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The effects of combination of methanolic leaf extract of Azadirachta indica and diminazene diaceturate in the treatment of experimental Trypanosoma brucei brucei infection in rats

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Asian Pacific Journal of Tropical Medicine 2011年第5期4卷 337-341页

作者： Omoja VU Anaga AO Obidike IR Ihedioha TE Umeakuana PU Mhomga LI Asuzu IU Anika sm Department of Veterinary Physiology and Pharmacology University of NigeriaNsukkaNigeria Veterinary Teaching Hospital University of NigeriaNsukkaNigeria Department of Animal Health and Production College of Veterinary MedicineFederal University of AgricultureMarkudiBenue StateNigeria

Objective:To investigate the effects of combination therapy of methanolic leaf extract of Azadirachta indica(***) and diminazene diaceturate(DDA) in the treatment of experimental Trypanosoma brucei brucei(*** brucei) infection in ***:Acute toxicity study of the drug and extract combinations were *** of the best drug and extract combinations was carried out using fifty four rats of both sexes separated into 9 *** dose combinations were derived from selection of the best drug and extract combinations used for the final study viz:7 mg/kg bw DDA plus 125 mg/kg bw extract(group B),3.5 mg/kg bw DDA plus 250 mg/kg bw extract(group C),and 1.8 mg/kg bw DDA plus 500 mg/kg bw extract(group D).The final study had in addition to the three groups derived from the dose response study,four other groups viz:uninfected untreated negative control(group F),infected and treated with 3 000 mg/kg bw extract alone(group E),infected and treated with 7 mg/kg bw DDA alone(group A),and infected untreated positive control(group G).The parameters assessed were onset of parasitaemia(OP), level of parasitaemia(LOP),clearance of parasites post treatment(COPPT),relapse infection period(RIP),post infection survival period(PIST).Results:There was no significant difference in OP between the groups(P<0.05).One day post treatment,the mean LOP of groups A,B,and C were found to be significantly lower than that of group D which in turn was lower than that of group E and G *** mean LOP of group E was significantly lower than group G two days post treatment and this trend continued throughout the experimental *** COPPT of group D was significantly longer than that of groups A,C and *** was no significant difference in the mean COPPT among groups B,C and *** mean RIP of group D was significantly shorter than group C,and that of group C was significantly shorter than that of group *** was no relapse of infection in group *** PIST of grou

关键词： Combination Relapse Therapy Trypanosomes

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The burden of chronic respiratory diseases in the Asia-Pacific region ——Now and the future

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中国呼吸与危重监护杂志 2002年第1期 10-11页

作者： Mary sm Ip Mary Hospital China Hongkong

Burden of respiratory diseaseThe concept of the total burden of a disease is tradi-tionally described by computing its prevalence and in-cidence, the morbidity and mortality. In recentyears, quantification of the economic and social bur-den caused by the disease has become increasingly rel-evant in an age of rapidly escalating health care ex-penditure and an changing populations demographics.

关键词： COPD Now and the future Asia

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Sexual Dimorphism of Foramen Magnum between Two Different Groups of Indian Population: A Cross‑Sectional Cone‑Beam Computed Tomography Study

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Journal of Forensic Science and Medicine 2018年第3期4卷 150-155页

作者： Vidisha Gargi Ravi Prakash sm Sangeeta Malik Nagaraju K Sumit Goel Swati Gupta Department of Oral Medicine and Radiology Subharti Dental CollegeMeerutUttar PradeshIndia

The foramen magnum (FM), being a vital landmark at the base of the skull, includes interests to many fields of medicine. Many authors haverecounted the usefulness of the FM in gender determination. The emphasis of this study is to evaluate the shape and dimensions of the FM among males and females and to establish its role in sexual dimorphism using cone-beam computed tomography (CBCT). Furthermore, to evaluate the area and FM index (FMI) among males and females and finally to evaluate the differences in FM measurements if any in twodifferent regions of an Indian population. One hundred and ten CBCT scans (55 males and 55 females;age range, 20–80 years) were selectedfor this study. The sagittal diameter, transverse diameter, area, FMI, and circumference of FM were measured, and data were subjected to discriminant analysis for the evaluation of sexual dimorphism. The area of FM was the best discriminant parameter which was used to study the sexual dimorphism with an overall accuracy of 90.9%. It can be concluded that the reconstructed CBCT image provides valuable measurements for the FM and could be used for gender determination.

关键词： Craniometry dimorphism foramen magnum

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Is COVID-19-induced liver injury different from other RNA viruses?

