检索结果-南通市图书馆

Thermal decomposition of poly(ethylene terephthalate)/mesoporous molecular sieve composites

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Chemical Science and Engineering 2007年第1期1卷 50-54页

作者： RUN Mingtao ZHANG Dayu wu sizhu wu Gang Key Lab of Beijing City on Preparation and Processing of Novel Polymer Materials Beijing University of Chemical TechnologyBeijing 100029China College of Chemistry&Environmental Science Hebei UniversityBaoding 071002China

The nonisothermal and isothermal degradation processes of poly(ethylene terephthalate)/mesoporous molecular sieve(PET/MMS)composites synthesized by in-situ polymerization were studied by using thermogravimetric analysis in *** nonisothermal degradation of the composite is found to be the first-order *** iso-conversional procedure developed by Ozawa is used to calcu-late the apparent activation energy(E),which is an average value of about 260 kJ/mol with the weight conversion from 0%to 30%,and is higher than that of neat *** degradation results are confirmed with the nonisothermal process,in which PET/MMS showed higher thermal stability than neat *** polymer in mesoporous channels has more stability due to the protection of the inorganic *** results indicate that mesoporous MMS in PET/MMS composites improve the stability of the polymer.

关键词： poly(ethylene terephthalate) mesoporous molecular sieve thermal degradation kinetics

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国大中城市社区碳排放现状分析

北京建筑大学学报 2024年第4期40卷 36-46页

作者：辛启迪石玉琼杨秀云武小钢山西农业大学城乡建设学院太谷030801 山西农业大学林学院太谷030801

统计35个大中城市2016—2020年社区碳排放情况,分别从碳排放量、碳排放强度和碳排放结构3个方面分析排放现状。研究发现,城市层面的碳排放总量和净碳排放量都呈持续增长状态,2020年碳排放总量、净碳排放量最高的城市分别为重庆、北京,... 详细信息

统计35个大中城市2016—2020年社区碳排放情况,分别从碳排放量、碳排放强度和碳排放结构3个方面分析排放现状。研究发现,城市层面的碳排放总量和净碳排放量都呈持续增长状态,2020年碳排放总量、净碳排放量最高的城市分别为重庆、北京,最低分别为乌鲁木齐、南昌;人均碳排放强度、地均碳排放强度和碳排放强度分别呈持续增长、先增后减再增、先减后增趋势,西安、郑州以北城市人均碳排放强度较高,长江、珠江三角洲城市碳排放强度普遍较低;碳排放结构以交通出行和电力消费为主,2020年分别占36.5%和36.0%,交通出行和电力消费碳排放占比最高的城市分别为昆明和福州,所占比例分别为52.0%和53.5%,结果为社区层面实现“双碳”目标提供科学依据和数据支撑。

关键词：社区碳排放排放系数法碳源碳汇净碳排放比较分析

Apoptosis-linked antifungal effect of ambroxol hydrochloride by cystolic calcium concentration disturbance in resistant Candida albicans

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2019年第12期62卷 1601-1604页

作者： xiuyun Li Xuexin wu Yan Gao Lina Hao Shujuan Sun Pharmaceutical Department Qilu Childrens Hospital of Shandong UniversityJinan 250022China Pharmaceutical Department Shandong Provincial Qianfoshan Hospitalthe First Hospital Affiliated with Shandong First Medical UniversityJinan 250014China

Dear Editor,Since the early 1980s,the incidence of fungal infections has significantly increased in immunocompromised individuals(WisplinghofF et al.,2004;Pfaller and Diekema,2007).However,due to the extensive and indiscriminate use of available antifungal agents,an increasing number of antifungal-resistant pathogens have been isolated over the past few decades(Sanglard and Odds,2002).***,an important opportunistic fxingal pathogen,is becoming increasingly resistant to several antifungal agents,particularly triazole *** resistance in *** has emerged as an important public health concern(Sanglard and Odds,2002).Although ambroxol hydrochloride(ABH)has recently been found to display antifungal activity against susceptible ***,its antifungal effect and mechanism against resistant *** have not yet been thoroughly *** aim of this study was to elucidate the antifungal effects(in vitro and in vivo)and mechanisms of ABH against resistant ***.

