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Migration mechanism and risk assessment of perand polyfluoroalkyl substances in the Ya'Er Lake oxidation pond area,China

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Journal of Environmental Sciences 2024年第2期136卷 301-312页

作者： Chang Li Huifang Zhong Jing Wu Lingyi Meng Yingjun Wang Chunyang liao Yawei Wang Yujian He University of Chinese Academy of Sciences Beijing 100049China Research Center for Eco-Environmental Sciences Chinese Academy of SciencesBeijing 100085China Institute of Biomedical and Health Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China China National Environmental Monitoring Centre Beijing 100012China Hubei Key Laboratory of Environmental and Health Effects of Persistent Toxic Substances Institute of Environment and HealthJianghan UniversityWuhan 430056China

The migration mechanisms,sources,and environmental risks of 29 legacy and emerging perfluorinated and polyfluoroalkyl species present in an oxidation pond(Ya'Er Lake)were investigated for treating sewage based on the analysis of their occurrence and *** concentration of per-and polyfluoroalkyl substances(PFAS)in pond area was between0.30 and 63.2 ng/g dw(dry weight),with the overall average concentration of 8.00 ng/g ***,the PFAS concentrations in the surface sediments near the sewage outlet in Pond-1(50.2 ng/g dw)and Pond-5(average 15.1 ng/g dw)were 1–2 orders of magnitude higher than those in other *** general,the legacy PFAS,i.e.,perfluorooctane sulfonic acid was considered to be the major pollutant in the polluted area,on average,accounting for 73.0%of the total concentration of PFAS *** evaluating the regional distribution of different PFAS homologs,the short-chain PFAS pollutants with lower K_(ow)were found to migrate farther in both horizontal and vertical *** sewage outlets in Pond-1 and Pond-5are the main pollution sources in polluted area and the emerging PFAS pollutants in Pond-5have replaced the legacy PFAS pollutants as the main *** on positive matrix factorization analysis,three main industrial sources of PFAS pollutants in the study area were identified:protective coating,fire-fighting,and food packaging ***,the environmental risk assessment results showed that most study areas exhibited medium environmental risk(0.01≤Risk quotient(RQ)ng that the ecological environment risks in this area need further attention.

关键词： Perfluoroalkyl substances Distribution Migration mechanism Risk assessment

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Characterizing the photodegradation-induced release of volatile organic compounds from bottled water containers

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Eco-Environment & Health 2024年第2期3卷 145-153页

作者： Ruijuan Liu Zhianqi liao Jing Zheng Xinni Wu Zongyi Tan Huase Ou Guangdong Key Laboratory of Environmental Pollution and Health School of EnvironmentJinan UniversityGuangzhou 511443China State Environmental Protection Key Laboratory of Environmental Pollution Health Risk Assessment South China Institute of Environmental SciencesMinistry of Ecology and EnvironmentGuangzhou 510655China Key Laboratory of Philosophy and Social Science in Guangdong Province of Community of Life for Man and Nature Jinan UniversityGuangzhou 511443China

While plastic water bottles are known to potentially release various volatile organic compounds(VOCs)when exposed to light,existing knowledge in this field remains *** this study,we systematically examined the composition,yield,and toxicity of VOCs released from six plastic containers obtained from different continents under UV-A and solar *** light exposure,all containers released VOCs,including alkanes,alkenes,alcohols,aldehydes,carboxylic acids,aromatics,*** 1#,3#,4#,5#,and 6#containers exhibited 35,32,19,24 and 37 species of VOCs,***,the 2#container released 28 and 32 series of VOCs after 1-day(short-term)and 7-day(long-term)UV-A irradiation,respectively,compared to 30 and 32 species under solar *** half of the VOCs identified were oxidized compounds alongside various short-chain *** differences in VOC compositions among the containers were observed,potentially originating from light-induced aging and degradation of the polyethylene terephthalate structure in the *** predictions unveiled distinctive toxic characteristics of VOCs from each *** example,among the various VOCs produced by the 2#container,straight-chain alkanes like n-hexadecane(544-76-3)were identified as the most toxic *** long-term irradiation,the yield of these toxic VOCs from the 2#container ranged from 0.11 ng/g to 0.79 ng/*** the small mass of a single bottle,the volatilization of VOCs from an individual container would be *** after prolonged exposure to light,the potential health risks associated with inhaling VOCs when opening and drinking bottled water appear manageable.