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World Journal of Meta-Analysis 2021年第2期9卷 108-127页

作者： Marwan sm Al-Nimer Department of Clinical Pharmacy Hawler Medical UniversityErbil 44001Iraq College of Medicine University of DiyalaBaqubah 32001Iraq

Coronavirus disease 2019 is a pandemic disease caused by a novel RNA coronavirus,SARS coronavirus 2(SARS-CoV-2),which is implicated in the respiratory ***-CoV-2 also targets extrapulmonary systems,including the gastrointestinal tract,liver,central nervous system and ***-CoV-2,like other RNA viruses,targets the liver and produces liver *** literature review showed that SARS-CoV-2-induced liver injury is different from other RNA viruses by a transient elevation of hepatic enzymes and does not progress to liver fibrosis or other unfavorable ***,SARS-CoV-2-induced liver injury usually occurs in the presence of risk factors,such as nonalcoholic liver fatty *** review highlights the important differences between RNA viruses inducing liver injury taking into consideration the clinical,biochemical,histopathological,postmortem findings and the chronicity of liver injury that ultimately leads to liver fibrosis and hepatocellular carcinoma.

关键词： Liver injury COVID-19 RNA-viruses Risk factors Liver enzymes Liver fibrosis

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Normal scalar curvature and a pinching theorem in S^m×R and H^m×R

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Science China Mathematics 2011年第9期54卷 1977-1984页

作者： CHEN Qun 1,2 & CUI Qing 3,1,1 School of Mathematics and Statistics,Wuhan University,Wuhan 430079,China 2 International Center for Theoretical Physics,Trieste 34100,Italy 3 School of Mathematics,Southwest Jiaotong University,Chengdu 610031,China School of Mathematics and Statistics Wuhan University Wuhan China International Center for Theoretical Physics Trieste Italy School of Mathematics Southwest Jiaotong University Chengdu China

We obtain an inequality in sm×R and Hm×R which is similar to DDVV *** an application,we show that a minimal submanifold in H m×R with nonnegative scalar curvature must be a surface of the type γ×R,where γ is a g... 详细信息

关键词： product spaces DDVV conjecture pinching theorem

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Additive potential of ginger starch on antifungal potency of honey against Candida albicans

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Asian Pacific Journal of Tropical Biomedicine 2012年第4期2卷 253-255页

作者： Ahmed Moussa Djebli Noureddine Hammoudi sm Aissat Saad Akila Bourabeh Hemida Houari Laboratory of Hygiene and Animal Pathology Institute of Veterinary Sciences University Ibn-KhadounTiaret Departments of Biology Faculty of SciencesMostaganem University Institute of Veterinary Sciences University Ibn-Khadoun Tiaret

Objective:To evaluate the additive action of ginger starch on the antifungal activity of honey against Candida albicans(***).Methods:*** was used to determine the minimum inhibitory concentration(MIC)of four varieties of Algerian *** concentrations of honey than the MIC were incubated with a set of concentrations of starch and then added to media to detennine the minimum additive inhibitory concentration(MAIC).Results:The MIC for the four varieties of honey without starch against *** ranged between 38%and 42%(v/v).When starch was incubated with honey and then added to media,a MIC drop was noticed with each *** of the four varieties ranged between 32%honey(v/v)with 4%starch and 36%honey(v/v) with 2%***:The use of ginger starch allows honey benefit and will constitute an alternative way against the resistance to antifungal agents.

关键词： Honey Ginger starch Antifungal potency Candida albicans

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光盘数据库及其在发展中国家的应用前景

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国外情报科学 1992年第2期10卷 64-66,F003页

作者： Ali,sm 张燕

发展中国家需要利用美英等发达国家的最新信息,尤其是科技领域的最新信息来促进本国的技术引进与研究开发工作。光盘技术有可能成为检索利用大量信息的一种新方法。人们可用它建立自有信息检索系统来利用其中存贮的几百万条记录。这种... 详细信息

发展中国家需要利用美英等发达国家的最新信息,尤其是科技领域的最新信息来促进本国的技术引进与研究开发工作。光盘技术有可能成为检索利用大量信息的一种新方法。人们可用它建立自有信息检索系统来利用其中存贮的几百万条记录。这种自有信息系统可以节省远程通讯费用,并使人们检索时不受限制。[第一段]

关键词：光盘数据库发展中国家

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Effects of long-term cultivation practices and nitrogen fertilization rates on carbon stock in a calcareous soil on the Chinese Loess Plateau

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Journal of Arid Land 2018年第1期10卷 129-139页

