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Biological characteristics and clinical management of uveal and conjunctival melanoma

Oncology Research 2024年第8期32卷 1265-1285页

作者： snježana kaštelan ana DIDOVIĆPAVIČIĆ DARIA PAŠALIĆ TAMARA NIKUŠEVA-MARTIĆ SAMIRČANOVIĆ PETRA KOVAČEVIĆ SUZana KONJEVODA School of Medicine University of ZagrebZagreb10000Croatia Department of Ophthalmology Clinical Hospital DubravaZagreb10000Croatia Department of Ophthalmology Zadar General HospitalZadar23000Croatia Department of Medical Chemistry Biochemistry and Clinical ChemistrySchool of MedicineUniversity of ZagrebZagreb10000Croatia Department of Biology and Genetics School of MedicineUniversity of ZagrebZagreb10000Croatia School of Medicine University of SplitSplit21000Croatia Department of Health Studies University of ZadarZadar23000Croatia

Uveal and conjunctival melanomas are relatively rare tumors;nonetheless,they pose a signiﬁcant risk of mortality for a large number of affected *** pathogenesis of melanoma at different sites is very similar,however,the prognosis for patients with ocular melanoma remains unfavourable,primarily due to its distinctive genetic proﬁle and tumor *** of considerable advances in understanding the genetic characteristics and biological behaviour,the treatment of uveal and conjunctival melanoma remains a formidable *** enhance the prospect of success,collaborative efforts involving medical professionals and researchers in theﬁelds of ocular biology and oncology are *** data show a lack of well-designed randomized clinical trials and limited beneﬁts in current forms of treatment for these *** advancements in the development of effective melanoma therapeutic strategies,all current treatments for uveal melanoma(UM)and conjunctival melanoma(CoM)remain unsatisfactory,resulting in a poor long-term *** trials offer hope for positive outcomes in advanced and metastatic tumors.A more comprehensive understanding of the genetic and molecular abnormalities involved in the development and progression of ocular melanomas opens the way for the development of personalized therapy,with various potential therapeutic targets currently under *** comprehension of the molecular pathogenesis of UM and CoM and their speciﬁcities may aid in the development of new and more effective systemic therapeutic agents,with the hope of improving the prognosis for patients with metastatic disease.

关键词： Uveal melanoma Conjunctival melanoma Genetic characteristics Immune checkpoint inhibitors Target molecular inhibitors

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Metamorphopsia as the first clinical sign of renal cell carcinoma

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International Journal of Ophthalmology(English edition) 2022年第8期15卷 1407-1409页

作者： Antonela Gverović-Antunica Velibor Puzović Zrinka Fabris Miletić Diana ArapovićSlavić MajaŠikić snježana kaštelan Department of Ophthalmology General Hospital DubrovnikUniversity of DubrovnikDubrovnikDr.Roka Mišetića 2Dubrovnik 20000Croatia Department of Pathology General Hospital DubrovnikDr.Roka Mišetića 2Dubrovnik 20000Croatia Department of Radiology General Hospital DubrovnikDr.Roka Mišetića 2Dubrovnik 20000Croatia Medical Centre Dubrovnik Dr.Ante Starčevićeva 1Dubrovnik 20000Croatia Department of Ophthalmology Clinical Hospital DubravaSchool of MedicineUniversity of ZagrebZagreb Avenija GojkaŠuška 6Zagreb 10000Croatia

Dear Editor,We would like to report visual disturbance due to choroidal metastasis as the first clinical sign of renal *** tumours are one of the most common type of intraocular malignancy in adults with the most common origins of metastasis being the lungs in men and breasts in women[1-2].Ocular choroidal metastases from renal cell carcinoma(RCC)are rare with 3.5%of ocular metastases originating from the kidneys[3].RCC predominantly occurs in individuals in their seventh and eighth decades of life and has been reported nearly twice as often in men as in women[1,3].

