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Single-cell transcriptomics systematically discloses the immune-inflammatory responses of peripheral blood mononuclear cells for diabetic nephropathy

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Genes & Diseases 2024年第4期11卷 82-85页

作者： jiangpeng wu Nan Hu Baochun Guo Hualin Ma Lulin Xie Yisha Huang siyu Xia Yuke jiang Zhije Li Jigang Wang Xinzhou Zhang Zhen Liang Department of Nephrology Shenzhen Key Laboratory of Kidney Diseasesand Shenzhen Clinical Research Centre for GeriatricsShenzhen People's Hospital(The Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSouthern University of Science and Technology)ShenzhenGuangdong 518020China Department of Geriatrics and Shenzhen Clinical Research Centre for GeriatricsShenzhen People's Hospital(The Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSouthern University of Science and Technology)ShenzhenGuangdong 518020China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Artemisinin Research Centerand Institute of Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing 100700China

Diabetic nephropathy(DN)has become the leading cause of end-stage renal disease with high morbidity and mortality among individuals with diabetes mellitus.Although functional alterations of renal infiltrating immune cells have been reported as part of the pathological mechanism of DN,the understanding of the immune response underlying peripheral blood mononuclear cells(PBMCs)in DN remains limited.Here,single-cell RNA sequencing(scRNA-seq)was used toprofile the transcriptomic signatures of PBMCs from DN patients.

关键词： nephropathy alterations mortality

Mechanical behavior of 2G NPR bolt anchored rock samples under static disturbance loading

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Journal of Mountain Science 2024年第7期21卷 2494-2516页

作者： WANG Jiong jiang Jian WANG siyu CHANG Yiwen LIU Peng HE Manchao CHENG Shuang State Key Laboratory for Tunnel Engineering China University of Mining and Technology(Beijing)Beijing 100083China School of Mechanics and Civil Engineering China University of Mining and Technology(Beijing)Beijing 100083China

The deep mining of coal resources is accompanied by severe environmental challenges and various potential engineering hazards.The implementation of NPR(negative Poisson's ratio)bolts are capable of controlling large deformations in the surrounding rock effectively.This paper focuses on studying the mechanical properties of the NPR bolt under static disturbance load.The deep nonlinear mechanical experimental system was used to study the mechanical behavior of rock samples with different anchored types(unanchored/PR anchored/2G NPR anchored)under static disturbance load.The whole process of rock samples was taken by high-speed camera to obtain the real-time failure characteristics under static disturbance load.At the same time,the acoustic emission signal was collected to obtain the key characteristic parameters of acoustic emission such as acoustic emission count,energy,and frequency.The deformation at the failure of the samples was calculated and analyzed by digital speckle software.The findings indicate that the failure mode of rock is influenced by different types of anchoring.The peak failure strength of 2G NPR bolt anchored rock samples exhibits an increase of 6.5%when compared to the unanchored rock samples.The cumulative count and cumulative energy of acoustic emission exhibit a decrease of 62.16%and 62.90%,respectively.The maximum deformation of bearing capacity exhibits an increase of 59.27%,while the failure time demonstrates a delay of 42.86%.The peak failure strength of the 2G NPR bolt anchored ones under static disturbance load exhibits an increase of 5.94%when compared to the rock anchored by PR(Poisson's ratio)bolt.The cumulative count and cumulative energy of acoustic emission exhibit a decrease of 47.16%and 43.86%,respectively.The maximum deformation of the bearing capacity exhibits an increase of 50.43%,and the failure time demonstrates a delay of 32%.After anchoring by 2G NPR bolt,anchoring support effectively reduces the risk of damage caused by static disturbance load.These results demonstrate

关键词： Anchored rock samples Static disturbance load Acoustic emission characteristics Digital speckle Negative Poisson's ratio

Effects of Dietary Changes on the Gut Microbiota of Cynops orientalis

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Asian Herpetological Research 2024年第2期15卷 63-72页

