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An overview for monitoring and prediction of pathogenic microorganisms in the atmosphere

Fundamental Research 2024年第3期4卷 430-441页

作者： Jianping Huang Danfeng Wang Yongguan Zhu Zifeng Yang Maosheng Yao Xiaoming Shi Taicheng An Qiang Zhang Cunrui Huang Xinhui Bi Jiang Li Zifa Wang Yongqin Liu Guibing Zhu siyu Chen Jian Hang Xinghua Qiu Weiwei Deng Huaiyu Tian Tengfei Zhang Tianmu Chen Sijin Liu Xinbo Lian Bin Chen Beidou Zhang Yingjie Zhao Rui Wang Han Li Collaborative Innovation Center for Western Ecological Safety College of Atmospheric SciencesLanzhou UniversityLanzhou 730000China Research Center for Eco-Environmental Sciences Chinese Academy of SciencesBeijing 100085China National Clinical Research Center for Respiratory Disease Guangzhou Institute of Respiratory HealthFirst Affiliated Hospital of Guangzhou Medical UniversityState Key Laboratory of Respiratory Disease(Guangzhou Medical University)Guangzhou 510230China College of Environmental Sciences and Engineering Peking UniversityBeijing 100871China China CDC Key Laboratory of Environment and Population Health National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijing 100021China Guangdong-hong Kong-Macao Joint Laboratory for Contaminants Exposure and Health School of Environmental Science and EngineeringInstitute of Environmental Health and Pollution ControlGuangdong University of TechnologyGuangzhou 510006China Ministry of Education Key Laboratory for Earth System Modeling Department of Earth System ScienceTsinghua UniversityBeijing 100084China Vanke School of Public Health Tsinghua UniversityBeijing 100084China State Key Laboratory of Organic Geochemistry and Guangdong Key Laboratory of Environmental Protection and Resources Utilization Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Center for Pan-third Pole Environment Lanzhou UniversityLanzhou 730000China College of Atmospheric Sciences Lanzhou UniversityLanzhou 730000China School of Atmospheric Sciences Sun Yat-sen Universityand Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai 510640

Corona virus disease 2019(COVID-19)has exerted a profound adverse impact on human health.Studies have demonstrated that aerosol transmission is one of the major transmission routes of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Pathogenic microorganisms such as SARS-CoV-2 can survive in the air and cause widespread infection among people.Early monitoring of pathogenic microorganism transmission in the atmosphere and accurate epidemic prediction are the frontier guarantee for preventing large-scale epidemic outbreaks.Monitoring of pathogenic microorganisms in the air,especially in densely populated areas,may raise the possibility to detect viruses before people are widely infected and contain the epidemic at an earlier stage.The multi-scale coupled accurate epidemic prediction system can provide support for governments to analyze the epidemic situation,allocate health resources,and formulate epidemic response policies.This review first elaborates on the effects of the atmospheric environment on pathogenic microorganism transmission,which lays a theoretical foundation for the monitoring and prediction of epidemic development.Secondly,the monitoring technique development and the necessity of monitoring pathogenic microorganisms in the atmosphere are summarized and emphasized.Subsequently,this review introduces the major epidemic prediction methods and highlights the significance to realize a multi-scale coupled epidemic prediction system by strengthening the multidisciplinary cooperation of epidemiology,atmospheric sciences,environmental sciences,sociology,demography,etc.By summarizing the achievements and challenges in monitoring and prediction of pathogenic microorganism transmission in the atmosphere,this review proposes suggestions for epidemic response,namely,the establishment of an integrated monitoring and prediction platform for pathogenic microorganism transmission in the atmosphere.

