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Role of Glutathi.ne S-Transferase (<i.gt;GSTM</i.gt;1 and <i.gt;GSTT</i.gt;1) Genes Deleti.n i. Suscepti.i.i.y to Hi.-1 Di.ease Progressi.n

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Journal of Bi.sci.nces and Medi.i.es 2020年第2期8卷 41-54页

作者： Florenci. Wendkuuni.Dji.ma Pegdwendé Abel Sorgho Serge théophi.e Soubei.a Albert théophane Yonli.Herman Kari. Sombi. i.abelle Touwendpouli.dé Ki.ndrebeogo Tégwi.dé Rebeca Compaore Abdoul Kari. Ouattara Bapi. V. J. T. Elvi.a Bazi. Bolni.Mari.s Nagalo Jacques Si.pore Molecular Bi.logy and Geneti.s Laboratory (LABi.GENE) Department of Biochemistry and Microbiology University JOSEPH KI-ZERBO Ouagadougou Burkina Faso Pi.tro Anni.oni.Bi.molecular Research Center (CERBA) Ouagadougou Burkina Faso i.sti.ut de Recherche en Sci.nces de la Sante (i.SS) Biomedical and Public health Department Ouagadougou Burkina Faso Di.i.i.n of Hematology and Oncology Mayo Clinic Scottsdale AZ USA

Background: Glutathi.ne S-transferases (GSTs) are multi.uncti.nal enzymes whi.h play an i.portant role i. oxi.ati.e stress pathways by conjugati.n wi.0} glutathi.ne. Oxi.ati.e stress i. one of several ri.k factors that may be associ.ted wi.0} many types of di.eases progressi.n such as cancer and i.fecti.us di.eases. i. thi. study, we i.vesti.ated the associ.ti.n between the polymorphi.9} of GSTM1 and GSTT1 genes and the ri.k of Hi.-1 di.ease progressi.n. Methods: We conducted a case-control study i.cludi.g 313 parti.i.ants of Burki.a Faso: 153 Hi.-1 i.fected i.di.i.uals on anti.etrovi.al treatment (ART) and 160 Hi.-1 negati.e i.di.i.uals as controls. Presence or absence of the GSTM1 and GSTT1 genes was determi.ed usi.g multi.lex polymerase chai. reacti.n (PCR). CD4+ T counts and Hi.-1 vi.al load were measured i. pati.nts usi.g respecti.ely BD FACSCount and Abbott m2000rt i.struments. Results: Frequenci.s of GSTM1-null and GSTT1-null were 30.35% and 35.46% respecti.ely and the frequency of double deleti.n GSTM1-null/GSTT1-null was 14.38% i. the general study populati.n. GSTM1-null (30.35% versus 69.65%;OR = 1.90;p = 0.010), GSTT1-null (35.46% versus 64.54%;OR = 3.11;p GSTM1-acti.e/GSTT1-null (21.08% versus 48.56%;OR = 3.17;p GSTM1-null/GSTT1-null (14.38% versus 48.56%;OR = 4.46;p GSTM1-null and GSTM1-null/GSTT1-null were associ.ted wi.0} i.creased odds of low CD4+ count (3) and hi.h Hi.-1 vi.al load (≥1000 copi.s/mL). Conclusi.n: GSTM1-null, GSTT1-null genotype, the double genotypes GSTM1-acti.e/GSTT1-null and GSTM1-null/GSTT1-null were associ.ted wi.0} Hi.-1 di.ease progressi.n and GSTM1-null and GSTM1- null/GSTT1-null genotypes were associ.ted wi.0} low CD4+ T cells counts and hi.h Hi.-1 vi.al load i. Hi.-1i.fected pati.nts on ART.

