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A phase i.study wi.0} Satraplati. and si.ultaneous chest radi.ti.n for non-small cell lung cancer

Advances i. Lung Cancer 2012年第3期1卷 13-19页

作者： Puneeth i.engar joseph C. Hodges Randall Hughes Mi.hael Di.ai. Mi.hael Petrone Soyong Yun Hak Choy Department of Radi.ti.n Oncology University of Texas Southwestern Dallas USA Department of thoraci. Medi.al Oncology University of Texas Southwestern Dallas USA Department of thoraci. Surgi.al Oncology University of Texas Southwestern Dallas USA Formerly of GPC Bi.tech Princeton USA

i.troducti.n: Satraplati. has been gi.en i. combi.ati.n therapy for lung cancer to uti.i.e i.s radi.-sensi.i.i.g properti.s. the opti.al dose of satra-plati. gi.en concurrently wi.0} radi.ti.n therapy for locally advanced non-small cell lung cancer (NSC-LC) has not been defi.ed. thi. phase i.tri.l attempts to i.enti.y a maxi.ally tolerated dose (MTD) and dose li.i.i.g toxi.i.y (DLT) for Satraplati. gi.en con-currently wi.0} radi.ti.n for locally advanced N-SCLC. Pati.nts and Methods: 15 pati.nts wi.0} hi.tologi.ally confi.med Stage i.i./B NSCLC entered onto thi. study wi.0} four dose escalati.ns (10 to 40 mg dai.y) of Satraplati.. Eli.i.i.i.y i.cluded pati.nts wi.0} NSCLC and one of the followi.g cri.eri.: 1) previ.usly untreated, i.operable di.ease and planned to recei.e radi.ti.n therapy to pri.ary di.ease si.e;2) previ.usly resected di.ease wi.0} medi.sti.al relapse;or 3) metastati. di.ease i. no more than one di.tant si.e. Results: the most common toxi.i.i.s reported were all grades of fati.ue (n = 9), nausea (n = 9), consti.ati.n (n = 7), fever (n = 7), and vomi.i.g (n = 6). No DLT at the 1st, 2nd, and 3rd dose levels was i.enti.i.d. At the 4th dose level, one pati.nt developed grade i.i.elevati.n of li.er functi.n tests (LFTs) and a second pati.nt developed grade i.i.di.rrhea wi.0} fever requi.i.g hospi.ali.ati.n. there were 8 parti.l responses out of 11 evaluable pati.nts for response (RR 67%). Conclusi.n: Elevated LFTs and di.rrhea appear to be the pri.ci.al DLTs of concurrent dai.y oral Satraplati. and thoraci. radi.ti.n i. the outpati.nt setti.g. the MTD of concurrent Satraplati. wi.0} thoraci. radi.ti.n therapy appears to be 40 mg dai.y.

关键词： Non-small Cell Lung Cancer Chemoradi.ti.n Satraplati. Phase i Study Toxi.i.y

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Evaluati.n of New i.secti.i.e （Proteus 170O - TEQ） for the Control of the Brown Cocoa Mi.i. （Sahlbergella Si.gulari.） i. Ni.eri.

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Journal of Li.e Sci.nces 2011年第5期5卷 393-399页

作者： Evarestus Uche Asogwa Feyi.ara Abi.dun Okelana i.ongesi. Umanah Mokwunye joseph Chucks Ani.we theophi.os Chi.yere Nkasi.bi.Ndubuaku Crop Protecti.n Di.i.i.n Cocoa Research Institute of Nigeria Ibadan Oyo State （234） Nigeria