关键词： Plastic contaminants Volatile organic compounds Drinking water safety Sunlight Ultraviolet

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Engineering versatile Au-based catalysts for solar-to-fuel conversion

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能源化学:英文版 2023年第8期83卷 341-362,I0010页

作者： Chunhua Wang Hongwen Zhang Feili Lai Zhirun Xie Yun Hau ng Bo Weng Xuejiao Wu Yuhe liao Department of Chemistry KU LeuvenCelestijinenlaan 200F3001 LeuvenBelgium cMACS Department of Microbial and Molecular SystemsKU LeuvenCelestijnenlaan 200F3001 LeuvenBelgium School of Energy and Environment City University of Hong Kong83 Tat Chee AvenueKowloonHong Kong 999077China Centre for Sustainable Catalysis and Engineering Faculty of Bioscience EngineeringKU Leuven3001 LeuvenBelgium Guangzhou Institute of Energy Conversion Chinese Academy of SciencesGuangzhou 510640GuangdongChina

Gold(Au) nanostructures(NSs) have been widely employed as cocatalysts to improve the photoactivity of semiconductor materials, while a systematic summary of the engineering approaches of Au NSs to maximize the solar-to-fuel conversion efficiency is still lacking. In this review, the recently developed strategies for elevating the overall photocatalytic performance of Au-based catalysts and the deep physical chemistry mechanisms are highlighted. Firstly, the synthetic approaches of Au NSs are summarized, followed by an elaboration on their multiple functions in improving photoactivity. Afterward, modification strategies of Au NSs used to enhance the photocatalytic efficiency of Au-semiconductor composites,including controlling the Au NSs morphology, size, crystal phase, defect engineering, alloying with different metals, modulating interfacial interaction, and introducing an external field, are summarized and discussed independently. Additionally, advanced characterization techniques that can provide insights into the charge dynamics of the photocatalysts are introduced. Finally, we share our opinion on the challenges and outline potentially promising opportunities and directions for efficient Au-based photocatalysis research moving forward. We sincerely look forward to this review can deliver insightful views to design efficient Au-based photocatalysts and spur certain innovations to other metal-based catalysts.

关键词： Au nanostructures Modification strategies Semiconductor Photocatalysis Solar-to-fuel conversion

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全膝關節置換術後硬膜外嗎啡的鎮痛效果研究

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镜湖医学 2024年第1期24卷 17-19页

作者：冼東鋒吳朝興廖婧吳俊晞吳達星曹麗勤澳門鏡湖醫院麻醉科中国

目的本文對全膝關節置換術後病人硬膜外單次給予嗎啡的鎮痛效果進行了研究。方法研究資料來自澳門鏡湖醫院,2021年4月~2022年8月60例全膝關節置換手術病人隨機分到試驗組(腰硬聯合麻醉:單次蛛網膜下腔注射0.5%布比卡因2-3ml+硬膜外注射... 详细信息

目的本文對全膝關節置換術後病人硬膜外單次給予嗎啡的鎮痛效果進行了研究。方法研究資料來自澳門鏡湖醫院,2021年4月~2022年8月60例全膝關節置換手術病人隨機分到試驗組(腰硬聯合麻醉:單次蛛網膜下腔注射0.5%布比卡因2-3ml+硬膜外注射嗎啡2mg)和對照組(單次蛛網膜下腔注射0.5%布比卡因2~3ml),兩組患者術中均行關節周圍浸潤。記錄患者術後0~6h、6~12h、12~24h、24~36h、36~48h的NRS(numerical rating scale)疼痛評分以及是否發生瘙癢、尿瀦留、噁心嘔吐、呼吸抑制。結果與對照組相比,試驗組術後48小時内NRS評分≧4分發生率較低(20.0%[6/30]vs.46.7%[14/30]P=0.028),試驗組尿瀦留發生率高於對照組(36.7%[11/30]vs.6.7%[2/30]P=0.005)。結論硬膜外小劑量嗎啡可以減少全膝關節置換術後病人中至重度疼痛發生率,但病人術後尿瀦留風險增加。

关键词：硬膜外鎮痛嗎啡全膝關節置換術

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FeCo alloy@N-doped graphitized carbon as an efficient cocatalyst for enhanced photocatalytic H2 evolution by inducing accelerated charge transfer

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Journal of Energy Chemistry 2021年第1期30卷 92-101,I0004页