关键词： metastasis clinical renal

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High-resolution multi-scale air pollution system:Evaluation of modelling performance and emission control strategies

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Journal of Environmental Sciences 2024年第3期137卷 65-81页

作者： Diogo Lopes Joana Ferreira Sandra Rafael ka In Hoi Xin Li Yuan Liu ka-Veng Yuen kai Meng Mok ana Isabel Miranda Department of Environment and Planning&CESAM University of AveiroAveiroPortugal Department of Civil&Environmental Engineering Faculty of Science and TechnologyUniversity of MacaoMacao SARChina

A high percentage of the world's population lives in areas where air pollutant concentrations exceed the World Health Organization *** work aims to develop and test,a high-resolution multi-scale air pollution modelling system by integrating a set of adequate *** system is able to provide detailed air pollutant concentrations in urban areas and support air quality management strategies through a better identification of different atmospheric *** also allows furthering the design and assessment of air pollution control measures for a specific *** evaluate its performance and suitability,the system was applied to the Macao Special Administrative Region(SAR),China,one of the most densely populated areas on earth,during a winter period when this area is affected by high levels of Particulate Matter(PM).Although the developed system tends to underestimate the PM concentrations,it revealed a good performance in reproducing the temporal and spatial air pollution *** exceedances of the Chinese air quality standards were calculated and high population exposure to PM pollution was *** tested urban atmospheric emission reduction scenarios have shown air quality improvements,indicating that emission reduction measures at urban level should focus on the domestic ***,it is crucial to implement joint pollution prevention strategies with neighbouring regions to improve the air quality in Macao *** approach developed in this work can support policymakers in defining new strategies to reduce atmospheric pollution in urban areas.

关键词： Urban areas High-resolution emission inventory Particulate matter Population exposure

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Anthropogenic noise interacts with the predation risk assessment in a free-ranging bird

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Current Zoology 2024年第3期70卷 277-283页

作者： Piotr Matyjasiak Patrycja Chacińska Piotr Książka Institute of Biological Sciences Cardinal Stefan Wyszyński University in WarsawWóycickiego 1/3PL-01-815 WarsawPoland Department of Environmental Acoustics Institute of Environmental Protection—National Research InstituteKolektorska 4PL-01-692 WarsawPoland

Anthropogenic noise can affect a number of behavioral,physiological,and ecological aspects of animals from major taxonomic groups,raising serious conservation *** example,noise pollution impacts communicative behavior and perception of signals,movements and distribution,as well as predator–prey interactions,such as hunting success or predator detection and predation risk *** have carried out an experimental playback study,in which we investigated whether exposure to anthropogenic noise(sound of a tractor)distracts free-ranging barn swallows Hirundo rustica from paying attention to an approaching human“predator”(the“cognitive distraction”hypothesis),or whether noise leads to increased responsiveness to this“predator”(the“increased threat”hypothesis).The subjects were male barn swallows attending their breeding territories during the time when the females were *** found that barn swallow males initiated fight at signifcantly greater distances to the approaching human“predator”in the noise treatment than during the quiet control *** results suggest that anthropogenic noise causes increased vigilance and reactivity rather than a distraction,enabling birds to avoid the“predator”more *** further discuss the mechanism behind the increased alertness in response to noise and contrast the“increased threat”mechanism,usually tested in previous studies,with an alternative“cognitive sensitization”mechanism.

关键词： anthropogenic noise barn Swallow cognitive distraction flight initiation distance Hirundo rustica predation risk assessment

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Selective deposition of a MOF at the spikes of Au nanostars for SERS detection

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Nano Research 2024年第10期17卷 9166-9173页

作者： Yi Liu ka Kit Chui Xinyue Xia Han Zhang Xiaolu Zhuo Jianfang Wang School of Science and Engineering The Chinese University of Hong KongShenzhen 518172China Department of Physics The Chinese University of Hong KongShatinHong Kong 999077China School of Materials Science and Engineering Zhejiang Sci-Tech UniversityHangzhou 310000China

