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最小子宫内膜异位症患者腹水中细胞因子及sICAM-1:寻找不孕和(或)子宫内膜异位症的识别因子

世界核心医学期刊文摘（妇产科学分册） 2006年第2期2卷 12-13页

作者： skrzypczak j. Szczepańska M. Puk E. M. Kurpisz 朱晓明 Unit of Reproductive Biology Institute of Human Genetics Pol. Acad. Sci. ul.Strzeszyńska 32 60-479 PoznańPoland

Obj.ctive: To evaluate cytokine levels (IL-1β,TNF-α,IL-6, IL-8), soluble intercellular adhesion molecule-1 (sICAM-1)-and number of macrophages in peritoneal fluid (PF)of women with no minimal endometriosis and associated (or not) infertility in order to discriminate between infertility and/or endometriosis. Study design: Cytokines and sICAM-1 were measured by using quantitative enzyme-linked immunosorbent assay (ELISA) while the macrophages were identified by May-Grunwald-Giemsa and non-specific esterase staining and presented as medians. The measurements were performed in 78 women belonging to four selected subgroups according to their endometriosis and/or infertility status. Statistical analysis was performed using Kruskal-Wallis non-parametric ANOVA test. Additionally, discriminant function analyses were performed. Results: We have found the most elevated macrophage numbers in the groups of women with endometriosis. IL-1βdid not present any statistically significant values differentiating the analysed subgroups. IL-6 (110.0 pg/ml) and TNF-αexhibited the highest concentrations (statistically significant) in a group of fertile women with endometriosis. IL-8 clearly differentiated between the subgroups with infertility and sICAM-1 was statistically significantly elevated in the subgroups of infertile women. In the forward discriminant analysis, when subdividing the studied population according to its infertility status (we considered macrophages, IL-8 and IL-6 in order of probability values), we have found striking probability value of 92%for the correct classification into an infertile population. Conclusion: Out of the range of the analysed factors we have found only the sICAM-1 to be singled out between the standard discriminant analysis and the forward one. However, this important flagging molecule might be of considerable value for discrimination between different types of pathology at the level of immune effector function. The increased levels of TNF-αand IL-6

关键词：子宫内膜异位症 sICAM-1 细胞因子非子宫内膜异位巨噬细胞不孕妇女 allis 函数分析

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