关键词： Aerosol transmission Epidemic monitoring methods Epidemic prediction modelsEpidemic response Multidisciplinary cooperation

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Genetic Algorithm‑Based SOTIF Scenario Construction for Complex Traffic Flow

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Automotive Innovation 2023年第4期6卷 531-546页

作者： Shulian Zhao Jianli Duan siyu Wu Xinyu Gu Chuzhao Li Kai Yin hong Wang The School of Vehicle and Mobility Tsinghua UniversityBeijingChina Yanshan University QinhuangdaoChina China Automotive Engineering Research Institute Co. LtdChongqingChina Beijing Jiaotong University BeijingChina

The Safety of The Intended Functionality(SOTIF)challenge represents the triggering condition by elements of a specific scenario and exposes the function limitation of an autonomous vehicle(AV),which leads to hazards.As for operationcontent-related features,the scenario is similar to AVs’SOTIF research and development.Therefore,scenario generation is a significant topic for SOTIF verification and validation procedure,especially in the simulation testing of AVs.Thus,in this paper,a well-designed scenario architecture is first defined,with comprehensive scenario elements,to present SOTIF trigger conditions.Then,considering complex traffic disturbance as trigger conditions,a novel SOTIF scenario generation method is developed.An indicator,also known as Scenario Potential Risk,is defined as the combination of the safety control intensity and the prior collision probability.This indicator helps identify critical scenarios in the proposed method.In addition,the corresponding vehicle motion models are established for general straight roads,curved roads,and safety assessment areas.As for the traffic participants’motion model,it is designed to construct the key dynamic events.To efficiently search for critical scenarios with the trigger of complex traffic flow,this scenario is encoded as genes and it is regenerated through selection,mutation,and crossover iteration processes,known as the Genetic Algorithm(GA).Experimental results show that the GA-based method could efficiently construct diverse and critical traffic scenarios,contributing to the construction of the SOTIF scenario library.

关键词： SOTIF triggers conditions Scenario generation Genetic algorithm Complex traffic disturbance

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Analysis of the internal charging data in medium earth orbit with numerical simulation and ground experiment

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Science China(Technological Sciences) 2022年第4期65卷 977-986页

作者： SONG siyu CHEN hongFei YU XiangQian ZOU hong ZONG QiuGang CHEN Ao SHI Weihong YE YuGuang Institute of Space Physics and Applied Technology School of Earth and Space SciencesPeking UniversityBeijing 100871China

The deep dielectric charging effect monitor(DDCEM)has been designed to study the internal charging effect by measuring the charging currents and potentials inside the spacecraft.It is equipped on three Chinese navigation satellites in a circular medium earth orbit(MEO)with 22000 km average height and 55°inclinations.Numerical simulation based on the Geant4-RIC method was used to evaluate the data of DDCEM.The data during May to November 2019 on one of the three satellites show that the charging currents of DDCEM were negatively enhanced when the satellite moved into the outer radiation belt.The currents reached the negative maximum during a significant electron enhancement in September 2019.Positive currents were also detected besides negative currents that were caused by the deposition of electrons in the sensor.The causation of positive currents in the space environment may be that the low-energy electrons cannot penetrate the satellite skin and make it charging to negative potential,the reference ground of DDCEM that is connected to the satellite skin drops below zero by the low-energy electrons so that the output currents turn to positive.Ground experiment was used to simulate the causation of positive currents and the result verified our theory.

关键词： deep dielectric charging effect monitor internal charging effect charging currents and potentials medium earth orbit space environment

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EI24在消化道肿瘤中的研究进展

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现代肿瘤医学 2024年第6期32卷 1132-1136页

作者：魏思宇洪流杨万里白寒空军军医大学西京医院胃肠外科陕西西安710032

EI24(etoposide-induced gene 24)是由依托泊苷诱导的DNA损伤相关基因,可由p53基因直接激活。EI24蛋白主要定位于内质网膜上,是一种激活自噬的重要蛋白,参与细胞自噬形成。同时,EI24还参与细胞凋亡、增殖、耐药、炎症、细胞转移、上皮-... 详细信息