In the pursuit of advancing molecular sensing through surface-enhanced Raman spectroscopy(SERS),the combination of plasmonic nanoparticles and metal-organic frameworks(MOFs)has emerged as a highly effective approach to enhance the sensitivity and selectivity of SERS ***,most prior investigations have predominantly focused on MOF-coated plasmonic nanoparticles in core@shell or layer-by-layer configurations,leaving a notable knowledge gap in exploring alternative *** we present a facile method to construct a particle-on-mirror architecture by selectively coating a MOF,zeolitic imidazolate framework-8(ZIF-8),onto the tips of Au nanostars and subsequently depositing the resultant nanoparticles onto a Au *** design integrates the electric field enhancement at the sharp tips and nanogaps,along with the molecular enrichment function within the porous MOF immobilized at the tips and nanogaps,leading to a substantial boost in the SERS signal *** a unique SERS platform enables consistent and outstanding SERS performance for analytes of different *** work opens up a promising strategy for constructing multifunctional nanostructures for sensitive SERS detection in real-life scenarios.

关键词： electric field enhancement gold nanostars metal-organic frameworks molecular enrichment plasmon coupling surfaceenhanced Raman spectroscopy(SERS)substrates

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Hydroxytyrosol and Parkinson's disease:protective actions against alpha-synuclein toxicity

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Neural Regeneration Research 2024年第7期19卷 1427-1428页

作者： Ruth Hornedo-Ortega ana M.Espinosa-Oliva Departamento de Nutrición y Bromatología Toxicología y Medicina LegalFacultad de FarmaciaUniversidad de SevillaSevilleSpain Instituto de Biomedicina de Sevilla IBiS/Hospital Universitario Virgen del Rocío/CSIC/Universidad de SevillaSevillaSpain Departamento de Bioquímica y Biología Molecular Facultad de FarmaciaUniversidad de SevillaSevillaSpain

Parkinson’s disease:Parkinson’s disease(PD) is the second most prevalent neurodegenerative disease,after Alzheimer’s disease,affecting 1%of the general population over the age of *** to data from the World Health Organization(WHO),its prevalence has doubled in the past 25 *** 2019,global estimates indicated over 8.5 million individuals with PD and it is suggested that PD caused 329000 deaths,an increase of over 100% since 2000(WHO,2022).

关键词： protective Alzheimer prevalence

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Modulation doping of p-type Cu_(12)Sb_(4)S_(13)toward improving thermoelectric performance

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Journal of Materials Science & Technology 2024年第4期171卷 71-79页

作者： Khak Ho Lim Mingquan Li Yu Zhang Yue Wu Qimin Zhou Qingyue Wang Xuan Yang Pingwei Liu Wen-Jun Wang ka Wai Wong ka Ming Ng Yu Liu Andreu Cabot Institute of Zhejiang University-Quzhou Quzhou 324000China College of Chemical and Biological Engineering Zhejiang UniversityHangzhou 310007China School of Chemistry and Chemical Engineering Hefei University of TechnologyHefei 230009China Materials Research Institute The Pennsylvania State UniversityUniversity ParkPA 16802USA Ostia Technologies Limited United Kingdom Department of Chemical and Biological Engineering The Hong Kong University of Science and TechnologyClear Water BayHong KongChina ICREA Pg.Lluis Companys 23Barcelona 08010Spain Catalonia Energy Research Institute-IREC Sant Adria del BesosBarcelona 08930Spain

The commercial viability of thermoelectric(TE)devices relies heavily on two factors:cost reduction and efficiency *** this study,we first produce p-type Cu_(12)Sb_(4)S_(16-x)(x=0,3,4)using a low-temperature bottom-up approach and demonstrate Cu_(12)Sb_(4)S_(13)to show the best TE performance among the three tested ***,the TE energy conversion efficiency of Cu_(12)Sb_(4)S_(13)is further enhanced by optimizing its electronic band structure through the incorporation of small amounts of *** an optimal Te content of 5 mol%,more than a twofold increase in the TE figure of merit(zT)is *** gain insight into the mechanism of improvement on the transport properties of the mate-rial,we compare the interphase transport mechanism by incorporating nanodomains of different metals(Ag and Cu)into the Cu_(12)Sb_(4)S_(13)*** improved electrical conductivity obtained with Cu_(12)Sb_(4)S_(13)-Te nanocomposites is attributed to a charge flooding of the Cu_(12)Sb_(4)S_(13)*** contrast,excessive down-ward band-bending at the interphases of Ag/Cu metal-semiconductor drastically reduces the electrical ***,a weighted mobility(μw)analysis shows a dominant thermal activation of carri-ers in Cu_(12)Sb_(4)S_(13)-Te *** this material,a strong decrease in lattice thermal conductivity is also found,which is associated with a phonon-carrier scattering *** work shows the impor-tance of proper band-engineering in TE nanocomposites to decouple electrical and thermal transport to enhance TE performance,and the efficacy ofμw for electrical and thermal transport analysis.

