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Advances in the treatment of autism spectrum disorder:Wharton jelly mesenchymal stem cell transplantation

World Journal of Methodology 2025年第1期15卷 72-79页

作者： Serdar Kabatas ErdinçCivelek eyüp Can Savrunlu Umut Karaaslan Özlem Yıldız Erdal Karaöz Department of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalIstanbul 34255Türkiye Department of Pediatric Allergy-Immunology Institute of Health Sciences Marmara UniversityIstanbul 34865Türkiye Center for Stem Cell&Gene Therapy Research and Practice University of Health Sciences TurkeyIstanbul 34255Türkiye Department of Child and Adolescent Psychiatry University of Health SciencesGaziosmanpaşa Training and Research HospitalIstanbul 34255Türkiye Department of Child and Adolescent Psychiatry Kocaeli University Faculty of MedicineKocaeli 41001Türkiye Center for Regenerative Medicine and Stem Cell Research&Manufacturing Liv HospitalIstanbul 34340Türkiye Department of Histology and Embryology Istinye UniversityFaculty of MedicineIstanbul 34010Türkiye Center for Stem Cell and Tissue Engineering Research and Practice Istinye UniversityIstanbul 34340Türkiye

BACKGROUND Autism spectrum disorder(ASD)is a complex neurodevelopmental disorder with multifaceted *** recent studies,neuroinflammation and immune dysregulation have come to the forefront in its *** are studies suggesting that stem cell therapy may be effective in the treatment of *** To evolve the landscape of ASD treatment,focusing on the potential benefits and safety of stem cell *** A detailed case report is presented,displaying the positive outcomes observed in a child who underwent intrathecal and intravenous Wharton’s jelly-derived mesenchymal stem cells(WJ-MSCs)transplantation combined with *** The study demonstrates a significant improvement in the child’s functional outcomes(Childhood Autism Rating Scale,Denver 2 Developmental Screening Test),especially in language and gross motor *** serious side effects were encountered during the 2-year *** The findings support the safety and effectiveness of WJ-MSC transplantation in managing ASD.

关键词： Autism spectrum disorder Neurorehabilitation Stem cell transplantation Wharton jelly mesenchymal stem cells Inflammation

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核苷二磷酸激酶C抑制人心力衰竭时的环磷酸腺苷生成

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中华高血压杂志 2017年第1期25卷 26-26页

作者：刘莉叶鹏 Abu-Taha IH Heijman J Hippe HJ Wolf NM El-Armouche A Nikolaev VO Sch?fer M Würtz C Neef S Voigt BaczkóI Varró A Müller M Meder B Katus HA Spiger K Vettel C Lehmann LH Backs J skolnik ey Lutz S Dobrev D Wieland T

慢性心力衰竭（chronic heart failure，CHF）与β肾上腺素受体／G蛋白耦联受体信号转导系统变化、环磷酸腺苷（cyclic adenosine monophosphate，cAMP）生成减少相关。核苷酸磷酸激酶（nucleoside diphosphate kinases，NDPK）在终末期... 详细信息

慢性心力衰竭（chronic heart failure，CHF）与β肾上腺素受体／G蛋白耦联受体信号转导系统变化、环磷酸腺苷（cyclic adenosine monophosphate，cAMP）生成减少相关。核苷酸磷酸激酶（nucleoside diphosphate kinases，NDPK）在终末期CHF患者的血浆质膜富集，但其功能在很大程度上是未知的，

关键词：慢性心力衰竭环磷酸腺苷磷酸激酶C 核苷酸 G蛋白耦联受体 β肾上腺素受体 kinases 信号转导系统

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A New Privacy-Preserving Data Publishing Algorithm Utilizing Connectivity-Based Outlier Factor and Mondrian Techniques

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Computers, Materials & Continua 2023年第8期76卷 1515-1535页

作者： Burak Cem Kara Can eyüpoglu Department of Computer Engineering Turkish Air Force AcademyNational Defence UniversityYesilyurtIstanbulTurkey Department of Computer Engineering Atatürk Strategic Studies and Graduate InstituteNational Defence UniversityBesiktasIstanbulTurkey