作者： Yuting WANG Yuning XIE siyu WU Wenwen ZHANG Xiner CHENG Zixuan LI Fangfei HAN Jiayi SHI Yingying SHI Zhirong HE Chunna ZHANG Yixin jiang Na ZHAO Jiaqi LI Supen WANG College of Life Sciences Anhui Normal UniversityWuhu 241000AnhuiChina Nanjing Institute of Environmental Sciences Ministry of Ecology and Environment of ChinaNanjing 210042JiangsuChina School of Ecology and Environment Anhui Normal UniversityWuhu 241002AnhuiChina Key Laboratory of Zoological Systematics and Evolution Institute of ZoologyChinese Academy of SciencesBeijing 100101China

The gut microbiota plays a pivotal role in the maintenance of health for amphibians,and it has been fully recognized,but the effectiveness of various influencing factors has not yet been fully clarified.Although this association should be considered while the amphibian order Caudata is facing a severe situation of population decline and extinction,there is little understanding of the association between diets and the diversity of gut microbiota in the amphibian order Caudata.Here,we conducted an extensive analysis of the gut microbiota of Cynops orientalis fed different diets using functional prediction and 16S rRNA amplicon sequencing techniques.First,we found that wild individuals had greater gut microbial diversity and richness in comparison to captive individuals.Second,we identified the bacterial taxa associated with diets and observed differences in the relative abundance of gut microbiota among people on various diets.Finally,we have a predictive comprehension of the selection and adaptative significance of shared core ASVs in the gut microbiota in maintaining the healthy survival of C.orientalis in a large-scale spatiotemporal map.Our study emphasizes how diets alter the gut microbiota of Caudata and offers fresh perspectives on the conservation and captive management of species in Caudata.

关键词： 16S rRNA Caudata core microbiota diet gut microbiota

组织行为与制度变迁——欧盟能源治理的三重逻辑

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世界经济与政治 2024年第2期 118-152,156,157页

作者：江思羽中国社会科学院世界经济与政治研究所北京100732

能源安全是地区能源治理的核心目标。通过分析欧盟能源治理制度的变迁,作者提出了能源治理环境与制度变迁的三种逻辑,分别是安全环境与生存性逻辑、技术环境与后果性逻辑以及制度环境与适当性逻辑。这三种逻辑分别与供应稳定、价格低廉... 详细信息

能源安全是地区能源治理的核心目标。通过分析欧盟能源治理制度的变迁,作者提出了能源治理环境与制度变迁的三种逻辑,分别是安全环境与生存性逻辑、技术环境与后果性逻辑以及制度环境与适当性逻辑。这三种逻辑分别与供应稳定、价格低廉和生态环保的能源安全目标相对应,体现了地区能源治理制度的不同特点。在欧盟能源治理制度变迁的过程中,其主导逻辑各不相同。在技术环境影响下,欧盟能源治理制度受后果性逻辑主导,强调欧盟在政治、经济和外交层面加强统一行动,旨在以高效率和低成本的方式实现能源安全目标。随着安全和技术环境趋于稳定,制度环境的显著变化为适当性逻辑发挥主导作用创造了条件,能源转型与应对气候变化被确立为地区能源治理制度的核心。2022年乌克兰危机的爆发深刻影响了欧盟对能源安全的认知,短期内生存性逻辑主导了欧盟能源治理制度的变迁。从长期来看,全球应对气候变化和可持续发展的制度环境并未改变,适当性逻辑仍将深刻影响欧盟能源治理的制度变迁。

关键词：欧盟能源治理制度变迁后果性逻辑适当性逻辑生存性逻辑

Ruscogenin alleviates LPS-triggered pulmonary endothelial barrier dysfunction through targeting NMMHC IIA to modulate TLR4signaling

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Acta Pharmaceutica Sinica B 2022年第3期12卷 1198-1212页