关键词： Modulation doping Thermoelectric Interphase transport Charge flooding Phonon-carrier scattering

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Grasslands Response to Livestock Grazing Intensity in the Austral Pampas (Argentina): Testing the Intermediate Disturbance Hypothesis

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PHYTON-INTERNATIONAL JOURNAL OF EXPERIMENTAL BOTANY 2024年第8期93卷 2037-2050页

作者： de Villalobos, ana Elena Long, Maria Andrea Consejo Nacl Invest Cient & Tecn CERZOS Grp Invest Ecosistemas Pastizal RA-8000 Bahia Blanca Buenos Aires Argentina Univ Nacl Sur Dept Biol Bioquim & Farm RA-8000 Bahia Blanca Buenos Aires Argentina

Livestock grazing has a significant impact on natural grasslands, with approximately one-third of the world's land area dedicated to this industry. Around 20% of global grasslands are highly degraded due to overgrazing, affecting their productivity and conservation capacity. Best practices are required to ensure sustainable livestock production that supports biodiversity. The Intermediate Disturbance Hypothesis (IDH) suggests that environments with moderate levels of disturbance exhibit a higher species diversity. Moderate grazing can reduce the dominance of certain species, thereby enhancing plant diversity. However, concerns arise regarding the increase of exotic and unpalatable species under moderate grazing levels, complicating grassland conservation efforts. The impact of livestock grazing on the functional structure of grasslands depends on factors such as grazing intensity, livestock species, and environmental conditions. Variations in grazing intensity may increase specific and functional diversity under moderate grazing, potentially masking the presence of invasive exotic species. In the Austral Pampas (Pampean phytogeographic province, Buenos Aires, Argentina), grasslands face various pressures from domestic livestock grazing that endanger their integrity if not properly managed. Therefore, our study aims to investigate potential differences in species richness and diversity, functional diversity, exotic plant abundance, and the number and distribution of plant functional groups across varying grazing intensities. The IDH is utilized as a tool to regulate livestock pressure for grassland conservation. Species and functional diversity indices were used to assess the impact of grazing on grassland diversity. Moderate grazing increased species and functional diversity, while intensively grazed or ungrazed areas showed reduced diversity. Livestock presence influenced the balance between native and exotic plants, with ungrazed areas having higher native plant a

关键词： Natural grasslands grazing effects disturbance speci fi c and functional diversity FERAL HORSES DIVERSITY INVASION VEGETATION PLANTS FIRE RAIN

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Sudden openings and gradual closures in canopy cover modulate acclimation,survival,and growth of a shade-tolerant rainforest tree species

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Journal of Forestry Research 2024年第5期35卷 78-90页

作者： ana Paula Moretti Flavia Yesica Olguin Juan Marcelo Gauna Corina Graciano INFIVE(CONICET-Universidad Nacional de La Plata) Diagonal 113 N°4951900 La PlataProvincia de Buenos AiresArgentina CONICET Godoy Cruz 2290C1425FQB Buenos AiresArgentina Facultad de Ciencias Agrariasy Forestales Universidad Nacional de La PlataCalle 60y 1181900 La PlataProvincia de Buenos AiresArgentina Facultad de Ciencias Forestales Universidad Nacional de MisionesBertoni 124 km 33380 EldoradoProvincia de MisionesArgentina