Developing a privacy-preserving data publishing algorithm that stops individuals from disclosing their identities while not ignoring data utility remains an important goal to *** finding the trade-off between data privacy and data utility is an NP-hard problem and also a current research *** existing approaches are investigated,one of the most significant difficulties discovered is the presence of outlier data in the *** data has a negative impact on data ***,k-anonymity algorithms,which are commonly used in the literature,do not provide adequate protection against outlier *** this study,a new data anonymization algorithm is devised and tested for boosting data utility by incorporating an outlier data detection mechanism into the Mondrian *** connectivity-based outlier factor(COF)algorithm is used to detect *** is selected because of its capacity to anonymize multidimensional data while meeting the needs of real-world ***,on the other hand,is used to discover outliers in high-dimensional datasets with complicated *** proposed algorithm generates more equivalence classes than the Mondrian algorithm and provides greater data utility than previous algorithms based on *** addition,it outperforms other algorithms in the discernibility metric(DM),normalized average equivalence class size(Cavg),global certainty penalty(GCP),query error rate,classification accuracy(CA),and F-measure ***,the increase in the values of theGCPand error ratemetrics demonstrates that the proposed algorithm facilitates obtaining higher data utility by grouping closer data points when compared to other algorithms.

关键词： Data anonymization privacy-preserving data publishing k-anonymity generalization mondrian

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Evaluation of Cytotoxicity and Genotoxicity of Insecticide Carbaryl to Flounder Gill Cells and Its Teratogenicity to Zebrafish Embryos

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Journal of Ocean University of China 2015年第2期14卷 362-374页

作者： ey Manish Raj GUO Huarong Laboratory of Evolution & Development Institute of Evolution & Marine Biodiversity Ocean University of China Key Laboratory of Marine Genetics and Breeding of Ministry of Education College of Marine Life SciencesOcean University of China

In this study, we determined the cytotoxicity and genotoxicity of carbamate insecticide carbaryl to flounder gill （FG） cells and its teratogenicity to zebrafish embryos. The cytotoxicity of carbaryl to FG cells was determined with methods including MTT and neutral red uptaking （NRU）, lactate dehydrogenase （LDH） releasing and Hoechst 33342 and propidiurn idodide （PI） double staining. Moderate cytotoxicity in a concentration-dependent manner was observed. The 24h-IC50 value of 53.48 ± 1.21, 59.13 ± 1.19 and 46.21 ± 1.24 mgL 1 carbaryl was obtained through MTT, NRU and LDH assays, respectively. Double fluorescence staining dem- onstrated that carbaryl induced the death of FG cells mainly through necrosis. There was no significant genotoxicity found in the FG cells exposed to the highest testing concentration of carbaryl （20mgL-1, P〉0.05） as was demonstrated by Comet assay. Zebrafish embryos exposed to carbaryl at concentrations 〉10 mg L-1 displayed moderate toxic effects on the survival, spontaneous movement, hatching, heart rates of the embryos and their development, which were evidenced by yolk and pericardial sac edemas, body length reduction and tail flexure in time- and concentration-dependent manners at specific stages. The 24h-, 48h- and 96h-LC50 values of carbaryl to zebra fish embryos were 41.80 ± 1.10, 17.80 ± 1.04 and 14.46 ± 1.05 mg L-1, respectively. These results suggested that car- baryl is moderately toxic to FG ceils cultured in vitro and zebrafish embryos, and the FG cells were similar to zebrafish embryos in their sensitivity to carbaryl as 24h-IC50 and LC50 indicated.

关键词： carbaryl cytotoxicity genotoxicity teratogenicity flounder gill cell zebrafish

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Automated diagnosis and staging of Fuchs’endothelial cell corneal dystrophy using deep learning

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eye and Vision 2020年第2期7卷 423-433页

作者： Taher Eleiwa Amr Elsawy eyüpÖzcan Mohamed Abou Shousha Bascom Palmer eye Institute Miller School of MedicineUniversity of MiamiMiamiFlorida 33136USA Department of Ophthalmology Faculty of MedicineBenha UniversityBenhaEgypt Electrical and Computer Engineering University of MiamiCoral GablesFloridaUSA Net eye Medical Center GaziantepTurkey Biomedical Engineering University of MiamiCoral GablesFloridaUSA

