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Ophthalmic manifestations in seropositive dengue fever patients during epidemics caused by predominantly different dengue serotypes

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Advances in Ophthalmology Practice and research 2022年第2期2卷 18-24页

作者： Ajeet M.Wagle smita r.hegde Srinivasan Sanjay Kah-Guan Au Eong International Eye Cataract retina Centre Mount Elizabeth Medical CentreSingapore International Eye Cataract retina Centre Farrer Park Medical CentreSingapore Khoo Teck Puat Hospital Singapore Alexandra Hospital Singapore Shree Shantinath Medical Trust-Jain Hospital MumbaiIndia Narayana Nethralaya BangaloreIndia Lee Kong Chian School of Medicine Nanyang Technological UniversitySingapore

Purpose:Dengue fever(DF)epidemics in Singapore in 2005–2006 and 2007 were caused predominantly by dengue virus serotypes 1(DENV-1)and 2(DENV-2)*** investigated the prevalence of ophthalmic manifestations during these consecutive ***:Seropositive DF patients admitted to the hospital during two separate dengue epidemics were enrolled from June 2005 to December ***,ophthalmic,and laboratory data were *** primary outcome measures were differences in ophthalmic and laboratory features across the two *** associated with increased risk of developing various DF-related ophthalmic manifestations were the secondary outcome ***:Of the 115 patients enrolled,109(94.7%;33 in 2005–2006 and 76 in 2007)completed the eye screening *** of patients were Chinese(65,59.6%)and males(81,74.3%).The mean age was 40.8 years(range,18–87).Colour vision impairment(12 vs 14[36.4%vs 18.7%];P?0.04),cotton wool spots(10 vs 3[30.3%vs 3.9%];Prmal liver function(mean alanine amino-transferase[150.2 U/L vs 68.28 U/L;P?0.001],mean aspartate amino-transferase[196.86 U/L vs 99.53 U/L;P?0.002],total protein[68.43 g/L vs 72.27 g/L;P?0.016],serum albumin[36.86 g/L vs 40.5 g/L;P?0.001])were noted more often in DF epidemics predominantly caused by DENV-1 compared to ***:A higher prevalence of colour vision impairment,cotton wool spots,bleeding diathesis,and abnormal liver function was found in DF epidemics predominantly caused by DENV-1 compared to DENV-2.

关键词： Dengue fever Ophthalmic manifestations Serotype Epidemic Singapore

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