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青少年体育锻炼及自我控制对偏差行为的影响

辽宁体育科技 2018年第5期40卷 74-78页

作者：李娜洪丝语胡广富颜春辉彭聪许昭山东体育学院研究生教育学院山东济南250102 山东体育学院运动与健康学院山东济南250102

目的:探讨体育锻炼、自我控制对青少年偏差行为的影响,并检验自我控制的中介作用。方法:运用国际身体活动问卷、中学生自我控制问卷、青少年偏差行为问卷等测量工具,选取某中学高一至高三共3个年级的232名学生进行测试。结果:(1)青少年... 详细信息

目的:探讨体育锻炼、自我控制对青少年偏差行为的影响,并检验自我控制的中介作用。方法:运用国际身体活动问卷、中学生自我控制问卷、青少年偏差行为问卷等测量工具,选取某中学高一至高三共3个年级的232名学生进行测试。结果:(1)青少年体育锻炼量、自我控制能力均处于中等水平,偏差行为处于低等程度。不同性别青少年的体育锻炼量与偏差行为均存在显著差异(P<0.05)。(2)不同体育锻炼强度青少年的自我控制、偏差行为均存在显著差异(P<0.05),体育锻炼量与偏差行为呈显著负相关(r=-0.165),与自我控制呈显著正相关(r=-0.251),自我控制与偏差行为呈显著负相关(r=-0.53)。(3)自我控制在体育锻炼与偏差行为之间起完全中介作用。结论:(1)青少年体育锻炼处于中等水平,男生的体育锻炼高于女生;青少年的自我控制能力处于中等水平,男女生没有性别上的差异;青少年偏差行为处于低等程度,男生的偏差行为高于女生。(2)体育锻炼可以预防和降低青少年偏差行为,体育锻炼对青少年偏差行为的影响通过自我控制来实现。

关键词：青少年体育锻炼自我控制偏差行为中介作用

Transforming Cu into Cu_(2)O/RuAl intermetallic heterojunction for lowering the thermodynamic energy barrier of the CO_(2) reduction and evolution reactions in Li-CO_(2) battery

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Journal of Energy Chemistry 2024年第11期98卷 531-540页

作者： Wenqing Ma Jiagang Hou siyu Liu Tianzhen Jian Jianping Ma Caixia Xu hong Liu Institute for Advanced Interdisciplinary Research(iAIR) Collaborative Innovation Center of Technology and Equipment for Biological Diagnosis and Therapy in Universities of ShandongSchool of Chemistry and Chemical EngineeringUniversity of JinanJinan 250022ShandongChina Kyiv College at Qilu University of Technology Qilu University of Technology(Shandong Academy of Sciences)Jinan 250353ShandongChina Nano-Science Center&Department of Chemistry University of CopenhagenCopenhagen 2100Denmark Shandong Sacred Sun Power Sources Co.Ltd. Qufu 273100ShandongChina State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100ShandongChina

The Li-CO_(2) battery has been under the spotlight of future battery technologies since it can achieve CO_(2)utilization and energy conversion ***,its advancement is hampered by poor energy efficiency and limited reversibility due to the sluggish kinetics of the CO_(2) reduction and evolution ***,a multiscale nanoporous interpenetrating phase nanohybrid of RuAl intermetallic and Cu_(2)O(MP-Cu_(2)O/RuAl) was carved by driving synchronous phase and microstructure evolutions through dealloying of one RuCuAl master *** built-in RuAl intermetallic and Cu_(2)O closely stack to form abundant nano-interfaces with revolutionized electronic structure,The theoretical simulations reveal that the Cu_(2)O/RuAl interface can distinctly reduce the energy barrier of the Li_(2)CO_(3) decomposition reaction,The interconnected pore channels with large surface area can enhance catalytic site accessibility,mass transfer,and uniform deposition of the discharge *** situ differential electrochemical mass spectrometry discloses that the CO_(2)-to-electron ratio during charging coincides with the theoretical value of 3/4,demonstrating the high efficacy of MP-Cu_(2)O/RuAl in achieving the recycling of CO_(2).The dealloying protocol provides an affordable platform to empower transition metal oxides into high-efficiency electrocatalysts by hybridizing with metallic nano-sponge for advancing the application of Li-CO_(2)batteries.

