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Journal of Materials Science & Technology 2021年第2期61卷 169-175页

作者： Bailiang Wang Jiahong Zeng Yishun Guo Lin Liang Yingyingjin siyuan qian Renjie Miao Liang Hu Fan Lu School of Ophthalmology&Optometry Eye HospitalWenzhou Medical UniversityWenzhou325027China

Eye trauma, decreased immunity, and contact lens wear often cause serious bacterial infections and irreversible corneal damage. To realize the responsive release of antibiotics such as gentamicin sulfate(GS), a novel antibacterial contact lens was constructed through self-assembly of antibiotics loaded ADAGS/PEI(polyethyleneimine) multilayer films on the surface. Both in vitro and in vivo antibacterial tests demonstrated high efficient and fast antibacterial property based on the smart responsive to bacterial infections and reversible drug loading and release.

关键词： Contact lens Corneal infections Dynamic chemical bonds Schiff base reaction Multilayer films

Mesenchymal stromal cells modulate unfolded protein response and preserve β-cell mass in type 1 diabetes

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BIOCELL 2024年第7期48卷 1115-1126页

作者： siyuan LIU YUAN ZHAO YU YU DOU YE qian WANG ZHAOYAN WANG ZUO LUAN Department of Pediatrics The Sixth Medical CenterChinese PLA General HospitalBeijing100037China

Introduction:Transplantation of mesenchymal stromal cells(MSCs)is a promising therapy for type 1 diabetes(T1D).However,whether the infused MSCs affect the endoplasmic reticulum stress or subsequent unfolded protein response inβcells remains unclear.Methods:To investigate this,we induced early-onset T1D in non-obese diabetic mice using streptozotocin.Subsequently,T1D mice were randomly assigned to receive either MSCs or phosphate-buffered saline.We observed the in vivo homing of MSCs and assessed their effectiveness by analyzing blood glucose levels,body weight,histopathology,pancreatic protein expression,and serum levels of cytokines,proinsulin,and C-peptide.Results:Infused MSCs were found in the lungs,liver,spleen,and pancreas of T1D mice.They exhibited various effects,including reducing blood glucose levels,regulating immunity,inhibiting inﬂammation,increasingβ-cell areas,and reducing the expression of key proteins in the unfolded protein response pathway.Fasting serum proinsulin and C-peptide levels were signiﬁcantly higher in the MSCs treatment group than in the T1D model group.However,there was no signiﬁcant difference in the biomarker ofβ-cell endoplasmic reticulum stress,the ratio of fasting serum proinsulin to C-peptide,between the two groups.Conclusion:Ourﬁndings reveal that MSCs infusion does not alleviate endoplasmic reticulum stress inβcells directly but modulates the unfolded protein response pathway to preserveβ-cell mass and function in T1D mice.

关键词： Type 1 diabetes Mesenchymal stromal cells Endoplasmic reticulum stress Unfolded protein response Non-obese diabetic mice

Pilot Test of Preparing 2-Alkylanthraquinone Using Alkylation-Oxidation Technology

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China Petroleum Processing & Petrochemical Technology 2024年第1期26卷 88-97页

作者： Zheng Bo qian Jianguo Shi Peng Pan Zhiyong Qie siyuan Zhang Yueqin Fei Jianqi Qiao Liang Zong Baoning SINOPEC Research Institute of Petroleum Processing Co. LtdBeijing 100083 Shijiazhuang United Petrochemical Co. LtdShijiazhuang 050011

To expedite the development of industrial technology for producing 2-alkylanthraquinone,a novel pilot test of alkylation-oxidation technology was conducted.The process mainly included anthracene alkylation,separation of anthracene and 2-alkylanthracene,oxidation of 2-alkylanthracene,and product purification.Optimal alkylation conditions yielded a 91.1%conversion of anthracene and a 71.73%selectivity for 2-alkylanthracene.To address the separation problem of anthracene and 2-alkylanthracene,solvent-assisted distillation technology was developed,resulting in a 98.9%purity of 2-alkylanthracene and a 91.82%separation yield.When the molar ratio of H2O_(2) to 2-alkylanthracene was 7:1,a 98.96%conversion of 2-alkylanthracene and a 99.94%selectivity for 2-alkylanthraquinone were achieved.A novel composition of 2-alkylanthraquinone,including 2-tert-butylanthraquinone,2-tert-amylanthraquinone,and 2-hexylanthraquinone,was developed.This composition could be effectively separated and purified through a combination of crystallization and washing processes.The elemental composition of the product met the existing standards,and its hydrogenation performance closely matched that of commercially available 2-tert-amylanthraquinone products.

