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Synthesis of biodegradable waterborne phosphatidylcholine polyurethanes for soft tissue engineering applications

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Regenerative Biomaterials 2017年第2期4卷 69-79页

作者： Hongye Hao Ya Deng Yingke Wu siyuan Liu Weiwei lin Jiehua Li Feng Luo College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065China

To further improve the biocompatibility of polyurethanes,a new lysine 2-(2-aminoethoxy)ethanol phosphatidylcholine(LAPC)is synthesized to use as chain extender for preparing a series of phosphatidylcholine polyurethanes(PCPUs).Poly(e-caprolactone)(PCL)and poly(ethylene glycol)(PEG)are used as soft segments,and L-lysine ethyl ester diisocyanate(LDI),LAPC and L-lysine are used as hard *** obtained PCPUs exhibit appropriate mechanical properties with break elongation of 1000–1700%,tensile strength of 7–22 MPa,and relatively high elastic modulus of 11–18 MPa,which could admirably satisfy the requirement for soft tissue engineering *** phosphatidylcholine structures can increase the hydrophilicity of PCPU surfaces,which effectively reduce protein adsorption and platelet adhesion while promoting the cell *** addition,the LAPC chain extender,PCPU films and ultimate degradation products of PCPUs are proved to be nontoxic in cytotoxicity *** interestingly,the cytokine release test of macrophages manifests that both LAPC and PCPU degradation products could effectively improve the proliferation of macrophages and induce them into a wound-healing ***,the obtained PCPUs have greatly potential applications of soft tissue engineering scaffolds for tissue repair and wound healing.

关键词： phosphatidylcholine polyurethane soft tissue engineering macrophage

不同纤维素醚含量对3D打印混凝土强度性能的影响研究

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国防交通工程与技术 2019年第3期17卷 27-29,34页

作者：赵文斌林思远邵明刚李佳盛李睿安蕊梅石家庄铁道大学土木工程学院河北石家庄050043 石家庄铁道大学经济管理学院河北石家庄050043

主要研究不同纤维素醚含量对3D打印混凝土的层间抗拉强度、纵向劈裂抗拉和纵向抗压强度的影响。浇筑不同纤维素醚含量的6组试件,养护龄期分别为43 h和56 h时,对试件进行纵向劈裂、层间劈裂和纵向受压试验;对每个劈裂试件进行有限元模拟... 详细信息

主要研究不同纤维素醚含量对3D打印混凝土的层间抗拉强度、纵向劈裂抗拉和纵向抗压强度的影响。浇筑不同纤维素醚含量的6组试件,养护龄期分别为43 h和56 h时,对试件进行纵向劈裂、层间劈裂和纵向受压试验;对每个劈裂试件进行有限元模拟分析,获得劈裂抗拉强度的计算系数,推求每组试件的强度。结果显示,纤维素醚含量小于0.5%时,随着纤维素醚含量的增加,层间劈裂和纵向劈裂抗拉强度均有提高,纵向抗压强度减小。为了提高3D打印混凝土层间粘结强度,同时保证纵向抗压强度,建议纤维素醚含量在0.1%～0.2%之间。

关键词： 3D打印混凝土纤维素醚层间劈裂抗拉强度纵向抗压强度纵向劈裂抗拉强度

Effect of Zhu-yuan decoction in patients with chronic rhinosinusitis after functional endoscopic sinus surgery

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Journal of Traditional Chinese Medicine 2018年第1期38卷 83-88页

作者： Li Jing Zheng Chunquan lin Hai Yang Chen Gu siyuan Wang Yi Duan Honggang Department of Otolaryngology Hangzhou First People's Hospital Nanjing Medical University Department of Otolaryngology Eye & ENT Hospital of Fudan University Department of Otolaryngology the Second Affiliated Hospital of Zhejiang University School of Medicine