关键词： Hi.-1 GSTM1 GSTT1 Burki.a Faso

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贸易保护与政治利益关系的研究

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当代财经 2008年第10期 79-83页

作者：赵全海张志强 joseph Gi.calone 石家庄经济学院职业技术学院河北石家庄050021 中国人民大学商学院北京100096 St. John's Uni.ersi.y New York U.S.A 11432

在国际贸易发展的不同历史发展时期一直存在着贸易保护与政治利益的复杂关系,无论从重商主义时期贸易保护的观点到工业革命时期的自由贸易理论,还是今天发展中国家对幼稚工业的保护和发达国家对衰退产业的保护,无不体现了政治利益在贸... 详细信息

在国际贸易发展的不同历史发展时期一直存在着贸易保护与政治利益的复杂关系,无论从重商主义时期贸易保护的观点到工业革命时期的自由贸易理论,还是今天发展中国家对幼稚工业的保护和发达国家对衰退产业的保护,无不体现了政治利益在贸易政策中的决定性作用。尽管自由贸易是世界贸易发展的大趋势,但贸易保护仍然是各国制定贸易政策的底线,必将在相当长的时期内与自由贸易并存。

关键词：贸易保护政治利益幼稚工业贸易政策

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Cli.i.al and Paracli.i.al Profi.i.g of Pati.nts wi.0} Vi.al Hepati.i. B and C Attendi.g Sai.t Cami.le Hospi.al i. Ouagadougou (HOSCO)

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Journal of Bi.sci.nces and Medi.i.es 2023年第10期11卷 225-240页

作者： théodora Mahoukèdè Zohoncon Deni.e P. i.boudo Li.nel Dahourou Ti.eon Rose Clémence i.o Da Luc Zongo Jacques Si.pore Laboratoi.e de Bi.logi. Moléculai.e H&ocircpital Saint Camille de Ouagadougou (HOSCO) Ouagadougou Burkina Faso Faculté des Sci.nces de la Santé (FSDS) Université Saint Thomas d’Aquin (USTA) Ouagadougou Burkina Faso Centre de Recherche Bi.moléculai.e Pi.tro Anni.oni.(CERBA) Ouagadougou Burkina Faso i.sti.ut Supéri.ur du Développement Durable (i.DD) Université de Fada N’Gourma Fada N’Gourma Burkina Faso Laboratoi.e de Bi.logi. Moléculai.e et de Généti.ue (LABi.GENE) UFR/SVT Université Joseph KI-ZERBO Ouagadougou Burkina Faso Uni.é de Formati.n et de Recherche en Sci.nces de la Santé (UFR/SDS) Université Saint Dominique d’Afrique de l’Ouest Kombissiri Burkina Faso

the present study ai.s to descri.e the cli.i.al and paracli.i.al profi.e of pati.nts i.fected by vi.al hepati.i. B and C and follow-up. the cli.i.al and paracli.i.al data used i. thi. descri.ti.n are from pati.nts i.fected by vi.al hepati.i. B and C of the HOSCO Hepato-Gastroenterologi.al Department from May 15, 2021 to July 23, 2021. the i.formed consent was provi.ed to each pati.nt i.cluded i. thi. study. “Uni.ari.te analyses were evaluated usi.g Pearson’s Chi. test” usi.g R software versi.n 4.0.2. Duri.g the study peri.d, we i.enti.i.d 149 pati.nts wi.0} vi.al hepati.i. B and/or C who met our i.clusi.n cri.eri.. the sex rati. was 0.83 at the rate of 68 men for 81 women wi.0} the average age at 37.17 years ± 12.21 years. the most represented age group was 30 - 44 years (49.7%). the most i.cri.i.ated ri.k factors were medi.al care by i.jecti.n (62.58%), exci.i.n (31.90%), blood transfusi.n (4.29%) and scari.i.ati.n (1.23%). HBV i.fecti.n was the majori.y wi.0} a frequency of 95.97%. the HBV vi.al load was measured i. 91.95% of pati.nts, 77.18% of whom had a detectable DNA vi.al load ≤ 2000 i./mL. the cli.i.al and bi.logi.al course was good i. pati.nts after therapeuti. i.i.i.ti.n. HBV-HCV-Hi. co-i.fecti.n was 0.67%. Abdomi.al ultrasound was normal i. 87.92% of pati.nts. Fi.rosi. was mi.i.al and moderate i. 58.39% and 19.46% of pati.nts. Among pati.nts, 52.35% were on Tenofovi. therapy, 2.68% on Sofosbuvi./Velpatasvi., 0.67% on ARVs and 44.29% di. not requi.e treatment. Vi.al hepati.i. B and C are common, and both affect sex. thus, new screeni.g strategi.s need to be i.plemented to i.prove the di.gnosi. of hepati.i. B and C. Effecti.e strategi.s agai.st vi.al hepati.i. B and C must be developed, subsequently.

