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儿童肺嗜酸性粒细胞增多症的临床特征研究

中华实用儿科临床杂志 2024年第6期39卷 433-439页

作者：徐筱蕾殷菊刘军刘秀云胡英惠沈惠青王国丽张晶张蕊苏雁吴润晖徐保平国家儿童医学中心国家呼吸系统疾病临床医学研究中心首都医科大学附属北京儿童医院呼吸科中国医学科学院儿童危重感染诊治创新单元儿科重大疾病研究教育部重点实验室北京100045 国家儿童医学中心首都医科大学附属北京儿童医院消化科北京100045 国家儿童医学中心首都医科大学附属北京儿童医院血液科北京100045

目的:分析儿童肺嗜酸性粒细胞增多症(ELD)的临床特征,以提高儿科医师对ELD相关疾病的认识。方法:通过回顾性横断面研究,收集2007年4月1日至2022年3月31日首都医科大学附属北京儿童医院收治的符合ELD诊断标准的患儿149例,应用卡方检验、F... 详细信息

目的:分析儿童肺嗜酸性粒细胞增多症(ELD)的临床特征,以提高儿科医师对ELD相关疾病的认识。方法:通过回顾性横断面研究,收集2007年4月1日至2022年3月31日首都医科大学附属北京儿童医院收治的符合ELD诊断标准的患儿149例,应用卡方检验、Fisher′s精确概率法、Mann Whitney U检验以及Kruskal-Wallis检验进行数据分析,总结归纳临床特征;采用Spearman相关性分析分析外周血与支气管肺泡灌洗液嗜酸性粒细胞的相关性,采用卡方检验、Kappa一致性检验比较支气管肺泡灌洗液或肺活检与血嗜酸性粒细胞增高伴胸部影像学异常诊断结果的差异性和一致性。结果:1.儿童ELD中单纯肺部受累最常见病因为变应性支气管肺曲霉病(9例),合并其他系统受累的最常见病因为特发性嗜酸粒细胞增多综合征(89例)。2.主要的呼吸系统表现为咳嗽(90例,60.4%)、咯痰(41例,27.5%),23.5%(35例)无呼吸系统症状;消化系统(50.3%)以及皮肤(40.9%)为常见合并受累器官。3.外周血与支气管肺泡灌洗液嗜酸性粒细胞相关系数r=0.3,P<0.05;支气管肺泡灌洗液或肺活检与血嗜酸性粒细胞增高伴胸部影像学异常诊断结果卡方检验P<0.05,一致性检验Kappa<0.2。结论:儿童中ELD多种病因均可致病,变应性支气管肺曲霉病为单纯肺部受累最常见病因。其常见表现为咳嗽、咯痰。肺外常见的受累器官为消化系统和皮肤。外周血与支气管肺泡灌洗液嗜酸性粒细胞水平相关性较差。

关键词：肺嗜酸性粒细胞增多症儿童临床特征诊断治疗

Induced Pib Expression and Resistance to Magnaporthe grisea are Compromised by Cytosine Demethylation at Critical Promoter Regions in Rice

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Journal of Integrative Plant Biology 2011年第10期53卷 814-823页

作者： Yuan Li Qiong Xia Hongping Kou Dan Wang xiuyun Lin Ying wu Chunming Xu Shaochen Xing Bao Liu Key Laboratory of Molecular Epigenetics of MOE and The Institute of Genetics ＆ Cytology Northeast Normal University Changchun 130024 China Department of Agronomy Jilin Agricultural University Changchun 130118 China Center of Agribiotechnology Jilin Academy of Agricultural Sciences Changchun 130033 China

Pib is a well-characterized rice blast-resistance gene belonging to the nucleotide binding site （NBS） and leucine-rich repeat （LRR） superfamily. Expression of Pib was low under non-challenged conditions, but strongly induced by the blast-causing fungal pathogen Magnaporthe grisea, thereby conferring resistance to the pathogen. It is generally established that cytosine methylation of the promoter-region often plays a repressive role in modulating expression of the gene in question. We report here that two critical regions of the Pib promoter were heavily CG cytosine-methylated in both cultivars studied. Surprisingly, induced expression of Pib by M. grisea infection did not entail its promoter demethylation, and partial demethylation by 5-azacytidine-treatment actually reduced Pib expression relative to wild- type plants. Accordingly, the blast disease-resistance was compromised in the 5＇-azaC-treated plants relative to wild-type. In contrast, the disease susceptibility was not affected by the 5＇-azaC treatment in another two rice cultivars that did not contain the Pib gene, ruling out effects of other R genes and *** genotoxic effects by the drug-treatment as a cause for the compromised Pib-conditioned blast-resistance. Taken together, our results suggest that promoter DNA methylation plays a novel enhancing role in conditioning high-level of induced expression of the Pib gene in times of M. grisea infection, and its conferred resistance to the pathogen.