Background:To describe the diagnostic performance of a deep learning algorithm in discriminating early-stage Fuchs’endothelial corneal dystrophy(FECD)without clinically evident corneal edema from healthy and late-stage FECD eyes using high-definition optical coherence tomography(HD-OCT).Methods:In this observational case-control study,104 eyes(53 FECD eyes and 51 healthy controls)received HDOCT imaging(Envisu R2210,Bioptigen,Buffalo Grove,IL,USA)using a 6 mm radial scan pattern centered on the corneal *** was clinically categorized into early(without corneal edema)and late-stage(with corneal edema).A total of 18,720 anterior segment optical coherence tomography(AS-OCT)images(9180 healthy;5400 early-stage FECD;4140 late-stage FECD)of 104 eyes(81 patients)were used to develop and validate a deep learning classification network to differentiate early-stage FECD eyes from healthy eyes and those with clinical *** 5-fold cross-validation on the dataset containing 11,340 OCT images(63 eyes),the network was trained with 80%of these images(3420 healthy;3060 early-stage FECD;2700 late-stage FECD),then tested with 20%(720 healthy;720 early-stage FECD;720 late-stage FECD).Thereafter,a final model was trained with the entire dataset consisting the 11,340 images and validated with a remaining 7380 images of unseen AS-OCT scans of 41 eyes(5040 healthy;1620 early-stage FECD 720 late-stage FECD).Visualization of learned features was done,and area under curve(AUC),specificity,and sensitivity of the prediction outputs for healthy,early and late-stage FECD were ***:The final model achieved an AUC of 0.997±0.005 with 91%sensitivity and 97%specificity in detecting early-FECD;an AUC of 0.974±0.005 with a specificity of 92%and a sensitivity up to 100%in detecting late-stage FECD;and an AUC of 0.998±0.001 with a specificity 98%and a sensitivity of 99%in discriminating healthy corneas from all ***:Deep learning algorithm is an accurate autonomous nove

关键词： Optical coherence tomography Descemet’s membrane Corneal endothelium Fuchs endothelial dystrophy

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HoLEP does not affect the overall sexual function of BPH patients： a prospective study

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Asian Journal of Andrology 2014年第6期16卷 873-877页

作者： Sung Hart Kim Hyung-Kook Yang Hahn-ey Lee Jae-Seung Paick Seung-June Oh Department of Urology Prostate Cancer Center National Cancer Center Goyang Korea Department of Epidemiology and Statistics and Cancer Policy Branch of National Cancer Control Research Institute National Cancer Center Goyang Korea Department of Urology Seoul National University Hospital Seoul Korea.

We aimed to prospectively evaluate the influence of holmium laser enucleation of the prostate （HoLEP） on the overall postoperative sexual function of benign prostatic hyperplasia （BPH） patients with lower urinary tract symptoms （LUTS） and to explore the relationship between sexual function and LUTS. From January 2010 to December 2011, sixty sexually active consecutive patients with BPH who underwent HoLEP were prospectively enrolled in the study. All patients filled out the Male Sexual Health Questionnaire （MSHQ） for evaluation of their overall sexual function and the International Prostatic Symptom Score （IPSS） for pre- and post-operative 6 months evaluation of their voiding symptoms. The LUTS and sexual function changes were statistically analyzed. The preoperative and 6 months postoperative status of the patients was compared using uroflowmetry and IPSS questionnaires. The analysis revealed significant improvements following HoLEP. Among the sub-domains of the MSHQ, postoperative sexual function, including erection, ejaculation, sexual satisfaction, anxiety or sexual desire, did not significantly change after HoLEP （P 〉 0.05）, whereas satisfaction scores decreased slightly due to retrograde ejaculation in 38 patients （63.3%）. Sexual satisfaction improved significantly and was correlated with the improvements of all LUTS and the quality-of-life （QoL） domains in IPSS after surgery （QoL; relative risk [RR]： -0.293; total symptoms, RR： -0.411; P 〈 0.05）. The nocturia score was associated with the erectile function score （odds ratio 0.318, P = 0.029）. The change in ejaculatory scores did not show significant association with IPSS scores. HoLEP did not influence overall sexual function, including erectile function. In addition, sexual satisfaction improved in proportion with the improvement of LUTS.

