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基于辅导员视域构建新时代和谐研究生导学关系

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科教文汇 2025年第1期 34-37页

作者：李思瑶吕经纬宋树洋北京航空航天大学北京100191

研究生教育作为高等教育中的高层次教育和国家科技创新体系的生力军,承担着高端人才供给和科学技术创新的双重使命,为实现教育强国、科技强国、人才强国提供重要智力引擎。努力提升导师队伍育人水平,持续完善创新型人才培养体系,加快培... 详细信息

研究生教育作为高等教育中的高层次教育和国家科技创新体系的生力军,承担着高端人才供给和科学技术创新的双重使命,为实现教育强国、科技强国、人才强国提供重要智力引擎。努力提升导师队伍育人水平,持续完善创新型人才培养体系,加快培养国家急需的高层次人才是研究生教育的重要使命。如何在新时代、新要求、新视角下,通过强化辅导员队伍的主体作用和协同作用,构建和谐的研究生导学关系,实现导师和研究生在思想价值上同心同德、在科学研究中同频共振、在个人发展中同向同行,该文对此进行了全面分析,并提出了体系化的建设思路与方案。

关键词：辅导员视域和谐研究生导学关系

外泌体调节复发性流产小鼠子宫内膜细胞上皮间充质转化的作用机制研究

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中国全科医学 2025年第8期28卷 962-972页

作者：李梦元李冠杉韩倩李思瑶郑舒畅辛明蔚尹晓丹王景尚武颖何军琴首都医科大学附属北京妇产医院/北京妇幼保健院中医科北京市100026

背景复发性流产(RSA)是常见的生殖障碍性疾病,在胚胎植入过程中,子宫内膜发生上皮间充质转化(EMT),RSA的发生与该过程减弱密切相关。子宫内膜来源外泌体及其携带的miRNA参与细胞间通讯,影响细胞EMT,与RSA关系密切,但具体作用机制尚不明... 详细信息

背景复发性流产(RSA)是常见的生殖障碍性疾病,在胚胎植入过程中,子宫内膜发生上皮间充质转化(EMT),RSA的发生与该过程减弱密切相关。子宫内膜来源外泌体及其携带的miRNA参与细胞间通讯,影响细胞EMT,与RSA关系密切,但具体作用机制尚不明确。目的本研究聚焦于外泌体在细胞EMT中的功能,通过实验验证子宫内膜来源外泌体及其分泌的miRNA-221对RSA小鼠子宫内膜细胞EMT的调控作用。方法2021年10月—2022年5月,选取SPF级、健康8周龄雌性小鼠24只,随机选取12只作为正常对照组,剩余12只小鼠制作RSA模型,造模结束后雌雄合笼,妊娠第4日处死雌性小鼠,分离和培养子宫内膜上皮细胞并收集外泌体,通过透射电镜和免疫印迹法(WB)进行外泌体鉴定;通过CCK-8、Transwell和流式细胞术检测外泌体干预前后两组细胞增殖、侵袭、迁移能力;细胞EMT相关蛋白[E-cadherin、N-cadherin、Vimentin、基质金属蛋白酶7(MMP-7)、MMP-9]及外泌体标志蛋白(CD63、CD81、TSG101)的表达;外泌体处理后的细胞EMT标志蛋白(CD24-APC、CD44-FITC)的表达;转染miRNA-221模拟物和抑制物分析外泌体源性miRNA-221对小鼠子宫内膜上皮细胞EMT的作用,并通过WB和双荧光素酶报告基因检测进行分析。结果RSA组小鼠的子宫内膜上皮细胞具有异常的EMT,小鼠子宫内膜上皮细胞能够分泌外泌体。添加外泌体的RSA组细胞增殖率、迁移能力、侵袭能力、CD44^(+)/CD24^(+)表达水平高于细胞上清液RSA组(P<0.05)。与细胞上清液RSA组相比,添加外泌体的RSA组细胞的EMT标志蛋白E-cadherin水平降低,间质样标志蛋白N-cadherin和Vimentin以及基质标志蛋白MMP-7、MMP-9蛋白水平升高(P<0.05)。RSA组miRNA-221表达水平低于正常对照组(P<0.05)。与对照随机miRNA相比,miRNA-221模拟物激活了PI3K-AKT通路、NF-κB通路和p38通路(P<0.05)。与对照随机miRNA相比,miRNA-221模拟物降低了PTEN mRNA的表达水平(P<0.05),而miRNA-221抑制剂转染则增加了PTEN mRNA的表达水平(P<0.05)。结论子宫内膜来源外泌体miRNA-221可通过负向调控Pten基因,激活PI3K-AKT通路,促进子宫内膜上皮细胞EMT,影响RSA妊娠结局。