关键词： DNA methylation Magnaporthe grisea blast-resistance induced Pib expression.

PROTAC mediated FKBP12 degradation enhances Hepcidin expression via BMP signaling without immunosuppression activity

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Signal Transduction and Targeted Therapy 2022年第6期7卷 1891-1894页

作者： Tianbai Zhong xiuyun Sun Li Yu Yongbo Liu Xin Lin Yu Rao Wei wu MOE Key Laboratory of Protein Sciences Beijing Advanced Innovation Center for Structural BiologySchool of Life SciencesTsinghua UniversityBeijing 100084P.R.China MOE Key Laboratory of Protein Sciences School of Pharmaceutical SciencesMOE Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical BiologyTsinghua UniversityBeijing 100084China Institute for Immunology and School of Medicine Tsinghua UniversityBeijing 100084China

Dear Editor,Hepcidin is a 25-amino acid peptide acting as a pivotal negative regulator in iron homeostasis,which can bind to an iron exporter,ferroportin 1,and induce its internalization and degradation.1 Hepcidin is produced in hepatocytes mainly under the control of BMP ***2/6,secreted by liver endothelial cells in response to iron level,binds to BMP type I and type II receptors and triggers the phosphorylation of Smad1/5/8 which directly promotes hepcidin expression.1 The immunophilin family protein FKBP12 is associated with BMP type I receptors to prevent uncontrolled receptor activation.

关键词： Hepcidin FKBP12 BMP

Role of Intracellular Distribution of Feline and Bovine SAMHD1 Proteins in Lentiviral Restriction

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Virologica Sinica 2021年第5期36卷 981-996页

作者： Chu Wang Lina Meng Jialin Wang Kaikai Zhang sizhu duan Pengyu Ren Yingzhe Wei Xinyu Fu Bin Yu Jiaxin wu Xianghui Yu National Engineering Laboratory for AIDS Vaccine School of Life SciencesJilin UniversityChangchun 130012China The First Hospital and Institute of Immunology Jilin UniversityChangchun 130012China Key Laboratory for Molecular Enzymology and Engineering the Ministry of EducationSchool of Life SciencesJilin UniversityChangchun 130012China

Human SAMHD1(h SAM)restricts lentiviruses at the reverse transcription step through its d NTP triphosphohydrolase(d NTPase)*** humans,several mammalian species such as cats and cows that carry their own lentiviruses also express ***,the intracellular distribution of feline and bovine SAMHD1(f SAM and b SAM)and its significance in their lentiviral restriction function is not ***,we demonstrated that f SAM and b SAM were both predominantly localized to the nucleus and nuclear localization signal(11KRPR14)-deleted f SAM and b SAM relocalized to the *** cytoplasmic f SAM and b SAM retained the antiviral function against different lentiviruses and cytoplasmic f SAM could restrict Vpx-encoding SIV and HIV-2 more efficiently than its wild-type(WT)protein as cytoplasmic h *** investigation revealed that cytoplasmic f SAM was resistant to Vpx-induced degradation like cytoplasmic h SAM,while cytoplasmic b SAM was not,but they all demonstrated the same in vitro d NTPase activity and all could interact with Vpx as their WT proteins,indicating that cytoplasmic h SAM and f SAM can suppress more SIV and HIV-2 by being less sensitive to Vpx-mediated *** results suggested that f SAM-and b SAM-mediated lentiviral restriction does not require their nuclear localization and that f SAM shares more common features with h *** findings may provide insights for the establishment of alternative animal models to study SAMHD1 in vivo.