作者： Yunhao Wu Xiu Yu Yuwei Wang Yalin Huang Jiahui Tang Shuaishuai Gong siyu jiang Yuanli Xia Fang Li Boyang Yu Yuanyuan Zhang Junping Kou State Key Laboratory of Natural Medicines Jiangsu Key Laboratory of TCM Evaluation and Translational ResearchDepartment of Pharmacology of Chinese Material MedicaSchool of Traditional Chinese PharmacyChina Pharmaceutical UniversityNanjing 211198China

Pulmonary endothelial barrier dysfunction is a hallmark of clinical pulmonary edema and contributes to the development of acute lung injury(ALI).Here we reported that ruscogenin(RUS),an effective steroidal sapogenin of Radix Ophiopogon japonicus,attenuated lipopolysaccharides(LPS)-induced pulmonary endothelial barrier disruption through mediating non-muscle myosin heavy chain IIA(NMMHC IIA)-Toll-like receptor 4(TLR4)interactions.By in vivo and in vitro experiments,we observed that RUS administration significantly ameliorated LPS-triggered pulmonary endothelial barrier dysfunction and ALI.Moreover,we identified that RUS directly targeted NMMHC IIA on its N-terminal and head domain by serial affinity chromatography,molecular docking,biolayer interferometry,and microscale thermophoresis analyses.Downregulation of endothelial NMMHC IIA expression in vivo and in vitro abolished the protective effect of RUS.It was also observed that NMMHC IIA was dissociated from TLR4 and then activating TLR4 downstream Src/vascular endothelial cadherin(VE-cadherin)signaling in pulmonary vascular endothelial cells after LPS treatment,which could be restored by RUS.Collectively,these findings provide pharmacological evidence showing that RUS attenuates LPS-induced pulmonary endothelial barrier dysfunction by inhibiting TLR4/Src/VE-cadherin pathway through targeting NMMHC IIA and mediating NMMHC IIA-TLR4 interactions.

关键词： Ruscogenin Acute lung injury Lipopolysaccharide Endothelial barrier Non-muscle myosin heavy chain IIA TLR4 VE-cadherin Interaction

基于技术接受模型的生态驾驶诱导辅助系统认知接受度

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同济大学学报（自然科学版） 2024年第4期52卷 592-603页

作者：涂然薛杉蒋思雨陈秋梓东南大学交通学院江苏南京211189

融合技术接受模型和信息系统成功模型框架,设计了李克特7级量表问卷,探究了不同驾驶场景下驾驶员对生态驾驶诱导辅助系统的使用意愿和对诱导信息的认知偏好。研究表明,驾驶员倾向于接受以语音形式警示非生态驾驶行为的诱导信息类型。在... 详细信息

融合技术接受模型和信息系统成功模型框架,设计了李克特7级量表问卷,探究了不同驾驶场景下驾驶员对生态驾驶诱导辅助系统的使用意愿和对诱导信息的认知偏好。研究表明,驾驶员倾向于接受以语音形式警示非生态驾驶行为的诱导信息类型。在城市道路上,提高诱导辅助系统的感知有用性和感知易用性有助于提高驾驶员对系统的接受度。在城市快速路上,诱导辅助系统的感知有用性和感知易用性仅对高峰场景下的驾驶员使用意愿有显著正向影响,平峰场景下影响驾驶员使用意愿的具体因素仍需在未来诱导实验中深入探究。

关键词：生态驾驶信息诱导技术接受模型车联网

One‑Step Gas-Solid‑Phase Diffusion‑Induced Elemental Reaction for Bandgap‑Tunable Cu_(a)Agm_(1)Bim_(2)I_(n)/CuI Thin Film Solar Cells

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Nano-Micro Letters 2023年第4期15卷 261-271页

作者： Erchuang Fan Manying Liu Kangni Yang siyu jiang Bingxin Li Dandan Zhao Yanru Guo Yange Zhang Peng Zhang Chuantian Zuo Liming Ding Zhi Zheng Key Laboratory of Micro‑Nano Materials for Energy Storage and Conversion of Henan Province College of Chemical and Materials EngineeringInstitute of Surface Micro and Nano MaterialsXuchang UniversityXuchang 461000People’s Republic of China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001People’s Republic of China Center for Excellence in Nanoscience(CAS) Key Laboratory of Nanosystem and Hierarchical Fabrication(CAS)National Center for Nanoscience and TechnologyBeijing 100190People’s Republic of China