关键词： anthracene 2-alkylanthracene 2-alkylanthraquinone alkylation oxidation hydrogen peroxide

Extracellular vesicles from human urine-derived stem cells delay aging through the transfer of PLAU and TIMP1

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1166-1186页

作者： Shanshan Rao Zehui He Zun Wang Hao Yin Xiongke Hu Yijuan Tan Tengfei Wan Hao Zhu Yi Luo Xin Wang Hongming Li Zhenxing Wang Xinyue Hu Chungu Hong Yiyi Wang Mingjie Luo Wei Du Yuxuan qian siyuan Tang Hui Xie Chunyuan Chen Department of Orthopedics Movement System Injury and Repair Research CenterXiangya HospitalCentral South UniversityChangsha 410008China Hunan Key Laboratory of Angmedicine Changsha 410008China Xiangya School of Nursing Central South UniversityChangsha 410013China Department of Pediatric Orthopedics Hunan Children’s HospitalUniversity of South ChinaChangsha 410007China Department of Respiratory Medicine Xiangya HospitalCentral South UniversityChangsha 410008China School of Nursing Xinjiang Medical UniversityUrumqiXinjiang 830000China Department of Rehabilitation Xiangya HospitalCentral South UniversityChangsha 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008China

Aging increases the risks of various diseases and the vulnerability to death.Cellular senescence is a hallmark of aging that contributes greatly to aging and aging-related diseases.This study demonstrates that extracellular vesicles from human urine-derived stem cells(USC-EVs)efficiently inhibit cellular senescence in vitro and in vivo.The intravenous injection of USC-EVs improves cognitive function,increases physical fitness and bone quality,and alleviates aging-related structural changes in different organs of senescence-accelerated mice and natural aging mice.The anti-aging effects of USC-EVs are not obviously affected by the USC donors’ages,genders,or health status.Proteomic analysis reveals that USC-EVs are enriched with plasminogen activator urokinase(PLAU)and tissue inhibitor of metalloproteinases 1(TIMP1).These two proteins contribute importantly to the anti-senescent effects of USC-EVs associated with the inhibition of matrix metalloproteinases,cyclin-dependent kinase inhibitor 2A(P16INK4a),and cyclin-dependent kinase inhibitor 1A(P21cip1).These findings suggest a great potential of autologous USC-EVs as a promising anti-aging agent by transferring PLAU and TIMP1 proteins.

关键词： Extracellular vesicles Urine-derived stem cells Cellular senescence Anti-aging PLAU TIMP1 Senescence-accelerated mice Natural aging mice

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低磷胁迫对薄壳山核桃幼苗生长发育的影响

果树学报 2022年第8期39卷 1432-1442页

作者：徐舰航钱思源王舒哲沈欣雨庄晨晨倪钟涛王正加浙江农林大学亚热带森林培育国家重点实验室培育基地杭州311300

【目的】探究缺磷条件下薄壳山核桃生长和生理生化的变化,为薄壳山核桃产业的磷肥施用量提供科学依据。【方法】以薄壳山核桃半年生实生苗为试验材料,采用水培法探究正常供磷(1 mmol·L^(-1)KH_(2)PO_(4),对照CK)、低磷处理(0.5 mmol·L... 详细信息

【目的】探究缺磷条件下薄壳山核桃生长和生理生化的变化,为薄壳山核桃产业的磷肥施用量提供科学依据。【方法】以薄壳山核桃半年生实生苗为试验材料,采用水培法探究正常供磷(1 mmol·L^(-1)KH_(2)PO_(4),对照CK)、低磷处理(0.5 mmol·L^(-1)KH_(2)PO_(4),LP)、无磷处理(0 mmol·L^(-1)KH_(2)PO_(4),NP)条件下对薄壳山核桃幼苗生长发育的影响。【结果】低磷处理(LP)90 d后薄壳山核桃幼苗根系P含量、蛋白质含量、地径、苗高较对照组(CK)分别下降了10.57%、30.79%、5.03%,8.40%。超氧化物歧化酶(SOD)活性、过氧化物酶(POD)活性、丙二醛(MDA)含量较CK有显著的升高,LP较CK分别升高了63.05%、59.42%、4.36%,NP较CK分别升高了178.76%、196.4%、38.76%(p<0.05)。NP处理使薄壳山核桃幼苗叶片的叶绿体体积膨大,淀粉粒体积增加。缺磷处理对薄壳山核桃幼苗的光合参数影响不明显,特别是净光合速率(P_(n))和胞间CO_(2)浓度(C_(i))差异都不显著。【结论】薄壳山核桃幼苗具有较强的抗低磷能力,苗期能适应低磷的土壤条件。