EI24(etoposide-induced gene 24)是由依托泊苷诱导的DNA损伤相关基因,可由p53基因直接激活。EI24蛋白主要定位于内质网膜上,是一种激活自噬的重要蛋白,参与细胞自噬形成。同时,EI24还参与细胞凋亡、增殖、耐药、炎症、细胞转移、上皮-间质转化(epithelial-mesenchymal transition,EMT)等生物学过程。EI24的异常表达与包括食管癌、肝癌、结直肠癌等在内的多种消化道肿瘤密切相关,具有一定的临床诊治及预后价值。本文就近年来有关EI24在消化道肿瘤中的研究进展作一综述,以期为消化道肿瘤的基础研究及临床诊治提供理论依据。

关键词： EI24 消化道肿瘤增殖自噬转移

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Analysis of solar radiation changes in Chinese solar greenhouses with different roof structures based on a solar radiation model

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International Journal of Agricultural and Biological Engineering 2022年第2期15卷 221-229页

作者： Kai Liu hongjun Xu hong Li Xiao Wu siyu Sang Jie Gao Department of horticulture College of HorticultureXinjiang Agricultural UniversityUrumqi 830052China Department of Horticulture Center for Postdoctoral Studies of Xinjiang Agricultural UniversityUrumqi 830052China

Chinese solar greenhouses(CSGs)are important agricultural production facilities.Under non-artificial heating conditions,solar radiation is the only CSGs energy source.It is highly important to optimally obtain solar energy in greenhouse construction and production.In this study,a solar radiation model for solar greenhouses was adopted to explore the quantities of solar radiation in greenhouses considering different front roof forms and angles.Herein,the solar radiation amounts corresponding to five roof forms,namely,double-section arc,parabolic,oval,arc,and linear roofs,are compared and analyzed during the four solar periods(beginning of spring,vernal equinox,beginning of winter,and winter solstice).It was found that the solar radiation of oval roof greenhouses on the ground was the largest and was 4.44%-23.68%higher than that of parabolic roofs.In addition,the cumulative sum of light on the linear roof greenhouse wall is also the largest and was 6.02%to 12.08%higher than the parabolic roof greenhouse in the four solar terms.Moreover,the solar radiation in CSGs was compared with front roof angles of 25°,30°,and 35°.It was observed that the solar radiation amount gradually increases with increasing angles.Notably,the variation at an angle of 35°influences the solar radiation of the paraboloidal CSGs ground and elliptical CSGs north wall to the greatest extent,which increased by 8.23%and 12.74%,respectively.This study confirms the role of front roof form and inclination angle in enhancing the greenhouse solar radiation level.

关键词： Chinese solar greenhouse roof structure roof angle solar radiation model

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CDK5 inhibition promotes osteoblastic differentiation of MSCs and blocks the migration of osteosarcoma MG-63 cells

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BIOCELL 2022年第4期46卷 1067-1078页

作者： hong FU HAOYU ZHAO YALI YANG siyu WANG KE DUAN TAILIN GUO College of Medicine Southwest Jiaotong UniversityChengdu610031China Provincial Laboratory of Orthopaedic Engineering Department of Bone and Joint SurgeryAffiliated Hospital of Southwest Medical UniversityLuzhou646000China

CDK5 belongs to the cyclin-dependent kinase family.CDK5 is multifunctional and plays an important role in neural differentiation.However,the role of CDK5 in osteoblastic differentiation remains unclear.The present study investigated functions and molecular mechanism of CDK5 in osteoblastic differentiation.It was found that,CDK5 inhibition promoted the expression of Runx2,ALP,OCN and OPN of MSCs and the mineralization of MC-3T3E1 cells and MSCs.CDK5 inhibition enhanced the development of F-actin,nuclear localization ofβ-catenin and YAP,as well as the expression of RMRP RNA.When F-actin was suppressed by Blebbistatin,the nuclear localization of YAP andβ-catenin,and expression of RMRP RNA as well as Runx2 and ALP were decreased.These indicate Seliciclib promotes osteoblastic differentiation mainly by F-actin.Moreover,Seliciclib also suppressed the migration of MG-63,suggesting a potential application for Seliciclib in bone defect repair and inhibition of the migration of osteosarcoma cells after osteosarcoma surgical resection.

