853USA Computational Biology Service Unit Cornell UniversityIthacaNew York 14853USA Department of Molecular Cellular and Developmental BiologyYale UniversityNew HavenConnecticut 6520USA Department of Cell and Systems Biology University of TorontoTorontoOntario 656362Canada Department of Plant Biology Cornell UniversityIthacaNew York 14853USA

Illumina deep sequencing technique is a powerful tool for plant biologists to define the plant transcriptome in *** this technique,we successfully examined the photosynthetic differentiation along a developing maize l...

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梅奥诊所及其所在地区新近诊断的房颤患者的结局

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世界核心医学期刊文摘（心脏病学分册） 2005年第4期1卷 28-29页

作者： patel P. J. Keating r. J. Gersh B. J. 郭宁

This study examined the prognostic significance of atrial fibrillation(AF) in a community-based cohort. AF,the most common cardiac dysrhythmia, frequently oc curs in the presence of concomitant medical illness. Population-based studies h ave associated AF with excess mortality, and this risk of death is independent o f concomitant cardiovascular disease. The effect of noncardiovascular medical il lnesses on mortality in patients who have AF has not been determined. We examine d a community-based cohort of 390 residents of Olmsted County, Minnesota, who h ad newly diagnosed AF; patients were identified retrospectively but followed pro spectively. The cohort in cluded all patients who had electrocardiographically proved first-onset AF; p atients were not excluded on the basis of medical illness. Mean age of the cohor t was 73±14 years(56%were men). Mean follow-up was 2.7±1.7 years. Onset of A F frequently occurred during hospitalization(78%). One hundred sixty-six death s occurred, a death rate significantly higher than expected for the cohort. Most deaths had a noncardiovascular cause. This trend was maintained for patients wh o had no previous cardiovascular disease and for those who had a cardiovascular diagnosis at the time AF was diagnosed. AF is observed frequently among hospital ized patients who are medically ill. The survival rate of these patients is low, but AF may be only a minor component of the excess mortality.

关键词：梅奥诊所心脏节律心血管疾病死亡风险明尼苏达州

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急性阑尾炎的处理——腹腔镜阑尾切除术对于女性病人尤为适用

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英国医学杂志中文版 2003年第2期6卷 76-77页

作者： Irving S Benjamin A G patel 陈雷 professor of surgery. consultant suryeon.King's College Hospital London WC2R 2LS

上溯到19世纪80年代就有人对没有穿孔的急性阑尾炎实施了早期阑尾切除手术。直到今日,这种手术依然是西方国家最常见的手术,在美国每年占去了100万个住院日。尽管有100多年的经验,外科大夫仍然很难准确地诊断阑尾炎,并且必须在避免阑尾... 详细信息

上溯到19世纪80年代就有人对没有穿孔的急性阑尾炎实施了早期阑尾切除手术。直到今日,这种手术依然是西方国家最常见的手术,在美国每年占去了100万个住院日。尽管有100多年的经验,外科大夫仍然很难准确地诊断阑尾炎,并且必须在避免阑尾穿孔及其并发症与切掉一个“阴性”阑尾之间进行权衡。“阴性阑尾”是指病人的腹疼是由其他原因所引起,其阑尾正常。这种阴性阑尾切除的发生率可高达20％,这本身就是一个大问题。

关键词：急性阑尾炎腹腔镜阑尾切除术女性伤口感染疼痛

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Aloin attenuates chronic constriction injury-induced neuropathic pain in rats by inhibiting inflammatory cytokines and oxidative stress

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Asian Pacific Journal of Tropical Biomedicine 2021年第5期11卷 205-213页

作者： Aarti S.Kale Avinash r.Wadkar Umesh B.Mahajan Lalit A.Birari Sateesh Belemkar Sameer N.Goyal Shreesh Ojha Sanjay J.Surana Chandragouda r.Patil Kalpesh r.Patil Department of Pharmacology R.C.Patel Institute of Pharmaceutical Education and ResearchShirpur-425405Dist.DhuleMaharashtraIndia School of Pharmacy&Technology Management SVKM's NMIMSMPTPShirpur-425405Dist-DhuleMaharashtraIndia Shri Vile Parle Kelavani Mandal's Institute of Pharmacy Dhule-424001MaharashtraIndia Department of Pharmacology and Therapeutics College of Medicine and Health SciencesUnited Arab Emirates UniversityP.O.Box 17666Al AinAbu DhabiUAE Department of Pharmacognosy R.C.Patel Institute of Pharmaceutical Education and ResearchShirpur-425405Dist.DhuleMaharashtraIndia

