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国际耳鼻咽喉头颈外科杂志 1994年第4期18卷 234-235页

作者： Herdman-sj 马连山

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数学译林 1995年第3期14卷 202-214页

作者： Chap.,sj 冯惠涛

强场下的Li-like氖复合机制X光激光的数值模拟

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计算物理 1996年第4期13卷 454-458页

作者：邵云峰 Rose.,sj 北京应用物理与计算数学研究所

论述了隧道电离和阈上电离加热过程。并把此二过程加到一个ｎｏｎＬＴＥ平均原子模型，用此模型来研究强场下光致电离类锂氖复合机制Ｘ射线激光。计算结果表明，当驱动激光脉冲为１００ｆｓ、波长为０２４８μｍ、功率密度为２×１... 详细信息

论述了隧道电离和阈上电离加热过程。并把此二过程加到一个ｎｏｎＬＴＥ平均原子模型，用此模型来研究强场下光致电离类锂氖复合机制Ｘ射线激光。计算结果表明，当驱动激光脉冲为１００ｆｓ、波长为０２４８μｍ、功率密度为２×１０１７Ｗｃｍ２，氖气的密度为１０３ｇｃｍ－３时，类锂氖精细结构跃迁３ｄ５／２→２ｐ３／２（λ＝９８）的最大增益系数约为１００ｃｍ－１，其维持时间约为１５ｐｓ。

关键词：隧道电离复合机制 X射线激光

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抗疟药的作用方式和抗药性产生机制

国外医学（寄生虫病分册） 1994年第5期21卷 200-204页

作者： Foote sj Cowman AF 杨彬

对抗叶酸制剂和喹淋类抗疟药的作用机制已研究了数十年,近年来的进展应有助于新药的研制以与越来越难制服的疟原虫作斗争。原虫对抗叶酸制剂抗性的分子水平描述已相当明确,归因于药物靶酶的结构改变。但与原虫逃避喹啉类抗疟药有关的因... 详细信息

对抗叶酸制剂和喹淋类抗疟药的作用机制已研究了数十年,近年来的进展应有助于新药的研制以与越来越难制服的疟原虫作斗争。原虫对抗叶酸制剂抗性的分子水平描述已相当明确,归因于药物靶酶的结构改变。但与原虫逃避喹啉类抗疟药有关的因子仍有待阐明。本综述讨论这些药物的作用方式及原虫用以对抗化疗的方法。

关键词：抗疟药疟原虫抗药性

细菌对抗生素敏感性的快速测定——微小菌落的抑制及图形分析

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国外医药（抗生素分册） 1992年第1期13卷 17-18,39页

作者： Hammonds sj 王鲁燕

检测细菌对抗生素敏感性现用的方法需在含抗生素的培养基中培养18～24小时,然后用肉眼观察。从实际需要出发,Jones(1982)、Spence 和 Wheat(1986)都曾详述了快速测试技术。这些作者所描述的几种方法比传统方法快得多,但其中大多数方法... 详细信息

检测细菌对抗生素敏感性现用的方法需在含抗生素的培养基中培养18～24小时,然后用肉眼观察。从实际需要出发,Jones(1982)、Spence 和 Wheat(1986)都曾详述了快速测试技术。这些作者所描述的几种方法比传统方法快得多,但其中大多数方法使用时都较为困难。比如。

关键词：抗生素细菌微菌落技术敏感性

WAVESURFER - AN OPEN SOURCE SPEECH TOOL

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WAVESURFER - AN OPEN SOURCE SPEECH TOOL

6～(th) International Conference on Spoken Language Processing

作者： Kare sjlander Jonas Beskow Centre for Speech Technology KTHDrottning Kristinas v(?g 31. SE-100 44 Sweden Centre for Speech Technology KTHDrottning Kristinas v(?g 31. SE-100 44 Sweden

＜正＞In the speech technology research community there is an inereasing trend to use open source solutions. We present a new tool in that spirit. WaveSurfer, which has been developed at the Centre for Speech Technology at KTH. It has been designed for tasks such as viewing, editing, and labeling of audio data. WaveSurfer is built around a small core to which most functionality is added in the form of plug-ins. The tool has been designed to work on most common platforms and with the aims that it should be easy to configure and extend. WaveSurfer is provided as open source, under the GPI. license with the explieit goal that the speech community jointly will improve and expand its scope and capabilities.