关键词： Intermetallic Cu_(2)O Heterostructure Nanoporous Lithium–CO_(2)battery

Analysis of the internal charging data in medium earth orbit with numerical simulation and ground experiment

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Science China(Technological Sciences) 2022年第4期65卷 977-986页

作者： SONG siyu CHEN hongFei YU XiangQian ZOU hong ZONG QiuGang CHEN Ao SHI Weihong YE YuGuang Institute of Space Physics and Applied Technology School of Earth and Space SciencesPeking UniversityBeijing 100871China

The deep dielectric charging effect monitor(DDCEM)has been designed to study the internal charging effect by measuring the charging currents and potentials inside the *** is equipped on three Chinese navigation satellites in a circular medium earth orbit(MEO)with 22000 km average height and 55°*** simulation based on the Geant4-RIC method was used to evaluate the data of *** data during May to November 2019 on one of the three satellites show that the charging currents of DDCEM were negatively enhanced when the satellite moved into the outer radiation *** currents reached the negative maximum during a significant electron enhancement in September *** currents were also detected besides negative currents that were caused by the deposition of electrons in the *** causation of positive currents in the space environment may be that the low-energy electrons cannot penetrate the satellite skin and make it charging to negative potential,the reference ground of DDCEM that is connected to the satellite skin drops below zero by the low-energy electrons so that the output currents turn to *** experiment was used to simulate the causation of positive currents and the result verified our theory.

关键词： deep dielectric charging effect monitor internal charging effect charging currents and potentials medium earth orbit space environment

Genetic Algorithm‑Based SOTIF Scenario Construction for Complex Traffic Flow

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Automotive Innovation 2023年第4期6卷 531-546页

作者： Shulian Zhao Jianli Duan siyu Wu Xinyu Gu Chuzhao Li Kai Yin hong Wang The School of Vehicle and Mobility Tsinghua UniversityBeijingChina Yanshan University QinhuangdaoChina China Automotive Engineering Research Institute Co. LtdChongqingChina Beijing Jiaotong University BeijingChina

The Safety of The Intended Functionality(SOTIF)challenge represents the triggering condition by elements of a specific scenario and exposes the function limitation of an autonomous vehicle(AV),which leads to *** for operationcontent-related features,the scenario is similar to AVs’SOTIF research and ***,scenario generation is a significant topic for SOTIF verification and validation procedure,especially in the simulation testing of ***,in this paper,a well-designed scenario architecture is first defined,with comprehensive scenario elements,to present SOTIF trigger ***,considering complex traffic disturbance as trigger conditions,a novel SOTIF scenario generation method is *** indicator,also known as Scenario Potential Risk,is defined as the combination of the safety control intensity and the prior collision *** indicator helps identify critical scenarios in the proposed *** addition,the corresponding vehicle motion models are established for general straight roads,curved roads,and safety assessment *** for the traffic participants’motion model,it is designed to construct the key dynamic *** efficiently search for critical scenarios with the trigger of complex traffic flow,this scenario is encoded as genes and it is regenerated through selection,mutation,and crossover iteration processes,known as the Genetic Algorithm(GA).Experimental results show that the GA-based method could efficiently construct diverse and critical traffic scenarios,contributing to the construction of the SOTIF scenario library.