关键词：复发性流产上皮间充质转化外泌体 miRNA-221 Pten基因 PI3K-AKT通路

CO_(2)-mediated bicarbonate conversion to concentrated formate in a CEM-based electrolyzer

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Journal of Energy Chemistry 2025年第1期100卷 605-611页

作者： Haocheng Xiong Donghuan Wu Haonan li Andrew li Qikun Hu siyao Song Bingjun Xu Qi Lu State Key Laboratory of Chemical Engineering Department of Chemical EngineeringTsinghua UniversityBeijing 100084China College of Chemistry and Molecular Engineering Peking UniversityBeijing 100871China Ordos Laboratory Inner Mongolia 017000China

Renewable energy-driven bicarbonate conversion to valuable chemicals presents an attractive strategy for mitigating CO_(2)emissions,as bicarbonate can be efficiently generated from the capture of atmospheric CO_(2)using alkaline solutions with reactive *** this work,we present a CO_(2)-mediated bicarbonate conversion to pure formate using a cation exchange membrane-based electrolyzer with a 25 cm^(2)electrode *** electrolysis achieved selectivities exceeding 75%for formate at a total current of 2.5 A,achieving formate concentrations up to 1.2 M and yields as high as 95%over extended *** techno-economic assessment confirmed the economic viability of the process,highlighting the potential for bicarbonate electrolysis as a sustainable method for producing valuable chemicals.

关键词： Electrocatalysis Techno-economic assessments Electrochemistry Flow electrolyzer

The evaluation of iron content in Alzheimer’s disease by magnetic resonance imaging: Phase and R2* methods

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Advances in Alzheimer's Disease 2013年第2期2卷 51-59页

作者： Bijing Zhou siyao li Huijin He Xiaoyuan Feng Department of Radiology Huashan Hospital Fudan University Shanghai China

Background: Magnetic resonance imaging (MRI) is the best imaging examination to evaluate abnormal iron deposition in the brain. Although phase of susceptibility weighted imaging (SWI) and R2* values have been used to probe iron deposition in Alzheimer’s disease (AD) brain, no study has exploited both techniques for quantification of iron deposition in AD. Purpose: Use phase and R2* to evaluate iron changes in AD brain. Investigate the correlation of two methods with the severity of cognitive impairment in AD *** and methods: Twenty-three patients with AD and eighteen normal controls underwent SWI and multi-echo gradient recalled-echo (GRE) imaging on a 3T MR scanner. The phase values from SWI and R2* values calculated from multi-echo GRE imaging of bilateral hippocampus, globus pallidus, putamen, caudate nucleus, thalamus, substantia nigra, red nucleus and dentate nucleus were evaluated. Results: In AD group, the phase values of bilateral hippocampus, globus pallidus, caudate nucleus, substantia nigra and left putamen were significantly lower than the control group. The R2* values of bilateral hippocampus, caudate nucleus, putamen and right globus pallidus were significantly higher than the control group. The phase and R2* values of the left putamen had the most significant correlation with mini-mental state examination (MMSE) scores in AD patients. Conclusion: The SWI phase value and R2* value can be used as effective methods to study the abnormality of iron deposition in AD brain, wherein phase had advantages in small brain structure. Phase value showed a higher correlation coefficient with MMSE scores, moreover the iron deposition of left putamen has a close relationship with the progression of AD.

关键词： MMSE Iron Deposition SWI Phase Cognitive Impairment

Research on the cooperative train control method in the metro system for energy saving

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Railway Sciences 2023年第3期2卷 371-394页

作者： siyao li Bo Yuan Yun Bai Jianfeng liu Railway Science and Technology Research and Development Center China Academy of Railway Sciences Corporation LimitedBeijingChina Transporatation Research Center Beijing Urban Construction Design&Research Institute Co.LtdBeijingChina School of Traffic and Transportation Beijing Jiaotong UniversityBeijingChina

