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Evaluation of Steroid Receptors mRNA Fingerprints in Two Groups of Normozoospermic Patients: Men from Unexplained Infertility Couples vs. Men from Couples with Tubal Factor Infertility

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Open Journal of Obstetrics and Gynecology 2017年第3期7卷 290-302页

作者： Katarzyna Jarzabek Agnieszka Mikucka-Niczyporuk Tomasz Bielawski Robert Milewski Jacek Z. Kubiak slawomir wolczynski Department of Biology and Pathology of Human Reproduction in Bialystok Institute of Animal Reproduction and Food Research in Olsztyn Polish Academy of Sciences Olsztyn Poland Department of Reproduction and Gynecological Endocrinology Medical University of Bialystok Bialystok Poland Department of Statistics and Medical Informatics Medical University of Bialystok Bialystok Poland Institute of Genetics and Development of Rennes Cell Cycle Group CNRS UMR 6290 Rennes France Faculty of Medicine University Rennes 1 UEB IFR 140 Rennes France Department of Regenerative Medicine and Cell Biology Military Institute of Hygiene and Epidemiology Warsaw Poland

The study of sperm cellular components at molecular level is crucial for the diagnosis of male unexplained infertility. The aim of the study was to compare the molecular profile of steroid receptors and aromatase in spermatozoa obtained from two normozoospermic groups of patients issued from couples treated for infertility. We investigated 46 male patients from unexplained infertility couples and from men, 38 where female partners presented with tubal infertility. Sperm ERs (estrogen receptors: alpha and beta), GPER (G protein-coupled estrogen receptor), AR (androgen receptor) and aromatase mRNA expression levels by TaqMan qPCR were analyzed. AR transcript level was significantly lower in sperm of men from unexplained infertility couples vs. men from couples with tubal factor infertility (P = 0.04). Although the AR mRNA expression level did not had any effect on embryo development and its implantation, a significant correlation between AR mRNA levels and clinical pregnancy in unexplained infertility patients was observed. Taken together, AR transcript presence in ejaculated spermatozoa could be a potential marker for unexplained infertility.

关键词： Androgen Receptor Unexplained Infertility Spermatozoa mRNA

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