关键词： antifungal effect thoroughly

不同类型豆科植物群落凋落物对城市土壤质量的影响

在线全文

学校读者我要写书评

暂无评论

林业调查规划 2024年第5期49卷 198-204页

作者：窦金萍武小钢杨秀云陈冠光靳雅君吴茜山西农业大学城乡建设学院山西太谷030801 山西农业大学林学院山西太谷030801

为了解不同豆科植物群落类型的凋落物特征对土壤质量的影响。选取太原市森林公园内3种不同群落类型(豆科落叶阔叶林、豆科与非豆科落叶阔叶树种混交林、豆科与常绿针叶树种混交林),通过对不同类型豆科植物群落凋落物性质和土壤质量进行... 详细信息

为了解不同豆科植物群落类型的凋落物特征对土壤质量的影响。选取太原市森林公园内3种不同群落类型(豆科落叶阔叶林、豆科与非豆科落叶阔叶树种混交林、豆科与常绿针叶树种混交林),通过对不同类型豆科植物群落凋落物性质和土壤质量进行差异性、相关性分析,探讨凋落物性质与土壤因子间的关系。结果表明,不同豆科植物群落类型间凋落物的理化性质存在差异。豆科落叶阔叶林群落凋落物全氮含量(17.68 g/kg)、N/P比值(4.15)显著高于豆科与非豆科落叶阔叶树种混交林、豆科与常绿针叶树种混交林。豆科与常绿针叶树种混交林群落凋落物的全磷含量(5.96 g/kg)显著高于豆科与非豆科落叶阔叶树种混交林(3.68 g/kg);不同豆科植物群落类型间土壤性质存在差异。豆科落叶阔叶林土壤全碳(127.28 g/kg)、碱性磷酸酶活性(0.6 g/kg)显著优于豆科与非豆科落叶阔叶树种混交林、豆科与常绿针叶树种混交林,脲酶活性(0.87 g/kg)显著优于豆科与非豆科落叶阔叶树种混交林;豆科与非豆科落叶阔叶树种混交林土壤有机碳(23.51 g/kg)、硝态氮(11.21 mg/kg)、全钾(20.88 g/kg)含量显著低于豆科落叶阔叶林、豆科与常绿针叶树种混交林;凋落物全碳、全氮、全磷、N/P与最大持水量、毛管持水量,土壤全碳、有机碳、全氮、硝态氮、全磷、全钾、速效钾含量,以及脲酶和过氧化氢酶活性间呈显著正相关;凋落物总量、全碳及全磷含量与土壤容重间呈极显著负相关,凋落物C/N与土壤全氮、全碳、有机碳含量间呈显著负相关。不同豆科植物群落类型凋落物可显著降低土壤容重,提升土壤养分和酶活性,且豆科落叶阔叶林、豆科与常绿针叶树种混交林土壤质量要优于豆科与非豆科落叶阔叶树种混交林。

关键词：豆科植物群落凋落物理化性质土壤质量酶活性相关性分析太原

Simultaneous pyridine biodegradation and nitrogen removal in an aerobic granular system

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2018年第5期30卷 318-329页

作者： Xiaodong Liu Shijing wu Dejin Zhang Jinyou Shen Weiqing Han xiuyun Sun Jiansheng Li Lianjun Wang Jiangsu Key Laboratory of Chemical Pollution Control and Resources Reuse School of Environmental and Biological EngineeringNanjing University of Science and Technology

Simultaneous pyridine biodegradation and nitrogen removal were successfully achieved in a sequencing batch reactor（SBR） based on aerobic granules. In a typical SBR cycle, nitritation occurred obviously after the majority of pyridine was removed, while denitrification occurred at early stage of the cycle when oxygen consumption was aggravated. The effect of several key operation parameters, i.e., air flow rate, influent NH4~＋-N concentration,influent p H and pyridine concentration, on nitritation, pyridine degradation and total nitrogen（TN） removal, was systematically investigated. The results indicated that high air flow rate had a positive effect on both pyridine degradation and nitritation but a negative impact of overhigh air flow rate. With the increase of NH4~＋ dosage, both nitritation and TN removal could be severely inhibited. Slightly alkaline condition, i.e., pH 7.0–8.0, was beneficial for both pyridine degradation and nitritation. High pyridine dosage often resulted in the delay of both pyridine degradation and nitritation. Besides, extracellular polymeric substances production was affected by air flow rate, NH4~＋ dosage, pyridine dosage and p *** addition, high-throughput sequencing analysis demonstrated that Bdellovibrio and Paracoccus were the dominant species in the aerobic granulation system. Coexistence of pyridine degrader, nitrification related species, denitrification related species, polymeric substances producer and self-aggregation related species was also confirmed by highthroughput sequencing.

