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Case Reports in Clinical Medicine 2014年第12期3卷 636-638页

作者： Tamás erdélyi Aniko Bohács Krisztina Vincze Zsuzsanna Kováts Veronika Sárosi András Sinkovicz Gyorgy Balázs Veronika Müller Department of Pulmonology Semmelweis UniversityBudapestHungary 1st Department of Internal Medicine Medical SchoolUniversity of PécsPécsHungary Department of Radiology The Heart and Vascular CenterSemmelweis UniversityBudapestHungary

Lymphangioleiomyomatosis (LAM) is a rare disease that affects women, especially in child-bearing age. Clinical manifestations include angiomyolipoma, pneumothorax, chylothorax, cystic changes of lungs and progressive pulmonary failure. In this article, we report a case of lung transplantation (LuTX) for end stage pulmonary LAM and the treatment of angiomyolipoma showing growth after LuTX resulting in complete remission with combination therapy of everolimus and tacrolimus.

关键词： Lymphangioleiomyomatosis Everolimus Angiomyolipoma Lung Transplant

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熔炼废旧饮料罐的沟槽式感应炉

轻合金加工技术 1993年第12期21卷 18-21,25页

作者： G.sjǒberg 冯滨江

1 前言近些年来,由于效率高的不堵塞的感应器与监控熔炉的计算机辅助系统的发展,沟槽式铝熔炼炉引起了人们极大的兴趣。对堵塞机理更深入的了解,以及改进感应器沟槽中金属的搅动方法,在不采用气体喷入等措施的情况下,使感应器获得了不... 详细信息

1 前言近些年来,由于效率高的不堵塞的感应器与监控熔炉的计算机辅助系统的发展,沟槽式铝熔炼炉引起了人们极大的兴趣。对堵塞机理更深入的了解,以及改进感应器沟槽中金属的搅动方法,在不采用气体喷入等措施的情况下,使感应器获得了不堵塞的性能。以前那些必须对感应器沟槽钻孔等麻烦的过程,在本文所述的瑞典芬斯蓬哥铝业公司(Finspong Aluminium AB)安装的新式熔炼废旧饮料罐(UBC)

关键词：饮料罐铝罐感应炉熔炼

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癌症的淋巴因子基因治疗

国外医学（生理病理科学与临床分册） 1992年第3期12卷 157-159页

作者： Russ.,sj 赵伟强

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海水—原油乳化液破乳脱水试验研究

石油学报 1991年第2期12卷 124-131页

作者： Johan sjфblom 李明远 Harald Hфiland 抚顺石油学院

对四氧乙稀壬基苯酚醚和甘油-酸酯为乳化剂制取的蒸馏水,人工海水/人工原油乳化液和海水/北海原油乳化液的破乳脱水试验表明,脂肪胺等有机溶剂对两类乳化液有相似的破乳效果,其趋势完全一致。脂肪胺为最佳破乳剂,脂肪醇次之,在破乳过程... 详细信息

对四氧乙稀壬基苯酚醚和甘油-酸酯为乳化剂制取的蒸馏水,人工海水/人工原油乳化液和海水/北海原油乳化液的破乳脱水试验表明,脂肪胺等有机溶剂对两类乳化液有相似的破乳效果,其趋势完全一致。脂肪胺为最佳破乳剂,脂肪醇次之,在破乳过程中脂肪胺与油水界膜中的表面活性基团发生强烈反应,而中等链长脂肪醇则靠扩散分离作用,当分散相为人工海水时破乳效果均减弱,界膜中有蜡晶存在时,脂肪胺破乳效果不变但脂肪醇的破乳效果明显下降,将脂肪酸与脂肪胺同时加入时,界膜处的酸/胺络合物将使界膜具有更强的亲水性而获得最佳破乳效果。

关键词：破乳脱水破乳剂试验

Phenytoin for acute optic neuritis

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中华物理医学与康复杂志 2017年第1期39卷 66-66页

作者： Raftopoulos R Hickman sj Toosy A

BACKGROUND AND OBJECTIVE Multiple sclerosis (MS) is an anti-inflammatory. demyelinating disorder of the central nervous system. Acute optic neuritis is a common feature of MS, which can damage vision through neurodegeneration of the optic nerve. As phenytoin has been found to be neuroprotective in preclinical models, this study was designed to determine whether this medication can be neuroprotective for patients with acute optic *** This randomized, double-blind, placebo-ontrolled trial included patients 18-60 years of age with MS and acute demyelinating optic neuritis. Participants were randomized to receive either phenytoin to achieve serum concentrations appropriate for epilepsy, or placebo. the patients were assessed by the treating physician at one and three months from baseline. The primary outcome measure was the change in retinal nerve fiber layer thickness (RNFL) in the affected eye at six months compared to the unaffected *** Of the 81 patients available for follow-up, the mean RNFL thickness remsined stsble in the unaffected eye. In the modified intention-to-treat population, the adiusted mean difference in six-month RNFL in the affected eye (phenytoin group minus placebo group) was 7.15 um (P=0.021). This represents a 30% reduction in the extent of RNFL loss with phenytoin as compared with *** This study of patients with multiple sclerosis and acute demyelinating optic neuritis, found that phenytoin can be neuroprotective, reducing the loss of RNFL thickness.