作者： Sibo Chen Yun Hau ng Jihai liao Qiongzhi Gao siyuan Yang Feng Peng Xinhua Zhong Yueping Fang Shengsen Zhang Key Laboratory for Biobased Materials and Energy of Ministry of Education College of Materials and EnergySouth China Agricultural UniversityGuangzhou 510643GuangdongChina Guangdong Laboratory for Lingnan Modern Agriculture Guangzhou 510643GuangdongChina School of Energy and Environment City University of Hong KongHongkong 999077China Department of Physics South China University of TechnologyGuangzhou 510640GuangdongChina School of Chemistry and Chemical Engineering Guangzhou UniversityGuangzhou 510006GuangdongChina

Cocatalysts play important roles in improving the activity and stability of most *** is of great significance to develop economical,efficient and stable ***,using Na2CoFe(CN)6 complex as precursor,a novel noble-metal-free FeCo@ngC cocatalyst(nano-FeCo alloy@N-doped graphitized carbon) is fabricated by a simple pyrolysis *** with g-C3 N4, the optimal FeCo@ngC/g-C3N4 receives a boosted visible light driven photocatalytic H2 evolution rate of 42.2 μmol h-1, which is even higher than that of 1.0 wt% Pt modified g-C3N4 *** on the results of density functional theory(DFT) calculations and practical experiment measurements,such outstanding photocatalytic performance of FeCo@ngC/g-C3N4 is mainly attributed to two *** is the accelerated charge transfer behavior,induced by a photogene rated electrons secondary transfer performance on the surface of FeCo alloy *** other is related to the adjustment of H adsorption energy(approaching the standard hydrogen electrode potential) by the presence of external ngC thin *** factors play key roles in the H2 evolution *** outstanding performance highlights an enormous potential of developing noble-metal-free bimetallic nano-alloy as inexpensive and efficient cocatalysts for solar applications.

关键词： FeCo alloy nanoparticles Cocatalyst N-doped graphitized carbon g-C3N4 Visible light Hydrogen evolution

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基于P38 MAPK/JNK信号通路研究二甲双胍对脓毒性心肌病的保护作用机制

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中华预防医学杂志 2024年第10期58卷 1567-1572页

作者：李莉廖杨刘志勇中南大学湘雅医院重症医学科国家老年疾病临床医学研究中心(湘雅医院) 长沙

基于丝裂原活化蛋白激酶P38(P38 MAPK)/c-Jun氨基末端激酶(JNK)信号通路探讨二甲双胍对脓毒性心肌病的保护机制。本文为动物实验研究设计, 于2023年1—12月在中南大学湘雅医院完成。采用随机数字表法将48只8周龄雌性 C57BL/6小鼠分为4... 详细信息

基于丝裂原活化蛋白激酶P38(P38 MAPK)/c-Jun氨基末端激酶(JNK)信号通路探讨二甲双胍对脓毒性心肌病的保护机制。本文为动物实验研究设计, 于2023年1—12月在中南大学湘雅医院完成。采用随机数字表法将48只8周龄雌性 C57BL/6小鼠分为4组:A组(对照组)、B组(模型组)、C组(模型+盐酸曲美他嗪)、D组(模型+二甲双胍组), 每组12只。B、C、D组均以LPS(15 mg/kg)腹腔注射构建脓毒性心肌病小鼠模型, 建模24 h后, A组、B组予以腹腔注射等量生理盐水, C组予以20 mg/kg盐酸曲美他嗪灌胃, D组予以腹腔注射二甲双胍200 mg/kg, 均连续干预14 d。采用超声成像系统检测心功能, 采用TUNEL法检测心肌组织细胞凋亡率;采用实时荧光定量聚合酶链反应(RT-qPCR)检测小鼠心肌组织中P38 MAPK/JNK信号通路JNK、P38 MAPK mRNA水平;采用酶联免疫吸附试验(ELISA)法测定各组小鼠血浆肌酸激酶同工酶(CK-MB)、脑利钠肽(BNP)、肿瘤坏死因子α(TNF-α)、白介素6(IL-6)含量;采用蛋白质印迹(Western blot)检测心肌组织中蛋白激酶C Eplison亚型(PKCε)、小窝蛋白-3(Cav-3)的蛋白表达。结果显示, 与A组左心室射血分数(LVEF)(79.51±6.62)%、左室短轴缩短率(FS)(45.66±4.13)、细胞凋亡率(4.34±0.36)%、JNK(0.96±0.06)、P38 MAPK(1.01±0.03)、CK-MB(2.37±0.13)μg/L、BNP(21.36±3.47)ng/L、TNF-α(176.22±19.24)ng/L、IL-6(35.43±3.84)ng/L、PKCε表达(1.98±0.26)、Cav-3表达(1.04±0.03)相比, B、C、D组细胞凋亡率(28.22±4.49、22.45±3.69、15.88±3.27)%、JNK(1.68±0.11、1.32±0.18、1.13±0.14)、P38 MAPK(2.47±0.71、1.77±0.35、1.49±0.05)、CK-MB(16.55±2.16、12.63±1.98、5.27±0.61)μg/L、BNP(48.92±5.67、33.78±4.11、27.55±3.84)ng/L、TNF-α(463.71±24.81、335.71±36.71、214.78±22.53)ng/L、IL-6(78.57±6.36、63.71±5.66、52.47±5.47)ng/L表达均升高, 而LVEF(49.38±5.27、55.47±5.03、62.26±5.14)%、FS(24.36±2.17、30.43±3.29、33.57±2.72)%、PKCε表达(1.33±0.21、1.54±0.23、1.75±0.22)、Cav-3表达(0.47±0.06、0.76±0.05、0.85±0.04)均下调(F=113.020、67.657、219.539、206.222、227.977、88.455、6285.186、135.877、65.924、96.362、17.532、314.419, P<0.05);与B组相比, C、D组细胞凋亡率、JNK、P38 MAPK、CK-MB、BNP、TNF-α、IL-6表达均降低, LVEF、FS、PKCε、Cav-3表达均上调, 且D组优于C组(P<0.05)。综上, 二甲双胍对脓毒性心肌病具有一定的保护作用, 其机制可能与抑制P38 MAPK/JNK信号通路的活化及上调PKCε、Cav-3表达有关。