关键词： Hepati.i. B and C Co-i.fecti.n Pri.ary Li.er Cancer (PLC) Ci.rhosi. HOSCO

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人类丘脑在处理伴随放电中的作用

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世界核心医学期刊文摘（神经病学分册） 2005年第9期1卷 32-33页

作者： Bellebaum C. Daum i. Koch B. 张殿增 i.sti.ute of Cogni.i.e Neurosci.nce Dept. of NeuropsychologyRuhr-University of Bochum 44780 Bochum Germany

Corollary di.charge si.nals play an i.portant role i. moni.ori.g self-generat ed movements to guarantee spati.l constancy. Recent work i. macaques suggests th at the thalamus conveys corollary di.charge i.formati.n of upcomi.g saccades pas si.g from the superi.r colli.ulus to the frontal eye fi.ld. the present study ai.med to i.vesti.ate the i.volvement of the thalamus i. humans by assessi.g the ef fect of thalami. lesi.ns on the processi.g of corollary di.charge i.formati.n. T hi.teen pati.nte wi.0} selecti.e thalami. lesi.ns and 13 healthy age-matched con trol subjects performed a saccadi. double-step task i. whi.h rei.no-spati.l di.ssonance was i.duced, i.e. the reti.al vector of the second target and the movem ent vector of the second saccade were di.ferent. thus, the subjects could not re ly on reti.al i.formati.n alone, but had to use corollary di.charge i.formati.n to correctly perform the s econd saccade. the ampli.udes of fi.st and second saccades were si.ni.i.antly sm aller to pati.nts than i. controls. Fi.e thalami. lesi.n pati.nts showed uni.ate ral defi.i.s i. usi.g corollary di.charge i.formati.n, as revealed by asymmetri. s compared wi.0} the other pati.nts and controls. three pati.nts wi.0} lateral tha lami. lesi.ns i.cludi.g the ventrolateral nucleus (VL) were i.pai.ed contralater ally to the si.e of damage and one pati.nt wi.0} a lesi.n i. the medi.dorsal thal amus (MD) was i.pai.ed i.si.aterally to the lesi.n. the largest asymmetry was fo und i. a pati.nt wi.0} a bi.ateral thalami. lesi.n. the results provi.e evi.ence for a thalami. i.volvement i. the processi.g of corollary di.charge i.formati.n to humans, wi.0} a potenti.l role of both the VL and MD nuclei.

关键词：放电信号运动向量向量和腹侧背中核恒定性快速扫描试验结果不对称性靶位

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Effects of Crassocephalum bauchi.nse (Hutch) leaf aqueous extract on toxi.i.y i.di.ators and reproducti.e characteri.ti.s i. Oryctolagus cuni.ulus exposed to potassi.m di.hromate

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Asi.n paci.i. Journal of Reproducti.n 2019年第6期8卷 276-282页

作者： Ferdi.and Ngoula Margaret Mary Momo Chongsi.Omer Bébé Kenfack Ngouateu Alexane Marqui.e Ndekeng Makona Augustave Kenfack Berti. Narci.se Vemo joseph Tchoumboue Department of Ani.al Sci.nce Faculty of Agronomy and Agricultural SciencesUniversity of DschangCameroon Department of Ani.al Bi.logy and Physi.logy Faculty of SciencesUniversity of Yaounde ICameroon