关键词： F-actin YAP Beta-catenin Nuclear localization MSC differentiation

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NIR-Ⅱ fluorescence/photoacoustic imaging of ovarian cancer and peritoneal metastasis

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Nano Research 2022年第10期15卷 9183-9191页

作者： siyu Lu Liru Xue Meng Yang Jingjing Wang Yang Li Yuxin Jiang Xuechuan hong Mingfu Wu Yuling Xiao State Key Laboratory of Virology Department GynecologyCancer Biology Research CenterTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Cardiology Zhongnan Hospital of Wuhan UniversitySchool of Pharmaceutical SciencesWuhan UniversityWuhan 430071China Department of Ultrasound State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China College of Science Research Center for EcologyLaboratory of Extreme Environmental Biological Resources and Adaptive EvolutionTibet UniversityLhasa 850000China Shenzhen Institute of Wuhan University Shenzhen 518057China

Ovarian cancer is a global problem,and is typically diagnosed in the middle or late stages,with a mysterious abdominal mass or atypical abdominal metastases due to the lack of specific initial diagnostic methods.Dual-modal near-infrared Ⅱ(NIR-Ⅱ,1,000–1,700 nm)fluorescence/photoacoustic imaging has great potential in early ovarian cancer diagnosis and image-guided surgery due to its high sensitivity and deep penetration.Herein,we report a novel organic NIR-Ⅱ dye(H10)with excellent aggregation-induced-emission(AIE)characteristics(I/I0>1.6)utilizing a selenadiazolo-[3,4-f]benzo[c][1,2,5]thiadiazole(ST)-based building block.Then,water-soluble and biocompatible H10@follicle-stimulating hormone(H10@FSH)dots with superior optical/photoacoustic properties and a tenfold increase in ovarian-specific targeting ability were synthesized.Finally,for the first time,in vivo dual-mode NIR-Ⅱ fluorescent/photoacoustic(PA)imaging and image-guided surgery of patient-derived tumor xenograft(PDTX)and micro-metastatic abdominal ovarian cancer lesions were investigated.This novel strategy will establish a new method for early detection of ovarian cancer and significantly improve the prognosis of ovarian cancer patients.

关键词： ovarian cancer peritoneal metastasis near-infraredⅡ(NIR-Ⅱ,1,000-1,700 nm)fluorescence/photoacoustic dual-modal imaging early detection

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南海东部水驱气藏水侵特征及开发技术政策

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中外能源 2024年第1期29卷 48-53页

作者：白美丽马云杰洪舒娜陈斯宇江利中海石油(中国)有限公司深圳分公司广东深圳518000

番禺气田为南海东部典型的水驱气藏,随着采出程度的提高,气田产水量逐年增加,产气量呈下降趋势。为此,以气田实际生产动态为基础,通过凝析水含量计算、水样测试分析、水气比变化判别法等方法对气井产水类型进行判别,形成水驱气藏早期水... 详细信息

番禺气田为南海东部典型的水驱气藏,随着采出程度的提高,气田产水量逐年增加,产气量呈下降趋势。为此,以气田实际生产动态为基础,通过凝析水含量计算、水样测试分析、水气比变化判别法等方法对气井产水类型进行判别,形成水驱气藏早期水侵综合识别方法。分析认为,气田目前已产地层水的单井有6口,另有3口单井存在产水早期预警,其余单井以产凝析水为主。通过水侵量及水侵速度计算,明确了气藏水侵强度及水侵速度。对典型出水井的地质资料及生产动态特征等进行综合分析,将番禺气田水侵特征曲线归纳为3种类型,其中缓慢上升型主要为气藏局部连通水体,台阶状上升型主要受储层非均质或者隔夹层影响,尖峰上升型主要受储层物性及水体大小影响。针对气藏水侵特征,结合海上气田开发特点及现场经验,番禺气田在开发策略上应该以控水和井口降压为主。