OBJECTIVE: To investigate the effectiveness and safety of Zhu-yuan decoction(ZYD) in patients after functional endoscopic sinus surgery(FESS).METHODS: A total of 85 patients were randomized into two groups: 44 were treated with intranasal corticosteroids(INC), and 41 were given Chinese herbal medicine(CHM). Patients with chronic rhinosinusitis(CRS) who underwent FESS were prospectively enrolled in the study. Before surgery, they were evaluated by visual analog scale(VAS), nasal endoscopy, computed tomography(CT), and routine blood test. After surgery, they were randomized to take ZYD or INC for 12 weeks and revaluated by VAS; nasal endoscopy at 4, 8, and 12 weeks;and CT at 12 weeks after ***: In the both groups, VAS and endoscopyscores decreased significantly at 4, 8, and 12 weeks,and CT scores after treatment declined at 12 weeks compared with baseline scores. No significant differences were observed with regard to postoperative VAS, endoscopy, or CT scores between ***, combined with surgery, can reduce VAS, nasal endoscopy, and CT scores and has the same efficacy and safety profile as INC in post-FESS *** fatalities or major adverse events occurred in either ***: Our findings suggest that ZYD has similar effects and safety profiles in patients after FESS compared with INC.

关键词： Chinese herbal medicine Adrenal cortex hormones Chronic rhinosinusitis Functional endoscopic sinus surgery Zhu-yuan decoction

Optimal compatible doses and effects of ephedrine and naloxone on neural plasticity in cerebral ischemia/reperfusion rats

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Neural Regeneration Research 2008年第12期3卷 1290-1296页

作者： Yuxia Chen Nong Xiao Xiaoping Zhang ling Liu Liyun lin siyuan Chen Bei XU Department of Convalescent Center Children＇s Hospital Chongqing Medical University Chongqing 400014 China Chongqing Research Institute of Pediatrics Chongqing 400014 China

BACKGROUND： Ephedrine promotes neural plasticity in rats following cerebral ischemia/reperfusion injury. Ephedrine has been combined with naloxone in some studies, and it has been confirmed that their combination has synergistic effects on increasing neural plasticity following cerebral ischemia/reperfusion injury. OBJECTIVE： To investigate the effects of ephedrine combined with various doses of naloxone on neural plasticity and to find an optimal dose of naloxone in rats after cerebral ischemia/reperfusion injury by analyzing growth associated protein-43 （GAP-43）, synaptophysin and β-endorphin expression in the hippocampal CA3 area. DESIGN, TIME AND SETTING： This immunohistochemical, randomized, controlled, animal experiment was performed at the Chongqing Research Institute of Pediatrics, China from September 2007 to June 2008. MATERIALS： Ephedrine hydrochloride injection and naloxone hydrochloride injection were respectively purchased from Shandong Lvliang Pharmaceutical Factory, China and Sichuan Jingwei Pharmaceutical Co., Ltd., China. A total of 192 healthy adult Sprague Dawley rats were used to establish models of left middle cerebral artery occlusion using the suture occlusion method. METHODS： At 2 hours following cerebral ischemia, the rats were intraperitoneally injected with 1.5 mg/kg/d ephedrine （ephedrine group）, with 0.1, 0.2, or 0.3 mg/kg/d naloxone （low, moderate and high doses of naloxone groups）, with 1.5 mg/kg/d ephedrine ＋ 0.1, 0.2, or 0.3 mg/kg/d naloxone （ephedrine ＋ low, moderate and high doses of naloxone groups）, and with 0.5 mL saline （model group）, respectively. MAIN OUTCOME MEASURES： GAP-43, synaptophysin and β -endorphin expression were detected in the hippocampal CA3 area using immunohistochemistry 1-4 weeks after surgery. Sensorimotor integration in rats was assessed using the beam walking test. RESULTS： GAP-43 and synaptophysin expression was greater in the ephedrine group, and in the ephedrine ＋ moderate and high doses of naloxone gro

关键词： cerebral ischemia/reperfusion neural plasticity growth associated protein-43 synaptophysin β -endorphin ephedrine naloxone

Reversible grafting of antibiotics onto contact lens mediated by labile chemical bonds for smart prevention and treatment of corneal bacterial infections

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Journal of Materials Science & Technology 2021年第2期61卷 169-175页

作者： Bailiang Wang Jiahong Zeng Yishun Guo lin Liang Yingyingjin siyuan Qian Renjie Miao Liang Hu Fan Lu School of Ophthalmology&Optometry Eye HospitalWenzhou Medical UniversityWenzhou325027China

Eye trauma, decreased immunity, and contact lens wear often cause serious bacterial infections and irreversible corneal damage. To realize the responsive release of antibiotics such as gentamicin sulfate(GS), a novel antibacterial contact lens was constructed through self-assembly of antibiotics loaded ADAGS/PEI(polyethyleneimine) multilayer films on the surface. Both in vitro and in vivo antibacterial tests demonstrated high efficient and fast antibacterial property based on the smart responsive to bacterial infections and reversible drug loading and release.