关键词：英语阅读理解康复医学

Effects of sex and generation on hepatitis B viral load in families with hepatocellular carcinoma

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World Journal of Gastroenterology 2017年第5期23卷 876-884页

作者： Ai-Ru Hsieh Cathy sj Fann Chau-Ting Yeh Hung-Chun Lin Shy-Yi Wan Yi-Cheng Chen Chia-Lin Hsu Jennifer Tai Shi-Ming Lin Dar-In Tai Graduate Institute of Biostatistics China Medical University Institute of Biomedical Sciences Academia Sinica Division of Hepatology Department of Gastroenterology and Hepatology Chang Gung Memorial Hospital Kaohsiung Medical University College of Medicine

AIM To explore factors associated with persistent hepatitis B virus (HBV) infection in a cohort of hepatocellular carcinoma (HCC)-affected families and then investigate factors that correlate with individual viral load among hepatitis B surface antigen (HBsAg)-positive relatives. METHODS questionnaire. Demographics, relationship to index case, HBsAg status of mothers and index cases were evaluated for association with the HBV persistent infection or viral load by generalized estimating equation analysis. RESULTS Among 729 relatives enrolled, parent generation (P = 0.0076), index generation (P = 0.0044), mothers positive for HBsAg (P = 0.0007), and HBsAg-positive index cases (P = 5.98 x 10(-8)) were associated with persistent HBV infection. Factors associated with HBV viral load were evaluated among 303 HBsAg-positive relatives. Parent generation (P = 0.0359) and sex (P = 0.0007) were independent factors associated with HBV viral load. The intra-family HBV viral load was evaluated in families clustered with HBsAg-positive siblings. An intra-family trend of similar HBV viral load was found for 27 of 46 (58.7%) families. Male offspring of HBsAg-positive mothers (P = 0.024) and older siblings were associated with high viral load. CONCLUSION Sex and generation play important roles on HBV viral load. Maternal birth age and nutritional changes could be the reasons of viral load difference between generations.

关键词： Familial generation Sex Hepatitis B virus Perinatal infection Viral replication

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贴报-P2临床毒理学、药理学和疗效研究

中国药理学与毒理学杂志 2006年第3期20卷 224-247页

作者： sj KANG HD WOO JY CHOI YJ LEE HW CHUNG School of Public Health Seoul National University 28Yonkon-dong Chongro-ku 110-460 Seoul Korea

5-Flourouracil（5-FU） is one of well known anti-cancer drugs, but its toxicity in normal lymphocytes remains a major problem in chemotherapy. The eastern traditional drug, Bupleuri radix（BR）, has been used for the ... 详细信息

关键词： P2 Clinical Toxicology Pharmacology Therapeutic Study

Eosinophil associated genes in the inflammatory bowel disease 4 region:Correlation to inflammatory bowel disease revealed

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World Journal of Gastroenterology 2012年第44期18卷 6409-6419页

作者： Kristin Blom Jenny Rubin Jonas Halfvarson Leif Trkvist Anders Rnnblom Per Sangfelt Mikael Lrdal Ulla-Britt Jnsson Urban sjqvist Lena Douhan Hkansson Per Venge Marie Carlson Department of Medical Sciences Clinical ChemistryUppsala University HospitalSE-75185 UppsalaSweden Division of Gastroenterology Department of Intestinal Medicinerebro University HospitalSE-70185 rebroSweden School of Health and Medical Sciences rebro UniversitySE-70185 rebroSweden IBD Clinical research group Karolinska University HospitalSE-17177 StockholmSweden Department for Clinical Science Intervention and TechnologyKarolinska University HospitalSE-17177 StockholmSweden Department of Medical Sciences Gastroenterology Research GroupUppsala UniversitySE-75185 UppsalaSweden Department of Medicine Karolinska InstitutetSE-17177 StockholmSweden