关键词： SOTIF triggers conditions Scenario generation Genetic algorithm Complex traffic disturbance

CRISPR-based genetic screens advance cancer immunology

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Science China Life Sciences 2024年第12期67卷 2554-2562页

作者： Yuanfang Cao Xueting Li Yumu Pan Huahe Wang siyu Yang Lingjuan hong Lupeng Ye Institute of Modern Biology Nanjing University

CRISPR technologies have revolutionized research areas ranging from fundamental science to translational medicine. CRISPR-based genetic screens offer a powerful platform for unbiased screening in various fields, such as cancer immunology. Immune checkpoint blockade(ICB)therapy has been shown to strongly affect cancer treatment. However, the currently available ICBs are limited and do not work in all cancer patients. Pooled CRISPR screens enable the identification of previously unknown immune regulators that can regulate T-cell activation,cytotoxicity, persistence, infiltration into tumors, cytokine secretion, memory formation, T-cell metabolism, and CD4+T-cell *** novel targets can be developed as new immunotherapies or used with the current ICBs as new combination therapies that may yield synergistic efficacy. Here, we review the progress made in the development of CRISPR technologies, particularly technological advances in CRISPR screens and their application in novel target identification for immunotherapy.

关键词： gene editing CRISPR/Cas genetic screening cancer immunotherapy immune cells

Analysis of solar radiation changes in Chinese solar greenhouses with different roof structures based on a solar radiation model

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International Journal of Agricultural and Biological Engineering 2022年第2期15卷 221-229页

作者： Kai Liu hongjun Xu hong Li Xiao Wu siyu Sang Jie Gao Department of horticulture College of HorticultureXinjiang Agricultural UniversityUrumqi 830052China Department of Horticulture Center for Postdoctoral Studies of Xinjiang Agricultural UniversityUrumqi 830052China

Chinese solar greenhouses(CSGs)are important agricultural production *** non-artificial heating conditions,solar radiation is the only CSGs energy *** is highly important to optimally obtain solar energy in greenhouse construction and *** this study,a solar radiation model for solar greenhouses was adopted to explore the quantities of solar radiation in greenhouses considering different front roof forms and ***,the solar radiation amounts corresponding to five roof forms,namely,double-section arc,parabolic,oval,arc,and linear roofs,are compared and analyzed during the four solar periods(beginning of spring,vernal equinox,beginning of winter,and winter solstice).It was found that the solar radiation of oval roof greenhouses on the ground was the largest and was 4.44%-23.68%higher than that of parabolic *** addition,the cumulative sum of light on the linear roof greenhouse wall is also the largest and was 6.02%to 12.08%higher than the parabolic roof greenhouse in the four solar ***,the solar radiation in CSGs was compared with front roof angles of 25°,30°,and 35°.It was observed that the solar radiation amount gradually increases with increasing ***,the variation at an angle of 35°influences the solar radiation of the paraboloidal CSGs ground and elliptical CSGs north wall to the greatest extent,which increased by 8.23%and 12.74%,*** study confirms the role of front roof form and inclination angle in enhancing the greenhouse solar radiation level.

关键词： Chinese solar greenhouse roof structure roof angle solar radiation model

CDK5 inhibition promotes osteoblastic differentiation of MSCs and blocks the migration of osteosarcoma MG-63 cells

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BIOCELL 2022年第4期46卷 1067-1078页

作者： hong FU HAOYU ZHAO YALI YANG siyu WANG KE DUAN TAILIN GUO College of Medicine Southwest Jiaotong UniversityChengdu610031China Provincial Laboratory of Orthopaedic Engineering Department of Bone and Joint SurgeryAffiliated Hospital of Southwest Medical UniversityLuzhou646000China

CDK5 belongs to the cyclin-dependent kinase ***5 is multifunctional and plays an important role in neural ***,the role of CDK5 in osteoblastic differentiation remains *** present study investigated functions and molecular mechanism of CDK5 in osteoblastic *** was found that,CDK5 inhibition promoted the expression of Runx2,ALP,OCN and OPN of MSCs and the mineralization of MC-3T3E1 cells and ***5 inhibition enhanced the development of F-actin,nuclear localization ofβ-catenin and YAP,as well as the expression of RMRP *** F-actin was suppressed by Blebbistatin,the nuclear localization of YAP andβ-catenin,and expression of RMRP RNA as well as Runx2 and ALP were *** indicate Seliciclib promotes osteoblastic differentiation mainly by ***,Seliciclib also suppressed the migration of MG-63,suggesting a potential application for Seliciclib in bone defect repair and inhibition of the migration of osteosarcoma cells after osteosarcoma surgical resection.