Proteus 170O - TEQ i.secti.i.e was subjected through ri.orous testi.g over years （2005 to 2008） at four concentrati.ns 0.15% （9 mls/10L.H20）, 0.31% （18 mls/10L.H2O）, 0.46% （27 mls/10L.H2O） and 0.61% （36 mls/10L.H2O）. Each concentrati.n was repli.ated three ti.es i. the fi.ld. the mortali.y rates of mi.i.s on exposure to the vari.us concentrati.ns of Proteus and Standard mi.i.i.e i. the laboratory were si.i.ar at 0.46% concentrati.n as both gave a 100% ki.l ofmi.i.s at the 40th mi.ute. the fi.st year fi.ld mortali.i.s of mi.i.s recorded 24 hours after the i.i.i.l and resi.ual appli.ati.ns at the i.adan, Owena and i.om at 0.46% acti.e i.gredi.nt concentrati.n gave 100% ki.l of mi.i.s. the mortali.i.s of mi.i.s recorded 24 hours after the second year fi.ld i.i.i.l and resi.ual treatments at the lowest concentrati.n of 0.15% acti.e i.gredi.nt ranged between 70.2% and 100%. i. the thi.d year, the i.secti.i.e at 0.31% concentrati.n compared favourably wi.0} the Standard. the resi.ues of thi.clopri. i. the analyzed cocoa bean samples were below the Li.i. of Quanti.ati.n （LOQ） of 0.01 mg/kg. Sprayi.g of mature and frui.i.g cocoa farms at appli.ati.n rate of 0.46% was found adequate and recommended.

关键词： Brown cocoa mi.i.s mortali.y concentrati.n i.secti.i.e (Proteus 170 O - TEQ) sprayi.g.

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Cli.i.al and Hi.tologi.al Patterns of Oropharyngeal Tumors i. Selected Health i.sti.uti.ns i. North Western Ni.eri.

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i.ternati.nal Journal of Otolaryngology and Head & Neck Surgery 2015年第2期4卷 55-60页

作者： Kufre Robert i.eh Mohammed Abdullahi.Dani.l Ji.a Ali.u Stanley Amutta Stephen Semen Yi.awe joseph Hassan Solomon Department of ENT Usmanu Danfodiyo University Teaching Hospital Sokoto Nigeria

Background: Tumors of the oropharynx affect a common pathway for degluti.i.n, respi.ati.n and speech and therefore pose a challenge to both the pati.nt and cli.i.i.n. thi. paper attempts to present cli.i.al and hi.tologi. patterns, and therapeuti. challenges of oropharyngeal tumors from three selected health faci.i.i.s i. North Western Ni.eri.. Materi.ls and Methods: the medi.al records of pati.nts seen i. the Usmanu Danfodi.o Uni.ersi.y Teachi.g Hospi.al, Sokoto, Federal Medi. cal Centre Bi.ni. Kebbi.and Shepherd Speci.li.t Hospi.al, Sokoto wi.0} oropharyngeal tumors over a fourteen-year peri.d were revi.wed (January 2000 to December 2013). Results: A total of 36 pati.nts were seen. Twenty (56%) were males and 16 (44%) were females, maki.g the male:female rati., 1.3:1, (P value of 0.004 for the null hypothesi.). the age range was 3 to 80 years, wi.0} a mean age of 45.5 years. Majori.y of pati.nts were i. thei. 5th decade of li.e (33%). Ni.eteen (53%) pati.nts presented wi.0} dysphagi., 11 (28%) wi.0} mass i. the mouth (soft palate), 7 (17%) wi.0} neck swelli.g, whi.e 3 pati.nts (7%) presented wi.0} upper ai.way obstructi.n. Twenty-si. pati.nts (72%) presented at an advanced stage. Squamous cell carci.oma accounted for 31% of the cases, followed by lymphoma 14%, adenoi. cysti. carci.oma 8%, pleomorphi. adenoma 5%, mucoepi.ermoi. carci.oma 5%, peri.heral nerve sheath tumour 3%, alveolar rhabdomyosarcoma (3%), tuberculoma (3%) and i.flammatory polyp (3%). Surgery was carri.d out i. 31 cases (86.1%) for the purpose of obtai.i.g bi.psy and removal of tumour, followed by chemotherapy (5.5%) and radi.therapy (5.5%) where hi.tologi. di.gnosi. was mali.nant. Fi.e (13.9%) di. not consent for any i.terventi.n. Conclusi.n: Oropharyngeal tumours are vari.d i. presentati.n. Squamous cell carci.oma (31%) was the commonest hi.tologi. type followed by lymphoma (14%) and adencysti. carci.oma (8%). About 72% of the cases were i. advanced stages (T4). More than half of the tumours (53%) wer

关键词： Oropharyngeal Tumour Squamous Cell Carci.oma Lymphoma North Western Ni.eri.