关键词：薄壳山核桃低磷胁迫生长指标生理生化指标细胞学观察

X80M钢管道全自动焊接接头裂纹尖端张开位移差异性

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焊接学报 2024年第2期45卷 98-104,I0008,I0009页

作者：文学汪宏辉李熙岩钱建康毕思源雷正龙中石化江苏油建工程有限公司扬州225009 哈尔滨工业大学材料结构精密焊接与连接全国重点实验室哈尔滨150001

针对不同预热条件下X80M钢管道全自动焊接接头,开展了裂纹尖端张开位移(crack tip opening displacement,CTOD)的差异性研究.采用单边缺口3点弯曲试样进行CTOD试验,按照GB/T21143-2014标准和ISO15653-2018标准推荐的公式分别进行CTOD值... 详细信息

针对不同预热条件下X80M钢管道全自动焊接接头,开展了裂纹尖端张开位移(crack tip opening displacement,CTOD)的差异性研究.采用单边缺口3点弯曲试样进行CTOD试验,按照GB/T21143-2014标准和ISO15653-2018标准推荐的公式分别进行CTOD值的计算.结果表明,两种计算公式结果不同,采用ISO 15653-2018标准推荐公式计算CTOD值结果与GB/T21143-2014标准相比平均偏高35%,差异出现的原因是两种标准的修正方式侧重点不同,即GB/T21143-2014标准针对裂纹长度变化进行修正,而ISO15653-2018标准针对测试温度的影响进行修正.预热温度为80℃的接头试样CTOD值整体较低,其中按GB/T21143-2014标准计算有3个试样低于标准,最低为0.16 mm,按ISO 15653-2018标准计算有1个试样低于标准,最低为0.20 mm;预热温度为120℃时,所有试样在两种标准下计算的CTOD值均满足标准要求,焊接接头断裂韧性更好.相同预热条件下,熔合区试样CTOD值整体高于焊缝区试样,且CTOD最大值均出现于熔合区,具有较好的断裂韧性,熔合区CTOD值受组织不均匀性的影响,不同位置间存在较大差异,存在性能的不均匀性.

关键词： X80M管线钢全自动焊预热温度裂纹尖端张开位移

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废旧智能手机回收再利用业务流程仿真与优化

计算机工程与应用 2021年第5期57卷 258-263页

作者：倪明钱思源杨善林南京财经大学营销与物流管理学院南京210023 合肥工业大学管理学院合肥230009

随着智能手机市场不断发展,我国已囤积了数量可观的废旧智能手机,对其进行高效的回收再利用迫在眉睫并逐渐受到各界关注。生产者责任延伸制的实行,推动了智能手机生产商从全生命周期角度构建废旧智能手机回收再利用业务流程。运用Petri... 详细信息

随着智能手机市场不断发展,我国已囤积了数量可观的废旧智能手机,对其进行高效的回收再利用迫在眉睫并逐渐受到各界关注。生产者责任延伸制的实行,推动了智能手机生产商从全生命周期角度构建废旧智能手机回收再利用业务流程。运用Petri网理论建立模型并验证模型性能,接着借助Tina软件对模型仿真。在分析仿真结果的基础上,给出该流程的优化建议,帮助相关企业缩减流程工作时间,提高回收再利用率,减少管理成本。

关键词：全生命周期废旧智能手机回收再利用流程 Petri网

1例重度支气管肺发育不良早产儿从医院到家庭过渡期的护理

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中华护理杂志 2024年第2期59卷 210-214页

作者：钱丽清陆晓燕李丽玲蒋思远胡晓静复旦大学附属儿科医院新生儿重症监护室上海市201102 复旦大学附属儿科医院护理部上海市201102

总结1例重度Ⅱ型支气管肺发育不良(bronchopulmonary dysplasia,BPD)极低出生体重早产儿从住院到家庭过渡期的护理。该患儿由BPD专病护士全程进行一对一护理,其从医院到家庭过渡期的护理要点:实施气管切开及机械通气护理,确保患儿血氧... 详细信息