关键词：丝裂原活化蛋白激酶/c-Jun氨基末端激酶二甲双胍脓毒性心肌病蛋白激酶C Eplison亚型小窝蛋白-3

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药物制剂技术课程教学改革与实施--以丸剂制备技术项目为例

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卫生职业教育 2024年第17期42卷 30-34页

作者：刘娱姗刘丽敏廖启元张强安徽中医药高等专科学校安徽芜湖241000

以“岗课赛证”融通为基础,对药物制剂技术课程进行教学改革,从教学内容、教学模式、教学资源、评价体系等方面探索教学改革的路径。以丸剂制备技术项目为例,从学情分析、教学目标、教学过程、课程思政等方面阐述项目教学实施过程。通... 详细信息

以“岗课赛证”融通为基础,对药物制剂技术课程进行教学改革,从教学内容、教学模式、教学资源、评价体系等方面探索教学改革的路径。以丸剂制备技术项目为例,从学情分析、教学目标、教学过程、课程思政等方面阐述项目教学实施过程。通过教学改革,提升了教学质量,改善了教学效果,为其他相关课程教学改革提供参考。

关键词：药物制剂技术岗课赛证丸剂制备技术

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新型SHP2衍生物NC-55-122在大鼠体内的药动学研究及其体内代谢产物分析

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药学学报 2024年第5期59卷 1422-1429页

作者：张莹崔杏汤磊廖伟科贵州医科大学药学院贵州贵阳550004 贵州省化学合成药物研发利用工程技术研究中心贵州贵阳550004

考察新型含Src同源2结构域蛋白酪氨酸磷酸酶(SHP2)蛋白抑制剂三唑并喹啉酮衍生物NC-55-122在大鼠体内的药代动力学特征,并在此基础上对化合物NC-55-122在大鼠体内的代谢产物进行分析。首先将大鼠随机分组,分别灌胃和静脉给予化合物NC-55... 详细信息

考察新型含Src同源2结构域蛋白酪氨酸磷酸酶(SHP2)蛋白抑制剂三唑并喹啉酮衍生物NC-55-122在大鼠体内的药代动力学特征,并在此基础上对化合物NC-55-122在大鼠体内的代谢产物进行分析。首先将大鼠随机分组,分别灌胃和静脉给予化合物NC-55-122,采集不同时间点的血样,以卡马西平为内标,采用超高效液相色谱-串联质谱法(UPLC-MS/MS)测定大鼠体内NC-55-122的浓度,并进行方法学的验证,用DAS 2.0软件计算主要的药代动力学参数,采用Graph Pad Prism 8.0.1软件绘制血药浓度-时间曲线;并同时建立超高液相色谱-四极杆-飞行时间质谱法(UPLC-Q-TOF/MS)对血浆样品进行分析,并运用UNIFI代谢产物预测软件分析经大鼠灌胃和静脉给药后的代谢产物。结果表明,化合物NC-55-122检测质量浓度的线性范围为1~1600 ng·m L^(-1),线性关系良好,在此线性范围内进行基质效应和提取回收率、精密度和准确度以及稳定性的考察,均符合生物分析要求;其次,药动学参数分析表明该化合物的口服生物利用度相对较低,仅为3.09%,但该化合物在体内吸收的速度较慢;最后通过分析离子流图以及结合UNIFI软件共推测出5个可能的代谢产物。本实验建立的检测方法灵敏度高,专属性强、快速、高效,适用于化合物NC-55-122在大鼠体内血药浓度的测定以及代谢产物的分析,为后期抗肿瘤药物NC-55-122的结构修饰以及成药性评价奠定基础。所有动物实验均经贵州医科大学实验动物伦理委员会批准(批准号:2200823)。