Forest disturbances at gap levels are one of the most important events for the regeneration and establishment of intermediate tree *** canopy openings expose plants to high light intensity and high evaporative demands that stress shade-acclimated ***,the slow closure of gaps reduces light availability to plants established when the incident irradiation was *** work evaluated the morphological and physiological acclimation of Cabralea canjerana(Vell)*** to sudden and to gradual changes in canopy cover.A pot experiment was carried out with plants exposed to a sudden opening.A few days after the light shock,plants rapidly increased photosynthetic rates and decreased leaf water *** two months,plants activated physiological responses at leaf and whole plant levels to high light and water stresses,e.g.,increased stoma-tal conductance,stomatal index and reduction of leaf:fine roots ratio and *** seven months,hydraulic conductivity of petioles and the whole leaf increased,and growth was much higher than plants that remained under the *** a field experiment in gaps in the rainforest,plants acclimated to all canopy *** years after planting,growth was maximum in open environments within the gaps,even if the canopy closed during the first 20 months after *** conclusion,if this species is planted to enrich the rainforest,positions within gaps with lower canopy cover should be chosen and gap closure will not affect *** manage *** natural regeneration,the opening of gaps and removal of understory will increase survival and growth without the risk that the stress caused by these sudden openings could lead to the death of ***-bining pot and field experiments helps to understand the autecology of trees with particular ecological interest,and to build sound restoration practices.

关键词： Cabralea canjerana Atlantic forest Abiotic stress Regeneration Seedling

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Design multifunctional Mg–Zr coatings regulating Mg alloy bioabsorption

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Journal of Magnesium and Alloys 2024年第4期12卷 1461-1478页

作者： Zohra Benzarti Sandesh Itani JoséDavid Castro Sandra Carvalho ana Sofia Ramos University of Coimbra CEMMPREARISEDepartment of Mechanical EngineeringRua Luís Reis Santos3030-788CoimbraPortugal Laboratory of Multifunctional Materials and Applications(LaMMA) Department of PhysicsFaculty of Sciences of SfaxUniversity of SfaxSoukra Road km 3.5B.P.1171Sfax3000Tunisia

Magnesium(Mg)alloys are widely used for temporary bone implants due to their favorable biodegradability,cytocompatibility,hemocompatibility,and close mechanical properties to ***,rapid degradation and inadequate strength limit their *** overcome this,the direct current magnetron sputtering technique is employed for surface coating in Mg-based alloys using various zirconium(Zr)*** approach presents a promising strategy for simultaneously improving corrosion resistance,maintaining biocompatibility,and enhancing strength without compromising *** leveraging Mg’s inherent biodegradability,it has the potential to minimize the need for secondary surgeries,thereby reducing costs and *** paper is a systematic study aimed at understanding the corrosion mechanisms of Mg–Zr coatings,denoted Mg-xZr(x=0–5 at.%).Zr-doped coatings exhibited columnar growth leading to denser and refined structures with increasing Zr *** analysis confirmed the presence of the Mg(00.2)basal plane,shifting towards higher angles(1.15°)with 5 at.%Zr doping due to lattice parameter changes(i.e.,decrease and increase of“c”and“a”lattice parameters,respectively).Mg–Zr coatings exhibited“liquidphilic”behavior,while Young’s modulus retained a steady value around 80 GPa across all ***,the hardness has significantly improved across all samples’coating,reaching the highest value of(2.2±0.3)GPa for 5 at.%*** testing in simulated body fluid(SBF)at 37℃ revealed a significant enhancement in corrosion resistance for Mg–Zr coatings containing 1.0–3.4 at.%*** with the 5 at.%Zr coating which exhibited a corrosion rate of 32 mm/year,these coatings displayed lower corrosion rates,ranging from 1 to 12 mm/*** synergistic enhancement in mechanical properties and corrosion resistance,achieved with 2.0–3.4 at.%Zr,suggests potential ability for reducing stress shielding and controlled degradation performance,and consequentl

关键词： Mg-Zr coatings Magnetron sputtering Nanoindentation Corrosion resistance Bone implants

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