Purpose–To address the problem that the current train operation mode that train selects one of several offline pre-generated control schemes before the departure and operates following the scheme after the departure,energy-saving performance of the whole metro system cannot be ***/methodology/approach–A cooperative train control framework is formulated to regulate a novel train operation *** classic train four-phase control strategy is improved for generating specific energy-efficient control schemes for each *** improved brute force(BF)algorithm with a two-layer searching idea is designed to solve the optimisation model of energy-efficient train control ***–Case studies on the actual metro line in Guangzhou,China verify the effectiveness of the proposed train control methods compared with four-phase control strategy under different kinds of train operation scenarios and calculation *** verification on the computation efficiency as well as accuracy of the proposed algorithm indicates that it meets the requirement of online ***/value–Most existing studies optimised energy-efficient train timetable or train control strategies through an offline process,which has a defect in coping with the disturbance or delays effectively and promptly during real-time train *** paper studies an online optimisation of cooperative train control based on the rolling optimisation idea,where energy-efficient train operation can be realised once train running time is determined,thus mitigating the impact of unpredictable operation situations on the energy-saving performance of trains.

关键词： Train operation scheme Energy saving Cooperative control Metro system

THE EXPERIENCE OF FIBRIN GLUEIN UROLOGICAL SURGERY

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Chinese Journal of Biomedical Engineering(English Edition) 1997年第3期6卷 208-209页

作者： li siyao(The Urological Department of Sun-YetSen Memorial Hospital)

Developmental Nonylphenol Exposure Induced Axonal Injury In Vivo and In Vitro:Involvement of Wnt-DvI-GSK-3β Cascade

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Developmental Nonylphenol Exposure Induced Axonal Injury In ...

母胎界面微环境障碍在复发性流产中的研究进展

2018环境与健康学术会议--精准环境健康：跨学科合作的挑战

作者： siyao li Yawen Fang Yufeng Dai Yi Wang Environment and Non-communicable Disease Research Center School of Public HealthChina Medical University

Objectives Nonylphenol(NP),one of the persistent organic pollutants(POPs) is ubiquitous throughout the *** central nervous system(CNS) is quite sensitive to POPs during perinatal ***,increasing evidence indicates that developmental NP exposure causes learning and memory *** is a basic and essential structure for learning and memory ***,we investigated whether NP exposure during perinatal period induced axonal injury and its effects on the development of axon in cultured ***,we explored the relationship between change of Wnt-Dvl-GSK-3β cascade and impairment of the axon caused by NP *** We established an in vivo model of rats perinatally exposed to *** addition,cultured neurons were also treated with it in *** rats were randomly divided into control and NP treatment *** treatment groups were given NP daily by oral gavage at 10,50,100 mg/(kg day),respectively,from gestational day 0 till postnatal day 21(PN21).The control group received the corn oil *** dams were permitted to rear the pups until weaning on *** silver staining and protein levels of axon associated proteins were assessed on PN21 and *** cortical neurons were prepared from newborn Wistar *** were treated with a final concentration(0,30,50,70 μM) of NP for 48 ***1-43 loading and destaining,and levels of axon associated proteins were ***-3β inhibitor SB216763(SB) was used to further analyze the role of Wnt-Dv1-GSK-3β cascade in axon impairments caused by *** Perinatal exposure to NP reduced the number of axon in offspring hippocampus on PN21 and ***,perinatal exposure to NP decreased microtubule-associated protein CRMP-2 levels and increased p-CRMP-2 ***,NP exposure significantly decreased the levels of p-GSK-3β,Dv1 and *** cultured neurons,NP significantly decreased the average length of neurites and the length of *** dye uptake and

关键词： Nonylphenol Neuron Axon Wnt-Dvl-GSK-3β cascade

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中国性科学 2025年第1期34卷 81-85页

作者：李思瑶何军琴首都医科大学附属北京妇产医院(北京妇幼保健院)中医科北京100026

复发性流产(RSA)指连续发生≥2次的自然流产,发病率为1%~5%,现仍有约50%原因不明,严重危害女性身心健康及家庭和谐。母胎界面免疫、血管微环境平衡对于胚胎着床和维持妊娠至关重要,当这种平衡发生障碍时会诱发RSA。本文从母胎界面免疫... 详细信息

复发性流产(RSA)指连续发生≥2次的自然流产,发病率为1%~5%,现仍有约50%原因不明,严重危害女性身心健康及家庭和谐。母胎界面免疫、血管微环境平衡对于胚胎着床和维持妊娠至关重要,当这种平衡发生障碍时会诱发RSA。本文从母胎界面免疫微环境及血管微环境两个方面在RSA中的作用及机制研究进行综述。

关键词：母胎界面复发性流产免疫细胞血管生成

Short-term passenger flow prediction of rail transit based on VMD-LSTM neural network combination model

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Short-term passenger flow prediction of rail transit based o...