关键词： F-actin YAP Beta-catenin Nuclear localization MSC differentiation

NIR-Ⅱ fluorescence/photoacoustic imaging of ovarian cancer and peritoneal metastasis

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Nano Research 2022年第10期15卷 9183-9191页

作者： siyu Lu Liru Xue Meng Yang Jingjing Wang Yang Li Yuxin Jiang Xuechuan hong Mingfu Wu Yuling Xiao State Key Laboratory of Virology Department GynecologyCancer Biology Research CenterTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Cardiology Zhongnan Hospital of Wuhan UniversitySchool of Pharmaceutical SciencesWuhan UniversityWuhan 430071China Department of Ultrasound State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China College of Science Research Center for EcologyLaboratory of Extreme Environmental Biological Resources and Adaptive EvolutionTibet UniversityLhasa 850000China Shenzhen Institute of Wuhan University Shenzhen 518057China

Ovarian cancer is a global problem,and is typically diagnosed in the middle or late stages,with a mysterious abdominal mass or atypical abdominal metastases due to the lack of specific initial diagnostic ***-modal near-infrared Ⅱ(NIR-Ⅱ,1,000–1,700 nm)fluorescence/photoacoustic imaging has great potential in early ovarian cancer diagnosis and image-guided surgery due to its high sensitivity and deep ***,we report a novel organic NIR-Ⅱ dye(H10)with excellent aggregation-induced-emission(AIE)characteristics(I/I0>1.6)utilizing a selenadiazolo-[3,4-f]benzo[c][1,2,5]thiadiazole(ST)-based building ***,water-soluble and biocompatible H10@follicle-stimulating hormone(H10@FSH)dots with superior optical/photoacoustic properties and a tenfold increase in ovarian-specific targeting ability were ***,for the first time,in vivo dual-mode NIR-Ⅱ fluorescent/photoacoustic(PA)imaging and image-guided surgery of patient-derived tumor xenograft(PDTX)and micro-metastatic abdominal ovarian cancer lesions were *** novel strategy will establish a new method for early detection of ovarian cancer and significantly improve the prognosis of ovarian cancer patients.

关键词： ovarian cancer peritoneal metastasis near-infraredⅡ(NIR-Ⅱ,1,000-1,700 nm)fluorescence/photoacoustic dual-modal imaging early detection

Cu/Al异种材料FSW接头的组织性能及断口分析

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电焊机 2018年第6期48卷 68-72页

作者：吴克彦刘鹏孙思宇洪昌王克勤泰安泰山高压开关有限公司山东泰安271000 山东建筑大学材料科学与工程学院山东济南250101

利用搅拌摩擦焊(FSW)实现紫铜(T2)与铝合金(5A06)的焊接。采用金相、拉伸试验机和扫描电镜研究Cu/Al接头的显微组织、力学性能和断裂特征。结果表明,当搅拌头转速950r/min、行走速度150mm/min时,可获得高质量的焊接接头,拉伸强度最大值... 详细信息

利用搅拌摩擦焊(FSW)实现紫铜(T2)与铝合金(5A06)的焊接。采用金相、拉伸试验机和扫描电镜研究Cu/Al接头的显微组织、力学性能和断裂特征。结果表明,当搅拌头转速950r/min、行走速度150mm/min时,可获得高质量的焊接接头,拉伸强度最大值约为296 MPa。金属铜和铝在焊核近铜侧呈层状交替结构特征,但在焊核区的铝侧为Cu和Al的混合结构特征。焊缝截面的宏观断裂表现出明显的层状特征,断裂中间层为具有韧性断裂特征的韧窝结构,韧窝中主要存在脆性Mg-Al系金属间化合物。

关键词： Cu/Al异种材料搅拌摩擦焊显微组织抗拉强度断裂