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离散控制自动贴地飞行的驾驶员命令接口

航空电子技术 1993年第A3期24卷 159-166页

作者： Moun.,sj 朱明诚

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白三烯B_4与炎症性疾病

中国药理学通报 1989年第3期5卷 190-192,150页

作者： McMillan RM Foster sj 赵维中

白三烯B_4(LTB_4)与其它的化学趋化剂相同,可激活中性白细胞的多种反应,包括化学运动、趋化、聚集和脱颗粒等反应。LTB_4的作用具有立体特异性,即LTB_4的几何或立体化学异构体,以及LTB_4的代谢物的生物活性均较LTB_4低得多。最近已经鉴... 详细信息

白三烯B_4(LTB_4)与其它的化学趋化剂相同,可激活中性白细胞的多种反应,包括化学运动、趋化、聚集和脱颗粒等反应。LTB_4的作用具有立体特异性,即LTB_4的几何或立体化学异构体,以及LTB_4的代谢物的生物活性均较LTB_4低得多。最近已经鉴定出在人中性白细胞上存在两类LTB_4的结合位点。

关键词： LTB 滑液 PMN 抑制剂滑膜浮选药剂脂氧酶中性白细胞 B4 炎症性疾病三烯

Pharmacology and drug discovery

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中国药理学与毒理学杂志 2019年第10期33卷 754-754页

作者： sj ENNA Departments of Physiology and of Pharmacology University of Kansas Medical Center

There are two general approaches to drug discovery. The oldest is the empirically-driven in vivo identification of a drug candidate, with little or no consideration given to identifying the active constituent. The alternative is mechanism-based, a process that entails the in vitro screening of purified chemical compounds to identify those that interact specifically with a selected biological target, after which they are tested for therapeutic potential. A major difference between these approaches is the extent to which the principles of pharmacology are employed to demonstrate safety and efficacy and to enable improvements in the therapeutic properties of the product. As a thorough pharmacological analysis of the pharmacokinetics and pharmacodynamics of a test agent requires that it be a stable, single, purified substance, such testing is more difficult with unpurified samples containing multiple compounds as compared to single agents. A lack of pharmacological information compromises the clinical utility of a test substance by leaving open questions about its bioavailability, metabolism, and mechanisms of therapeutic actions and toxicities. Although drug discovery success has be achieved with both the empirically-driven and mechanism-based approaches, the proper application of pharmacological techniques in the drug discovery process maximizes efficacy, safety and the chance for regulatory approval. In addition, pharmacological data provides information needed for improving the therapeutic properties of an agent, enhancing its clinical utility, and extending the product lifespan.

关键词： pharmacological techniques drug discovery mechanism-based approaches

Immunohistochemical analysis of p53,cyclinD1,RB1,c-fos and N-ras gene expression in hepatocellular carcinoma in Iran

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World Journal of Gastroenterology 2007年第4期13卷 588-593页

作者： sj Moghaddam EN Haghighi S Samiee N Shahid AR Keramati S Dadgar MR Zali Research Center for Gastroenterology and Liver Disease Shaheed Beheshti University of Medical Sciences and Academy of Medical Sciences Iran

AIM： TO study the effect of some genes especially those involved in cell cycle regulation on hepatocellular carcinoma. METHODS： Paraffin-embedded tissue samples of 25 patients （18 males and 7 females） with hepatocellular carcinoma were collected from 22 pathology centers in Tehran during 2000-2001, and stained using immunohistochemistry method （avidin-biotin-peroxidase） for detection of p53, cyclinD1, RB1, c-los and N-ras proteins. RESULTS： Six （24%）, 5 （20%）, 12 （48%） and 2 samples （8%） were positive for p53, cyclinDl, C-los and N-ras expression, respectively. Twenty-two （88%） samples had alterations in the （31 cell-cycle checkpoint protein expression （RBI or cyclinD1）. P53 positive samples showed a higher （9 times） risk of being positive for RBI protein than p53 negative samples. Loss of expression of RBI in association with p53 over-expression was observed in 4 （66.7%） of 6 samples. Loss of expression of RBI was seen in all cyclinD1 positive, 20 （90.9%） N-ras negative, and ii （50%） C-fos positive samples, respectively. CyclinD1 positive samples showed a higher （2.85 and 4.75 times） risk of being positive for c-los and N-ras expression than cyclinD1 negative samples. CONCLUSION： The expression of p53, RB1 and c-los genes appears to have a key role in the pathogenesis of hepatocellular carcinoma in Iran. Simultaneous overexpression of these genes is significantly associated with their loss of expression during development of hepatocellular carcinoma.

关键词： Hepatocellular Carcinoma Iran Expressionof p53, cyclinD1, RB1, c-fos and N-ras genes