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From herbal small RNAs to one medicine

Science China(Life Sciences) 2019年第3期62卷 285-287页

作者： Chao Ji skirmantas kriaucionis Benedikt M.Kessler Chengyu Jiang Institute of Basic Medical Sciences Chinese Academy of Medical SciencesDepartment of PharmacologyPeking Union Medical College Ludwig Institute for Cancer Research University of Oxford Target Discovery Institute Nuffield Department of MedicineCAMS-Oxford InstituteUniversity of Oxford State Key Laboratory of Medical Molecular Biology Institute of Basic Medical SciencesCAMS-Oxford InstituteChinese Academy of Medical SciencesDepartment of BiochemistryPeking Union Medical College

In this special topic "Herbal small RNAs, novel precision medicine from Mother Nature", we present four original articles that study the entry of small RNAs derived from herbs used in traditional Chinese medicine into mammalian cells and their function within human and mouse cells, and one review paper focusing on current trends in herb genomics (Du et al., 2017;Huang et al., 2018;Zhang et al., 2018;Li et al., 2019;Xin et al., 2018).

关键词： From herbal small RNAs one medicine

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Selection Methodology of High-Cycle Fatigue Analysis Approach for Damage Estimation in Welded Structural Joints

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Journal of Marine Science and Application 2022年第4期21卷 116-133页

作者： skirmantas Pargalgauskas Xiaoli Jiang Marcel Edelkamp Dingena Schott Department of Maritime and Transport Technology Delft University of TechnologyDelft 2628CDNetherlands In Summa Inovation B.V. Raamsdonksveer 4941VVNetherlands

The main purpose of this paper is to provide a summarized general guideline to aid decision making of choosing the type of fatigue analysis approach,best suited for modelling and evaluating high-cycle fatigue damage in welded structural *** describes how addition of stress concentration and stress direction information into fatigue assessment methodology affect simulated fatigue damage accumulation results and when it is beneficial or necessary to use a particular fatigue damage estimation *** focus is on stress-life curve based approaches,particularly when deciding between variants of nominal,hot-spot or multiaxial fatigue assessment approaches for evaluating fatigue damage within welded joint *** is illustrated through application of proposed methodology to choose and perform fatigue assessment for a non-conventional load-bearing tubular joint structure within a floating lemniscate crane upper arm,which has been observed of being prone to aggressive crack propagation within its *** within the structure is estimated using two non-optimal fatigue analysis approaches to verify applicability of proposed selection *** are then summarized through comparative assessment and findings are discussed based on what leads to result changes within each fatigue damage analysis approach.

关键词： Fatigue analysis Multiaxial fatigue Hot-spot fatigue Methodology Welded joints

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