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Inflammatory niche:Mesenchymal stromal cell priming by soluble mediators

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World Journal of Stem Cells 2020年第9期12卷 922-937页

作者： Aleksandra Jauković Tamara Kukolj Hristina Obradović Ivana Okić-Đorđević slavko mojsilović Diana Bugarski Laboratory for Experimental Hematology and Stem Cells Institute for Medical ResearchUniversity of BelgradeBelgrade 11129Serbia

Mesenchymal stromal/stem cells(MSCs)are adult stem cells of stromal origin that possess self-renewal capacity and the ability to differentiate into multiple mesodermal cell *** play a critical role in tissue homeostasis and wound healing,as well as in regulating the inammatory microenvironment through interactions with immune ***,MSCs have garnered great attention as promising candidates for tissue regeneration and cell *** the inflammatory niche plays a key role in triggering the reparative and immunomodulatory functions of MSCs,priming of MSCs with bioactive molecules has been proposed as a way to foster the therapeutic potential of these *** this paper,we review how soluble mediators of the inflammatory niche(cytokines and alarmins)influence the regenerative and immunomodulatory capacity of MSCs,highlighting the major advantages and concerns regarding the therapeutic potential of these inflammatory primed *** data summarized in this review may provide a significant starting point for future research on priming MSCs and establishing standardized methods for the application of preconditioned MSCs in cell therapy.

关键词： Mesenchymal stem cells Pro-inflammatory cytokines Alarmins Priming Boosting the therapeutic potential

Dental mesenchymal stromal/stem cells in different microenvironments— implications in regenerative therapy

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World Journal of Stem Cells 2021年第12期13卷 1863-1880页

作者： Ivana Okić-Đorđević Hristina Obradović Tamara Kukolj Anđelija Petrović slavko mojsilović Diana Bugarski Aleksandra Jauković Laboratory for Experimental Hematology and Stem Cells Institute for Medical ResearchUniversity of BelgradeBelgrade 11129Serbia

Current research data reveal microenvironment as a significant modifier of physical functions,pathologic changes,as well as the therapeutic effects of stem *** comparing regeneration potential of various stem cell types used for cytotherapy and tissue engineering,mesenchymal stem cells(MSCs)are currently the most attractive cell source for bone and tooth regeneration due to their differentiation and immunomodulatory potential and lack of ethical issues associated with their *** microenvironment of donors and recipients selected in cytotherapy plays a crucial role in regenerative potential of transplanted MSCs,indicating interactions of cells with their microenvironment indispensable in MSC-mediated bone and dental *** a variety of MSC populations have been procured from different parts of the tooth and tooth-supporting tissues,MSCs of dental origin and their achievements in capacity to reconstitute various dental tissues have gained attention of many research groups over the *** review discusses recent advances in comparative analyses of dental MSC regeneration potential with regards to their tissue origin and specific microenvironmental conditions,giving additional insight into the current clinical application of these cells.

关键词： Microenvironment Dental mesenchymal stem cells Modulation of regenerative potential Tissue origin Hypoxia microenvironment Inflammatory microenvironment Clinical application

The effect of reactive plasticizer on viscoelastic and mechanical properties of solid rocket propellants based on different types of HTPB resin

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Defence Technology（防务技术） 2024年第3期33卷 66-77页

作者： Tihomir Kovacevic slavko Mijatov Jelena Grzetic Suzana Cakic Bojana Fidanovski Sasa Brzic Military Technical Institute Ministry of DefenceRatka Resanovica 1BelgradeSerbia Faculty of Technology University of NisBulevar osloboCenja 124LeskovacSerbia

Conventional plasticizers deteriorate mechanical and viscoelastic properties of the propellants due to their migration upon aging and long-term storage,which affects reliability and safety properties during *** address this issue,conventional plasticizer,dioctyl adipate(DOA),is replaced by reactive one,castor oil(CO).In addition,three different types of HTPB were used to obtain propellants with designed viscoelastic and mechanical *** CO increased propellants viscosity,without a significant impact on the propellant processability,regardless to the type of ***,mechanical properties were different depending on the type of resin,which were further analyzed by gel permeation chromatography(GPC).Addition of CO formed a denser polymer network and shifted T_(g) to higher values,compared to the compositions with *** tensile strength of CO-containing propellants was lower at +20℃ and +50℃ compared to the reference compositions,while the strain at maximum load and strain at break were significantly increased with pronounced plastic deformation,especially for samples at -30℃.The inclusion of CO in the propellants composition gives more room for adjusting a wide range of mechanical properties.