Lead-free inorganic copper-silver-bismuth-halide materials have attracted more and more attention due to their environmental friendliness,high element abundance,and low cost.Here,we developed a strategy of one-step gas-solid-phase diffusioninduced reaction to fabricate a series of bandgap-tunable Cu_(a)Agm_(1)Bim_(2)I_(n)/CuI bilayer films due to the atomic diffusion effect for the first time.By designing and regulating the sputtered Cu/Ag/Bi metal film thickness,the bandgap of Cu_(a)Agm_(1)Bim_(2)I_(n)/CuI could be reduced from 2.06 to 1.78 eV.Solar cells with the structure of FTO/TiO_(2)/Cu_(a)Agm_(1)Bim_(2)I_(n)/CuI/carbon were constructed,yielding a champion power conversion efficiency of 2.76%,which is the highest reported for this class of materials owing to the bandgap reduction and the peculiar bilayer structure.The current work provides a practical path for developing the next generation of efficient,stable,and environmentally friendly photovoltaic materials.

关键词： Cu_(a)Agm_(1)Bim_(2)I_(n)/CuI Elemental reaction Bandgap tuning Solar cells Gas-solid phase

Global climate governance in the new era:Potential of business actors and technological innovation

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Chinese Journal of Population,Resources and Environment 2020年第3期18卷 165-171页

作者： siyu jiang Junfeng Li Institute of World Economics and Politics Chinese Academy of Social SciencesBeijing 100732China National Center for Climate Change Strategy and International Cooperation Beijing 100035China

The United Nations Framework Convention on Climate Change(UNFCCC)has established a climate governance mechanism with intergovernmental negotiations among sovereign states as the core.After nearly 30 years,progress in combating climate change has remained very modest compared with the numerous challenges raised.The global climate governance has entered a new era,such that incorporating other factors into the governance process is timely.Therefore,the study emphasizes technological innovation and business actors in climate governance after the Paris Agreement.Technological innovation can provide effective solutions for combating climate change and has been a crucial driving force in climate governance's evolution.Business actors are significant because they are actual implementers of technological innovation and can apply different types of power and influence on climate governance processes at various levels.In summary,business actors,as well as technological innovation in line with governments and the UNFCCC governance frameworks,create a new potential for climate governance in the new era.

关键词： Global climate governance Technological innovation Business actors

集群化发展模式下风电场预测、规划及控制关键技术综述

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电力工程技术 2024年第1期43卷 86-99页

作者：陶思钰江福庆南京航空航天大学自动化学院江苏南京211106

随着我国风电行业的快速发展,规模化发展风电对能源转型的推进至关重要。然而,由于风电场所处的复杂环境和高昂的建设运营成本等因素,集群化发展模式下的风电场面临着一系列技术难点和挑战。因此,文中针对集群化发展模式下风电场的建设... 详细信息

随着我国风电行业的快速发展,规模化发展风电对能源转型的推进至关重要。然而,由于风电场所处的复杂环境和高昂的建设运营成本等因素,集群化发展模式下的风电场面临着一系列技术难点和挑战。因此,文中针对集群化发展模式下风电场的建设和运营,重点总结了相关的预测、规划及控制关键技术。文中围绕风电场集群的关键技术与研究思路进行了归纳总结;针对风电场集群的特点,包括风资源量化表征与预测技术、多风电场协同优化规划技术以及多风电场控制与运行技术进行了详细探讨,对于每个技术领域,分析了当前的研究现状和取得的成果;最后,阐明了风电场集群建设和运营关键技术领域的发展趋势,并指出了待解决的技术难点,通过总结这些技术的研究成果为我国风电的规模化、集群化开发提供参考。

关键词：风电场集群风电机组组合预测协同规划协调控制人工智能(AI)