作者： CAI Miao CHEN Zhujun ZHOU Jianbin HAN Jichang SHI Qianyun College of Natural Resources and Environment Northwest A&F UniversityYangling 712100China Shaanxi Provincial Land Engineering Construction Group Xi'an 710075China

Soil organic carbon （SOC） and soil inorganic carbon （SIC） are important C pools in the Loess Plateau of Northwest China, however, variations of SOC and SIC stocks under different cultivation practices and nitrogen （N） fertilization rates are not clear in this area. A long-term field experiment started in June 2003 was conducted to investigate the SOC and SIC stocks in a calcareous soil of the Chinese Loess Plateau under four cultivation practices, i.e., fallow （FA）, conventional cultivation （CC）, straw mulch （sm）, and plastic film-mulched ridge and straw-mulched furrow （RF）, in combination with three N fertilization rates, i.e., 0 （NO）, 120 （N120）, and 240 （N240） kg N/hm2. Results indicate that the crop straw addition treatments （sm and RF） increased the contents of soil microbial biomass C （smBC） and SOC, and the SOC stock increased by 10.1%-13.3% at the upper 20 cm soil depth in comparison to the 8-year fallow （FA） treatment. Meanwhile, SIC stock significantly increased by 19% at the entire tested soil depth range （0-100 cm） under all crop cultivation practices in comparison to that of soil exposed to the long-term fallow treatment, particularly at the upper 60 cm soil depth. Furthermore, moderate N fertilizer application （120 kg N/hm2） increased SOC stock at the upper 40 cm soil depth, whereas SIC stock decreased as the N fertilization rate increased. We conclude that the combined application of crop organic residues and moderate N fertilization rate could facilitate the sequestrations of SOC and SIC in the calcareous soil.

关键词： calcareous soil cultivation practices N appfication rate soil C stock Loess Plateau

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Microbiota modification by probiotic supplementation reduces colitis associated colon cancer in mice

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World Journal of Gastroenterology 2018年第18期24卷 1995-2008页

作者： Maria Carolina S Mendes Daiane sm Paulino Sandra R Brambilla Juliana A Camargo Gabriela F Persinoti José Barreto C Carvalheira Department of Internal Medicine Faculty of Medical Sciences State University of Campinas (UNICAMP) Brazilian Bioethanol Science and Technology Laboratory (CTBE) Brazilian Center for Research in Energy and Materials (CNPEM)

AIM To investigate the effect of probiotic supplementation during the development of an experimental model of colitis associated colon cancer(CAC). METHODS C57 BL/6 mice received an intraperitoneal injection of azoxymethane(10 mg/kg), followed by three cycles of sodium dextran sulphate diluted in water(5% w/v). Probiotic group received daily a mixture of Lactobacillus acidophilus, Lactobacil us rhamnosus and Bifidobacterium bifidum. Microbiota composition was assessed by 16 Sr RNA Illumina Hi Seq sequencing. Colon samples were collected for histological analysis. Tumor cytokines was assessed by Real Time-PCR(Polymerase Chain Reaction); and serum cytokines by Multiplex assay. All tests were two-sided. The level of significance was set at P sm 5.0. The project was approved by the institutional review board committee. RESULTS At day 60 after azoxymethane injection, the mean number of tumours in the probiotic group was 40% lower than that in the control group, and the probiotic group exhibited tumours of smaller size(10 expression in the colon. CONCLUSION Our results suggest a potential chemopreventive effect of probiotic on CAC. Probiotic supplementation changes microbiota structure and regulates the inflammatory response, reducing colitis and preventing CAC.

关键词： Intestinal microbiota Chemoprevention Lactobacillus acidophilus Lactobacillus rhamnosus Bifidobacterium bifidum

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Non-universal Gauge Bosons Z'and the Process e~+e~- →f

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Communications in Theoretical Physics 2004年第3期41卷 419-424页

作者： YUE Chong-Xing~1 WANG Shun-Zhi~2 1 Department of Physics,Liaoning Normal University,Dalian 116029,China 2 College of Physics and Information Engineering,Henan Normal University,Xinxiang 453002,China Department of Physics Liaoning Normal University Dalian 116029 College of Physics and Information Engineering Henan Normal University Xinxiang 453002

Introduetion Altl、ough the standard model(sm)that bases on thega、lge gro、ip SU:(2)xU(1)has been sueeessful in de-seribing the Physies of eleetroweak interaetions,the meeh-anisn,of the eleetroweak symmetry breaking(... 详细信息

关键词： non-universal gauge bosons cross section TC2 models

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