总结1例重度Ⅱ型支气管肺发育不良(bronchopulmonary dysplasia,BPD)极低出生体重早产儿从住院到家庭过渡期的护理。该患儿由BPD专病护士全程进行一对一护理,其从医院到家庭过渡期的护理要点:实施气管切开及机械通气护理,确保患儿血氧饱和度稳定;提供营养支持,改善患儿的营养状况;实施循序渐进的康复训练,改善患儿的神经运动发育;实施家庭参与式护理,促进患儿的主要照护者掌握照护知识与技能;开展多学科团队个体化出院随访,提高患儿居家护理质量。患儿住院106 d后顺利带气管切开套管出院,2岁6个月时行气管切开闭合术,术后患儿可自主呼吸,无呼吸困难症状,回归正常家庭生活。

关键词：支气管肺发育不良婴儿极低出生体重早产儿过渡期新生儿护理

盾形术前设计在男性大面积雄激素性脱发的临床应用

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中国美容整形外科杂志 2024年第1期35卷 9-11页

作者：朱思媛刘茜刘驰吴巍东台市中医院江苏盐城224200 抚州第六医院江西抚州344000 鞍钢集团总医院医疗美容科辽宁鞍山114002 上海交通大学医学院附属第九人民医院整形外科上海200011

目的评估盾形术前设计的毛囊单位提取(follicular unit extraction,FUE)技术治疗男性大面积雄激素性脱发的有效性和安全性。方法自2020年5月至2022年8月,上海交通大学医学院附属第九人民医院整形外科对61例NorwoodHamiltonⅤ-Ⅵ级的男... 详细信息

目的评估盾形术前设计的毛囊单位提取(follicular unit extraction,FUE)技术治疗男性大面积雄激素性脱发的有效性和安全性。方法自2020年5月至2022年8月,上海交通大学医学院附属第九人民医院整形外科对61例NorwoodHamiltonⅤ-Ⅵ级的男性雄激素性脱发患者,进行盾形术前设计的FUE技术治疗。观察患者的一般状况、手术信息、毛发自然度、患者满意度和不良反应。结果61例患者平均移植(3799±444)FUs,单根移植密度为60 FUs/cm^(2),多根移植密度为30~50 FUs/cm^(2),平均手术时间为(9.5±1.0)h。李克特(Likert)量表评分结果:患者对毛发自然度和手术满意度的平均评分分别为4.90分和4.74分;医师对毛发自然度和手术满意的平均评分分别为4.87分和4.82分。术后随访6~12个月,无严重并发症发生。结论采用盾形设计的FUE技术治疗男性大面积雄激素性脱发,术后移植毛发具有相对自然的密度与外观,患者满意度较高,而且术后并发症较少,值得临床推广应用。

关键词：雄激素性脱发毛发移植盾形术前设计毛囊单位提取技术

Nanoparticles targeting tumor-associated macrophages:A novel anti-tumor therapy

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Nano Research 2022年第3期15卷 2177-2195页

作者： siyuan Chen Furong Qin Manni Wang Yuquan Wei Zhiyong qian Xiawei Wei Laboratory of Aging Research and Cancer Drug Target State Key Laboratory of BiotherapyNational Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengdu 610041China

The immunosuppressive tumor microenvironment(TME)is crucial in the occurrence of tumorigenesis,metastasis,and drug resistance.Among all stromal cells,tumor-associated macrophages(TAMs)are recognized as vital components causing the TME to be favorable for cancer cells and are also main targets in cancer immunotherapy.To date,nanoparticle(NP)-based drug delivery systems,as new technology platforms,have exhibited considerable advantages,such as targeted drug delivery at tumor sites,enhanced drug transport efficiency,and controllable drug release profiles,which provide new approaches for cancer therapy.Regarding TAM-targeting nanoparticles,various therapeutic strategies have been developed by varying their design,namely,by blocking TAM recruitment,promoting TAM transformation,and directly diminishing existing TAMs.In the current review,we provide a brief overview of the role of TAMs in the tumor microenvironment and their functions and highlight strategies for TAM targeting.Moreover,the applications of nanoparticles in targeting TAMs to improve cancer therapeutic efficiency are summarized.

关键词： tumors immunotherapy tumor-associated macrophages nanoparticles