关键词：水驱气藏地层水凝析水水气比水侵特征开发策略

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Improving the Initial Coulombic Efficiency of Carbonaceous Materials for Li/Na‑Ion Batteries:Origins,Solutions,and Perspectives

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Electrochemical Energy Reviews 2023年第1期6卷 651-679页

作者： Zheng Tang siyu Zhou Yuancheng Huang hong Wang Rui Zhang Qi Wang Dan Sun Yougen Tang Haiyan Wang Hunan Provincial Key Laboratory of Chemical Power Sources College of Chemistry and Chemical EngineeringCentral South UniversityChangsha 410083HunanChina

Carbonaceous materials for lithium(Li)/sodium(Na)-ion batteries have attracted significant attention because of their widespread availability,renewable nature,and low cost.During the past decades,although great efforts have been devoted to developing high-performance carbonaceous materials with high capacity,long life span,and excellent rate capability,the low initial Coulombic efficiency(ICE)of high-capacity carbonaceous materials seriously limits their practical applications.Various methods have been successfully exploited,and a revolutionary impact has been achieved through the utilization of different techniques.Different carbonaceous materials possess different ion storage mechanisms,which means that the initial capacity loss may vary.However,there has rarely been a special review about the origins of and progress in the ICE for carbonaceous materials from the angle of the crystal structure.Hence,in this review,the structural differences between and ion storage mechanisms of various carbonaceous materials are first introduced.Then,we deduce the correlative factors of low ICE and thereafter summarize the proposed strategies to address these issues.Finally,some challenges,perspectives,and future directions on the ICE of carbonaceous materials are given.This review will provide deep insights into the challenges of improving the ICE of carbonaceous anodes for high-energy Li/Na-ion batteries,which will greatly contribute to their commercialization process.

关键词： Lithium/sodium-ion batteries Initial Coulombic efficiency Carbonaceous materials Energy storage

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Spatial Pattern of Cotton Yield Variability and Its Response to Climate Change in Cotton Belt of Pakistan

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Chinese Geographical Science 2023年第2期33卷 351-362页

作者： YU Shan DU Wala ZHANG Xiang hong Ying LIU Yang hong Mei CHEN siyu College of Geographic Science Inner Mongolia Normal UniversityHohhot 010022China Inner Mongolia Key Laboratory of Remote Sensing and Geographic Information Systems Hohhot 010022China Institute of Grassland Research Chinese Academy of Agricultural SciencesHohhot 010000China College of Science Inner Mongolia University of TechnologyHohhot 010051China

Cotton is a revenue source for cotton-producing countries;as the second-largest crop in Pakistan,it significantly contributes to its economy.Over the past few decades,cotton productivity has become unstable in Pakistan,and climate change is one of the main factors that impact cotton yield.Due to climate change,it becomes very important to understand the change trend and its impact on cotton yield at the regional level.Here,we investigate the relationship of standardized cotton yield variability with the variability of climate factors using a 15-yr moving window.The piecewise regression was fitted to obtain the trend-shifting point of climate factors.The results show that precipitation has experienced an overall decreasing trend of–0.64 mm/yr during the study period,with opposing trends of–1.39 mm/yr and 1.52 mm/yr before and after the trend-shifting point,respectively.We found that cotton yield variability increased at a rate of 0.17%/yr,and this trend was highly correlated with the variability of climate factors.The multiple regression analysis explains that climate variability is a dominant factor and controlled 81%of the cotton production in the study area from 1990 to 2019,while it controlled 73%of the production from 1990 to 2002 and 84%from 2002 to 2019.These findings reveal that climate factors affact the distinct spatial pattern of changes in cotton yield variability at the tehsil level.

关键词： cotton crop yield variability climate impact on cotton yield regression analysis 15-yr moving window Pakistan

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