关键词： Aerobic granule Biodegradation Nitritation Denitrification Pyridine

七氟烷后处理对大鼠脑缺血再灌注损伤保护作用的研究

在线全文

学校读者我要写书评

暂无评论

精准医学杂志 2024年第2期39卷 125-129,133页

作者：毛艺锟王士雷吴秀云赵芹李瑜青岛大学附属医院麻醉科山东青岛266555

目的探讨七氟烷后处理对大鼠脑缺血再灌注(I/R)损伤的保护作用及其机制。方法选择SPF级成年健康雄性SD大鼠80只,随机分为假手术组(S组)、脑缺血再灌注组(I/R组)、脑I/R+七氟烷后处理组(ISP组)、脑I/R+七氟烷后处理+核因子E2相关因子2(Nr... 详细信息

目的探讨七氟烷后处理对大鼠脑缺血再灌注(I/R)损伤的保护作用及其机制。方法选择SPF级成年健康雄性SD大鼠80只,随机分为假手术组(S组)、脑缺血再灌注组(I/R组)、脑I/R+七氟烷后处理组(ISP组)、脑I/R+七氟烷后处理+核因子E2相关因子2(Nrf2)抑制剂组(ISPB组),每组20只。除S组外,其余组大鼠均用线栓法闭塞大脑中动脉2 h并再灌注24 h的方法制备脑I/R损伤大鼠模型(S组大鼠只在大脑中动脉下穿线不结扎)。ISP组大鼠于再灌注即刻吸入3%七氟烷30 min,ISPB组在缺血前30 min腹腔注射Nrf2抑制剂鸦胆子苦醇(2 mg/kg),其余处理同ISP组。建模成功后通过神经功能评分评估各组大鼠神经功能损害程度。随后获取大鼠左心室血及脑组织病理切片,以2,3,5-氯化三苯基四氮唑(TTC)染色测定各组大鼠脑梗死体积百分比,采用酶联免疫吸附试验检测大鼠血清中炎症因子白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)和氧化应激相关因子丙二醛(MDA)及超氧化物歧化酶(SOD)水平,采用免疫印迹实验检测大鼠脑组织中凋亡相关蛋白B细胞淋巴瘤-2(Bcl-2)、Bcl-2相关联x(Bax)、半胱胺酸天冬氨酸蛋白酶-3(Caspase-3)及Nrf2信号通路相关蛋白Nrf2和血红素加氧酶1(HO-1)表达,采用免疫荧光实验检测大鼠脑组织细胞核内外Nrf2表达。结果与I/R组相比,ISP组大鼠神经功能缺损评分、脑梗死体积百分比,以及血清IL-1β、TNF-α、MDA水平和脑组织总蛋白Bax、Caspase-3水平均下降(t=5.76~18.39,P<0.05);血清中SOD水平及脑组织总蛋白Nrf2、HO-1、Bcl-2水平均升高(t=5.73~14.08,P<0.05),Nrf2免疫荧光强度增强。与ISP组相比,ISPB组神经功能缺损评分、脑梗死体积百分比,以及血清中IL-1β、TNF-α、MDA水平和脑组织总蛋白Bax、Caspase-3水平均升高(t=3.06~8.19,P<0.05);血清中SOD水平和脑组织总蛋白Nrf2、HO-1、Bcl-2水平均下降(t=2.67~9.01,P<0.05),Nrf2免疫荧光强度减弱。结论七氟烷后处理可以通过激活Nrf2信号通路抑制氧化应激、炎症反应和细胞凋亡,减轻大鼠脑I/R损伤。

关键词：七氟烷缺血后处理脑缺血再灌注损伤 NF-E2相关因子2 信号传导大鼠,Sprague-Dawley

维持性血液透析病人容量管理行为影响因素及预测模型

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

蚌埠医学院学报 2024年第8期49卷 1091-1094,1101页

作者：李芸芸吴仲华王秀云姚尧安徽省阜阳市人民医院血液净化科 236000

目的:调查维持性血液透析(MHD)病人容量管理行为现状,探讨相关影响因素。方法:共收集115例病人临床相关资料,对病人进行问卷资料收集,包括一般资料、容量管理行为、自我效能、健康素养等,分析MHD病人容量管理行为现状,以及维持性血透病... 详细信息

目的:调查维持性血液透析(MHD)病人容量管理行为现状,探讨相关影响因素。方法:共收集115例病人临床相关资料,对病人进行问卷资料收集,包括一般资料、容量管理行为、自我效能、健康素养等,分析MHD病人容量管理行为现状,以及维持性血透病人容量管理行为的影响因素,并建立容量管理行为预测模型。结果:115例MHD病人容量管理行为总分(18.47±2.66)分。血液透析相关指标得分为(12.24±1.95)分,饮食管理得分为(6.23±1.41)分,容量管理较差46例,管理较好69例。单因素分析显示,不同性别、年龄、学历、工作状态、透析龄、营养不良风险的病人容量管理行为差异有统计学意义(P<0.05)。logistic回归分析结果显示,学历、透析龄、营养不良风险、自我效能、健康素养是维持性血液透析病人容量管理行为的影响因素(P<0.05)。构建列线图预测模型显示模型预测良好。结论:维持性血液透析病人容量管理行为受多种因素影响,临床可通过预测模型进行预警筛查,对学历较低的、透析龄超过5年以上的、有营养不良风险的、自我效能得分较低的、健康素养差的病人需多关注,进行多种形式和有针对性的干预措施,以提高容量管理行为。