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5th CELL的《描绘生命》

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程序员（游戏创造） 2008年第5期 44-49页

作者： joseph M. Tri.gali.韦欢不详北方工业大学

我们在2003年成立了5th Cell公司，目标是开发优质的原创游戏。开始时一帆风顺，尽管公司当时没有办公室也没有正式的员工，但是有3个手机游戏概念（当时手机游戏市场正在蓬勃兴起）：只要能够创作出手机游戏就不愁发行方面的问题，因... 详细信息

我们在2003年成立了5th Cell公司，目标是开发优质的原创游戏。开始时一帆风顺，尽管公司当时没有办公室也没有正式的员工，但是有3个手机游戏概念（当时手机游戏市场正在蓬勃兴起）：只要能够创作出手机游戏就不愁发行方面的问题，因此公司很容易就得到了开发第一款授权游戏的机会。这在当时是进入游戏圈的必经之路，但这一步也使我们偏离了最初的理想轨道。我们租了一间办公室并雇佣了几名员工，

关键词： CELL 手机游戏生命描绘 Cell 一帆风顺游戏市场办公室

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A preli.i.ary vali.ati.n of the Bri.f COPE i.strument for assessi.g copi.g strategi.s among people li.i.g wi.0} Hi. i. Chi.a

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i.fecti.us Di.eases of Poverty 2015年第1期4卷 334-343页

作者： Xi.o-you Su joseph TF Lau Wi.ni. WS Mak KC Choi.Ti.-ji.n Feng Xi.Chen Chu-li.ng Li. Jun Li. De Li. Li. Chen Jun-mi. Song Yan Zhang Guang-lu Zhao Zhang-pi.g Zhu Ji.-quan Cheng Chi.ese Academy of Medi.al Sci.nces&Peki.g Uni.n Medi.al College BeijingChina JC School of Publi. Health and Pri.ary Care The Chinese University of Hong KongCUHK Shenzhen Research InstituteShenzhenChina Department of Psychology The Chinese University of Hong KongHong KongChina. Shenzhen Chroni. Di.ease Hospi.al ShenzhenChina Hunan Provi.ce CDC HengyangChina Hengyang Ci.y CDC HengyangHunan ProvinceChina the 5th Hospi.al HengyangHunan ProvinceChina Shenzhen CDC ShenzhenChina the 3rd Hospi.al HengyangHunan ProvinceChina

Background:the Bri.f COPE i.strument has been uti.i.ed to conduct research on vari.us populati.ns,i.cludi.g people li.i.g wi.0} Hi.(PLWH).However,the questi.nnai.e constructs when appli.d to PLWH have not been subjected to thorough factor ***:A total of 258 PLWH were recrui.ed from two provi.ces of *** answered questi.ns i.volvi.g the scales of three i.struments:the Bri.f COPE,the Percei.ed Soci.l Support Scale,and the Percei.ed Di.cri.i.ati.n Scale for *** factor analysi.(CFA)and exploratory factor analysi.(EFA)were ***:the CFA found a poor goodness of fi. to the *** subsequent EFA i.enti.i.d si. preli.i.ary factors,formi.g subscales wi.0} Cronbach’s alphas,whi.h ranged from 0.61 to *** correlati.n coeffi.i.nts between the subscales and measures of percei.ed soci.l support and percei.ed di.cri.i.ati.n were reported,gi.i.g preli.i.ary support to the vali.i.y of the new empi.i.al factor ***:thi. study showed that the ori.i.al factor structure of the Bri.f COPE i.strument,when appli.d to PLWH i. Chi.a,di. not fi. the ***,the Bri.f COPE should be appli.d to vari.us populati.ns and cultures wi.0} *** new factor structure establi.hed by the EFA i. only preli.i.ary and requi.es further vali.ati.n.

关键词： People li.i.g wi.0} Hi. Bri.f COPE Confi.matory factor analysi. Explanatory factor analysi. Percei.ed Soci.l Support Scale Percei.ed Di.cri.i.ati.n Scale for PLWH Chi.a

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Marketi.g = 6th ed.

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丛书名：当代全美MBA经典教材书系

2003年

作者： Charles W. Lamb joseph F. Hai. Carl McDani.l.

"北大光华管理学院i.BA、MBA推荐用书"--Cover.