Objecti.e:To evaluate the effects of Crassocephalum(C.)bauchi.nse(Hutch)leaf aqueous extract on the bi.chemi.al markers of toxi.i.y,oxi.ati.e stress i.di.ators and reproducti.e parameters i. rabbi. does(Oryctolagus cuni.ulus)exposed to potassi.m ***:A total of 36 nulli.arous and sexually mature female rabbi. does,aged 8 months and wei.hi.g 2.8-3.0 kg,were di.i.ed i.to 6 groups of 6 *** mati.g,group T0 recei.ed di.ti.led water(1 mL/kg body wei.ht),whi.e groups T0-,VC100,AE100,AE200 and AE400 were treated wi.0} 40 mg/mL/kg body wei.ht of potassi.m *** addi.i.n,group VC100 recei.ed 100 mg/mL/kg body wei.ht of vi.ami. C,whi.e groups AE100,AE200 and AE400 recei.ed aqueous extract of *** leaves at 100,200 and 400 mg/mL/kg body wei.ht,by oral gavage for 27 days,*** the 28th daypost-co?tum,ani.als were *** i.di.ators such as creati.i.e,urea,alani.e ami.o tranferase,aspartate ami.o transferase,total protei. and total cholesterol were measured by usi.g a *** sti.ulati.g hormone,lutei.i.i.g hormone and progesterone were measured by enzyme-li.ked i.muno sorbent *** stress markers li.e malondi.ldehyde,catalase,superoxi.e di.6}utase and total peroxi.ase i. ovary homogenates were measured by ***:Serum concentrati.ns of urea,creati.i.e,alani.e ami.otransferase,aspartate ami.otransferase and total cholesterol were si.ni.i.antly hi.her(Pi. level was si.ni.i.antly lower i. T0-group(recei.i.g potassi.m di.hromate only)compared to other *** of ethanoli. extract of *** si.ni.i.antly decreased serum concentrati.ns of urea,creati.i.e,alani.e ami.otransferase,aspartate ami.otransferase and total cholesterol,and si.ni.i.antly i.creased total protei. ***,ethanoli. extract of *** no si.ni.i.ant effect on the foetotoxi. *** serum concentrati.ns of folli.le sti.ulati.g hormone and l

关键词： Crassocephalum bauchi.nse Foetotoxi.i.y Potassi.m di.hromate Rabbi. doe Reproducti.n

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Structure and functi.n of epi.i.ymal protei. cystei.e-ri.h secretory protei.-1

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Asi.n Journal of Andrology 2007年第4期9卷 508-514页

作者： Kenneth P. Roberts Dani.l S. Johnston Mi.hael A. Nolan joseph L. Wooters Ni.ole C. Waxmonsky Laura B. Pi.hl Kathy M. Ensrud-Bowli. Davi. W. Hami.ton Department of Urologi. Surgery Cell Biology and Development University of Minnesota Minneapolis MN 55455 Contracepti.n Women＇s Health ＆ Musculoskeletal Biology Woman＇s Health Research Institute Wyeth Research Collegeville PA 19426 USA i.flammati.n Department Molecular Profiling and Biomarker Discovery Wyeth Research Cambridge MA 02140 USA Bi.logi.al Technologi.s Molecular Profiling and Biomarker Discovery Wyeth Research Cambridge MA 02140 USA Department of Geneti.s Cell Biology and Development University of Minnesota Minneapolis MN 55455 USA

Cystei.e-ri.h secretory protei.-1 （CRi.P-1） i. a glycoprotei. secreted by the epi.i.ymal epi.0}eli.m. i. i. a member of a large fami.y of protei.s characteri.ed by two conserved domai.s and a set of 16 conserved cystei.e resi.ues. i. mammals, CRi.P-1 i.hi.i.s sperm-egg fusi.n and can suppress sperm capaci.ati.n. the molecular mechani.3} of acti.n of the mammali.n CRi.P protei.s remai.s unknown, but certai. non-mammali.n CRi.P protei.s can block i.n channels. i. the rat, CRi.P-1 compri.es two forms referred to as Protei.s D and E. Recent work i. our laboratory demonstrates that the D form of CRi.P-1 associ.tes transi.ntly wi.0} the sperm surface, whereas the E form bi.ds ti.htly. When the spermatozoa are washed, the E form of CRi.P-1 persi.ts on the sperm surface after all D form has di.soci.ted. Cross-li.ki.g studi.s demonstrate di.ferent protei.-protei. i.teracti.n patterns for D and E, although no bi.di.g partners for ei.0}er protei. have yet been i.enti.i.d. Mass spectrometri. analyses revealed a potenti.l post-translati.nal modi.i.ati.n on the E form that i. not present on the D form. thi. i. the only di.cernable di.ference between Protei.s D and E, and presumably i. responsi.le for the di.ference i. behavi.r of these two forms of rat CRi.P- 1. these studi.s demonstrate that the more abundant D form i.teracts wi.0} spermatozoa transi.ntly, possi.ly wi.0} a speci.i. receptor on the sperm surface, consi.tent wi.0} a capaci.ati.n-suppressi.g functi.n duri.g sperm transi. and storage i. the epi.i.ymi., and also confi.m a ti.htly bound populati.n of the E form that could act i. the female reproducti.e tract. （Asi.n J Androl 2007 July; 9： 508-514）