AIM： To study the association between inflammatory bowel disease （IBD） and genetic variations in eosinophil protein X （EPX） and eosinophil cationic protein （ECP）. METHODS： DNA was extracted from ethylene diamine tetraacetic acid blood of 587 patients with Crohn＇s disease （CD）, 592 with ulcerative colitis （UC） and 300 healthy subjects. The EPX405 （G 〉 C, rs2013109）, ECP434 （G 〉 C, rs2073342） and ECP562 （G 〉 C, rs2233860） gene polymorphisms were analysed, by the 5＇-nuclease allelic discrimination assay. For de- termination of intracellular content of EPX and ECP in granulocytes, 39 blood samples was collected and extracted with a buffer containing cetyltrimethylam- monium bromide. The intracellular content of EPX was analysed using an enzyme-linked immunosorbent as- say. The intracellular content of ECP was analysed with the UniCAP system as described by the manufacturer. Statistical tests for calculations of results were χ2 test, Fisher＇s exact test, ANOVA, Student-Newman-Keuls test, and Kaplan-Meier survival curve with Log-rank test for trend, the probability values of P 〈 0.05 were considered statistically ***： The genotype frequency for males with UC and with an age of disease onset of ≥ 45 years （n = 57） was for ECP434 and ECP562, GG = 37%, GC = 60%, CC = 4% and GG = 51%, GC = 49%, CC = 0% respectively. This was significantly different from the healthy subject＇s genotype frequencies of ECP434 （GG = 57%, GC = 38%, CC = 5%; P = 0.010） and ECP562 （GG = 68%, GC = 29%,CC = 3%; P = 0.009）. The genotype frequencies for females, with an age of dis- ease onset of ≥ 45 years with CD （n = 62）, was for the ECP434 and ECP562 genotypes GG = 37%, GC =52%, CC = 11% and GG = 48%, GC = 47% and CC = 5% respectively. This was also statistically different from healthy controls for both ECP434 （P = 0.010） and ECP562 （P = 0.013）. The intracellular protein concen- tration of EPX and ECP was calculated in μg/10^6 eosi- nophils and then correlated to the EPX 405 genotypes

关键词： Eosinophil derived neurotoxin RNase 2 RNase 3 Single nucleotide polymorphism Inflamma-tion bowel disease Crohn's disease Ulcerative colitis

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反应停在移植物抗宿主病治疗中的作用

国外医学（输血及血液学分册） 1991年第5期14卷 312-313页

作者： Wood PMD Proctor sj 徐开林

目前治疗移植物抗宿主病(GVHD)的主要问题是:①缺乏特异性的治疗方法,使用免疫抑制剂增加了并发感染的机会;②预防和治疗的药物本身有毒性,对病人可有致命的威胁。为此,人们把研究目标转移到其他免疫抑制剂上,如反应停。反应停在GVHD中... 详细信息

目前治疗移植物抗宿主病(GVHD)的主要问题是:①缺乏特异性的治疗方法,使用免疫抑制剂增加了并发感染的机会;②预防和治疗的药物本身有毒性,对病人可有致命的威胁。为此,人们把研究目标转移到其他免疫抑制剂上,如反应停。反应停在GVHD中的作用 Vogelsang等报告,动物(鼠)的GVHD发生后,用管饲法给反应停,50或/100mg/kg/日,共40天,在23只动物中,22只成功地消除了GVHD。停止反应停治疗后,22只动物中19只未再出现GVHD,其余3只于3周后产生了慢性GVHD.皮肤移植物被接受超过100天,嵌合体得以证实。同样的研究表明,反应停亦可作为预防GVHD的有效药物。移植当天起就给反应停,持续40天,移植后,22只鼠中14只未发生GVHD,其余8只仅有轻微GVHD。

关键词：反应停移植物抗宿主病

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臂间血压差异与冠状动脉粥样硬化的相关性

中华高血压杂志 2017年第8期25卷 783-785页

作者： Park sj Son JW Park SM Choi HH Hong KS 机构不详

臂间血压差异（interm-arm blood pressure difference,IABPD）是较易获得的无创参数,从20世纪早期开始,临床医生已开始研究其用途[1]。右臂血压通常高于左臂血压,因为与右侧锁骨下动脉相比,左侧锁骨下动脉来源于主动脉,形成一个锐角,... 详细信息

臂间血压差异（interm-arm blood pressure difference,IABPD）是较易获得的无创参数,从20世纪早期开始,临床医生已开始研究其用途[1]。右臂血压通常高于左臂血压,因为与右侧锁骨下动脉相比,左侧锁骨下动脉来源于主动脉,形成一个锐角,导致紊流,降低血流和血压,造成IABPD。英国国家卫生与临床研究所推出的新高血压临床指南建议,IABPD〈10mm Hg（1mm Hg=0.133kPa）可考虑为正常。

关键词：锁骨下动脉临床研究所临床指南狭窄程度临床医生左旋支前降支多支血管病变心血管病平均动脉压