关键词：维持性血液透析容量管理行为健康素养

PROTACs: great opportunities for academia and industry

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2019年第1期4卷 1-33页

作者： xiuyun Sun Hongying Gao Yiqing Yang Ming He Yue wu Yugang Song Yan Tong Yu Rao Ministry of Education(MOE)Key Laboratory of Protein Sciences School of Pharmaceutical SciencesMOE Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical BiologyTsinghua UniversityBeijing 100084P.R.China Tsinghua-Peking Center for Life Sciences Beijing 100084P.R.China School of Pharmaceutical Sciences Zhengzhou UniversityZhengzhou 450001China

Although many kinds of therapies are applied in the clinic,drug-resistance is a major and unavoidable *** disturbing statistic is the limited number of drug targets,which are presently only 20–25%of all protein targets that are currently being ***,the focus of current explorations of targets are their enzymatic functions,which ignores the functions from their scaffold *** a promising and appealing technology,PROteolysis TArgeting Chimeras(PROTACs)have attracted great attention both from academia and industry for finding available approaches to solve the above *** regulate protein function by degrading target proteins instead of inhibiting them,providing more sensitivity to drug-resistant targets and a greater chance to affect the nonenzymatic *** have been proven to show better selectivity compared to classic *** can be described as a chemical knockdown approach with rapidity and reversibility,which presents new and different biology compared to other gene editing tools by avoiding misinterpretations that arise from potential genetic compensation and/or spontaneous *** have been widely explored throughout the world and have outperformed not only in cancer diseases,but also in immune disorders,viral infections and neurodegenerative *** PROTACs present a very promising and powerful approach for crossing the hurdles of present drug discovery and tool development in biology,more efforts are needed to gain to get deeper insight into the efficacy and safety of PROTACs in the *** target binders and more E3 ligases applicable for developing PROTACs are waiting for exploration.

关键词： industry presently editing

西藏林芝牦牛源产气荚膜梭菌的分离鉴定及耐药性分析

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国兽医学报 2024年第1期44卷 97-106页

作者：蔡重振罗润波黄家旗吴丹郭晓庆白吉格桑卓玛边巴央拉索朗斯珠西藏农牧学院动物科学学院西藏林芝860000 西藏动物疫病预防控制中心西藏拉萨850000

为了解西藏林芝牦牛源产气荚膜梭菌的流行特点及耐药情况,为当地牦牛源产气荚膜梭菌病的防治提供理论基础和数据支持。对采集自西藏林芝市的87份牦牛腹泻粪便样品中的产气荚膜梭菌进行分离鉴定、毒素分型、药敏试验及耐药基因检测,并分... 详细信息

为了解西藏林芝牦牛源产气荚膜梭菌的流行特点及耐药情况,为当地牦牛源产气荚膜梭菌病的防治提供理论基础和数据支持。对采集自西藏林芝市的87份牦牛腹泻粪便样品中的产气荚膜梭菌进行分离鉴定、毒素分型、药敏试验及耐药基因检测,并分析耐药基因与耐药表型的相关性。结果显示:从87份牦牛腹泻粪便样品中分离鉴定得到20株产气荚膜梭菌,分离率为22.99%;其中17株为A型,3株为D型。遗传进化分析发现Nyingchi-C12(OQ704284)与北京人源(KP944151.1)产气荚膜梭菌具有较近的亲缘性。分离株对氨基糖苷类药物耐药率分别为庆大霉素85.0%、卡那霉素90.0%,对多黏菌素B、磺胺甲噁唑的耐药率分别为80.0%、85.0%;对头孢唑啉、头孢噻吩、多西环素、米诺霉素100%敏感;35.0%的菌株4重耐药,甚至出现6重及7重耐药的情况。检测到qnrS(55%)、aac(6′)-Ib(100%)、aac(6′)/aph(2″)(10%)、flor(95%)、bla_(TEM)(10%)、tetM(45%)、tetA(P)(15%)、tetB(P)(10%)、sul2(65%)、sul3(20%)共10种耐药基因;抗磺胺类耐药基因与耐药表型的相符率最高,为70.6%。表明林芝市存在牦牛源产气荚膜梭菌的流行,并存在不同程度的耐药情况,提示我们需持续监测产气荚膜梭菌的流行及耐药情况,合理防控牦牛产气荚膜梭菌病。

关键词：产气荚膜梭菌牦牛分离鉴定进化分析耐药表型耐药基因