关键词： benign prostatic hyperplasia ejaculation erectile dysfunction lasers prostatectomy sex disorders

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Effects of exosomes from mesenchymal stem cells on functional recovery of a patient with total radial nerve injury: A pilot study

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World Journal of Stem Cells 2024年第1期16卷 19-32页

作者： ErdinçCivelek Serdar Kabatas eyüp Can Savrunlu Furkan Diren Necati Kaplan Demet Ofluoğlu Erdal Karaöz Department of Neurosurgery University of Health SciencesGaziosmanpaşa Training and Research HospitalGaziosmanpaşa 34255IstanbulTurkey Department of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalGaziosmanpaşa 34255IstanbulTurkey Center for Stem Cell&Gene Therapy Research and Practice University of Health Sciences TurkeyGaziosmanpaşa 34255IstanbulTurkey Department of Neurosurgery Nevşehir State HospitalNevşehir 50300Turkey Department of Neurosurgery Istanbul Rumeli UniversityÇorlu Reyap HospitalÇorlu 59860TekirdağTurkey Department of Physical Medicine and Rehabilitation Ofluoğlu KlinikGöztepe 34728IstanbulTurkey Liv Hospital Center for Regenerative Medicine and Stem Cell Research&Manufacturing(LivMedCell)Beşiktaş34340IstanbulTurkey Department of Histology and Embryology Istinye UniversityFaculty of MedicineZeytinburnu 34010IstanbulTurkey Istinye University Center for Stem Cell and Tissue Engineering Research and PracticeBeşiktaş34340IstanbulTurkey

BACKGROUND Peripheral nerve injury can result in significant clinical complications that have uncertain ***,there is a lack of effective pharmacological interventions for nerve damage,despite the existence of several small compounds,Despite the objective of achieving full functional restoration by surgical intervention,the persistent challenge of inadequate functional recovery remains a significant concern in the context of peripheral nerve *** To examine the impact of exosomes on the process of functional recovery following a complete radial nerve *** A male individual,aged 24,who is right-hand dominant and an immigrant,arrived with an injury caused by a knife *** cut is located on the left arm,specifically below the *** neurological examination and electrodiagnostic testing reveal evidence of left radial nerve *** sural autograft was utilized for repair,followed by the application of 1 mL of mesenchymal stem cell-derived exosome,comprising 5 billion *** exosome was split into four equal volumes of 0.25 mL each and delivered microsurgically to both the proximal and distal stumps using the subepineural *** patient was subjected to a period of 180 d during which they had neurological examination and electrodiagnostic *** The duration of the patient’s follow-up period was 180 *** increasing Tinel’s sign and sensory-motor recovery were detected even at the 10th wk following nerve *** the conclusion of the 6-mo post-treatment period,an evaluation was conducted to measure the extent of improvement in motor and sensory functions of the *** assessment was based on the British Medical Research Council scale and the Mackinnon-Dellon *** results indicated that the level of improvement in motor function was classified as M5,denoting an excellent ***,the level of improvement in sensory function was classified as S3+,indicating a good *** is

关键词： Mesenchymal stem cell Exosomes Radial nerve Sural nerve

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急性肺损伤的肺泡巨噬细胞TNF—α及IL—8免疫组织化学研究

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中华病理学杂志 1996年第1X期26卷 43-44页

作者：梁延杰 Chi.,ey

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The Improvements of the Backhoe-Loader Arms

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Modeling and Numerical Simulation of Material Science 2013年第4期3卷 142-148页

作者： Ahmet Erklig eyüp Yeter Department of Mechanical Engineering Faculty of Engineering University of Gaziantep Gaziantep Turkey

In this study, static structural analysis of backhoe-loader arms has been performed with the finite element method (FEM). The aim of this study is to simulate and strengthen the back and front arms of the backhoe-loader concerning with stress under maximum loading condition and different boundary conditions. According to analysis result, back and front arms of the backhoe-loader are strengthened with the use of reinforcements. As a result of the study, strength of the arms has been increased by nearly 20%.

关键词： Backhoe-Loader Finite Element Simulation ANSYS

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Acute cyanide poisoning due to apricot kernel ingestion

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Journal of Acute Disease 2017年第2期6卷 87-88页

作者： Mehmet Tatli Gokhan eyüpoglu Hilal Hocagil Department of Emergency Medicine Kayseri Training and Research HospitalKayseriTurkey Department of Emergency Medicine Bitlis State HospitalBitlisTurkey Department of Emergency Medicine Faculty of MedicineBulent Ecevit UniversityZonguldakTurkey

Cyanide is a toxin and one of the most rapidly acting fatal poisons that human being is aware. If it is not treated promptly, encountering to cyanide poison will lead to die in minutes. Cyanide avoids cellular oxygen usage by inactivating mitochondrial cytochrome oxidase thus inhibits cellular respiration. In this case, we represent a case report describing uncommon cyanide intoxication owing to consumption of a few portion of apricot kernels and its rapid treatment with dicobalt edetate after suspection of cyanide poisoning.

关键词： Apricot Cyanide Toxication Dicobalt edetate

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