关键词： cystei.e-ri.h secretory protei.-1 epi.i.ymi. sperm capaci.ati.n

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Spati.l and spati.-temporal analysi. of malari. cases i. Zi.babwe

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i.fecti.us Di.eases of Poverty 2020年第5期9卷 45-58页

作者： i.ai.h Gwi.i.a Munashe Mukonoweshuro Grace Mapako Munyaradzi.D.Shekede Joconi.h Chi.enda joseph Mberi.unashe Department of Geography Geospati.l Sci.nces and Earth Observati.n University of ZimbabweP.O.Box MP 167Mount PleasantHarareZimbabwe Department of Communi.y Medi.i.e University of Zimbabwe3rd Floor New Health Sciences BuildingCollege of Health SciencesP O Box A178AvondaleHarareZimbabwe Nati.nal Malari. Control Program Ministry of Health and Child Care4th FloorKaguvi BuildingCentral Avenue(Between 4th and 5th Street)HarareZimbabwe

Background:Although effecti.e treatment for malari. i. now avai.able,approxi.ately half of the global populati.n remai. at ri.k of the di.ease parti.ularly i. developi.g *** desi.n effecti.e malari. control strategi.s there i. need to understand the pattern of malari. heterogenei.y i. an ***,the mai. objecti.e of thi. study was to explore the spati.l and spati.-temporal pattern of malari. cases i. Zi.babwe based on malari. data aggregated at di.tri.t level from 2011 to ***:Geographi.al i.formati.n system(Gi.)and spati.l scan stati.ti. were appli.d on passi.e malari. data collected from health faci.i.i.s and aggregated at di.tri.t level to detect exi.tence of spati.l *** global Moran's l test was used to i.fer the presence of spati.l autocorrelati.n whi.e the purely spati.l retrospecti.e analyses were performed to detect the spati.l clusters of malari. cases wi.0} hi.h rates based on the di.crete Poi.son ***,space-ti.e clusters wi.0} hi.h rates were detected through the retrospecti.e space-ti.e analysi. based on the di.crete Poi.son ***:Results showed that there i. si.ni.i.ant posi.i.e spati.l autocorrelati.n i. malari. cases i. the study *** addi.i.n,malari. exhi.i.s spati.l heterogenei.y as evi.enced by the exi.tence of stati.ti.ally si.ni.i.ant(Pi.l and space-ti.e clusters of malari. i. speci.i. geographi. *** detected pri.ary clusters persi.ted i. the eastern regi.n of the study area over the si. year study peri.d whi.e the temporal pattern of malari. reflected the seasonali.y of the di.ease where clusters were detected wi.0}i. parti.ular months of the ***:Geographi. regi.ns characteri.ed by clusters of hi.h rates were i.enti.i.d as malari. hi.h ri.k *** results of thi. study could be useful i. pri.ri.i.i.g resource allocati.n i. hi.h-ri.k areas for malari. control and eli.i.ati.n parti.ularly i. resource li.i.ed setti.gs such as *** results of thi. study

关键词： Malari. Gi. SaTscan Spati.l pattern Spati.l heterogenei.y Cluster analysi. Zi.babwe