关键词： Contact lens Corneal infections Dynamic chemical bonds Schiff base reaction Multilayer films

A portable viable Salmonella detection device based on microfluidic chip and recombinase aided amplification

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Chinese Chemical Letters 2023年第2期34卷 268-273页

作者： Wuzhen Qi siyuan Wang Lei Wang Xinge Xi Shangyi Wu Yanbin Li Ming Liao Jianhan lin Key Laboratory of Agricultural Information Acquisition Technology Ministry of Agriculture and Rural AffairsChina Agricultural UniversityBeijing 100083China Department of Biological and Agricultural Engineering University of ArkansasFayetteville 72701United States College of Veterinary medicine South China Agricultural UniversityGuangzhou 510642China

creening of foodborne pathogens is important to prevent contaminated foods from their supply chains.n this study, a portable detection device was developed for rapid, sensitive and simple detection of viable almonella using a finger-actuated microfluidic chip and an improved recombinase aided amplification (RAA) assay. Improved propidium monoazide(PMAxx) was combined with RAA to enable this device to distinguish viable bacteria from dead ones. The modification of PMAxx into dead bacteria, the magnetic xtraction of nucleic acids from viable bacteria and the RAA detection of extracted nucleic acids were performed using the microfluidic chip on its supporting device by finger press-release operations. The fluorescent signal resulting from RAA amplification of the nucleic acids was collected using a USB camera nd analyzed using a self-developed smartphone App to quantitatively determine the bacterial concenration. This device could detect Salmonella typhimurium in spiked chicken meats from 1.3 × 10^(2) CFU/m L o 1.3 × 10^(7) CFU/m L in 2 h with a lower detection limit of 130 CFU/m L, and has shown its potential for on-site detection of foodborne pathogens.

关键词： Finger-actuated microfluidic chip PMAxx Recombinase aid amplification Smartphone App Viable bacterial detection

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有机肥小分子化促进作物增产增效的研究进展

中国农学通报 2024年第15期40卷 59-65页

作者：林思远袁军委侯俊何文祥蔡亮吴俊达刘超刘翔农业农村部长江中游作物绿色高效生产重点实验室(部省共建)/长江大学农学院湖北荆州434020 荆门法麦克斯农业科技有限公司湖北荆门448200 中化现代农业有限公司北京100032 汉川市农业技术推广中心湖北汉川431200

施用化肥能提高作物的产量,但过度施用化肥会对环境造成严重的污染;施用传统有机肥能够减少环境的污染,但其营养不足、质量不稳定、起效慢等缺点决定了它不能满足作物生长的需求。有机肥小分子化产品(小分子有机肥,下同)是一种含有多类... 详细信息

施用化肥能提高作物的产量,但过度施用化肥会对环境造成严重的污染;施用传统有机肥能够减少环境的污染,但其营养不足、质量不稳定、起效慢等缺点决定了它不能满足作物生长的需求。有机肥小分子化产品(小分子有机肥,下同)是一种含有多类小分子有机物的肥料,其能被作物根系直接吸收,提高土壤肥力和土壤微生物活性;此外,其也能和化肥化学键合,从而实现提高化肥利用效率、化肥减施和农业提质增效的目的。为了研究克服了化肥和有机肥的不足的小分子有机肥,归纳了小分子有机肥的种类,阐述其在不同作物上的施用效果以及对土壤理化性质和土壤微生物群落变化的影响,探讨了小分子有机肥的主要生产工艺、存在的问题和未来的发展方向。

关键词：有机肥有机肥小分子化生产工艺新型肥料土壤微生物活性

Effects of exogenous ganglioside-1 on learning and memory in a neonatal rat model of hypoxia-ischemia brain injury

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Neural Regeneration Research 2008年第9期3卷 1004-1009页