Objective:To investigate the effect of aloin against chronic constriction injury(CCI)-induced neuropathic pain in ***:rats were randomly divided into 7 groups:GroupⅠ(normal control),GroupⅡ(sham-operated),GroupⅢ(CCI control)and GroupⅣ,Ⅴ,Ⅵ,andⅦ,which underwent CCI surgery and then were administered with aloin(5 mg/kg,p.o.;25 mg/kg,p.o.;125 mg/kg,p.o.)and gabapentin(50 mg/kg,p.o.),respectively for 14 *** neuropathy was induced by silk ligatures(4-0)loosely placed around the sciatic *** thresholds against mechanical stimuli(Von-Frey filaments)and thermal stimuli(12℃and 40℃)were measured at midplantar paw region ipsilateral to the compressed nerve on day-3,7,11,and *** concentration of cytokines including tumor necrosis factor-α(TNF-α),interleukin-6,and interleukin-1βwas estimated at *** day 14,motor nerve conduction velocity was determined under urethane anesthesia(1.25 g/kg).Oxidative stress parameters(malondiadehyde,glutathione,catalase,and superoxide dismutase)were estimated in sciatic nerve homogenates at day *** nerve samples were processed for histological ***:Aloin significantly reduced CCI-induced mechanical and thermal *** also improved motor nerve conduction velocity and decreased oxidative stress in nerve *** addition,it decreased pro-inflammatory cytokine levels and restored the histoarchitecture of compressed sciatic ***:Aloin mitigates CCI-induced neuropathic pain in rats by inhibiting oxidative stress and pro-inflammatory cytokines in the afflicted sciatic nerve.

关键词： Aloin Chronic constriction injury Antioxidant Neuropathic pain

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纤维素纤维运动服面料

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国际纺织导报 2021年第9期49卷 44-46页

作者： A.Chakrabarty S.Bhaumik K.patel r.Nagpure A.Bansode 靳美琦(译) 孟粉叶(校) Grasim工业有限公司纺织研发中心(TrADC)(印度) 不详

旨在研究运动服面料中纤维素纤维含量的可行性和兼容性,特别是Aditya Birla集团开发的Birla莫代尔纤维,其针织结构面料的性能可与市售针织运动服面料相媲美。在运动服装中加入纤维素纤维有助于减少环境中的碳排放量,提高可持续性。基于... 详细信息

旨在研究运动服面料中纤维素纤维含量的可行性和兼容性,特别是Aditya Birla集团开发的Birla莫代尔纤维,其针织结构面料的性能可与市售针织运动服面料相媲美。在运动服装中加入纤维素纤维有助于减少环境中的碳排放量,提高可持续性。基于此,开发了不同的纱线和针织面料以增加运动服的商业附加值。以疏水纤维和亲水纤维比例约为60/40的褶裥织物和单面纬平针织和为研究对象,对作为运动服服用面料的首要要求即吸湿排汗及穿着舒适性能进行了考察。

关键词：运动服面料纤维素纤维吸湿性能舒适性

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类风湿病中左心室收缩功能障碍:一种未被认识的负荷?

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世界核心医学期刊文摘（心脏病学分册） 2006年第8期2卷 58-59页

作者： Bhatia G.S. Sosin M.D. patel J.V. r.C. Davis 孙凯 University Department of Medicine City Hospital Dudley Road Birmingham West Midlands United Kingdom Dr.

OBJECTIVES: This study sought to ascertain whether left ventricular systolic dysfunction(LVSD) is more common among clinic patients with rheumatoid disease(rD) compared with the general population, and to assess the diagnostic utility of brain natriuretic peptide(BNP). BACKGrOUND:Patients with rD are at increased risk of ischemic heart disease. However, there are few large echocardiographic studies identifying cardiac dysfunction in rD. We hypothesized that LVSD would be more prevalent in rD patients than in the general population. METHODS: A total of 226 hospital out-patients with rD(65% women) underwent clinical evaluation, electrocardiography(ECG), echocardiography, and plasma BNP assay(218 patients). Prevalence of LVSD was compared with local population estimates. rESULTS: Definite LVSD(left ventricular ejection fractionrred in 5.3% of the rD group: standardized prevalence ratio,3.20; 95% confidence interval, 1.65 to 5.59. Median BNP values were higher in patients with LVSD compared with those without: 16.6 pmol/l versus 8.5 pmol/l, proups overlapped. One in nine patients with an abnormal ECG had definite LVSD. CONCLUSIONS: Definite LVSD was three times more common in rD patients than in the general population. Given the prognostic benefits of treating LVSD, echocardiographic screening of rD patients with an abnormal ECG may be worthwhile.

关键词：左心室收缩功能障碍类风湿病脑利钠肽(BNP) 超声心动图检查 ECG异常正常人群负荷缺血性心脏病左室射血分数

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