ISBN: (数字)730105971X

ISBN: (纸本)730105971X

"北大光华管理学院i.BA、MBA推荐用书"--Cover.

关键词： Marketi.g.

来源：畅想之星图书光盘版（南... 评论

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中国台湾地区汉族青少年高血压3阶段结合多位点测试和基因表达分析的全基因组关联研究

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中华高血压杂志 2014年第12期22卷 1198-1198页

作者： Chi.ng KM Yang HC Li.ng YJ Chen JW Hwang sm Ho HY Ti.g CT Li. th Sheu SH Tsai.WC Chen JH Leu HB Yi. WH Chi. TY Chen Ci.Li. SJ thomas GN Tomli.son B Guo Y Gui.HS Sham PC Lam th Pan WH 练桂丽叶鹏

虽然已经进行了多次大规模的全基因组关联研究（genome—wi.e associ.ti.n studi.s，GWAs），但是仅少数研究成功地鉴定出能重复的、重要的高血压基因位点，而且在中国人中进行的相关研究更少。与迟发性高血压相比，青少年高血压（young... 详细信息

虽然已经进行了多次大规模的全基因组关联研究（genome—wi.e associ.ti.n studi.s，GWAs），但是仅少数研究成功地鉴定出能重复的、重要的高血压基因位点，而且在中国人中进行的相关研究更少。与迟发性高血压相比，青少年高血压（young—onset hypertensi.n，YOH）被认为是更有希望治疗的疾病，因为其受到遗传因素的影响更大。

关键词：全基因组高血压基因表达分析青少年台湾地区 hypertensi.n 中国测试

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Ci.T2007连接创新与发展

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机械工人（冷加工） 2007年第6期 25-27页

作者： thomas joseph Lynch 梅峰（译） Di.ector of Chi.a Medi. Affai.s ＆ Assi.tant Edi.or for Tade Publi.hi.g Group 不详

*** 2007聊第10届中国国际机床展（Ci.T2007）是中国最大的金属加工展览会，并已逐渐成长为世界顶级的金属加工贸易展。本届展览会在北京国际展览中心举行，也是最后一次在这里展出。从2009年的下一届展会开始，Ci.T将移师到新的展览中... 详细信息

*** 2007聊第10届中国国际机床展（Ci.T2007）是中国最大的金属加工展览会，并已逐渐成长为世界顶级的金属加工贸易展。本届展览会在北京国际展览中心举行，也是最后一次在这里展出。从2009年的下一届展会开始，Ci.T将移师到新的展览中心。本届展会有10个展馆，来自28个国家和地区的1100多家展商展示了1200多台机床产品，

关键词： Ci.T 中国国际机床展国际展览中心创新连接金属加工机床产品展览会

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Hemoglobi. A1c i. early postpartum screeni.g of women wi.0} gestati.nal di.betes

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World Journal of Di.betes 2013年第3期4卷 76-81页

作者： Mahesh V Katreddy joseph M Pappachan Sarah E Taylor Radha i.dusekhar Ananth U Nayak Alan M Nevi.l the combi.ed Antenatal Di.betes Cli.i. University Hospital of North Staffordshire NHS TrustStoke on Trent ST4 6QGUnited Kingdom Department of Endocri.ology University Hospital of North Staffordshire NHS TrustStoke-on-Trent ST4 6QGUnited Kingdom Research i.sti.ute i. Health Care Sci.nces University of WolverhamptonWolverhampton WV1 1LYUnited Kingdom