关键词：抗肿瘤含Src同源2结构域蛋白酪氨酸磷酸酶药代动力学代谢产物分析

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Fe_(2)TiO_(5)nanochains as anode for high-performance lithium-ion capacitor

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Rare Metals 2021年第9期40卷 2424-2431页

作者： Rong Kang Wang-Qin Zhu Sheng Li Bo-Bo Zou liao-liao Wang Guo-Chun Li Xian-Hu Liu Dickon H.L.ng Jing-Xia Qiu Yan Zhao Fen Qiao Jia-Biao Lian Key Laboratory of Zhenjiang Institute for Energy ResearchJiangsu UniversityZhenjiang 212013China Key Laboratory of Materials Processing and Mold(Zhengzhou University) Ministry of EducationZhengzhou UniversityZhengzhou 450002China Department of Physics The Chinese University of Hong KongShatinHong Kong 999077China

The unique crystal structure and multiple redox couples of iron titanate(Fe_(2)TiO_(5)) provide it a high theoretical capacity and good cycling stability when used as an electrode. In this study, the electrospinning method is employed to synthesize one-dimensional(1 D) Fe_(2)TiO_(5) nanochains. The as-prepared Fe_(2)TiO_(5) nanochains exhibited superior specific capacity(500 mAh·g^(-1) at 0.10 A·g^(-1)),excellent rate performance(180 mAh·g^(-1) at 5.00 A·g^(-1)),and good cycling stability(retaining 100% of the initial specific capacity at a current density of 1.00 A·g^(-1) after1000 cycles). The as-assembled Fe_(2)TiO_(5)/SCCB lithiumion capacitor(LIC) also delivered a competitive energy density(137.8 Wh·kg^(-1))andpowerdensity(11,250 W·kg^(-1)). This study proves that the as-fabricated1 D Fe_(2)TiO_(5) nanochains are promising anode materials for high-performance LICs.

关键词： Lithium-ion capacitors High energy/power densities Anode material Fe_(2)TiO_(5)nanochains Electrospinning

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正交试验优选紫归方最佳提取工艺

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辽宁中医杂志 2024年第10期51卷 132-135页

作者：陈晓文廖明娟上海交通大学医学院附属第九人民医院上海200011

目的建立紫归方中紫草及当归的含量测定方法,并优选其提取工艺。方法以高效液相色谱波长切换联合梯度洗脱法同时测定紫归方中阿魏酸和左旋紫草素的含量。以液料比、提取溶剂、提取时间为考察因素,分别以左旋紫草素和阿魏酸含量为评价指... 详细信息

目的建立紫归方中紫草及当归的含量测定方法,并优选其提取工艺。方法以高效液相色谱波长切换联合梯度洗脱法同时测定紫归方中阿魏酸和左旋紫草素的含量。以液料比、提取溶剂、提取时间为考察因素,分别以左旋紫草素和阿魏酸含量为评价指标,采用L9(34)正交实验设计,优选紫草和当归的提取工艺并验证。结果左旋紫草素在5.15~206 ng(R^(2)=0.9997)范围内与吸收度呈良好的线性关系,平均加样回收率为110.5%,RSD为1.1%。阿魏酸在5.13~205.2 ng(R^(2)=0.9999)范围内与吸收度呈良好的线性关系,平均加样回收率为110.5%,RSD为1.1%。最佳提取工艺为:液料比1:35,75%乙醇作为提取溶剂,超声提取40分钟,出膏率约为36.5%。结论优选的工艺和方法简便可行,可用于紫归方中紫草及当归的质量控制和提取。

关键词：高效液相色谱法正交实验紫归方左旋紫草素阿魏酸

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