关键词： HTPB-based composite propellants Castor oil Reactive plasticizer Gel permeation chromatography Sol-gel analysis Mechanical and viscoelastic properties

Polyphenols isolated from Acacia mearnsii bark with anti-inflammatory and carbolytic enzyme inhibitory activities

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Chinese Journal of Natural Medicines 2017年第11期15卷 816-824页

作者： XIONG Jia GRACE Mary H ESPOSITO Debora KOMARNYTSKY slavko WANG Fei LILA Mary Ann Department of Chemical Engineering Jiangsu Key Lab of Biomass-based Green Fuels and Chemicals Nanjing Forestry University Plants for Human Health Institute Department of Food Bioprocessing and Nutrition Sciences North Carolina State UniversityNorth Carolina Research Campus

The present study was designed to characterize the polyphenols isolated from Acacia mearnsii bark crude extract(B) and fractions(B1-B7) obtained by high-speed counter-current chromatography(HSCCC) and evaluate their anti-inflammatory and carbolytic enzymes(α-glucosidase and α-amylase) inhibitory activities. Fractions B4, B5, B6, B7(total phenolics 850.3, 983.0, 843.9, and 572.5 mg·g^(-1)), respectively; proanthocyanidins 75.7, 90.5, 95.0, and 44.8 mg·g^(-1)), respectively) showed significant activities against reactive oxygen species(ROS), nitric oxide(NO) production, and expression of pro-inflammatory genes interleukin-1β(IL-1β) and inducible nitric oxide synthase(iNOS) in a lipopolysaccharide(LPS)-stimulated mouse macrophage cell line RAW 264.7. All the extracts suppressed α-glucosidase and α-amylase activities, two primary enzymes responsible for carbohydrate digestion. A. mearnsii bark samples possessed significantly stronger inhibitory effects against α-glucosidase enzyme(IC_(50) of 0.4-1.4 μg·mL^(-1)) than the pharmaceutical acarbose(IC_(50) 141.8 μg·mL^(-1))). B6 and B7(IC_(50) 17.6 and 11.7 μg·mL^(-1), respectively) exhibited α-amylase inhibitory activity as efficacious as acarbose(IC_(50) 15.4 μg·mL^(-1))). Moreover, B extract, at 25 μg·mL^(-1), significantly decreased the non-mitochondrial oxidative burst that is often associated with inflammatory response in human monocytic macrophages.

关键词： acacia mearnsii Proanthocyanidins Anti-inflammatory α-Amylase α-Glucosidase

Resistor-Capacitor Circuit as a Dynamic System

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Journal of Applied Mathematics and Physics 2024年第10期12卷 3307-3314页

作者： slavko Đurić Faculty of Transport and Traffic Engineering Doboj University of East Sarajevo Doboj Bosnia and Herzegovina

The paper considers the response to the accumulated energy in the resistor (R)-capacitor (C) circuit. In the (RC) circuit, the capacitor C is initially charged with the “capacitive” voltage U0. At that moment t=0, the P circuit switch turns on. By using Kirchhoff’s laws on the elements, a homogeneous differential equation of the first order with constant coefficients is obtained with the initial condition UC(0)=U0. The solution of the differential equation is presented in exponential form UC(t)=U0⋅e−t/τ. Qualitative analysis RC of the circuit gives a phase portrait on the line. From the phase portrait on the line, it can be seen that the charge UC(t)→UC∗=0when t→∞stabilizes, regardless of the initial conditions. It is shown that from UC(t)=U0⋅e−t/τa dynamic system defined by the function φ(t,UC)=UC⋅e−t/τcan be formed from. It has also been shown that, from the formed dynamic system, an autonomous system (circuit equation RC) can be found whose solution describes the formed dynamic system. It is also shown that the dynamic system φ(t,UC)=UC⋅e−t/τhas one attractive fixed point UC=0.

关键词： RC Circuit Voltage Dynamic System

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南斯拉夫铝土矿的采矿方法

轻金属 1991年第5期 7-11,32页

作者： slavko Vujec 赵金福

1.导言南斯拉夫于上个世纪在伊斯的利亚首先开采铝土矿,在世界上或许也是第一个。当时是用地下开采法开采黄铁矿化的铝土矿作为生产明礬的原料。 1914年,作为铝工业原料的铝土矿,也是从伊斯的利亚地区首先开采出来的(PAmbrosi,1955)。... 详细信息