关键词： SAMHD1 Feline SAMHD1(fSAM) Bovine SAMHD1(bSAM) Nuclear localization signal(NLS) Vpx Degradation Viral restriction

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针灸干预慢性失眠障碍的脑网络机制研究进展

长春中医药大学学报 2024年第9期40卷 1044-1048页

作者：吴倩温秀云林德晖王舢泽梁雪松符文彬广州中医药大学第二附属医院/广东省中医院广州510120 广东药科大学广州510006

慢性失眠障碍为临床常见病症,严重影响患者的生活质量。针灸已被证实能提升失眠障碍患者的睡眠质量,然而其效应机制尚未清楚。脑影像研究表明,慢性失眠障碍患者存在大脑网络功能连接的特异性改变,尤其体现在默认模式网络(DMN)、突显网络... 详细信息

慢性失眠障碍为临床常见病症,严重影响患者的生活质量。针灸已被证实能提升失眠障碍患者的睡眠质量,然而其效应机制尚未清楚。脑影像研究表明,慢性失眠障碍患者存在大脑网络功能连接的特异性改变,尤其体现在默认模式网络(DMN)、突显网络(SN)、认知控制网络(CCN)、负性情绪网络(AN)的脑网络内部以及网络之间的连接性上。这为探索针灸脑网络神经机制提供了新的切入点。本文回顾了慢性失眠伴障碍的大脑网络连接的变化特征以及针灸干预对其脑网络连接的改变,旨在为深入探讨针灸治疗慢性失眠障碍的潜在机制提供理论依据和未来研究展望。

关键词：针灸慢性失眠障碍脑功能脑网络连接性机制综述

Transcriptome shock in an interspecific F1 triploid hybrid of Oryza revealed by RNA sequencing

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Journal of Integrative Plant Biology 2016年第2期58卷 150-164页

作者： Ying wu Yue Sun Xutong Wang xiuyun Lin Shuai Sun Kun Shen Jie Wang Tingting Jiang Silin Zhong Chunming Xu Bao Liu Key Laboratory of Molecular Epigenetics of the Ministry of Education(MOE) Northeast Normal UniversityChangchun 130024China Jilin Academy of Agricultural Sciences Changchun 130032China State Key Laboratory of Agrobiotechnology School of Life SciencesThe Chinese University of Hong KongHong KongChina

Interspecific hybridization is a driving force in evolution and speciation of higher plants. Interspecific hybridization often induces immediate and saltational changes in gene expression, a phenomenon collectively termed ＂transcriptome shock＂. Although transcriptome shock has been reported in various plant and animal taxa, the extent and pattern of shock-induced expression changes are often highly idiosyncratic, and hence entails additional investigations. Here, we produced a set of interspecific F1 triploid hybrid plants between Oryza sativa, ssp. japonica （2n=2x=24, genome AA） and the tetraploid form of O. punctata （2n=4x =48, genome, BBCC）, and conducted RNA-seq transcriptome profiling of the hybrids and their exact parental plants. We analyzed both homeolog expression bias and overall gene expression level difference in the hybrids relative to the in silico ＂hybrids＂（parental mixtures）. We found that approximately 16% （2,541） of the 16,112 expressed genes in leaf tissue of the F1 hybrids showed nonadditive expression, which were specifically enriched in photosynthesis-related pathways. Interestingly, changes in the maternal homeolog expression, including non-stochastic silencing, were the major causes for altered homeolog expression partitioning in the F1 hybrids. Our findings have provided further insights into the tran- scriptome response to interspecific hybridization and heterosis.

关键词： Cis- and trans-regulation homeolog expression rewiring interspecific hybrid Oryza promoter divergence transcriptome shock

以视物晃动首诊于眼科的29例振动幻视患者临床特征分析

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眼科 2024年第1期33卷 9-14页

作者：崔世磊彭静婷孔秀云吴京王佳伟江汉秋首都医科大学附属北京同仁医院神经内科北京100730

目的回顾性分析视物晃动患者的临床特征、眼动异常类型以及相关病因、治疗预后。设计回顾性病例系列。研究对象2019年1月至2023年1月首诊于北京同仁医院眼科,而后转诊至神经内科的振动幻视患者29例。方法回顾患者的临床病历资料,包括视... 详细信息