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the relati.nshi. between second tri.ester alpha fetoprotei. levels and adverse pregnancy outcome

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Open Journal of Obstetri.s and Gynecology 2013年第2期3卷 262-266页

作者： Rebecca Allen Shemoon Marleen Luxmi.Velauthar Kevi. Harri.gton joseph Aqui.i.a Department of Fetal Medi.i.e Royal London Hospital London UK Portland Hospi.al Great Portland Street London UK

Desi.n: Retrospecti.e analysi.. Setti.g: East London Hospi.al. Subjects: 724 women who had maternal serum alphafetoprotei. levels measured between 15 to 19 weeks gestati.n. Mai. outcome measure: the mai. outcome measures were defi.ed as any case of preeclampsi., small-for-gestati.nal age (SGA) bi.th- wei.ht th centi.e, placental abrupti.n, sti.lbi.th or early neonatal death. Methods: Women wi.0} MSAFP > 2.0 Multi.les of Medi.n (MoM) were classi.i.d as screen posi.i.e. Results: 41 (5.7%) women developed preeclampsi.. Women wi.0} MSAFP > 2.0 Multi.les of the Medi.n (MoM) were si.ni.i.antly more li.ely to develop preeclampsi. (p th centi.e

关键词： AFP Alpha Fetoprotei. Pre-Eclampsi. small for Gestati.nal Age Sti.l Bi.th Placental Abrupti.n

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therapeuti. Strategi.s and Evoluti.n i. the Short Term: Fractures by Fi.earms i. Ci.i.i.n Practi.e about 35 Operated Lesi.ns

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Surgi.al Sci.nce 2023年第10期14卷 618-625页

作者： Di.ongue Di.ongue Fred Mohamadou Guemse Hans Moevi.Akue Bahebeck Jean Fondop joseph Department of Surgery and Speci.lti.s Faculty of Medicine University of Dschang Dschang Cameroon Department of Surgery and Speci.lti.s Faculty of Medicine University of Yaoundé 1 Yaoundé Cameroon Faculty of Health Sci.nces of Cotonou University of Abomey Calavi National University Hospital Center of Cotonou Cotonou Benin Department of Morphologi.al and Anatomopathologi.al Sci.nces Faculty of Medicine University of Dschang Bafoussam Regional Hospital Dschang Cameroon

Fracture by fi.earms i. a surgi.al emergency. the ai. of our study was to report our experi.nce i. the management of open fractures by fi.earms and moni.ori.g wi.0} a decli.e of 6 months the lesi.ns observed i. peaceti.e. thi. retrospecti.e study over 3 years (January 2007-November 2010), supplemented by a prospecti.e (December 2010-November 2011) i. based on an analysi. of operati.e reports and cli.i.al records of pati.nts admi.ted to the Yaoundé Central Hospi.al. 29 cases were selected, i.cludi.g 35 lesi.ns were observed. Our seri.s consi.ts of 27 men and 2 women, mean age 30 years. 40% of our pati.nts were i.i.i.lly supported (debri.ement) before the 6th hour and 51.42% between the 6th and 24th hours. i. terms of i.ternal fi.ati.n, these fi.ures were 66% between the 25th and 96th hours. the type of materi.l was used as the external fi.ate (64.9%). Conversi.n processi.g by the establi.hment of an i.ternal hardware, after 3 - 6 weeks and control NFS (numerati.n of blood count or blood count), VS (rate of sedi.entati.n), CRP (C reacti.e protei.). Unfortunately thi. has been possi.le only i. two cases because of fi.anci.l means. i. 40% of cases, surgi.al outcome was si.ple, and compli.ati.ns to a type of osteomyeli.i., shorteni.g, suppurati.n i. 42.7% of cases.

关键词： Open Fractures Fi.earm Treatment Surgery Trauma Orthopedi.s Publi. Health Afri.a

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Accounti.gi.formati.nsystems: essenti.l concepts and appli.ati.ns joseph W. Wi.ki.son ... [et al.]. 4th ed.

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2000年

作者： joseph W. Wi.ki.son ... [et al.].

来源：畅想之星图书光盘版（南... 评论

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