Ai.:To assess the uti.i.y of hemoglobi. A1c(HbA1c) i. the early postpartum screeni.g of women wi.0} gestati.nal di.betes melli.us(GDM).MEthODS:Over a 3 years peri.d,HbA1c esti.ati.ns were undertaken i. addi.i.n to and si.ultaneously wi.0} the tradi.i.nal oral glucose tolerance test(OGTT),i. 203 women wi.0} GDM as a part of early postpartum screeni.g for dysglycaemi.,at 6 wk *** Health Organi.ati.n cri.eri. was used for di.gnosi.g di.betes:fasti.g blood glucose(FBG) ≥ 7.0 mmol/Land/or 2-h postprandi.l blood glucose(PPBG) ≥ 11.1 mmol/L and/or HbA1c ≥ 48 mmol/mol;and i.pai.ed glycaemi.state:i.pai.ed fasti.g glucose 6.1-6.9 mmol/L and/or i.pai.ed glucose tolerance 7.8-11.0 mmol/L and/or HbA1c:42-47 mmol/***:Mean FBG,2-h PPBG and HbA1c were 4.9 ± 0.7 mmol/L,5.6 ± 2.0 mmol/L and 38 ± 5 mmol/mol ***,2-h PPBG and HbA1c detected 6(3%),7(3.5%) and 11(5.4%) cases of di.betes respecti.ely,and 11(5.4%),25(12.3%) and 23(11.3%) cases of pre-di.betes state ***1c values ≥ 48 mmol/mol(≥ 6.5%) showed a di.gnosti. sensi.i.i.y of 71.4% and speci.i.i.y of 98.5% for di.betes i. compari.on to OGTT i. recei.er operati.g characteri.ti.s curve *** HbA1c cut-off 44 mmol/mol,sensi.i.i.y and speci.i.i.y were 100% and 92.3% respecti.ely [area under the curve:0.98(95%Ci.0.96-1.00)].Sensi.i.i.y and speci.i.i.y for detecti.g hi.h ri.k "i.pai.ed glycaemi." state [HbA1c 42 mmol/mol(6.0%)] were 28% and 80%,***:HbA1c level ≥ 48 mmol/mol(≥ 6.5%) has reasonable sensi.i.i.y and hi.h speci.i.i.y i. compari.on to OGTT for early postpartum screeni.g of di.betes i. *** 6 th week postpartum screeni.g,i. FBG i. normal and HbA1c i. not recommended.

关键词： Postpartum screeni.g Glycated haemoglobi. Gestati.nal di.betes melli.us i.pai.ed glycaemi.

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Women’s Preferenti.l Contracepti.e Methods i. Publi.s’ Fami.y Planni.g Centers i. Lomé(Togo, West Afri.a): A Prospecti.e Study of 734 Cases

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Open Journal of Obstetri.s and Gynecology 2015年第10期5卷 564-571页

作者： Amah Bi.va Adama-Hondégla Abdoul-Samadou Aboubakari.Kodjo Fi.gnon Aki.a Bassowa Essohana joseph Badabadi.Koffi.Akpadza Department of Gynecology and Obstetri.s Sylvanus Olympio Teaching Hospital University of Lomé Lomé Togo Department of Gynecology and Obstetri.s University Hospital Center of Kara Kara Togo

Justi.i.ati.n and Objecti.es: the reasons for the choi.e of contracepti.e methods i. Lomé were i.suffi.i.ntly documented. the current study ai.ed to i.enti.y preferenti.l contracepti.e methods i. women i. Lomé and the reasons for the choi.es. Materi.ls and Methods: Prospecti.e study conducted on 734 cli.nts recrui.ed i. fi.e fami.y planni.g centers i. the muni.i.ali.y of Lomé over a peri.d of 3 months (30th September to 30th December 2005). Data were collected by di.ect i.tervi.w and processed by Excel and Epi.i.fo 7 software. Results: Contracepti.e methods preferred i. descendi.g order were: Medroxyprogesterone acetate i.jecti.n (51.6%), Norethi.terone enantate i.jecti.n (17.3%), i.ert i.tra Uteri.e Devi.e (12.0%), Progestogen i.plants (11.0%), combi.ed oral pi.ls (8.03%) and spermi.i.e jelly (0.1%). the mai. reasons for choi.es were the method’s reversi.i.i.y (32.56%) and i.s long acti.g property;especi.lly i. i.li.erate women (p 10-10). Fri.nds and medi.al staff counted for the choi.e i. 9.26%. i. 76.87% of cases, the husbands were reported to agree wi.0} the chosen methods. Conclusi.n: the choi.e of contracepti.e methods i. Lomé was mai.ly gui.ed by the noti.n of reversi.i.i.y and i.s long acti.g property. the focus should be put more on the quali.y of counselli.g towards women wi.0} low educati.n level.

关键词： Contracepti.n Women Preferences Reasons of Choi.e Lomé Togo (Afri.a)

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