1.导言南斯拉夫于上个世纪在伊斯的利亚首先开采铝土矿,在世界上或许也是第一个。当时是用地下开采法开采黄铁矿化的铝土矿作为生产明礬的原料。 1914年,作为铝工业原料的铝土矿,也是从伊斯的利亚地区首先开采出来的(PAmbrosi,1955)。到第二次世界大战时,已有许多地方小规模生产铝土矿(Obrovac,Mostar)。

关键词：铝矿床采矿南斯拉夫

Two synchronous somatostatinomas of the duodenum and pancreatic head in one patient

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World Journal of Gastroenterology 2009年第46期15卷 5859-5863页

作者： Radoje B olovi slavko V Mati Marjan T Micev Nikica M Grubor Henry Dushan Atkinson Stojan M Latini The First Surgical Clinic Clinical Center of Serbia Surgical Directorate Imperial College School of MedicineSt Mary's HospitalPraed St

Somatostatinomas are extremely rare neuroendocrine tumors of the gastrointestinal tract,f irst described in the pancreas in 1977 and in the duodenum in *** may be functional and cause somatostatinoma or inhibi-tory syndrome,but more frequently are non-functioning pancreatic endocrine tumors that produce somatostatin *** are usually single,malignant,large lesions,frequently associated with metastases,and generally with poor *** present the unique case of a 57-year-old woman with two synchronous non-function-ing somatostatinomas,one solid duodenal lesion and one cystic lesion within the head of the pancreas,that were successfully resected with a pylorus-preserving Whipple's *** secondaries were found in the liver,or in any of the removed regional lymph *** patient had an uneventful recovery,and remains well and symptom-free at 18 mo *** is an extremely rare case of a patient with two synchro-nous somatostatinomas of the duodenum and the *** condition is discussed with reference to the literature.

关键词： Somatostatinoma Duodenal neoplasms Pancreatic neoplasms

Experimental Investigation of Pyrolysis Process of Woody Biomass Mixture

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Journal of Thermal Science 2014年第3期23卷 290-296页

作者： Tijana R.Kosanic Mirjana B.Ceranic slavko N.Duric Vojin R.Grkovic Milan M.Milotic Sasa D.Brankov Faculty of Technical Sciences University of Novi SadRepublic of Serbia Faculty of Transport and Traffic Engineering University of East SarajevoDoboj Bosnia and Herzegovina

This paper describes an experimental investigation of pyrolysis of woody biomass mixture. The mixture consists of oak, beech, fir, cherry, walnut and linden wood chips with equal mass fractions. During the experiment, the sample mass inside the reactor was 10 g with a particle diameter of 5-10 mm. The sample in the reactor was heated in the temperature range of 24-650℃. Average sample heating rates in the reactor were 21, 30 and 54 ℃/min. The sample mass before, during and after pyrolysis was determined using a digital scale. Experimental results of the sample mass change indicate that the highest yield of pyrolytic gas was achieved at the temperature slightly above 650℃ and ranged from 77 to 85%, while char yield ranged from 15 to 23%. Heating rate has sig- nificant influence on the pyrolytic gas and char yields. It was determined that higher pyrolysis temperatures and heating rates induce higher yields of pyrolytic gas, while the char mass reduces. Condensation of pyrolytic gas at the end of the pyrolysis process at 650℃ produced 2.4-2.72 g of liquid phase. The results obtained represent a starting basis for determining material and heat balance of pyrolysis process as well as woody biomass pyrolysis equipment.

关键词： pyrolysis woody biomass mixture pyrolysis temperature gas yield

Variational Approach to Heat Conduction Modeling

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Journal of Applied Mathematics and Physics 2024年第1期12卷 234-248页

作者： slavko Đurić Ivan Aranđelović Milan Milotić Faculty of Traffic Engineering University of East Sarajevo Doboj Bosnia and Herzegovina Faculty of Mechanical Engineering University of Belgrade Belgrade Republic of Serbia

It is known that Fourier’s heat equation, which is parabolic, implies an infinite velocity propagation, or, in other words, that the mechanism of heat conduction is established instantaneously under all conditions. This is unacceptable on physical grounds in spite of the fact that Fourier’s law agrees well with experiment. However, discrepancies are likely to occur when extremely short distances or extremely short time intervals are considered, as they must in some modern problems of aero-thermodynamics. Cattaneo and independently Vernotte proved that such process can be described by Heaviside’s telegraph equation. This paper shows that this fact can be derived using calculus of variations, by application of the Euler-Lagrange equation. So, we proved that the equation of heat conduction with finite velocity propagation of the thermal disturbance can be obtained as a solution to one variational problem.

关键词： Telegraph Equation Heat Equation Heat Conduction Calculus of Variations