目的回顾性分析视物晃动患者的临床特征、眼动异常类型以及相关病因、治疗预后。设计回顾性病例系列。研究对象2019年1月至2023年1月首诊于北京同仁医院眼科,而后转诊至神经内科的振动幻视患者29例。方法回顾患者的临床病历资料,包括视物晃动特征、视频眼震图的特征、颅脑MRI、病因诊断、治疗方案及转归等。主要指标视物晃动特征、视频眼震图、颅脑MRI。结果29例患者均表现为视物晃动及视觉相关性头晕,27例(93.1%)为双眼症状,其中18例为垂直性视物晃动,8例为水平性视物晃动,1例为跷跷板性(垂直和扭转混合型)视物晃动;2例(6.9%)为单眼症状,分别为扭转性、水平性视物晃动。27例(93.1%)为持续性症状,2例(6.9%)为发作性症状。视频眼震图显示,视物晃动方向、眼别与异常眼动一致,23例(79.3%)为眼震,其中下跳性眼震17例,周期性交替性眼震、获得性摆动性眼震和摆动性跷跷板眼震分别为3例、2例和1例;3例为(10.3%)扫视侵入;2例(6.9%)为前庭功能低下;1例(3.4%)为上斜肌颤搐。所有患者均接受至少一次颅脑MRI检查,21例(87.5%)有小脑扁桃体或视神经等部位的阳性异常改变,14例(48.3%)患者经手术减压或加巴喷丁、巴氯芬或氯硝西泮等治疗后好转。结论振动幻视患者以双眼垂直性、水平性视物晃动最为常见。病因多样,其特征与异常眼动类型相关,其中获得性眼震最为常见。

关键词：视物晃动振动幻视眼震眼震样异常眼动

Rheological Behaviour for Polymer Melts and Concentrated Solutions Part Ⅰ:A New Multiple Reptation Model to Predict the Nonlinear Visco-elasticity with Nagai Chain Constraints in Entangled Polymer Melts

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Journal of Materials Science & Technology 1995年第1期11卷 15-30页

作者： Mingshi SONG and sizhu wu(Dept. of Polymer Science, Beijing University of Chemical Technology Beijing, 100029, China)

An approach of stochastically statistical mechanics and a unified molecular theory of nonlinear viscoelasticity with constraints of Nagai chain entanglement for polymer melts have been proposed. A multimode model structure for a single polymer chain with n tail segments and N reversible entanglement sites on the test polymer chain is developed. Based on the above model structure and the mechanism of molecular flow by the dynamical reorganization of entanglement sites, the probability distribution function of the end-to-end vectr for a single polymer chain at entangled state and the viscoelastic free energy of deformation for polymer melts are calculated by using the method of the stochastically statistical mechanics. The four types of stress-strain relation and the memory function are derived from this thery. The above theoretical relations are verified by the experimentaf data for various polymer melts. These relations are found to be in good agreement with the experimental results

关键词： Rheological Behaviour for Polymer Melts and Concentrated Solutions Part A New Multiple Reptation Model to Predict the Nonlinear Visco-elasticity with Nagai Chain Constraints in Entangled Polymer Melts

子宫静脉内平滑肌瘤超声检查特征及漏、误诊分析

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医学影像学杂志 2024年第8期34卷 103-105,110页

作者：芦金秀尹艳雪董秀云王波吴红英冷俊红山东省济南市妇幼保健院超声科山东济南250000 山东省济南市妇幼保健院病理科山东济南250000

目的探讨子宫静脉内平滑肌瘤(IVL)超声特征及漏、误诊分析,以提高超声诊断准确率。方法选取在我院检查并经手术病理确诊的IVL患者15例,分析超声声像图特征,探讨漏、误诊原因。结果 15例中超声诊断明确4例(准确率26%),误诊11例(误诊率7... 详细信息

目的探讨子宫静脉内平滑肌瘤(IVL)超声特征及漏、误诊分析,以提高超声诊断准确率。方法选取在我院检查并经手术病理确诊的IVL患者15例,分析超声声像图特征,探讨漏、误诊原因。结果 15例中超声诊断明确4例(准确率26%),误诊11例(误诊率74%)。其中误诊为子宫肌瘤9例(1例误诊为阔韧带肌瘤,1例误诊为子宫腺肌病);误诊为附件区肿瘤2例。结论 IVL缺乏特异性表现及超声科医师对于该病的认识有限,是导致漏、误诊的重要原因。

关键词：子宫静脉内平滑肌瘤超声检查