作者： Shizhi Li Nong Xiao Xiaoping Zhang ling Liu Liyun lin siyuan Chen Yuxia Chen Bei Xu Department of Rehabilitation Center Children＇s Hospital of Chongqing Medical University Chongqing 400014 China Pediatric Research Institute Children＇s Hospital of Chongqing Medical University Chongqing 400014 China

BACKGROUND： Exogenous ganglioside-1 （GM1） can cross the blood-brain barrier and play a protective role against hypoxia-ischemia-induced brain damage. OBJECTIVE： To examine the possible mechanisms of exogenous GM1 protection in hypoxia-ischemia-induced brain damage in a neonatal rat model by measuring changes in brain mass, pathological morphology, growth-associated protein-43 expression, and neurobehavioral manifestations. DESIGN, TIME AND SETTING： A randomized block-design study was performed at the Immunohistochemistry Laboratory of the Pediatric Research Institute, Children＇s Hospital of Chongqing Medical University from August 2005 to August 2006. MATERIALS： A total of 36 neonatal, 7-day-old, Sprague Dawley rats were used in this experiment. The hypoxia-ischemia-induced brain damage model was established by permanently occluding the right carotid artery, followed by oxygen inhalation at a low concentration （8% O2, 92% N2） for 2 hours, METHODS： All rats were randomly divided into the following groups： GMI, model, and sham operation, with 12 rats each group. Rats in the GM 1 and model groups received hypoxic/ischemic-induced brain damage. Rats in the GM1 group received injections of GM1 （i.p., 20 mg/kg） at 0, 24, 48, 72, 96, 120, and 144 hours following models established, and rats in the model group were administered （i.p.） the same amount of saline. The right carotid artery was separated, but not ligated, in the sham operation group rats. MAIN OUTCOME MEASURES： At 1 week after surgery, expression of growth-associated protein-43, a marker of neural development and plasticity, was detected in the hippocampal CA3 region by immunohistochemistry. Brain mass was measured, and the pathological morphology was observed. At 4 weeks after surgery, behavioral changes in the remaining rats were tested by Morris water maze, and growth-associated protein-43 expression was measured. RESULTS：（1） In the GMI and sham operation groups, growth-associated protein-43 expression was g

关键词： ganglioside growth-associated protein-43 hypoxia-ischemia brain damage Morris water maze

A microfluidic biosensor for rapid detection of Salmonella typhimurium based on magnetic separation,enzymatic catalysis and electrochemical impedance analysis

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Chinese Chemical Letters 2022年第6期33卷 3156-3160页

作者： Yingjia Liu Dong Jiang siyuan Wang Gaozhe Cai Li Xue Yanbin Li Ming Liao Jianhan lin Key Laboratory of Agricultural Information Acquisition Technology Ministry of Agriculture and Rural AffairsChina Agricultural UniversityBeijing 100083China Department of Biological and Agricultural Engineering University of ArkansasFayettevilleAR 72701United States College of Veterinary medicine South China Agricultural UniversityGuangzhou 510642China

Rapid screening of foodborne pathogens is of great significance to ensure food safety.A microfluidic biosensor based on immunomagnetic separation,enzyme catalysis and electrochemical impedance analysis was developed for rapid and sensitive detection of ***,the bacterial sample,the magnetic nanoparticles(MNPs)modified with capture antibodies,and the enzymatic probes modified with detection antibodies and glucose oxidase(GOx)were simultaneously injected into the microfluidic chip,followed by mixing and incubation to form MNP-bacteria-probe sandwich ***,glucose with high impedance was injected into the chip and catalyzed by the GOx on the complexes into hydrogen peroxide with high impedance and gluconic acid with low impedance,which was finally measured using the low-cost interdigitated microelectrode and the electrochemical impedance analyzer to determine the target *** the optimal conditions,this biosensor could quantitatively detect *** at the concentrations from 1.6×10^(2) CFU/m L to 1.6×10^(6) CFU/m L in 1 h with the low detection limit of 73 CFU/m ***,this biosensor was demonstrated with good feasibility for practical applications by detecting the *** spiked chicken meat samples.

关键词： Biosensor Microfluidic chip Electrochemical impedance Interdigitated microelectrode Foodborne bacteria